2024
Structural neural plasticity evoked by rapid-acting antidepressant interventions
Liao C, Dua A, Wojtasiewicz C, Liston C, Kwan A. Structural neural plasticity evoked by rapid-acting antidepressant interventions. Nature Reviews Neuroscience 2024, 1-14. PMID: 39558048, DOI: 10.1038/s41583-024-00876-0.Peer-Reviewed Original ResearchAntidepressant interventionsStructural neural plasticityNeural plasticityPsychoactive drugsRapid-acting antidepressant drugsAction of psychoactive drugsRepetitive transcranial magnetic stimulationExcitatory synaptic functionAntidepressant effectsPrefrontal cortexDepressive disorderNon-invasive neurostimulationAntidepressant drugsMood disordersNeurobiological actionsTranscranial magnetic stimulationElectroconvulsive therapyPsychedelic drugsCortical pyramidal neuronsMechanisms of plasticityLongitudinal effectsGrowth of dendritic spinesPyramidal neuronsStructural plasticitySynaptic function
2020
Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines
Ali F, Gerhard DM, Sweasy K, Pothula S, Pittenger C, Duman RS, Kwan AC. Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines. Nature Communications 2020, 11: 72. PMID: 31911591, PMCID: PMC6946708, DOI: 10.1038/s41467-019-13809-8.Peer-Reviewed Original ResearchConceptsDendritic spinesN-methyl-D-aspartate receptor antagonistPrefrontal cortexPrefrontal dendritic spinesApical dendritic spinesSomatostatin-expressing (SST) interneuronsCortico-cortical connectivityElevated calcium levelsMedial prefrontal cortexKetamine actsAntidepressant effectsGABAergic neuronsSST interneuronsKetamine actionPyramidal neuronsNMDAR antagonismReceptor antagonistSubanesthetic ketamineSubanesthetic doseDendritic inhibitionAwake miceCortical interneuronsSynaptic inputsCalcium levelsCalcium transients