2024
Ketamine induces multiple individually distinct whole-brain functional connectivity signatures
Moujaes F, Ji J, Rahmati M, Burt J, Schleifer C, Adkinson B, Savic A, Santamauro N, Tamayo Z, Diehl C, Kolobaric A, Flynn M, Rieser N, Fonteneau C, Camarro T, Xu J, Cho Y, Repovs G, Fineberg S, Morgan P, Seifritz E, Vollenweider F, Krystal J, Murray J, Preller K, Anticevic A. Ketamine induces multiple individually distinct whole-brain functional connectivity signatures. ELife 2024, 13: e84173. PMID: 38629811, PMCID: PMC11023699, DOI: 10.7554/elife.84173.Peer-Reviewed Original ResearchConceptsResponse to ketamineAcute ketamineBehavioral effectsQuantified resting-state functional connectivityEffects of acute ketamineSymptom variationResting-state functional connectivityTreatment-resistant depressionFunctional connectivity signaturesGlobal brain connectivitySingle-subject levelInter-individual variabilityPlacebo-controlled studyFunctional connectivityConnectivity signaturesBrain connectivityHealthy participantsSingle-blind placebo-controlled studyNeural variationsTreatment conditionsKetamineGene expression targetsPharmacological biomarkersPilot awardParvalbumin
2014
Altered global brain signal in schizophrenia
Yang GJ, Murray JD, Repovs G, Cole MW, Savic A, Glasser MF, Pittenger C, Krystal JH, Wang XJ, Pearlson GD, Glahn DC, Anticevic A. Altered global brain signal in schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 7438-7443. PMID: 24799682, PMCID: PMC4034208, DOI: 10.1073/pnas.1405289111.Peer-Reviewed Original ResearchConceptsGlobal brain signalBrain dysfunctionHealthy subjectsBipolar patientsCortical powerBipolar disorderNeuropsychiatric conditionsFunctional MRIPatient samplesBrain connectivitySchizophreniaComplex neurobiologyDiagnostic specificityPatientsBrain signalsAlterationsDysfunctionSymptomsFindingsBaselineBrainMRIVentral Anterior Cingulate Connectivity Distinguished Nonpsychotic Bipolar Illness From Psychotic Bipolar Disorder and Schizophrenia
Anticevic A, Savic A, Repovs G, Yang G, McKay DR, Sprooten E, Knowles EE, Krystal JH, Pearlson GD, Glahn DC. Ventral Anterior Cingulate Connectivity Distinguished Nonpsychotic Bipolar Illness From Psychotic Bipolar Disorder and Schizophrenia. Schizophrenia Bulletin 2014, 41: 133-143. PMID: 24782562, PMCID: PMC4266289, DOI: 10.1093/schbul/sbu051.Peer-Reviewed Original ResearchConceptsVentral anterior cingulate cortexBipolar illnessPsychosis historyWhole-brain connectivityBipolar patientsConnectivity alterationsBrain connectivityCo-occurring psychosisChronic schizophrenia patientsHealthy comparison subjectsBipolar disorder patientsPsychotic bipolar disorder patientsBipolar disorder groupAnterior cingulate cortexFunctional connectivity studiesPsychotic bipolar disorderLifetime psychosisChronic schizophreniaPsychotic symptomsDisorder patientsPatientsComparison subjectsSchizophrenia patientsBipolar disorderCingulate cortexThe Frontoparietal Control System
Cole MW, Repovš G, Anticevic A. The Frontoparietal Control System. The Neuroscientist 2014, 20: 652-664. PMID: 24622818, PMCID: PMC4162869, DOI: 10.1177/1073858414525995.Peer-Reviewed Original Research
2013
Amygdala Connectivity Differs Among Chronic, Early Course, and Individuals at Risk for Developing Schizophrenia
Anticevic A, Tang Y, Cho YT, Repovs G, Cole MW, Savic A, Wang F, Krystal JH, Xu K. Amygdala Connectivity Differs Among Chronic, Early Course, and Individuals at Risk for Developing Schizophrenia. Schizophrenia Bulletin 2013, 40: 1105-1116. PMID: 24366718, PMCID: PMC4133672, DOI: 10.1093/schbul/sbt165.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsAmygdala connectivityHigh riskSymptom severityOrbitofrontal cortexWhole-brain functional connectivityHR individualsResting-state connectivitySchizophrenia symptom severityFunctional magnetic resonanceAmygdala seedArousal nucleiInitial episodeSchizophrenia neuropathologyChronic schizophreniaBrainstem regionsIllness phasePsychosis onsetElevated riskAmygdala circuitsEarly courseComparison subjectsFunctional alterationsClinical groupsFunctional connectivityGlobal Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder
Anticevic A, Hu S, Zhang S, Savic A, Billingslea E, Wasylink S, Repovs G, Cole MW, Bednarski S, Krystal JH, Bloch MH, Li CS, Pittenger C. Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder. Biological Psychiatry 2013, 75: 595-605. PMID: 24314349, PMCID: PMC3969771, DOI: 10.1016/j.biopsych.2013.10.021.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPrefrontal cortexResting-state functional connectivity dataStriatum/nucleus accumbensVentral striatum/nucleus accumbensResting-state functional connectivity studiesVentral anterior cingulate cortexCortico-striatal circuitsMagnetic Resonance Imaging AnalysisAnterior cingulate cortexFunctional connectivity studiesBasal gangliaControl subjectsFunctional connectivity dataAnterior thalamusRight putamenFrontal cortexNucleus accumbensDorsal striatumCerebellar cortexAbnormal neural connectivityCerebellar dysconnectivityCingulate cortexWhole brainFunctional magnetic resonance imaging (fMRI) analysisMulti-task connectivity reveals flexible hubs for adaptive task control
Cole MW, Reynolds JR, Power JD, Repovs G, Anticevic A, Braver TS. Multi-task connectivity reveals flexible hubs for adaptive task control. Nature Neuroscience 2013, 16: 1348-1355. PMID: 23892552, PMCID: PMC3758404, DOI: 10.1038/nn.3470.Peer-Reviewed Original ResearchCharacterizing Thalamo-Cortical Disturbances in Schizophrenia and Bipolar Illness
Anticevic A, Cole MW, Repovs G, Murray JD, Brumbaugh MS, Winkler AM, Savic A, Krystal JH, Pearlson GD, Glahn DC. Characterizing Thalamo-Cortical Disturbances in Schizophrenia and Bipolar Illness. Cerebral Cortex 2013, 24: 3116-3130. PMID: 23825317, PMCID: PMC4224238, DOI: 10.1093/cercor/bht165.Peer-Reviewed Original ResearchConceptsThalamo-cortical systemThalamic connectivityBipolar illnessResting-state functional magnetic resonance imagingSensory-motor cortexSevere mental illnessFunctional magnetic resonance imagingMagnetic resonance imagingThalamic dysconnectivityThalamic seedsClinical presentationNeuropsychiatric syndromeBrain dysconnectivityThalamic nucleiBipolar patientsSchizophrenia patientsSensory gatingMental illnessResonance imagingDysconnectivityCerebellar regionsDiagnostic membershipPrefrontal cortexSchizophreniaIllnessRelationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans
Driesen NR, McCarthy G, Bhagwagar Z, Bloch M, Calhoun V, D'Souza DC, Gueorguieva R, He G, Ramachandran R, Suckow RF, Anticevic A, Morgan PT, Krystal JH. Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans. Molecular Psychiatry 2013, 18: 1199-1204. PMID: 23337947, PMCID: PMC3646075, DOI: 10.1038/mp.2012.194.Peer-Reviewed Original ResearchConceptsFunctional connectivityNegative symptomsGamma-aminobutyric acid (GABA) neuronsNMDA receptor antagonist ketamineAspartate glutamate receptor antagonistContinuous ketamine infusionGlutamate receptor antagonistsNMDA-R antagonistsCortical functional connectivityNMDA-R antagonist ketamineSchizophrenia-like symptomsHealthy human subjectsNegative Syndrome ScaleBrain functional connectivityPrimary samplesRegion-specific mannerFunctional magnetic resonanceKetamine infusionReceptor antagonistPathological increaseSyndrome ScaleSymptomsPreclinical researchKetamineBrain oscillations
2012
The role of default network deactivation in cognition and disease
Anticevic A, Cole MW, Murray JD, Corlett PR, Wang XJ, Krystal JH. The role of default network deactivation in cognition and disease. Trends In Cognitive Sciences 2012, 16: 584-592. PMID: 23142417, PMCID: PMC3501603, DOI: 10.1016/j.tics.2012.10.008.Peer-Reviewed Original ResearchConceptsDMN suppressionDefault network deactivationGoal-directed cognitionSpecific behavioral tasksDefault mode networkCognitive neurosciencePharmacological neuroimagingSuppression deficitsBehavioral tasksFocused attentionClinical neuroscienceTheoretical neuroscienceBrain regionsNeuroscienceCognitionSevere mental illnessMental illnessConsiderable bodyNeuroimagingTaskDeficitsDMNExternal environmentMindDiseaseNMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16720-16725. PMID: 23012427, PMCID: PMC3478611, DOI: 10.1073/pnas.1208494109.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsBrainCognitionDouble-Blind MethodExcitatory Amino Acid AntagonistsFemaleHumansInfusions, IntravenousKetamineMagnetic Resonance ImagingMaleMemoryModels, NeurologicalPattern Recognition, VisualPsychomotor PerformanceReceptors, N-Methyl-D-AspartateSchizophreniaSynaptic TransmissionYoung AdultConceptsNeural systemsLarge-scale brain systemsTask-dependent activationN-methyl-D-aspartate receptorsRealistic computational modelingSevere neuropsychiatric illnessNMDA glutamate receptor antagonistGlutamate receptor antagonistsBrain systemsNMDA receptor functionTask performanceMultiple interacting regionsCognitionCortical disinhibitionGlutamatergic neurotransmissionReceptor antagonistCortical computationGlutamate's roleReciprocal relationshipNeuropsychiatric illnessLocal circuitsReceptor functionSchizophreniaPresent findingsComputational modelingGlobal Prefrontal and Fronto-Amygdala Dysconnectivity in Bipolar I Disorder with Psychosis History
Anticevic A, Brumbaugh MS, Winkler AM, Lombardo LE, Barrett J, Corlett PR, Kober H, Gruber J, Repovs G, Cole MW, Krystal JH, Pearlson GD, Glahn DC. Global Prefrontal and Fronto-Amygdala Dysconnectivity in Bipolar I Disorder with Psychosis History. Biological Psychiatry 2012, 73: 565-573. PMID: 22980587, PMCID: PMC3549314, DOI: 10.1016/j.biopsych.2012.07.031.Peer-Reviewed Original ResearchConceptsPsychosis historyRisk factorsBipolar patientsSymptom severityResting-state functional magnetic resonanceAmygdala-mPFC connectivityFronto-limbic dysfunctionSevere clinical courseBipolar I patientsEmotion regulation regionsPsychotic symptom severityFunctional magnetic resonanceClinical courseI patientsLimbic structuresBipolar illnessConnectivity deficitsAmygdala findingsConnectivity abnormalitiesPathophysiological modelBipolar IPatientsBipolar disorderDysconnectivityAbnormal inhibitionA broken filter: Prefrontal functional connectivity abnormalities in schizophrenia during working memory interference
Anticevic A, Repovs G, Krystal JH, Barch DM. A broken filter: Prefrontal functional connectivity abnormalities in schizophrenia during working memory interference. Schizophrenia Research 2012, 141: 8-14. PMID: 22863548, PMCID: PMC3879404, DOI: 10.1016/j.schres.2012.07.007.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceBrain MappingFemaleFunctional LateralityHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMemory DisordersMemory, Short-TermMiddle AgedNerve NetNeural PathwaysNeuropsychological TestsOxygenPrefrontal CortexSchizophreniaSchizophrenic PsychologyConceptsFunctional connectivity abnormalitiesConnectivity abnormalitiesMedio-dorsal thalamusTask-based functional connectivityFinal common pathwayMaintenance phasePrefrontal cortical regionsDorsolateral prefrontal cortex activationPrefrontal cortex activationFunctional deficitsHealthy controlsSub-cortical regionsExtended amygdalaPatientsCortex activationCognitive deficitsCortical regionsFunctional connectivityLife outcomesAbnormalitiesDLPFC networkCommon pathwaySchizophrenia researchSchizophreniaMemory abnormalitiesGlobal Connectivity of Prefrontal Cortex Predicts Cognitive Control and Intelligence
Cole MW, Yarkoni T, Repovš G, Anticevic A, Braver TS. Global Connectivity of Prefrontal Cortex Predicts Cognitive Control and Intelligence. Journal Of Neuroscience 2012, 32: 8988-8999. PMID: 22745498, PMCID: PMC3392686, DOI: 10.1523/jneurosci.0536-12.2012.Peer-Reviewed Original ResearchConceptsCognitive controlHuman intelligenceSuch cognitive controlHigh control demandsControl of thoughtsHigh global connectivityLPFC regionsMemory taskFluid intelligenceIndividual differencesFrontoparietal networkControl demandsPrefrontal cortexSelective relationshipControl processRegion activityIntelligenceDiverse contextsGlobal connectivityConnectivityLPFCTaskCortexThoughtContext
2011
Working Memory Encoding and Maintenance Deficits in Schizophrenia: Neural Evidence for Activation and Deactivation Abnormalities
Anticevic A, Repovs G, Barch DM. Working Memory Encoding and Maintenance Deficits in Schizophrenia: Neural Evidence for Activation and Deactivation Abnormalities. Schizophrenia Bulletin 2011, 39: 168-178. PMID: 21914644, PMCID: PMC3523909, DOI: 10.1093/schbul/sbr107.Peer-Reviewed Original ResearchConceptsSCZ subjectsWM pathologySample WM taskWhole-brain levelDorsolateral prefrontal cortex functioningDefault mode systemFunctional magnetic resonanceHealthy subjectsWM phasesAbnormalitiesSchizophreniaWM areasActivation differencesLess recruitmentPrefrontal regionsMaintenance phaseDeficitsPrefrontal cortex functioningSubstantial evidencePathologySubjectsMaintenance deficitsRecent findingsActivationMagnetic resonanceAutomated landmark identification for human cortical surface-based registration
Anticevic A, Repovs G, Dierker DL, Harwell JW, Coalson TS, Barch DM, Van Essen DC. Automated landmark identification for human cortical surface-based registration. NeuroImage 2011, 59: 2539-2547. PMID: 21925612, PMCID: PMC3476835, DOI: 10.1016/j.neuroimage.2011.08.093.Peer-Reviewed Original ResearchNegative and Nonemotional Interference with Visual Working Memory in Schizophrenia
Anticevic A, Repovs G, Corlett PR, Barch DM. Negative and Nonemotional Interference with Visual Working Memory in Schizophrenia. Biological Psychiatry 2011, 70: 1159-1168. PMID: 21861986, DOI: 10.1016/j.biopsych.2011.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmygdalaAnalysis of VarianceArousalAttentionCase-Control StudiesCerebral CortexDiscrimination, PsychologicalEmotionsFemaleField Dependence-IndependenceHumansLinear ModelsMagnetic Resonance ImagingMaleMatched-Pair AnalysisMemory, Short-TermMiddle AgedReference ValuesSchizophreniaSchizophrenic PsychologyVisual PerceptionConceptsControl subjectsSCZ subjectsDSM-IV-diagnosed schizophreniaAberrant salience processingLevel-dependent imagingAbility of patientsFunctional magnetic resonance imagingMagnetic resonance imagingPosterior cortical regionsFunctional magnetic resonanceLevel-dependent activityPathophysiological mechanismsPatientsResonance imagingCortical regionsAberrant responsesSalience processingSchizophreniaPrefrontal regionsEffects of distractionSubjectsSpecific deficitsDeficitsMagnetic resonanceSimilar responsesVariable Global Dysconnectivity and Individual Differences in Schizophrenia
Cole MW, Anticevic A, Repovs G, Barch D. Variable Global Dysconnectivity and Individual Differences in Schizophrenia. Biological Psychiatry 2011, 70: 43-50. PMID: 21496789, PMCID: PMC3204885, DOI: 10.1016/j.biopsych.2011.02.010.Peer-Reviewed Original ResearchConceptsIndividual differencesWechsler Adult Intelligence Scale-Third EditionDorsolateral prefrontal cortex regionsState functional connectivity magnetic resonanceFunctional connectivity magnetic resonanceFocal brain regionsPrefrontal cortex regionsSternberg taskCognitive functioningPFC involvementCognitive deficitsDSM-IV schizophreniaSymptom domainsConnectivity methodsBrain regionsNegative symptomsSymptom severitySymptom presentationCortex regionsDysconnectivityHub regionsNeuropathology of schizophreniaSchizophreniaSuch findingsSymptom expressionEmotion Effects on Attention, Amygdala Activation, and Functional Connectivity in Schizophrenia
Anticevic A, Repovs G, Barch DM. Emotion Effects on Attention, Amygdala Activation, and Functional Connectivity in Schizophrenia. Schizophrenia Bulletin 2011, 38: 967-980. PMID: 21415225, PMCID: PMC3446234, DOI: 10.1093/schbul/sbq168.Peer-Reviewed Original ResearchConceptsAmygdala activationAmygdala recruitmentEmotional processingSimple perceptual decision tasksHigh-level cognitive processesFunctional connectivityRapid event-related fMRIPerceptual decision taskTask-based functional connectivityProcessing of affectEvent-related fMRIMinimal cognitive loadSCZ subjectsLevel of behaviorSignificant group differencesEmotion effectsNeutral distractionAffective cuesMoment perceptionsAffective stimuliNegative stimuliCognitive processesDecision taskNegative distractionCognitive load
2010
Amygdala Recruitment in Schizophrenia in Response to Aversive Emotional Material: A Meta-analysis of Neuroimaging Studies
Anticevic A, Van Snellenberg JX, Cohen RE, Repovs G, Dowd EC, Barch DM. Amygdala Recruitment in Schizophrenia in Response to Aversive Emotional Material: A Meta-analysis of Neuroimaging Studies. Schizophrenia Bulletin 2010, 38: 608-621. PMID: 21123853, PMCID: PMC3329999, DOI: 10.1093/schbul/sbq131.Peer-Reviewed Original ResearchConceptsAmygdala activationCritical clinical featuresGroup differencesAbnormal amygdala activationClinical featuresSchizophrenia showPatientsBilateral amygdalaMeta-AnalysisIntact recruitmentNeuroimaging studiesSchizophreniaMeta-analytic approachEmotional dysfunctionAmygdala recruitmentDysfunctionPresent findingsAmygdalaEmotional stimuliNumber of studiesActivationFormal meta-analytic approachRecruitmentResponseStimuli