2024
Illusory generalizability of clinical prediction models
Chekroud A, Hawrilenko M, Loho H, Bondar J, Gueorguieva R, Hasan A, Kambeitz J, Corlett P, Koutsouleris N, Krumholz H, Krystal J, Paulus M. Illusory generalizability of clinical prediction models. Science 2024, 383: 164-167. PMID: 38207039, DOI: 10.1126/science.adg8538.Peer-Reviewed Original Research
2023
Personalized symptom clusters that predict depression treatment outcomes: A replication of machine learning methods
Chen Y, Stewart J, Ge J, Cheng B, Chekroud A, Hellerstein D. Personalized symptom clusters that predict depression treatment outcomes: A replication of machine learning methods. Journal Of Affective Disorders Reports 2023, 11: 100470. DOI: 10.1016/j.jadr.2023.100470.Peer-Reviewed Original ResearchHamilton Rating ScaleSymptom clustersTreatment trajectoriesQuick InventoryTreatment outcomesDouble-blind clinical trialDepressive Symptomatology-Self ReportRating ScaleBest baseline predictorsHAM-D scoresDepression treatment outcomesAnxiety disorder diagnosisQIDS-SR16Depressive illnessEscitalopram monotherapyBaseline variablesClinical trialsBaseline predictorsTreatment efficacyUnipolar depressionDifferent treatment trajectoriesTreatment planLogistic regressionDisorder diagnosisDual treatment
2020
Precision non-implantable neuromodulation therapies: a perspective for the depressed brain
Borrione L, Bellini H, Razza L, Avila A, Baeken C, Brem A, Busatto G, Carvalho A, Chekroud A, Daskalakis Z, Deng Z, Downar J, Gattaz W, Loo C, Lotufo P, da Graça M. Martin M, McClintock S, O’Shea J, Padberg F, Passos I, Salum G, Vanderhasselt M, Fraguas R, Benseñor I, Valiengo L, Brunoni A. Precision non-implantable neuromodulation therapies: a perspective for the depressed brain. Brazilian Journal Of Psychiatry 2020, 42: 403-419. PMID: 32187319, PMCID: PMC7430385, DOI: 10.1590/1516-4446-2019-0741.Peer-Reviewed Original ResearchConceptsMajor depressive disorderSide effectsCurrent first-line treatmentMultiple medication trialsMagnetic seizure therapyFirst-line treatmentCognitive side effectsTranscranial direct current stimulationTranscranial magnetic stimulationDirect current stimulationCognitive behavioral therapyCost-effectiveness analysisClinical respondersSeizure therapyElectroconvulsive therapyMedication trialsPathophysiological mechanismsClinical trialsDepressed patientsDepressive disorderDepressed brainMagnetic stimulationNeuromodulation techniquesCurrent stimulationTherapySymptom clusters in adolescent depression and differential response to treatment: a secondary analysis of the Treatment for Adolescents with Depression Study randomised trial
Bondar J, Caye A, Chekroud A, Kieling C. Symptom clusters in adolescent depression and differential response to treatment: a secondary analysis of the Treatment for Adolescents with Depression Study randomised trial. The Lancet Psychiatry 2020, 7: 337-343. PMID: 32199509, DOI: 10.1016/s2215-0366(20)30060-2.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBayes TheoremChildCognitive Behavioral TherapyCombined Modality TherapyDepressive Disorder, MajorDiagnostic and Statistical Manual of Mental DisordersFemaleFluoxetineHumansMalePsychiatric Status Rating ScalesSelective Serotonin Reuptake InhibitorsTreatment OutcomeUnited StatesConceptsChildren's Depression Rating Scale-RevisedCognitive behavioral therapyCDRS-R scoresSymptom clustersDepression StudyTreatment efficacySecondary analysisMajor depressive disorderDSM-IV diagnosisCo-occurring symptomsSpecific symptom clustersPlacebo groupAcute phaseClinical profileActive treatmentSymptom scoresSleep disturbancesClinical trialsDepressive disorderPill placeboTreatment responseTherapeutic modalitiesSpecific symptomsNew therapiesPhysical complaints
2017
Trajectories of relapse in randomised, placebo-controlled trials of treatment discontinuation in major depressive disorder: an individual patient-level data meta-analysis
Gueorguieva R, Chekroud AM, Krystal JH. Trajectories of relapse in randomised, placebo-controlled trials of treatment discontinuation in major depressive disorder: an individual patient-level data meta-analysis. The Lancet Psychiatry 2017, 4: 230-237. PMID: 28189575, PMCID: PMC5340978, DOI: 10.1016/s2215-0366(17)30038-x.Peer-Reviewed Original ResearchConceptsActive medicationActive treatmentClinical trialsDepression severityHamilton Depression Rating Scale scoresDepression Rating Scale scoresClinical Global Impression scoresIndividual patient-level dataDouble-blind treatmentPlacebo-controlled trialPatterns of relapseGlobal Impression scoresIndividual patient dataPrevention of relapseTrajectory class membershipTreatment of depressionMajor depressive disorderRating Scale scoresPatient-level dataPost-traumatic stress disorderTreatment discontinuationAntidepressant treatmentClinical responseAlcohol Research CenterAntidepressant medication