2023
Molecular findings in myeloid neoplasms
Tran T, Siddon A. Molecular findings in myeloid neoplasms. International Journal Of Laboratory Hematology 2023, 45: 442-448. PMID: 37345257, DOI: 10.1111/ijlh.14118.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaMyeloid neoplasmsNext-generation sequencingMyeloproliferative neoplasmsInternational diagnostic guidelinesSomatic gene mutationsHematologic cancersMyeloid leukemiaDiagnostic guidelinesClinical relevanceMyeloid disordersPatient careNeoplasmsCytogenetic findingsMolecular findingsGene mutationsNew molecular technologiesMolecular technologiesMutationsLeukemiaCancerPrognosticationCliniciansFindingsModifier mutations
2022
Automated analysers underestimate atypical basophil count in myeloid neoplasms
Shah HP, Tormey CA, Siddon AJ. Automated analysers underestimate atypical basophil count in myeloid neoplasms. International Journal Of Laboratory Hematology 2022, 44: 831-836. PMID: 35609868, DOI: 10.1111/ijlh.13882.Peer-Reviewed Original ResearchConceptsMyeloid neoplasmsBasophil percentageBasophil countsMyeloproliferative neoplasmsManual differentialMyeloid disordersFlow cytometryTertiary care centerChronic myeloid leukemiaMyeloid neoplasms patientsControl patientsMyelodysplastic diseasesMean ageNeoplasm patientsControl subjectsCare centerMyeloid leukemiaPatientsNeoplasmsAtypical appearanceScatter propertiesMyeloid diseasesBasophilsDisorder diagnosisCytometry
2021
Genetic Landscape of Myeloproliferative Neoplasms with an Emphasis on Molecular Diagnostic Laboratory Testing
Easwar A, Siddon AJ. Genetic Landscape of Myeloproliferative Neoplasms with an Emphasis on Molecular Diagnostic Laboratory Testing. Life 2021, 11: 1158. PMID: 34833034, PMCID: PMC8625510, DOI: 10.3390/life11111158.Peer-Reviewed Original ResearchAdditional mutationsChromatin modificationsSignal transductionDNA methylationPhiladelphia chromosome-negative myeloproliferative neoplasmsJAK-STATConstitutive activationGenetic landscapeDriver eventsMyeloproliferative neoplasmsSomatic mutationsMolecular landscapeMutationsMolecular alterationsHematopoietic stem cell neoplasmsSplicingTransductionGenesMethylationLandscapeSequencing panelTranslocationStem cell neoplasmChronic myeloid leukemiaPathwayClinical and Molecular Approach to Adult-Onset, Neoplastic Monocytosis
Shallis RM, Siddon AJ, Zeidan AM. Clinical and Molecular Approach to Adult-Onset, Neoplastic Monocytosis. Current Hematologic Malignancy Reports 2021, 16: 276-285. PMID: 33890194, DOI: 10.1007/s11899-021-00632-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPersistent monocytosisAppropriate diagnosisMyelomonocytic leukemiaPCM1-JAK2 fusionChronic myelomonocytic leukemiaAcute myeloid leukemiaAcute myelomonocytic leukemiaNegative predictive valuePurpose of ReviewInMyelodysplastic syndromeReactive monocytosisFGFR1 rearrangementAdult onsetMyeloid leukemiaMonocytosisBCR-ABL1Predictive valueASXL1 mutationsMyeloproliferative neoplasmsDiagnostic approachCytometric analysisMarrow tissuesLeukemiaDiagnosisMonocytic differentiationBehind the scenes with basophils: an emerging therapeutic target
Shah H, Eisenbarth S, Tormey CA, Siddon AJ. Behind the scenes with basophils: an emerging therapeutic target. Immunotherapy Advances 2021, 1: ltab008. PMID: 35919744, PMCID: PMC9327101, DOI: 10.1093/immadv/ltab008.Peer-Reviewed Original ResearchChronic myeloid leukemiaImmunoregulatory functionsMyeloproliferative neoplasmsType 2 cytokinesCD4 T cell differentiationDevelopment of immunotherapyNon-malignant diseasesT cell differentiationB cell activationBasophil biologyMalignant disease statesAllergic inflammationInflammatory mediatorsBasophil degranulationPeripheral bloodAllergic responsesIL-4Th2 cellsAberrant immunophenotypeMyeloid leukemiaAdaptive immunityHematological malignanciesMast cellsMyeloid neoplasmsDiagnostic criteria