2024
CD23+IgG1+ memory B cells are poised to switch to pathogenic IgE production in food allergy
Ota M, Hoehn K, Fernandes-Braga W, Ota T, Aranda C, Friedman S, Miranda-Waldetario M, Redes J, Suprun M, Grishina G, Sampson H, Malbari A, Kleinstein S, Sicherer S, Curotto de Lafaille M. CD23+IgG1+ memory B cells are poised to switch to pathogenic IgE production in food allergy. Science Translational Medicine 2024, 16: eadi0673. PMID: 38324641, PMCID: PMC11008013, DOI: 10.1126/scitranslmed.adi0673.Peer-Reviewed Original ResearchMeSH KeywordsAllergensChildFood HypersensitivityHumansImmunoglobulin EImmunoglobulin GMemory B CellsPeanut HypersensitivityConceptsMemory B cellsB cellsIgE-producing cellsPeanut allergySerum peanut-specific IgEFood allergyInterleukin-4 (IL-4)-B cell memoryPeanut-specific IgEAllergen-specific immunoglobulin EHigh-affinity B cellsPersistent IgE responsesConcentration of IgESingle-cell RNA sequencing experimentsMemory populationRNA sequencing experimentsIgE productionImmune responseImmunoglobulin ECirculating concentrationsIgE responseAllergySequencing experimentsAra h 2Long-term persistence
2021
Elevated N-Linked Glycosylation of IgG V Regions in Myasthenia Gravis Disease Subtypes.
Mandel-Brehm C, Fichtner ML, Jiang R, Winton VJ, Vazquez SE, Pham MC, Hoehn KB, Kelleher NL, Nowak RJ, Kleinstein SH, Wilson MR, DeRisi JL, O'Connor KC. Elevated N-Linked Glycosylation of IgG V Regions in Myasthenia Gravis Disease Subtypes. The Journal Of Immunology 2021, 207: 2005-2014. PMID: 34544801, PMCID: PMC8492536, DOI: 10.4049/jimmunol.2100225.Peer-Reviewed Original ResearchConceptsMyasthenia gravisB-cell-mediated autoimmune diseasesBCR repertoireCell-mediated autoimmune diseaseTotal BCR repertoireTotal circulating IgGSubset of patientsB cell repertoireElevated NGene segment usageMG subtypesAutoimmune disordersAutoimmune diseasesHealthy donorsCell repertoireDisease subtypesDistinct subtypesReceptor repertoireAdaptive immune receptor repertoiresV regionsAutoantigen bindingPatientsSegment usageSubtypesImmune receptor repertoires