2025
Structure-function coupling in network connectivity and associations with negative affectivity in a group of transdiagnostic adolescents
Kanel D, Zugman A, Stohr G, Scheinberg B, Cardinale E, Winkler A, Kircanski K, Fox N, Brotman M, Linke J, Pine D. Structure-function coupling in network connectivity and associations with negative affectivity in a group of transdiagnostic adolescents. Journal Of Mood And Anxiety Disorders 2025, 9: 100094. DOI: 10.1016/j.xjmad.2024.100094.Peer-Reviewed Original ResearchStructure-function couplingNegative affectFronto-parietal control networkMeasures of psychopathologyDevelopment of psychopathologyResting-state functional MRIDomain-specific factorsTreatment-seeking youthGroup of adolescentsMultimodal MRI methodsTransdiagnostic groupsFunctional network reorganizationBifactor modelPsychopathologyFunctional MRIFunctional connectivityBrain connectivityStudy of brain connectivityPsychological outcomesFunctional connectivity matricesControl networkNetwork reorganizationAffectAdolescentsAnxiety
2021
Recent advances in understanding neural correlates of anxiety disorders in children and adolescents
Zugman A, Winkler A, Pine D. Recent advances in understanding neural correlates of anxiety disorders in children and adolescents. Current Opinion In Psychiatry 2021, 34: 617-623. PMID: 34475352, PMCID: PMC8490291, DOI: 10.1097/yco.0000000000000743.Peer-Reviewed Original ResearchConceptsAnxiety disordersBrain regionsMedial prefrontal cortexNeural indicesLow-level threatNeural correlatesSmall effect sizesPrefrontal cortexNeural circuitryBrain circuitryCircuitry dysfunctionBrain connectivityCommon psychiatric diagnosesFearEffect sizeMost mental illnessesStria terminalisBed nucleusAnxietyAdolescentsPsychiatric diagnosisMental illnessRecent workDisordersChildren
2020
Ultra-high field imaging reveals increased whole brain connectivity underpins cognitive strategies that attenuate pain
Schulz E, Stankewitz A, Winkler A, Irving S, Witkovský V, Tracey I. Ultra-high field imaging reveals increased whole brain connectivity underpins cognitive strategies that attenuate pain. ELife 2020, 9: e55028. PMID: 32876049, PMCID: PMC7498261, DOI: 10.7554/elife.55028.Peer-Reviewed Original ResearchConceptsPain attenuationBrain connectivityAttenuation of painCognitive strategiesHigher functional connectivityWhole-brain connectivityTonic cold painWhite matter integrityPain processingLower painFunctional imaging dataCold painPainCingulate cortexBrain regionsFunctional connectivityHealthy participantsTrialsCognitive interventionsDiffusion tensorTrial variabilityBrain dataImaging dataParticipants
2016
Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia
Kochunov P, Ganjgahi H, Winkler A, Kelly S, Shukla D, Du X, Jahanshad N, Rowland L, Sampath H, Patel B, O'Donnell P, Xie Z, Paciga S, Schubert C, Chen J, Zhang G, Thompson P, Nichols T, Hong L. Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia. Human Brain Mapping 2016, 37: 4673-4688. PMID: 27477775, PMCID: PMC5118078, DOI: 10.1002/hbm.23336.Peer-Reviewed Original ResearchConceptsAge-related declineWhite matterSchizophrenia patientsFractional anisotropyFA valuesDiagnosis interactionFaster age-related declinePathophysiology of schizophreniaHum Brain MappEffect of diagnosisLower fractional anisotropyPatient-control differencesT Siemens MRI scannerBrain white matterClinical burdenRegional FA valuesPatientsAbnormal rateBrain connectivityTract developmentAdolescent maturationSpecific tractsRegional reductionDiagnosisSchizophrenia
2015
A positive-negative mode of population covariation links brain connectivity, demographics and behavior
Smith S, Nichols T, Vidaurre D, Winkler A, Behrens T, Glasser M, Ugurbil K, Barch D, Van Essen D, Miller K. A positive-negative mode of population covariation links brain connectivity, demographics and behavior. Nature Neuroscience 2015, 18: 1565-1567. PMID: 26414616, PMCID: PMC4625579, DOI: 10.1038/nn.4125.Peer-Reviewed Original Research