2022
Benefits of weight loss of 10% or more in patients with overweight or obesity: A review
Tahrani AA, Morton J. Benefits of weight loss of 10% or more in patients with overweight or obesity: A review. Obesity 2022, 30: 802-840. PMID: 35333446, DOI: 10.1002/oby.23371.Peer-Reviewed Original ResearchConceptsObesity-related complicationsModest weight lossWeight lossBariatric surgeryLarge weight lossReduced cancer riskWeight-related complicationsCardiovascular risk factorsHealth-related qualityWeight management programType 2 diabetesGreater weight lossMain treatment targetsCost-effective interventionLifestyle modificationLifestyle interventionSevere obesityKnee osteoarthritisSleep apneaRisk factorsCancer riskGlucose metabolismPatientsOverweightTreatment targets
2019
Using Machine Learning Applied to Real-World Healthcare Data for Predictive Analytics: An Applied Example in Bariatric Surgery
Johnston SS, Morton JM, Kalsekar I, Ammann EM, Hsiao CW, Reps J. Using Machine Learning Applied to Real-World Healthcare Data for Predictive Analytics: An Applied Example in Bariatric Surgery. Value In Health 2019, 22: 580-586. PMID: 31104738, DOI: 10.1016/j.jval.2019.01.011.Peer-Reviewed Original ResearchConceptsLarge US healthcare claims databasesLaparoscopic metabolic surgeryHealthcare claims databasesType 2 diabetesStudy inclusion criteriaLogistic regression modelsDays postindexMedication cessationBariatric surgeryMetabolic surgeryT2D diagnosisCessation ratesPatient selectionMedication treatmentClaims databaseInclusion criteriaTreatment responseDiscriminative accuracyPatientsExternal validationSurgeryRegression modelsHealthcare dataTreatmentUseful predictive models
2017
Comparative effectiveness of primary bariatric operations in the United States
Sudan R, Maciejewski ML, Wilk AR, Nguyen NT, Ponce J, Morton JM. Comparative effectiveness of primary bariatric operations in the United States. Surgery For Obesity And Related Diseases 2017, 13: 826-834. PMID: 28236529, DOI: 10.1016/j.soard.2017.01.021.Peer-Reviewed Original ResearchConceptsBPD/DSPrimary bariatric operationsBariatric surgery centerBariatric operationsAdverse eventsSurgery centersBody mass index unitWeight lossCo-morbidity resolutionMore adverse eventsMultiple surgical centersSerious adverse eventsType 2 diabetesGreater weight lossLarge multisite cohortCurrent bariatric operationsT2D resolutionComorbidity resolutionBaseline characteristicsGastric bypassDuodenal switchSurgical centersInverse probability weightingMultisite cohortOdds ratio
2016
Effect of Vagal Nerve Blockade on Moderate Obesity with an Obesity-Related Comorbid Condition: the ReCharge Study
Morton JM, Shah SN, Wolfe BM, Apovian CM, Miller CJ, Tweden KS, Billington CJ, Shikora SA. Effect of Vagal Nerve Blockade on Moderate Obesity with an Obesity-Related Comorbid Condition: the ReCharge Study. Obesity Surgery 2016, 26: 983-989. PMID: 27048437, PMCID: PMC4831996, DOI: 10.1007/s11695-016-2143-y.Peer-Reviewed Original ResearchConceptsObesity-related comorbid conditionsBody mass indexModerate obesityComorbid conditionsPercentage excess weight lossWeight lossImplant site painVagal nerve blockadeCommon adverse eventsExcess weight lossObesity-related comorbiditiesWeight management counselingType 2 diabetesGreater weight lossSite painAdverse eventsBlockade therapyPrespecified subgroupsSevere obesitySham deviceMass indexNerve blockadeSleep apneaSafety profileClinical trials
2014
Metabolic surgery: Action via hormonal milieu changes, changes in bile acids or gut microbiota? A summary of the literature
Sweeney TE, Morton JM. Metabolic surgery: Action via hormonal milieu changes, changes in bile acids or gut microbiota? A summary of the literature. Best Practice & Research Clinical Gastroenterology 2014, 28: 727-740. PMID: 25194186, PMCID: PMC4399638, DOI: 10.1016/j.bpg.2014.07.016.Peer-Reviewed Original ResearchConceptsDifferent bariatric surgical techniquesGut microbiomeWeight lossBile acid changesDifferent bariatric proceduresBariatric surgical techniquesBile acid signalingType 2 diabetesDiabetes remissionDiabetes resolutionGastric bypassGut hormonesBariatric proceduresBariatric surgeryBile flowSurgical techniqueGLP-1Gut microbiotaMetabolic proceduresBile acidsSustained increaseBeneficial effectsMilieu changesGut bacteriaMultiple studies