2004
Restoration of tumor specific human leukocyte antigens class I-restricted cytotoxicity by dendritic cell stimulation of tumor infiltrating lymphocytes in patients with advanced ovarian cancer
SANTIN A, BELLONE S, PALMIERI M, BOSSINI B, CANE S, BIGNOTTI E, ROMAN J, CANNON M, PECORELLI S. Restoration of tumor specific human leukocyte antigens class I-restricted cytotoxicity by dendritic cell stimulation of tumor infiltrating lymphocytes in patients with advanced ovarian cancer. International Journal Of Gynecological Cancer 2004, 14: 64-75. DOI: 10.1111/ijgc-00009577-200401000-00008.Peer-Reviewed Original ResearchCD8+ T cellsAdvanced ovarian cancerPeripheral blood lymphocytesAdvanced ovarian cancer patientsTumor-infiltrating lymphocytesTumor infiltrationOvarian cancer patientsCytotoxic T lymphocytesDendritic cell stimulationOvarian cancerT cellsLymphoblastoid cell linesInfiltrating lymphocytesDendritic cellsKilling of autologous tumor cellsTumor-specific cytotoxic T lymphocytesTumor-specific T-cell responsesAnti-HLA class I mAbCD8+ T cell populationsCancer patientsAutologous ovarian cancer cellsAutologous tumor target cellsCD8+ CTL responsesLevels of CD56 expressionTumor antigen-loaded DC
2003
Restoration of Tumor-Specific HLA Class I Restricted Cytotoxicity in Tumor Infiltrating Lymphocytes of Advanced Breast Cancer Patients by in vitro Stimulation with Tumor Antigen-Pulsed Autologous Dendritic Cells
Kass R, Bellone S, Palmieri M, Canè S, Bignotti E, Henry-Tillman R, Hutchins L, Cannon MJ, Klimberg S, Santin AD. Restoration of Tumor-Specific HLA Class I Restricted Cytotoxicity in Tumor Infiltrating Lymphocytes of Advanced Breast Cancer Patients by in vitro Stimulation with Tumor Antigen-Pulsed Autologous Dendritic Cells. Breast Cancer Research And Treatment 2003, 80: 275-285. PMID: 14503800, DOI: 10.1023/a:1024938215782.Peer-Reviewed Original ResearchConceptsPeripheral blood lymphocytesCytotoxic T lymphocytesTumor-specific cytotoxic T lymphocytesTumor-specific lytic activityAdvanced breast cancer patientsBreast cancer patientsCancer patientsInterleukin-2Breast cancerAnti-HLA class I mAbsNK-sensitive cell line K562Tumor-specific T-cell responsesChemotherapy-resistant breast cancerAdoptive T-cell immunotherapyAutologous dendritic cellsTh1 cytokine biasAutologous tumor cellsResistant breast cancerT cell responsesTumor-Infiltrating LymphocytesDendritic cell stimulationT cell populationsT-cell immunotherapyPotential of tumorHLA class I