2024
First Results of the Primary Outcome of a Phase II Prospective Clinical Trial to Assess the Feasibility of Preoperative Radiation Boost in Breast Cancer Patients
Yehia Z, Sherwani Z, Chakraborty M, Ohri N, Grann A, Eladoumikdachi F, Kowzun M, Kumar S, Potdevin L, Blackwood M, Toppmeyer D, Haffty B. First Results of the Primary Outcome of a Phase II Prospective Clinical Trial to Assess the Feasibility of Preoperative Radiation Boost in Breast Cancer Patients. International Journal Of Radiation Oncology • Biology • Physics 2024 PMID: 39241809, DOI: 10.1016/j.ijrobp.2024.08.043.Peer-Reviewed Original ResearchWhole breast RTBreast-conserving therapyBoost volumePostoperative RTRT boostPrimary outcomeBreast RTRadiation therapyCosmetic outcomeWound complicationsBreast cancerClinically node-negative breast cancerPhase II prospective clinical trialMedian clinical tumor sizePostoperative whole-breast RTProspective phase 2 trialIncidence of grade 3Node-negative breast cancerProspective phase 2 studyRate of postoperative wound complicationsDuctal carcinoma in situClinical tumor sizeCarcinoma in situPhase 2 studyPhase 2 trialPTCOG international survey of practice patterns and trends in utilization of proton therapy for breast cancer
Choi J, Hardy-Abeloos C, Lozano A, Hanlon A, Vargas C, Maduro J, Bradley J, Offersen B, Haffty B, Pankuch M, Amos R, Kim N, MacDonald S, Kirova Y, Mutter R. PTCOG international survey of practice patterns and trends in utilization of proton therapy for breast cancer. Clinical And Translational Radiation Oncology 2024, 48: 100847. PMID: 39280125, PMCID: PMC11399555, DOI: 10.1016/j.ctro.2024.100847.Peer-Reviewed Original ResearchProton beam therapyBreast cancer patientsParticle Therapy Co-Operative GroupPatient selection methodsBreast cancerCancer patientsTreat breast cancer patientsRegional nodal irradiationFisher's exact testSurvey of practice patternsModerate hypofractionationNodal irradiationRadiation oncologistsBeam therapyPBT patientsProton therapyExact testU.S. centersDescriptive statisticsEuropean centersPractice patternsPatientsResponding centersBreastAsian centersWhy Basic Science Education Matters in Radiation Oncology.
Wallner P, Steinberg M, Burmeister J, Curran W, Das P, Davis B, Haffty B, Marples B, Zietman A. Why Basic Science Education Matters in Radiation Oncology. American Journal Of Clinical Oncology 2024 PMID: 38948937, DOI: 10.1097/coc.0000000000001130.Peer-Reviewed Original ResearchRadiation therapy for triple-negative breast cancer: from molecular insights to clinical perspectives
Kim J, Fahmy V, Haffty B. Radiation therapy for triple-negative breast cancer: from molecular insights to clinical perspectives. Expert Review Of Anticancer Therapy 2024, 24: 211-217. PMID: 38502143, DOI: 10.1080/14737140.2024.2333320.Peer-Reviewed Original ResearchTriple-negative breast cancerPoly (ADP-ribose) polymeraseLocoregional controlRadiation therapyBreast cancerImpact of post-mastectomy radiation therapyPost-mastectomy radiation therapyEffects of radiotherapySynergistic effects of radiotherapyPersonalized treatment approachesImproved survival ratesIntegration of radiomicsImmunotherapy combinationsBRCA1/2 mutationsRadiotherapy responseOvercome radioresistanceTargeted radiosensitizationImprove patient outcomesRadiosensitizing strategiesNovel radiosensitizersTarget biological pathwaysTreatment strategiesTreatment outcomesMolecular profilingRadiotherapyReply to G.B. Mann et al and S. Sorscher
Jagsi R, Griffith K, Harris E, Wright J, Recht A, Taghian A, Lee L, Moran M, Small W, Johnstone C, Rahimi A, Freedman G, Muzaffar M, Haffty B, Horst K, Powell S, Sharp J, Sabel M, Schott A, El-Tamer M. Reply to G.B. Mann et al and S. Sorscher. Journal Of Clinical Oncology 2024, 42: 1998-2000. PMID: 38489573, DOI: 10.1200/jco.24.00224.Peer-Reviewed Original ResearchThe Present and Future of Postmastectomy Radiation
Ohri N, George M, Omene C, Haffty B. The Present and Future of Postmastectomy Radiation. International Journal Of Radiation Oncology • Biology • Physics 2024, 118: 466-467. PMID: 38220259, DOI: 10.1016/j.ijrobp.2023.10.002.Peer-Reviewed Original Research
2023
Omission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA
Jagsi R, Griffith K, Harris E, Wright J, Recht A, Taghian A, Lee L, Moran M, Small W, Johnstone C, Rahimi A, Freedman G, Muzaffar M, Haffty B, Horst K, Powell S, Sharp J, Sabel M, Schott A, El-Tamer M. Omission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA. Journal Of Clinical Oncology 2023, 42: 390-398. PMID: 38060195, DOI: 10.1200/jco.23.02270.Peer-Reviewed Original ResearchBreast-conserving surgeryIpsilateral breast eventsEndocrine therapyPostmenopausal patientsBreast cancerCrude rateLower riskBreast cancer-specific survival ratesUnifocal invasive breast cancersYears of ETCancer-specific survival ratesStage I breast cancerHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Omission of radiotherapyYounger postmenopausal patientsPatients age 50Primary end pointBreast conserving surgeryGrowth factor receptor 2I breast cancerInvasive breast cancerRecurrence 5 yearsPatients age 65Single-arm trial
2010
Poly(ADP-ribose) polymerase-1 (PARP-1) expression in patients treated with breast-conserving surgery and radiation therapy (BCS+RT).
Goswami J, Goyal S, Wu H, Moran M, Haffty B. Poly(ADP-ribose) polymerase-1 (PARP-1) expression in patients treated with breast-conserving surgery and radiation therapy (BCS+RT). Journal Of Clinical Oncology 2010, 28: 582-582. DOI: 10.1200/jco.2010.28.15_suppl.582.Peer-Reviewed Original Research