2024
Reaching for 90:90:90 in Correctional Facilities in South Africa and Zambia: Virtual Cross-Section of Coverage of HIV Testing and Antiretroviral Therapy During Universal Test and Treat Implementation
Hoffmann C, Herce M, Chimoyi L, Smith H, Tlali M, Olivier C, Topp S, Muyoyeta M, Reid S, Hausler H, Charalambous S, Fielding K. Reaching for 90:90:90 in Correctional Facilities in South Africa and Zambia: Virtual Cross-Section of Coverage of HIV Testing and Antiretroviral Therapy During Universal Test and Treat Implementation. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2024, 96: 465-471. PMID: 38985444, DOI: 10.1097/qai.0000000000003456.Peer-Reviewed Original ResearchHIV testingCross-sectional analysisAntiretroviral therapyCoverage of HIV testingHIV statusHIV testing coverageUniversal testingHIV epidemic controlTreatment dataCohort-based studyAntiretroviral therapy initiationRoutine dataUTT implementationBackground PeopleCorrectional facilitiesCensus listsZambian sitesHIVSouth AfricaSouth African sitesEpidemic controlUTTCorrectional settingsTherapyFacilitiesLung outcomes and related risk factors in patients after SARS-CoV-2 infection: a hospitalised single-centre cohort from Johannesburg, South Africa
Glover N, Ivanova O, Sathar F, Riess F, Shambhu R, Mekota A, Zurba L, Menezes C, van Blydenstein S, Kalla I, Hoelscher M, Saathoff E, Charalambous S, Rachow A. Lung outcomes and related risk factors in patients after SARS-CoV-2 infection: a hospitalised single-centre cohort from Johannesburg, South Africa. EClinicalMedicine 2024, 71: 102588. PMID: 38623400, PMCID: PMC11016864, DOI: 10.1016/j.eclinm.2024.102588.Peer-Reviewed Original ResearchSt George's Respiratory QuestionnaireBody mass indexWorld Health OrganizationRisk factorsChest CTAssessed body mass indexSARS-CoV-2 infectionCOVID-19 severityTB diseaseGeorge's Respiratory QuestionnaireMedian 6MWT distanceChris Hani Baragwanath Academic HospitalSt George's Respiratory Questionnaire total scoreQuality of lifeGt;35 kg/m<sup>2</sup>High-resolution chest CTObservational cohort studySingle-centre cohortPost-SARS-CoV-2 infectionRespiratory QuestionnairePost-COVID-19 sequelaePost-dischargeSARS-CoV-2Significant risk factorsHospitalised adultsA pilot cross-sectional study of non-communicable diseases in TB household contacts
Hamada Y, Lugendo A, Ntshiqa T, Kubeka G, Lalashowi J, Mwastaula S, Ntshamane K, Sabi I, Wilson S, Copas A, Velen K, Ntinginya N, Minja L, Abubakar I, Charalambous S, Rangaka M. A pilot cross-sectional study of non-communicable diseases in TB household contacts. 2024, 1: 154-159. PMID: 38988408, PMCID: PMC11231826, DOI: 10.5588/ijtldopen.23.0579.Peer-Reviewed Original ResearchNon-communicable diseasesTB household contactsNon-communicable disease screeningStudy of non-communicable diseasePrevalence of non-communicable diseasesPilot cross-sectional studyContact investigationCross-sectional studyIntegrated screeningHousehold contactsHemoglobin A1cNeighborhood householdsPrevalenceBlood pressureBlood glucoseSouth AfricaAdult contactsScreeningCareNeighborhoodIndividualsA1cDiabetesDiseasePilotExploring the syndemic interaction between social, environmental and structural contexts of HIV infection in peri-mining areas in South Africa: a qualitative study
Chimoyi L, Ndini P, Oladimeji M, Seatlholo N, Mawokomatanda K, Charalambous S, Setswe G. Exploring the syndemic interaction between social, environmental and structural contexts of HIV infection in peri-mining areas in South Africa: a qualitative study. BMJ Open 2024, 14: e076198. PMID: 38521520, PMCID: PMC10961556, DOI: 10.1136/bmjopen-2023-076198.Peer-Reviewed Original ResearchConceptsFemale sex workersFocus group discussionsIn-depth interviewsInjection drug usersUptake of HIV prevention servicesHealthcare workersHIV prevention servicesHIV infectionHIV prevention programmesPre-exposure prophylaxisAssociated with HIV acquisitionAccessibility to alcoholSocio-behavioral factorsCommunity-based organisationsPreventive servicesHIV prevalencePrevention programmesAreas of South AfricaSyndemic factorsQualitative studyHIV transmissionHIV acquisitionInclusion criteriaFactors affecting peopleSex workersFeasibility and acceptability of the smart pillbox and medication label with differentiated care to support person-centered tuberculosis care among ASCENT trial participants – A multicountry study
Tadesse A, Mganga A, Dube T, Alacapa J, van Kalmthout K, Letta T, Mleoh L, Garfin A, Maraba N, Charalambous S, Foster N, Jerene D, Fielding K. Feasibility and acceptability of the smart pillbox and medication label with differentiated care to support person-centered tuberculosis care among ASCENT trial participants – A multicountry study. Frontiers In Public Health 2024, 12: 1327971. PMID: 38444445, PMCID: PMC10913790, DOI: 10.3389/fpubh.2024.1327971.Peer-Reviewed Original ResearchDigital adherence technologiesMedication labelsPragmatic cluster randomized trialBehaviour (COM-BPhone ownershipFacility-level clusteringCluster randomized trialCross-sectional surveyLikert-scale responsesCOM-BHealth facilitiesDisclosure concernsTB burden settingsTB projectMedication adherenceTuberculosis careDifferentiated carePillbox usersPhone accessTrial participantsMean scoreCare supportMulticountry studyLabel usersBurden settings
2023
PA-738 Evaluation of QIAreach QuantiFERON-TB lateral-flow nanoparticle fluorescence assay for TB infection testing among TB household contacts in three high-burden settings
Ntshiqa T, Hamada Y, Matete M, Kubeka G, Lalashowi J, Budiaki L, Mahlalela M, Kisinda A, Charalambous S, Stender S, Velen K, Rangaka M. PA-738 Evaluation of QIAreach QuantiFERON-TB lateral-flow nanoparticle fluorescence assay for TB infection testing among TB household contacts in three high-burden settings. 2023, a116.3-a117. DOI: 10.1136/bmjgh-2023-edc.285.Peer-Reviewed Original ResearchPA-736 TB infection treatment eligibility among household contacts of microbiologically confirmed pulmonary TB patients in high TB settings
Ntshiqa T, Velen K, Minja T, Lalashowi J, Matete M, Sabi I, Stender S, Lönnroth K, Niemann S, Copas A, Ntinginya N, Rangaka M, Charalambous S. PA-736 TB infection treatment eligibility among household contacts of microbiologically confirmed pulmonary TB patients in high TB settings. 2023, a116.1-a116. DOI: 10.1136/bmjgh-2023-edc.283.Peer-Reviewed Original Research“It’s about time they taught us”: a qualitative study evaluating the barriers to finding and screening child contacts under five at risk for TB in Gauteng Province, South Africa from the provider and caregiver perspectives
Munedzimwe F, Chetty-Makkan C, Mukora R, Charalambous S, Turner K, Chihota V. “It’s about time they taught us”: a qualitative study evaluating the barriers to finding and screening child contacts under five at risk for TB in Gauteng Province, South Africa from the provider and caregiver perspectives. BMC Health Services Research 2023, 23: 1415. PMID: 38102646, PMCID: PMC10722712, DOI: 10.1186/s12913-023-10359-0.Peer-Reviewed Original ResearchConceptsTB preventive treatmentTB prevention strategiesIsoniazid preventive therapyTB staffSemi-structured questionnaireTB transmissionFacility staffPrevention strategiesPrimary health clinicsPrevention of tuberculosisEnd TB goalChild contactsYears of ageFacility observationsSemi-structured interview guidePreventive therapyTB preventionTB screeningTB treatmentPreventive servicesPreventive treatmentEkurhuleni DistrictHealth clinicsHigh riskCaregiver perspectivesTransitional community adherence support for people leaving incarceration in South Africa: a pragmatic, open-label, randomised controlled trial
Mabuto T, Woznica D, Ndini P, Moyo D, Abraham M, Hanrahan C, Charalambous S, Zack B, Baral S, Owczarzak J, Hoffmann C. Transitional community adherence support for people leaving incarceration in South Africa: a pragmatic, open-label, randomised controlled trial. The Lancet HIV 2023, 11: e11-e19. PMID: 38071994, PMCID: PMC10894448, DOI: 10.1016/s2352-3018(23)00235-7.Peer-Reviewed Original ResearchConceptsHIV treatment servicesUsual care groupTreatment servicesAntiretroviral therapyPrimary outcomeCare groupSouth African National Clinical Trials RegisterDifferentiated service delivery modelsClinical Trials RegisterPeer-led interventionsPassive referralAdherence supportTrials RegisterUsual careAdherence clubsAdverse eventsTreat analysisHIV treatmentMultifactorial barriersCorrectional facilitiesService delivery modelsFinal analysisMental healthMonthsNational InstituteThe use of digital technologies in adherence to anti-tuberculosis treatment
Fielding K, Subbaraman R, Khan A, Celan C, Charalambous S, Franke M, Huddart S, Katamba A, Law S, Stagg H. The use of digital technologies in adherence to anti-tuberculosis treatment. 2023, 170-184. DOI: 10.1183/2312508x.10002223.Peer-Reviewed Original ResearchImpact of youth lay health workers on HIV service delivery in South Africa: A pragmatic cluster randomized trial of the Youth Health Africa program
Tollefson D, Dasgupta S, Setswe G, Reeves S, Charalambous S, Duerr A. Impact of youth lay health workers on HIV service delivery in South Africa: A pragmatic cluster randomized trial of the Youth Health Africa program. PLOS ONE 2023, 18: e0294719. PMID: 38033029, PMCID: PMC10688901, DOI: 10.1371/journal.pone.0294719.Peer-Reviewed Original ResearchConceptsHIV service deliveryHIV testingTreatment initiationIntervention facilitiesHealth workersYoung adultsAdolescents/young adultsProportion of patientsPragmatic clusterSecondary outcomesHIV positivityPrimary outcomeTreat analysisHIV servicesHIV programsHealth facilitiesHIVBaseline outcomesTrialsService deliveryNull trialsCareImmediate increaseOutcomesGreater improvementUsing mHealth technologies for case finding in Tuberculosis and other infectious diseases in Africa: A systematic review (Preprint)
Mudzengi D, Chomutare H, Nagudi J, Ntshiqa T, Davis L, Charalambous S, Velen K. Using mHealth technologies for case finding in Tuberculosis and other infectious diseases in Africa: A systematic review (Preprint). JMIR MHealth And UHealth 2023 DOI: 10.2196/53211.Peer-Reviewed Original Research
2018
The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result
Hanifa Y, Fielding K, Chihota V, Adonis L, Charalambous S, Foster N, Karstaedt A, McCarthy K, Nicol M, Ndlovu N, Sinanovic E, Sahid F, Stevens W, Vassall A, Churchyard G, Grant A. The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result. Gates Open Research 2018, 2: 22. DOI: 10.12688/gatesopenres.12815.1.Peer-Reviewed Original ResearchNegative Xpert resultHIV-positive adultsXpert resultsTB treatmentHigh riskXpert MTB/RIF testingMTB/RIF testingXpert MTB/RIFAppropriate diagnostic modalitiesMonths of enrollmentHIV-positive individualsMTB/RIFInitial negative resultMycobacterium tuberculosis cultureTB diagnostic testsFurther investigationHIV careActive tuberculosisMicrobiological confirmationSputum samplesDiagnostic modalitiesNational guidelinesSputumTuberculosis cultureInvestigation pathway