2010
Heart Rate and Blood Pressure Changes During Autonomic Nervous System Challenge in Panic Disorder Patients
Martinez JM, Garakani A, Kaufmann H, Aaronson CJ, Gorman JM. Heart Rate and Blood Pressure Changes During Autonomic Nervous System Challenge in Panic Disorder Patients. Psychosomatic Medicine 2010, 72: 442-449. PMID: 20368476, DOI: 10.1097/psy.0b013e3181d972c2.Peer-Reviewed Original ResearchConceptsLower heart rate variabilityMean diastolic blood pressureHigher heart rateHeart rate variabilityDiastolic blood pressureBlood pressureHealthy controlsHeart ratePanic disorder patientsPD patientsLF/HFOrthostatic challengeSympathovagal balanceDisorder patientsHigher mean diastolic blood pressureGreater cardiac riskIllness severity ratingsLess ill patientsSystolic blood pressureBlood pressure changesSeverity of illnessHigher low-frequency componentsAutonomic nervous systemIll patientsCardiac risk
2008
Effect of medication and psychotherapy on heart rate variability in panic disorder
Garakani A, Martinez JM, Aaronson CJ, Voustianiouk A, Kaufmann H, Gorman JM. Effect of medication and psychotherapy on heart rate variability in panic disorder. Depression And Anxiety 2008, 26: 251-258. PMID: 18839407, DOI: 10.1002/da.20533.Peer-Reviewed Original ResearchConceptsHeart rate variabilityHeart rateRate variabilityLower heart rate variabilitySignificant clinical improvementWeeks of treatmentWeeks of CBTEffects of medicationPanic disorder patientsEffect of treatmentClinical improvementCardiac riskPD patientsCardiovascular diseaseTreatment respondersClinical measuresElevated riskDisorder patientsTreatment phasePatientsSymptom reductionPanic disorderHyperventilation challengeStatistical ManualSignificant decrease