2020
Convergent molecular, cellular, and cortical neuroimaging signatures of major depressive disorder
Anderson KM, Collins MA, Kong R, Fang K, Li J, He T, Chekroud AM, Yeo BTT, Holmes AJ. Convergent molecular, cellular, and cortical neuroimaging signatures of major depressive disorder. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 25138-25149. PMID: 32958675, PMCID: PMC7547155, DOI: 10.1073/pnas.2008004117.Peer-Reviewed Original ResearchMeSH KeywordsAstrocytesAutopsyBrainCerebral CortexDepressive Disorder, MajorFemaleGene Expression ProfilingGene Expression RegulationGene OntologyGene Regulatory NetworksGenome-Wide Association StudyGenomicsHumansInterneuronsMaleMultifactorial InheritanceNeuroimagingSignal TransductionSingle-Cell AnalysisSomatostatinConceptsGenome-wide association studiesTranscriptional dataTranscriptional correlatesMajor depressive disorderCorrelates of depressionGene transcriptionSpecific genesGene expressionGene dysregulationIntegrative analysisBiological pathwaysAssociation studiesExpression dataGenesMolecular pathwaysCortical gene expressionDepressive disorderEx vivo geneCells associatesIntegrated analysisVivo geneBiological systemsRegulationPathwayUK Biobank
2019
Altered functional connectivity and low-frequency signal fluctuations in early psychosis and genetic high risk
Tang Y, Zhou Q, Chang M, Chekroud A, Gueorguieva R, Jiang X, Zhou Y, He G, Rowland M, Wang D, Fu S, Yin Z, Leng H, Wei S, Xu K, Wang F, Krystal JH, Driesen NR. Altered functional connectivity and low-frequency signal fluctuations in early psychosis and genetic high risk. Schizophrenia Research 2019, 210: 172-179. PMID: 30685394, DOI: 10.1016/j.schres.2018.12.041.Peer-Reviewed Original ResearchConceptsFunctional connectivityHigh-risk individualsAltered functional connectivityHealthy comparison subjectsGenetic high riskGenetic high-risk individualsLow-frequency signal fluctuationsFunctional magnetic resonanceALFF abnormalitiesALFF measuresFunctional connectivity measuresBasal gangliaFirst episodeHigh riskEarly psychosisComparison subjectsSchizophrenia diathesisSchizophrenia vulnerabilityFESzGenetic riskLow-frequency fluctuationsIllnessSchizophreniaVoxel connectivityGHR
2017
The Role of microRNA Expression in Cortical Development During Conversion to Psychosis
Zheutlin AB, Jeffries CD, Perkins DO, Chung Y, Chekroud AM, Addington J, Bearden CE, Cadenhead KS, Cornblatt BA, Mathalon DH, McGlashan TH, Seidman LJ, Walker EF, Woods SW, Tsuang M, Cannon TD. The Role of microRNA Expression in Cortical Development During Conversion to Psychosis. Neuropsychopharmacology 2017, 42: 2188-2195. PMID: 28186095, PMCID: PMC5603810, DOI: 10.1038/npp.2017.34.Peer-Reviewed Original ResearchConceptsNorth American Prodrome Longitudinal StudyCortical thinningDisease onsetClinical high-risk individualsProinflammatory cytokine levelsHigh-risk individualsGray matter reductionsOnset of psychosisCortical gray matter reductionMicroRNA expressionMicroglial actionCytokine levelsProinflammatory cytokinesCortical maturationImmune cellsHealthy controlsInflammatory responsePeripheral leukocytesCortical developmentHigh riskImmune functionSynaptic plasticityImmune systemConversion statusResident macrophages
2014
Cerebellar and cortical abnormalities in paediatric opsoclonus‐myoclonus syndrome
Anand G, Bridge H, Rackstraw P, Chekroud A, Yong J, Stagg C, Pike M. Cerebellar and cortical abnormalities in paediatric opsoclonus‐myoclonus syndrome. Developmental Medicine & Child Neurology 2014, 57: 265-272. PMID: 25290446, DOI: 10.1111/dmcn.12594.Peer-Reviewed Original ResearchConceptsOpsoclonus-myoclonus syndromePediatric opsoclonus-myoclonus syndromeGray matter volumeCortical thicknessDiffusion-weighted imagesCerebellar atrophyFlocculonodular lobeMatter volumeMagnetic resonance spectroscopy scansCerebral cortical thicknessTract-based spatial statisticsT1-weighted structural imagesCerebellar gray matter volumeWhole-brain levelWhole-brain analysisWhite matter integrityCerebellar gray matterPersistent symptomatologyClinical outcomesMotor sequelaeChronic phaseCortical abnormalitiesMotor cortexBrain levelsOMS group