2015
New‐Onset Panic, Depression with Suicidal Thoughts, and Somatic Symptoms in a Patient with a History of Lyme Disease
Garakani A, Mitton AG. New‐Onset Panic, Depression with Suicidal Thoughts, and Somatic Symptoms in a Patient with a History of Lyme Disease. Case Reports In Psychiatry 2015, 2015: 457947. PMID: 25922779, PMCID: PMC4397473, DOI: 10.1155/2015/457947.Peer-Reviewed Case Reports and Technical NotesChronic Lyme diseasePanic attacksLyme diseaseDepressive symptomsPhysical symptomsLong-term antibioticsSevere depressive symptomsInpatient psychiatric hospitalizationSubsyndromal depressive symptomsComorbid psychiatric diagnosesChronic physical symptomsBack spasmsLyme titersNeuromuscular complaintsCLD patientsNeuropathic painJoint painTick bitePsychiatric hospitalizationAnxiolytic treatmentPsychiatric symptomsPsychiatric historyPsychiatric diagnosisNeurological disordersSuicidal ideationHeart rate and respiratory response to doxapram in patients with panic disorder
Martinez JM, Garakani A, Aaronson CJ, Gorman JM. Heart rate and respiratory response to doxapram in patients with panic disorder. Psychiatry Research 2015, 227: 32-38. PMID: 25819170, PMCID: PMC4420657, DOI: 10.1016/j.psychres.2015.03.001.Peer-Reviewed Original ResearchConceptsPD patientsLF/HFPanic disorderHealthy controlsAnticipatory anxietyPD subjectsParasympathetic componentRespiratory responsesLF/HF ratioSensation of dyspneaHeart rate variability indicesHigher sympathetic activityInjection of salinePanic statesSympathetic activityRespiratory abnormalitiesBrain stemRespiratory stimulantHeart rateParasympathetic responsePanic attacksPatientsExaggerated fear responsePanic symptomsHF ratio
2007
The effect of doxapram on brain imaging in patients with panic disorder
Garakani A, Buchsbaum MS, Newmark RE, Goodman C, Aaronson CJ, Martinez JM, Torosjan Y, Chu KW, Gorman JM. The effect of doxapram on brain imaging in patients with panic disorder. European Neuropsychopharmacology 2007, 17: 672-686. PMID: 17560768, PMCID: PMC2695988, DOI: 10.1016/j.euroneuro.2007.04.002.Peer-Reviewed Original ResearchConceptsPanic disorder patientsDisorder patientsPlacebo saline solutionEffects of doxapramNormal control subjectsHeart rate increasePositron emission tomographyGreater heart rate increasePlacebo dayControl subjectsRespiratory stimulantCingulate gyrusDoxapramNormal volunteersPatientsPanic patientsPanic attacksPanic disorderDoxapram hydrochlorideSeparate daysEmission tomographyInhibitory centersFunctional imagingAmygdala activityCounterbalanced order