Featured Publications
Chest pain and coronary endothelial dysfunction after recovery from COVID‐19: A case series
Shah SM, Odanovic N, Kunnirickal S, Feher A, Pfau SE, Spatz ES. Chest pain and coronary endothelial dysfunction after recovery from COVID‐19: A case series. Clinical Case Reports 2022, 10: e05612. PMID: 35425611, PMCID: PMC8991764, DOI: 10.1002/ccr3.5612.Peer-Reviewed Case Reports and Technical NotesThe Challenge of Myocardial Bridging
Shah S, Quesada O, Henry T. The Challenge of Myocardial Bridging. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100545. PMID: 39129805, PMCID: PMC11308591, DOI: 10.1016/j.jscai.2022.100545.Commentaries, Editorials and LettersComprehensive Management of ANOCA, Part 1—Definition, Patient Population, and Diagnosis JACC State-of-the-Art Review
Samuels B, Shah S, Widmer R, Kobayashi Y, Miner S, Taqueti V, Jeremias A, Albadri A, Blair J, Kearney K, Wei J, Park K, El-Farra A, Holoshitz N, Janaszek K, Kesarwani M, Lerman A, Prasad M, Quesada O, Reynolds H, Savage M, Smilowitz N, Sutton N, Sweeny J, Toleva O, Henry T, Moses J, Fearon W, Tremmel J, Network M. Comprehensive Management of ANOCA, Part 1—Definition, Patient Population, and Diagnosis JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2023, 82: 1245-1263. PMID: 37704315, DOI: 10.1016/j.jacc.2023.06.043.Peer-Reviewed Original ResearchConceptsCoronary function testingMyocardial bridgingCoronary angiographyMultiple medical providersNonobstructive coronary arteriesCoronary microvascular dysfunctionDiagnostic coronary angiographyIschemic heart diseaseInvasive coronary angiographyCoronary flow reserveCardiac catheterization laboratoryCoronary abnormalitiesCoronary vasospasmEpicardial spasmMicrocirculatory resistanceEndothelial dysfunctionMicrovascular dysfunctionHemodynamic assessmentProvocative testingCoronary arteryFunction testingPatient populationHeart diseaseJACC StateFlow reserveComprehensive Management of ANOCA, Part 2—Program Development, Treatment, and Research Initiatives JACC State-of-the-Art Review
Smilowitz N, Prasad M, Widmer R, Toleva O, Quesada O, Sutton N, Lerman A, Reynolds H, Kesarwani M, Savage M, Sweeny J, Janaszek K, El-Farra A, Holoshitz N, Park K, Albadri A, Blair J, Jeremias A, Kearney K, Kobayashi Y, Miner S, Samuels B, Shah S, Taqueti V, Wei J, Fearon W, Moses J, Henry T, Tremmel J, Network M. Comprehensive Management of ANOCA, Part 2—Program Development, Treatment, and Research Initiatives JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2023, 82: 1264-1279. PMID: 37704316, DOI: 10.1016/j.jacc.2023.06.044.Peer-Reviewed Original ResearchConceptsCoronary function testingFunction testingFuture large-scale clinical trialsLarge-scale clinical trialsNonobstructive coronary arteriesStandardized symptom assessmentMultidisciplinary care teamTreatment of anginaIndividual patient needsQuality of lifeAngina burdenTherapeutic optionsCoronary arterySymptom assessmentClinical trialsCare teamTitrate therapyPatient needsANOCAComprehensive managementTreatmentComprehensive programAnginaPatientsArteryMultimodality Evaluation of Spontaneous Coronary Artery Dissection in a Patient With Connective Tissue Disease: A Case Report
Shah T, Shah N, Baldassarre L, Freed L, Mojibian H, Shah S. Multimodality Evaluation of Spontaneous Coronary Artery Dissection in a Patient With Connective Tissue Disease: A Case Report. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101125. PMID: 39129904, PMCID: PMC11308843, DOI: 10.1016/j.jscai.2023.101125.Peer-Reviewed Case Reports and Technical NotesIllness Perception and the Impact of a Definitive Diagnosis on Women With Ischemia and No Obstructive Coronary Artery Disease: A Qualitative Study.
Tseng L, Göç N, Schwann A, Cherlin E, Kunnirickal S, Odanovic N, Curry L, Shah S, Spatz E. Illness Perception and the Impact of a Definitive Diagnosis on Women With Ischemia and No Obstructive Coronary Artery Disease: A Qualitative Study. Circulation Cardiovascular Quality And Outcomes 2023, 16: 521-529. PMID: 37476997, DOI: 10.1161/circoutcomes.122.009834.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary function testingCoronary artery diseaseInvasive coronary angiographyArtery diseaseCoronary angiographyFunction testingDefinitive diagnosisYale-New Haven HospitalNon-Hispanic blacksMore patient-centered careNew Haven HospitalPatient-centered careStructured telephone interviewQuality of lifeHealth care experiencesNon-Hispanic whitesGroup of womenCoronary functionIllness perceptionsMean ageINOCAUncertain causeMultidisciplinary teamPatient careDetermining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry
Shah S, Tremmel J, Henry T, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Samady H, Samuels B, Lerman A, Moses J, Pietras C, Zhang Z, Tirziu D, Parise H, Cristea E, Chamié D, Grubman D, Henrici K, Matmusaeva E, Latif N, Cigarroa N, Lansky A. Determining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102046. PMID: 39132594, PMCID: PMC11308755, DOI: 10.1016/j.jscai.2024.102046.Peer-Reviewed Original ResearchCoronary function testingObstructive coronary artery diseaseCoronary artery diseaseNonobstructive coronary arteriesLong-term outcomesFollow-upVasomotor disordersEnd pointsComposite of cardiovascular deathCoronary arteryLong-term follow-upCoronary microvascular dysfunctionDiagnostic coronary angiographyCardiovascular adverse eventsAdverse cardiovascular eventsCoronary vasomotor disordersOptical coherence tomographySymptomatic myocardial bridgingShort-term end pointsAtherosclerotic plaque burdenIschemic heart diseaseLong-term end pointsINOCA patientsAcetylcholine provocationPatient-reported outcome measuresEvaluating Ischemic Heart Disease in Women: Focus on Angina With Nonobstructive Coronary Arteries (ANOCA)
Maayah M, Latif N, Vijay A, Gallegos C, Cigarroa N, Martinez E, Mazure C, Miller E, Spatz E, Shah S. Evaluating Ischemic Heart Disease in Women: Focus on Angina With Nonobstructive Coronary Arteries (ANOCA). Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 102195. DOI: 10.1016/j.jscai.2024.102195.Peer-Reviewed Original ResearchIschemic heart diseaseNonobstructive coronary arteriesCoronary artery diseaseArtery diseaseObstructive coronary artery diseaseCoronary arteryLong-term cardiovascular prognosisHeart diseaseSuspected ischemic heart diseaseAtherosclerotic coronary artery diseaseCoronary vasomotor disordersPretest probability of diseasePragmatic diagnostic algorithmExpert consensus documentEvaluating ischemic heart diseaseImpact quality of lifeQuality of lifeSymptomatic patientsPretest probabilityANOCACardiovascular prognosisVasomotor disordersDiagnostic evaluationPersistent symptomsDiagnostic strategies
2024
The Path to a Match for Interventional Cardiology Fellowship: A Major SCAI Initiative
Douglas E. Drachman, Tayo Addo, Robert J. Applegate, Robert C. Bartel, Anna E. Bortnick, Francesca M. Dea, Tarek Helmy, Timothy D. Henry, Adnan Khalif, Ajay J. Kirtane, Michael Levy, Michael J. Lim, Ehtisham Mahmud, Nino Mihatov, Sahil A. Parikh, Laura Porter, Abhiram Prasad, Sunil V. Rao, Louai Razzouk, Samit Shah, Adhir Shroff, Jacqueline E. Tamis-Holland, Poonam Velagapudi, Fredrick G. Welt, J. Dawn Abbott, The Path to a Match for Interventional Cardiology Fellowship: A Major SCAI Initiative, Journal of the Society for Cardiovascular Angiography & Interventions, Volume 3, Issue 7, 2024, 101980, ISSN 2772-9303Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsFinding the Optimal Strategy for Nonculprit Revascularization in Acute Myocardial Infarction: The Role of Angiography-Derived Physiology
Odanovic N, Parikh R, Shah S. Finding the Optimal Strategy for Nonculprit Revascularization in Acute Myocardial Infarction: The Role of Angiography-Derived Physiology. Circulation Cardiovascular Interventions 2024, 17: e014129. PMID: 38771908, DOI: 10.1161/circinterventions.124.014129.Commentaries, Editorials and LettersClinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach.
Regan C, Scierka L, Dardik A, Tonnessen B, Iyad Ochoa Chaar C, Ionescu C, Aboian E, Cardella J, Nassiri N, Guzman R, Attaran R, Nagpal S, Shah S, Smolderen K, Mena-Hurtado C. Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach. Vascular 2024, 17085381241246318. PMID: 38669051, DOI: 10.1177/17085381241246318.Peer-Reviewed Original ResearchDual antiplatelet therapyPeripheral arterial diseaseCYP2C19 testingCYP2C19 mutationsHeterogeneity of treatment effectsPeripheral vascular interventionsConsensus statementKnowledge questionsAntiplatelet therapyGenetic testingVascular surgeryAcademic health systemBarriers to implementationInterquartile rangeCYP2C19 genotype testingVascular diseaseInterventional cardiologyModified Delphi methodPatient's metabolic statusManagement of patientsCritical limb ischemiaPerceived barriersPeripheral vascular diseaseArterial vascular diseaseClinician perspectivesReal-World Experience and Outcomes With Percutaneous Coronary Intervention for Protected Versus Unprotected Left Main Coronary Artery Disease: Insights from the Veteran Affairs Clinical Assessment Reporting and Tracking Program
Gonzalez P, Hebbe A, Hussain Y, Khera R, Banerjee S, Plomondon M, Waldo S, Pfau S, Curtis J, Shah S. Real-World Experience and Outcomes With Percutaneous Coronary Intervention for Protected Versus Unprotected Left Main Coronary Artery Disease: Insights from the Veteran Affairs Clinical Assessment Reporting and Tracking Program. The American Journal Of Cardiology 2024, 222: 39-50. PMID: 38677666, DOI: 10.1016/j.amjcard.2024.04.039.Peer-Reviewed Original ResearchULM percutaneous coronary interventionPercutaneous coronary interventionPropensity-matched cohortMyocardial infarctionCoronary interventionAll-cause mortalityTracking programUS clinical practiceOne-year MACEOne-year outcomesIncidence of rehospitalizationAdverse cardiovascular eventsUnprotected left main coronary artery diseaseAcute coronary syndromeCoronary artery diseaseRates of MIMechanical circulatory supportLeft main percutaneous coronary interventionPCI patientsUrgent revascularizationPractice patternsCart programLeft main bifurcationPrimary outcomeMatched cohortCardiovascular Disorders Related to Substance Use
The ASAM principles of addiction medicine. Shahu, A. Pfau, S. Shah SM. Publisher: Wolters Kluwer 2025 Seventh edition.Chapters
2023
Coronary Microvascular Dysfunction
Sandoval Y, Cigarroa J, Dangas G, Lansky A, Naidu S, Rao S, Seto A, Shah S, Shroff A, Toleva O, Tremmel J, Riley R, Henry T, Consortium S, Baumgard C, Bijoux I, Cavaliere L, Culbertson C, Deible R, El-Sabban M, Jackson J, Jackson M, Kalich B, Long V, Newell A, Perkins D, Ramakrishnan K, Russell K, Sharma V, West N, Whalen-Morton C, Underwood P, Winterfeldt K, Wojcik C, Zizzo S. Coronary Microvascular Dysfunction. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 3: 101230. PMID: 39131786, PMCID: PMC11307378, DOI: 10.1016/j.jscai.2023.101230.Peer-Reviewed Original ResearchAntiplatelet Strategies Following PCI: A Review of Trials Informing Current and Future Therapies
Thomas A, Gitto M, Shah S, Saito Y, Tirziu D, Chieffo A, Stefanini G, Lansky A. Antiplatelet Strategies Following PCI: A Review of Trials Informing Current and Future Therapies. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100607. PMID: 39130709, PMCID: PMC11307978, DOI: 10.1016/j.jscai.2023.100607.Peer-Reviewed Original ResearchDual antiplatelet therapyAntiplatelet regimensPatient-specific risk profileShorter DAPT durationDuration of therapyPercutaneous coronary interventionDAPT strategyIschemic riskAntiplatelet therapyDAPT durationAntiplatelet strategiesCoronary interventionOngoing trialsMajor trialsRecent trialsPractice guidelinesFuture therapiesRisk profileTherapyStent technologyTrialsRegimensNumber of trialsSignificant reductionSignificant changes
2022
Use of a Novel Catheter, the MOT-C, for Selective Angiography of the Internal Mammary Artery From Ipsilateral Radial Access.
Kunnirickal S, Pfau S, Moran E, Shah S. Use of a Novel Catheter, the MOT-C, for Selective Angiography of the Internal Mammary Artery From Ipsilateral Radial Access. Journal Of Invasive Cardiology 2022, 34: e408-e411. PMID: 35394451, DOI: 10.25270/jic/21.00233.Peer-Reviewed Original ResearchConceptsBypass angiographyInternal mammary arteryContrast volumeFemoral accessRadial accessMammary arteryNovel catheterIpsilateral radial accessLower contrast useCatheter-related complicationsSignificant differencesIMA graftsArtery catheterDiagnostic angiographySelective angiographyDiagnostic angiogramContrast useAngiographyCatheterArteryMinimal manipulationThe 2021 AHA/ACC Guideline for the Evaluation and Diagnosis of Chest Pain: An Interventionalist’s Viewpoint
Riley R, Batchelor W, Goldstein J, Al-Lamee R, Shah S, Tremmel J, Jaffer F, Henry T. The 2021 AHA/ACC Guideline for the Evaluation and Diagnosis of Chest Pain: An Interventionalist’s Viewpoint. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100305. PMID: 39131964, PMCID: PMC11308083, DOI: 10.1016/j.jscai.2022.100305.Commentaries, Editorials and Letters
2020
The Foundational Role of Cardiovascular Imaging in the Characterization of Mental Stress–Induced Myocardial Ischemia in Patients with Coronary Artery Disease
Meadows JL, Shah S, Burg MM, Pfau S, Soufer R. The Foundational Role of Cardiovascular Imaging in the Characterization of Mental Stress–Induced Myocardial Ischemia in Patients with Coronary Artery Disease. Current Cardiology Reports 2020, 22: 162. PMID: 33037938, DOI: 10.1007/s11886-020-01407-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCoronary artery diseaseArtery diseaseMyocardial ischemiaMental Stress–Induced Myocardial IschemiaNon-obstructive coronary artery diseaseStable coronary artery diseaseHalf of patientsEpicardial coronary stenosisMental stress testingMyocardial oxygen demandUnderstanding of pathophysiologyCoronary macroAnginal symptomsCardiac eventsAdverse prognosisEarly mortalityIschemic phenomenaCoronary perfusionCoronary stenosisCoronary microvasculatureInvasive studiesClinical careMyocardial perfusionStress-mediated changesCardiac responseEffects of Psychological Stress on Vascular Physiology: Beyond the Current Imaging Signal
Shah SM, Meadows JL, Burg MM, Pfau S, Soufer R. Effects of Psychological Stress on Vascular Physiology: Beyond the Current Imaging Signal. Current Cardiology Reports 2020, 22: 156. PMID: 33037500, DOI: 10.1007/s11886-020-01406-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPsychological stressCardiovascular diseaseMental stress-induced myocardial ischemiaStress-induced myocardial ischemiaMental stressVascular smooth muscleMental stress effectsVascular systemCardiovascular imaging modalitiesEntire vascular systemCardiovascular manifestationsVascular effectsMicrovascular resistanceMicrovascular responsesVascular changesVascular mechanismsVascular responsesCardiovascular responsesMyocardial ischemiaLong-term consequencesSmooth muscleMicrovascular compartmentTherapeutic interventionsReviewThis reviewStandardized psychological assessmentsImpact of the COVID‐19 pandemic on interventional cardiology training in the United States
Shah S, Castro‐Dominguez Y, Gupta T, Attaran R, Byrum GV, Taleb A, Pettyjohn A, Bartel RC, Szerlip M, Henry TD, Mahmud E, Applegate RJ. Impact of the COVID‐19 pandemic on interventional cardiology training in the United States. Catheterization And Cardiovascular Interventions 2020, 96: 997-1005. PMID: 32767717, PMCID: PMC7436398, DOI: 10.1002/ccd.29198.Peer-Reviewed Original Research