2024
The trajectory of anxiety symptoms during the transition from childhood to young adulthood is predicted by IQ and sex, but not polygenic risk scores
Salto A, Salum G, Hoffmann M, Santoro M, Zugman A, Pan P, Belangero S, Ito L, Doretto V, Croci M, Brañas M, de Giusti C, Da Silva‐Jr F, Ribeiro S, Miguel E, Leckman J. The trajectory of anxiety symptoms during the transition from childhood to young adulthood is predicted by IQ and sex, but not polygenic risk scores. JCPP Advances 2024 DOI: 10.1002/jcv2.12268.Peer-Reviewed Original ResearchAnxiety symptomsIntelligence quotientTrajectory class membershipPolygenic risk scoresTrajectory classesLate adolescenceCourse of anxiety symptomsScreen for Child Anxiety Related DisordersTrajectories of anxiety symptomsBrazilian High-Risk CohortYoung adulthoodEffect of intelligence quotientAnxiety related disordersHigh-decreasing classClass membershipLongitudinal studyConfirmatory factor analysisGrowth mixture modelingIncidence of anxiety symptomsInternalizing symptomatologyLow-increasing classHigher IQCognitive abilitiesAnxiety riskFactor analysisScoping Review: Digital Mental Health Interventions for Children and Adolescents Affected by War
Danese A, Martsenkovskyi D, Remberk B, Khalil M, Diggins E, Keiller E, Masood S, Awah I, Barbui C, Beer R, Calam R, Gagliato M, Jensen T, Kostova Z, Leckman J, Lewis S, Lorberg B, Myshakivska O, Pfeiffer E, Rosner R, Schleider J, Shenderovich Y, Skokauskas N, Tolan P, Caffo E, Sijbrandij M, Ougrin D, Leventhal B, Weisz J, Network T. Scoping Review: Digital Mental Health Interventions for Children and Adolescents Affected by War. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024 PMID: 38735431, DOI: 10.1016/j.jaac.2024.02.017.Peer-Reviewed Original ResearchDigital mental health interventionsMental health interventionsHealth interventionsTraditional mental health servicesComplex mental health needsMental health servicesMental health supportMental health needsRandomized controlled trialsAPA PsychInfoHealth needsHealth servicesHealth supportEvidence baseSystematic searchControlled trialsGlobal healthInterventionGoogle ScholarSelf-guidedAdolescentsYoung peopleImplementation potentialChildrenPsychINFOThe Effects of Shaoma Zhijing Granules and its Main Components on Tourette Syndrome
Zhao Q, Hu Y, Yan Y, Song X, Yu J, Wang W, Zhou S, Su X, Bloch M, Leckman J, Chen Y, Sun H. The Effects of Shaoma Zhijing Granules and its Main Components on Tourette Syndrome. Phytomedicine 2024, 129: 155686. PMID: 38759346, DOI: 10.1016/j.phymed.2024.155686.Peer-Reviewed Original ResearchTourette syndromeChina National Knowledge Infrastructure (CNKI) databasesNerve damageRepair of nerve damageClinical trialsEffective treatmentImprove sleep disordersNeurotransmitter imbalanceSleep disordersReducing neuroinflammationSyndromeComprehensive searchClinical applicationChinese medicine compoundObsessive-compulsive disorderAn evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis
Ramakrishnan D, Farhat L, Vattimo E, Levine J, Johnson J, Artukoglu B, Landeros-Weisenberger A, Zangen A, Pelissolo A, de B Pereira C, Rück C, Costa D, Mataix-Cols D, Shannahoff-Khalsa D, Tolin D, Zarean E, Meyer E, Hawken E, Storch E, Andersson E, Miguel E, Maina G, Leckman J, Sarris J, March J, Diniz J, Kobak K, Mallet L, Vulink N, Amiaz R, Fernandes R, Shavitt R, Wilhelm S, Golshan S, Tezenas du Montcel S, Erzegovesi S, Baruah U, Greenberg W, Kobayashi Y, Bloch M. An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis. Journal Of Psychiatric Research 2024, 173: 387-397. PMID: 38598877, DOI: 10.1016/j.jpsychires.2024.03.044.Peer-Reviewed Original ResearchConceptsYale-Brown Obsessive-Compulsive ScaleObsessive-compulsive disorderCGI-IRandomized-controlled trialsAdult obsessive-compulsive disorderClinical Global Impression ImprovementObsessive-Compulsive ScaleTreatment responseIndividual-patient data meta-analysisPosttreatment scoresEvaluation of treatment responseMeta-analysis of randomized-controlled trialsFirst-line therapyCGIIndividual participant dataMeta-analysisNovel treatment modalitiesExpert consensusIndividual participant data meta-analysisSystematic reviewDisordersData meta-analysisPosttreatmentRemission definitionsImpressive improvement
2023
Cognitive training for children with ADHD: composite cognitive score outcome in a randomized controlled trial
Bikic A, Dalsgaard S, Pittman B, Leckman J, Wexler B. Cognitive training for children with ADHD: composite cognitive score outcome in a randomized controlled trial. Nordic Journal Of Psychiatry 2023, 78: 87-91. PMID: 37905332, DOI: 10.1080/08039488.2023.2270954.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderCognitive trainingDeficit/hyperactivity disorderComposite cognition scoreSessions of trainingCognitive functioningHyperactivity disorderCognitive improvementCognition scoresTraining sessionsMixed resultsFrequency of trainingTrainingChildrenSessionsIntervention groupCognitionInterventionFunctioningPost Hoc AnalysisScore outcomesControl groupPrevious studiesDisordersOutcomesRepetitive Thoughts and Behaviors in ASD: Assessment and Treatment
Thom R, McDougle C, Leckman J. Repetitive Thoughts and Behaviors in ASD: Assessment and Treatment. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 62: s69. DOI: 10.1016/j.jaac.2023.07.354.Peer-Reviewed Original ResearchNeurodevelopmental Disorders: Stereotypical Movement Disorders and Tic Disorders
Vitulano L, Vitulano M, King R, Yazgan M, Leckman J. Neurodevelopmental Disorders: Stereotypical Movement Disorders and Tic Disorders. 2023, 1-23. DOI: 10.1007/978-3-030-42825-9_45-1.Peer-Reviewed Original ResearchStereotypic movement disorderTic disordersDevelopmental coordination disorderMovement disordersMotor disordersCoordination disorderMotor skillsNeurodevelopmental disorder groupMagnetic resonance imaging techniquesBest practice assessmentHead bangingHand flappingNeurobiological disorderDisorder groupMotor behaviorDisordersNonrhythmic movementsSuch childrenPractice assessmentUnwanted attentionChildrenImaging techniquesSkillsYearsRecurrentFunctional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome
Morand-Beaulieu S, Crowley M, Grantz H, Leckman J, Sukhodolsky D. Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome. Psychological Medicine 2023, 53: 7857-7864. PMID: 37485677, PMCID: PMC10755221, DOI: 10.1017/s0033291723001940.Peer-Reviewed Original ResearchConceptsVoluntary tic suppressionTic suppressionVocal tic severityFunctional connectivityTic severityTourette syndromeRight superior frontal gyrusFirst-line treatmentBehavior therapyComprehensive Behavioral InterventionSuperior frontal gyrusRight angular gyrusVocal ticsFunctional brain networksBehavioral interventionsUsual control conditionFrontal gyrusBaselineAngular gyrusSeverityBrain networksSyndromeChildrenTherapyGyrusGenome-Wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome
Tsetsos F, Topaloudi A, Jain P, Yang Z, Yu D, Kolovos P, Tumer Z, Rizzo R, Hartmann A, Depienne C, Worbe Y, Müller-Vahl K, Cath D, Boomsma D, Wolanczyk T, Zekanowski C, Barta C, Nemoda Z, Tarnok Z, Padmanabhuni S, Buxbaum J, Grice D, Glennon J, Stefansson H, Hengerer B, Yannaki E, Stamatoyannopoulos J, Benaroya-Milshtein N, Cardona F, Hedderly T, Heyman I, Huyser C, Mir P, Morer A, Mueller N, Munchau A, Plessen K, Porcelli C, Roessner V, Walitza S, Schrag A, Martino D, Group T, TSAICG T, Barr C, Batterson J, Berlin C, Budman C, Coppola G, Cox N, Darrow S, Dion Y, Freimer N, Grados M, Greenberg E, Hirschtritt M, Huang A, Illmann C, King R, Kurlan R, Leckman J, Lyon G, Malaty I, McMahon W, Neale B, Okun M, Osiecki L, Robertson M, Rouleau G, Sandor P, Singer H, Smit J, Sul J, Initiative T, Androutsos C, Basha E, Farkas L, Fichna J, Janik P, Kapisyzi M, Karagiannidis I, Koumoula A, Nagy P, Puchala J, Szejko N, Szymanska U, Tsironi V, Group T, Apter A, Ball J, Bodmer B, Bognar E, Buse J, Vela M, Fremer C, Garcia-Delgar B, Gulisano M, Hagen A, Hagstrøm J, Madruga-Garrido M, Pellico A, Ruhrman D, Schnell J, Silvestri P, Skov L, Steinberg T, Gloor F, Turner V, Weidinger E, Network T, Alexander J, Aranyi T, Buisman W, Buitelaar J, Driessen N, Drineas P, Fan S, Forde N, Gerasch S, van den Heuvel O, Jespersgaard C, Kanaan A, Möller H, Nawaz M, Nespoli E, Pagliaroli L, Poelmans G, Pouwels P, Rizzo F, Veltman D, van der Werf Y, Widomska J, Zilhäo N, Group T, Brown L, Cheon K, Coffey B, Fernandez T, Gilbert D, Hong H, Ibanez-Gomez L, Kim E, Kim Y, Kim Y, Koh Y, Kook S, Kuperman S, Leventhal B, Maras A, Murphy T, Shin E, Song D, Song J, State M, Visscher F, Wang S, Zinner S, Tischfield J, Heiman G, Willsey A, Dietrich A, Davis L, Crowley J, Mathews C, Scharf J, Georgitsi M, Hoekstra P, Paschou P. Genome-Wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome. Biological Psychiatry 2023, 96: 114-124. PMID: 36738982, PMCID: PMC10783199, DOI: 10.1016/j.biopsych.2023.01.023.Peer-Reviewed Original ResearchExpression quantitative trait lociGenome-wide significant lociWide association study dataComplex genetic architectureQuantitative trait lociAssociation study dataGenetic architectureTrait lociChromosome 5q15Significant lociSignificant enrichmentLociNovel insightsNeurodevelopmental disordersChildhood-onset neurodevelopmental disorderHistonesRNAsGenesPolygenic riskFuture studiesEnrichment
2022
Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids
Brady M, Mariani J, Koca Y, Szekely A, King R, Bloch M, Landeros-Weisenberger A, Leckman J, Vaccarino F. Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids. Molecular Psychiatry 2022, 27: 5007-5019. PMID: 36447010, PMCID: PMC9949887, DOI: 10.1038/s41380-022-01880-5.Peer-Reviewed Original ResearchConceptsTourette syndromeInterneuron deficitsGABAergic interneuronsHealthy controlsNeurodevelopmental underpinningsNeuropathological deficitsBG circuitryNeuropsychiatric disordersDecreased differentiationT patientsInterneuronsAltered expressionPotential mechanismsCilia disruptionSonic hedgehogOrganoidsStem cellsTS individualsPluripotent stem cellsGli transcription factorsDeficitsOrganoid differentiationEarly stagesCholinergicPatientsTICS AND TOURETTE'S DISORDER: RECENT DEVELOPMENTS AND CLINICAL IMPLICATIONS
Abi-Jaoude E, Leckman J. TICS AND TOURETTE'S DISORDER: RECENT DEVELOPMENTS AND CLINICAL IMPLICATIONS. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 61: s18-s19. DOI: 10.1016/j.jaac.2022.07.082.Peer-Reviewed Original ResearchCOMMUNICATION AND LANGUAGE DISORDERS IN CHILDREN AND ADOLESCENTS
Petti T, Leckman J. COMMUNICATION AND LANGUAGE DISORDERS IN CHILDREN AND ADOLESCENTS. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 61: s136. DOI: 10.1016/j.jaac.2022.07.541.Peer-Reviewed Original ResearchCAREGIVER RESILIENCE, PSYCHOPATHOLOGY, AND THE RELATION WITH SOCIAL-EMOTIONAL ADJUSTMENT OF YOUNG CHILDREN AFFECTED BY ARMED CONFLICT IN COLOMBIA
Johnson I, Hein S, Ponguta L, Flores J, Tobón A, Larran J, Leckman J. CAREGIVER RESILIENCE, PSYCHOPATHOLOGY, AND THE RELATION WITH SOCIAL-EMOTIONAL ADJUSTMENT OF YOUNG CHILDREN AFFECTED BY ARMED CONFLICT IN COLOMBIA. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 61: s271. DOI: 10.1016/j.jaac.2022.09.411.Peer-Reviewed Original ResearchTourette's Syndrome: When Habit-Forming Systems Form Habits of Their Own?
Leckman J, Riddlet M. Tourette's Syndrome: When Habit-Forming Systems Form Habits of Their Own? 2022, 153-158. DOI: 10.4324/9780203822937-15.Peer-Reviewed Original ResearchA Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome
Peterson B, Shudlarski P, Anderson A, Zhang H, Gatenby J, Lacadie C, Leckman J, Gore J. A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome. 2022, 198-205. DOI: 10.4324/9780203822937-19.Peer-Reviewed Original ResearchMRI signal changesFunctional MRI signal changesFunctional debilityTourette syndromeTic suppressionNeuropsychiatric disordersNormal brain processesMagnetic resonance imaging studyResonance imaging studyFunctional magnetic resonance imaging studySignal changesFrequent causeBlood flowNeuronal activityImaging studiesStatistical significanceSignificant increaseSyndromeBehavioral problemsDebilityDisordersFailed inhibitionBrain processesImpulse controlIndirect measureCourse of Tic Severity in Tourette Syndrome: The First Two Decades
Leckman J, Zhang H, Vitale A, Lahnin F, Lynch K, Bondi C, Kim Y, Peterson B. Course of Tic Severity in Tourette Syndrome: The First Two Decades. 2022, 80-85. DOI: 10.4324/9780203822937-8.Peer-Reviewed Original ResearchYears of ageDecades of lifeTic severityTourette syndromeTS patientsTic onsetClinical evaluationPrevalence studySeverity of ticsInitial clinical evaluationConsistent time courseTime courseHigh rateOnset of pubertyInitial followPatient's coursePrognostic valueYale Child Study CenterBirth-year cohortsPatientsNatural historySyndromeCurve analysisSeverityStudy centersA Family Study of Gilles de la Tourette Syndrome
Pauls D, Raymond C, Stevenson J, Leckman J. A Family Study of Gilles de la Tourette Syndrome. 2022, 64-73. DOI: 10.4324/9780203822937-6.Peer-Reviewed Original ResearchObsessive-compulsive disorderTourette syndromeChronic ticsTS probandsGilles deFirst-degree relativesRelatives of probandsRelatives of controlsFamilies of probandsBiological relativesMorbid riskNormal subjectsNormal probandsFamilial disorderSyndromeProbandsCompulsive disorderFamily studiesTotal sampleDisordersPresent studyFurther evidenceRelativesPrevious studiesControl samplesForeword
Martino D, Leckman J. Foreword. 2022, vii-viii. DOI: 10.1093/med/9780197543214.002.0005.Peer-Reviewed Original ResearchNeuroimmunoendocrinology of Tourette Syndrome
Martino D, Johnson I, Escobar A, Leckman J. Neuroimmunoendocrinology of Tourette Syndrome. 2022, 257-276. DOI: 10.1093/med/9780197543214.003.0016.Peer-Reviewed Original ResearchTourette syndromeImmune-modulatory interventionsImmune competent cellsGeneration of ticsCortico-subcortical circuitsNormal brain developmentNeuroimmune interactionsKey molecular pathwaysGut dysbiosisAllergic illnessHigh riskImmune pathwaysPostnatal lifeTherapeutic interventionsImmune primingImmune systemRelated disordersNeural circuitsBrain developmentNeurodevelopmental disordersDisordersMolecular pathwaysSyndromeDate summaryMolecular mechanismsPhenomenology of Tics and Sensory Urges
Leckman J, Bloch M, Sukhodolsky D, Artukoğlu B, Scahill L, King R. Phenomenology of Tics and Sensory Urges. 2022, 6-25. DOI: 10.1093/med/9780197543214.003.0002.Peer-Reviewed Original Research