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Mehran M Sadeghi, MD

Professor
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About

Titles

Professor

Biography

Mehran M. Sadeghi, MD, studied medicine at Necker Enfants Malades School of Medicine and earned his medical degree from the University of Paris in 1991. Prior to establishing the Cardiovascular Molecular Imaging Laboratory, Dr. Sadeghi completed his residency and fellowship training at Yale New Haven Hospital followed by a postdoctoral fellowship at the Boyer Center for Molecular Medicine.

The goal of the Cardiovascular Molecular Imaging Laboratory is to develop novel in vivo imaging approaches to visualize, characterize and quantify molecular and cellular processes involved in the development of cardiovascular diseases, and to address novel aspects of vascular and valvular biology. This is a comprehensive, multi-disciplinary effort, involving the researchers with expertise in vascular and molecular biology, molecular imaging, medical physics and chemistry. The research focus is on vascular remodeling, fibrosis and inflammation, key features of atherosclerosis, aneurysm, cardiomyopathy, and calcific aortic valve disease.

Dr. Sadeghi is a recipient of the Hermann Blumgart Award from the Society of Nuclear Medicine and Molecular Imaging and a past president of the Cardiovascular Council of the Society of Nuclear medicine and Molecular Imaging. He is a member of American College of Cardiology, Society of Nuclear Medicine and Molecular Imaging, American Society of Nuclear Cardiology, and the North American Vascular Biology Organization.

Appointments

Education & Training

Cardiology, Nuclear Cardiology and Vascular Biology Fellow
Yale University (2000)
Resident
Yale-New Haven Hospital (1995)
MD
Necker-Enfants Malades (1991)

Research

Overview

Despite remarkable recent progress in molecular and vascular biology research, little has been achieved in adapting traditional imaging modalities to detect molecular pathobiology in vivo. Molecular imaging provides a unique opportunity to link vascular and molecular biology and imaging, ultimately leading to the development of novel imaging approaches, both for research and clinical diagnostics. The ultimate goal of research in my laboratory is to develop novel imaging approaches to detect the molecular pathobiology of the vessel wall in vivo. Our comprehensive approach includes several components. Through basic vascular biology research we identify relevant molecular processes and potential targets for imaging (and therapeutics). Next, we use the state of the art technology to develop novel tracers targeted at relevant molecular markers, and establish molecular vascular imaging protocols in animal models of human disease. Finally, we exploit these techniques to further advance vascular biology and clinical research. We have made significant progress towards achieving these goals in the past few years. Specifically, we have focused on vascular remodeling, as the prototypic pathological vascular process shared by many vascular diseases, including atherosclerosis, graft arteriosclerosis, post-angioplasty restenosis, and aneurysm formation. Our federally funded studies of the pathophysiology of vascular remodeling in graft arteriosclerosis, performed under the umbrella of the Interdepartmental Program in Vascular Biology and Transplantation at Yale have led to the identification novel molecular markers, including a neuropilin-like protein, ESDN, as a potential target for diagnosis and therapy of vascular remodeling. We have demonstrated that ESDN is upregulated in vascular remodeling, and have defined its function as regulator of vascular cell proliferation in vivo. We are currently in the process of defining other aspects of ESDN function, including its role in growth factor and integrin signaling pathways, and identification of ESDN ligands. In molecular imaging arena, we have identified and validated avß3 integrin activation as a target for imaging the proliferative process in vascular remodeling, and have demonstrated the suitability of avß3-targeted tracers for imaging graft arteriosclerosis. Matrix metalloproteinase (MMP) activation, as a key regulator of vascular remodeling, was targeted for in vivo imaging of injury-induced vascular remodeling and aneurysm formation using high resolution microSPECT imaging in conjunction with CT angiography for anatomical localization. We are currently in the process of optimizing the technical aspects of in vivo microSPECT/CT imaging to improve visualization and quantitation of molecular targets. In parallel, we have developed a novel “tracer design” concept for in vivo applications and have been involved in the development of a novel intravascular detection system which combines scintigraphy with high resolution optical coherence tomography imaging.

  • Molecular Imaging of Vascular and Valvular Remodeling
  • Molecular Imaging of Plaque Vulnerability and Aneurysm
  • Neuropilin-like Proteins in Vascular Remodeling

Medical Subject Headings (MeSH)

Analytical, Diagnostic and Therapeutic Techniques and Equipment; Aneurysm; Aortic Aneurysm; Aortic Diseases; Aortic Valve; Aortic Valve Stenosis; Biomedical Technology; Cardiomyopathies; Cardiovascular Diseases; Diagnostic Techniques and Procedures; Diseases; Early Diagnosis; Health Care; Heart Diseases; Industry; Molecular Biology; Molecular Imaging; Molecular Probes; Optical Imaging; Peripheral Vascular Diseases; Positron-Emission Tomography; Radioactive Tracers; Single Photon Emission Computed Tomography Computed Tomography; Technology; Tomography, X-Ray Computed; Vascular Diseases

Research at a Glance

Yale Co-Authors

Frequent collaborators of Mehran M Sadeghi's published research.

Publications

2024

2023

Academic Achievements & Community Involvement

  • honor

    Hermann Blumgart Award

Clinical Care

Overview

Mehran Sadeghi, MD, is a cardiologist who treats patients at Yale New Haven Hospital and the VA Medical Center.

He is the principal investigator of the Cardiovascular Molecular Imaging Laboratory, which aims to develop new imaging techniques to visualize, characterize, and quantify molecular and cellular processes involved in cardiovascular diseases. Dr. Sadeghi and his lab focus their research on vascular remodeling, fibrosis, inflammation, aneurysms, cardiomyopathy, and aortic valve disease.

Dr. Sadeghi is a recipient of the Hermann Blumgart Award from the Society of Nuclear Medicine and Molecular Imaging. He is also a member of the American College of Cardiology, the Society of Nuclear Medicine and Molecular Imaging, and the American Society of Nuclear Cardiology.

He is a professor of medicine (cardiology) at Yale School of Medicine.

Clinical Specialties

Cardiovascular Medicine

Get In Touch

Contacts

Academic Office Number
Secondary Academic Office Number
Office Fax Number
Mailing Address

Cardiovascular Medicine

950 Campbell Avenue, #111B

West Haven, CT 06516

United States

Locations

  • Yale Cardiovascular Research Center

    Lab

    300 George Street, Ste 7th floor

    New Haven, CT 06511

  • Yale Cardiovascular Research Center

    Academic Office

    300 George Street, Ste 770G

    New Haven, CT 06511

    Appointments

    203.737.6954
  • VA Connecticut Healthcare

    Academic Office

    950 Campbell Avenue

    West Haven, CT 06516

  • Cardiovascular Molecular Imaging Laboratory

    Lab

    VA Connecticut Healthcare

    950 Campbell Avenue, Ste Building 2, Room 5226

    West Haven, CT 06516

    Appointments

    203.932.5711 x5705
  • Patient Care Locations

    Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.