Publications

Zhang F, Zarkada G, Han J, Li J, Dubrac A, Ola R, Genet G, Boyé K, Michon P, Künzel SE, Camporez JP, Singh AK, Fong GH, Simons M, Tso P, Fernández-Hernando C, Shulman GI, Sessa WC, Eichmann A: Lacteal junction zippering protects against diet-induced obesity. Science. 2018 Aug 10. PMID: 30093598

Ola R, Künzel SH, Zhang F, Genet G, Chakraborty R, Pibouin-Fragner L, Martin K, Sessa W, Dubrac A, Eichmann A: SMAD4 Prevents Flow Induced Arterial-Venous Malformations by Inhibiting Casein Kinase 2. Circulation. 2018 Jul 5; 2018 Jul 5. PMID: 29976569

Luciano AK, Zhou W, Santana JM, Kyriakides C, Velazquez H, Sessa WC: CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues. J Biol Chem. 2018 Jun 8; 2018 Mar 27. PMID: 29588368

Lee MY, Gamez-Mendez A, Zhang J, Zhuang Z, Vinyard DJ, Kraehling J, Velazquez H, Brudvig GW, Kyriakides TR, Simons M, Sessa WC: Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis. Arterioscler Thromb Vasc Biol. 2018 Apr; 2018 Feb 15. PMID: 29449333

Kuo A, Lee MY, Yang K, Gross RW, Sessa WC: Caveolin-1 regulates lipid droplet metabolism in endothelial cells via autocrine prostacyclin-stimulated, cAMP-mediated lipolysis. J Biol Chem. 2018 Jan 19; 2017 Dec 4. PMID: 29203526

MacLauchlan SC, Calabro NE, Huang Y, Krishna M, Bancroft T, Sharma T, Yu J, Sessa WC, Giordano F, Kyriakides TR: HIF-1α represses the expression of the angiogenesis inhibitor thrombospondin-2. Matrix Biol. 2018 Jan; 2017 Aug 5. PMID: 28789925

Jin Y, Xie Y, Ostriker AC, Zhang X, Liu R, Lee MY, Leslie KL, Tang W, Du J, Lee SH, Wang Y, Sessa WC, Hwa J, Yu J, Martin KA: Opposing Actions of AKT (Protein Kinase B) Isoforms in Vascular Smooth Muscle Injury and Therapeutic Response. Arterioscler Thromb Vasc Biol. 2017 Dec; 2017 Oct 12. PMID: 29025710

Hoffmann R, Grabińska K, Guan Z, Sessa WC, Neiman AM: Long-Chain Polyprenols Promote Spore Wall Formation in Saccharomyces cerevisiae. Genetics. 2017 Dec; 2017 Oct 4. PMID: 28978675

Protack CD, Foster TR, Hashimoto T, Yamamoto K, Lee MY, Kraehling JR, Bai H, Hu H, Isaji T, Santana JM, Wang M, Sessa WC, Dardik A: Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency. Sci Rep. 2017 Nov 13; 2017 Nov 13. PMID: 29133876

Grabińska KA, Edani BH, Park EJ, Kraehling JR, Sessa WC: A conserved C-terminal RXG motif in the NgBR subunit of cis-prenyltransferase is critical for prenyltransferase activity. J Biol Chem. 2017 Oct 20; 2017 Aug 23. PMID: 28842490

Jiang Y, Lin X, Tang Z, Lee C, Tian G, Du Y, Yin X, Ren X, Huang L, Ye Z, Chen W, Zhang F, Mi J, Gao Z, Wang S, Chen Q, Xing L, Wang B, Cao Y, Sessa WC, Ju R, Liu Y, Li X: Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK. Proc Natl Acad Sci U S A. 2017 Oct 3; 2017 Sep 18. PMID: 28923916

Nakamura T, Fujiwara Y, Yamada R, Fujii W, Hamabata T, Lee MY, Maeda S, Aritake K, Roers A, Sessa WC, Nakamura M, Urade Y, Murata T: Mast cell-derived prostaglandin D2 attenuates anaphylactic reactions in mice. J Allergy Clin Immunol. 2017 Aug; 2017 Apr 27. PMID: 28457595

Luciano AK, Santana JM, Velazquez H, Sessa WC: Akt1 Controls the Timing and Amplitude of Vascular Circadian Gene Expression. J Biol Rhythms. 2017 Jun; 2017 Apr 28. PMID: 28452287

Kuo A, Lee MY, Sessa WC: Lipid Droplet Biogenesis and Function in the Endothelium. Circ Res. 2017 Apr 14; 2017 Jan 24. PMID: 28119423

Kraehling JR, Sessa WC: Contemporary Approaches to Modulating the Nitric Oxide-cGMP Pathway in Cardiovascular Disease. Circ Res. 2017 Mar 31. PMID: 28360348

Ola R, Dubrac A, Han J, Zhang F, Fang JS, Larrivée B, Lee M, Urarte AA, Kraehling JR, Genet G, Hirschi KK, Sessa WC, Canals FV, Graupera M, Yan M, Young LH, Oh PS, Eichmann A: PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia. Nat Commun. 2016 Nov 29; 2016 Nov 29. PMID: 27897192

Kraehling JR, Chidlow JH, Rajagopal C, Sugiyama MG, Fowler JW, Lee MY, Zhang X, Ramírez CM, Park EJ, Tao B, Chen K, Kuruvilla L, Larriveé B, Folta-Stogniew E, Ola R, Rotllan N, Zhou W, Nagle MW, Herz J, Williams KJ, Eichmann A, Lee WL, Fernández-Hernando C, Sessa WC: Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells. Nat Commun. 2016 Nov 21; 2016 Nov 21. PMID: 27869117

Grabińska KA, Park EJ, Sessa WC: cis-Prenyltransferase: New Insights into Protein Glycosylation, Rubber Synthesis, and Human Diseases. J Biol Chem. 2016 Aug 26; 2016 Jul 11. PMID: 27402831

Ulrich V, Rotllan N, Araldi E, Luciano A, Skroblin P, Abonnenc M, Perrotta P, Yin X, Bauer A, Leslie KL, Zhang P, Aryal B, Montgomery RL, Thum T, Martin K, Suarez Y, Mayr M, Fernandez-Hernando C, Sessa WC: Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice. EMBO Mol Med. 2016 Jun; 2016 Jun 1. PMID: 27137489

Liu D, Lei L, Desir M, Huang Y, Cleman J, Jiang W, Fernandez-Hernando C, Di Lorenzo A, Sessa WC, Giordano FJ: Smooth Muscle Hypoxia-Inducible Factor 1α Links Intravascular Pressure and Atherosclerosis--Brief Report. Arterioscler Thromb Vasc Biol. 2016 Mar; 2016 Jan 21. PMID: 26800562

Marin EP, Jozsef L, Di Lorenzo A, Held KF, Luciano AK, Melendez J, Milstone LM, Velazquez H, Sessa WC: The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics. Arterioscler Thromb Vasc Biol. 2016 Feb; 2015 Dec 29. PMID: 26715683

Park EJ, Grabińska KA, Guan Z, Sessa WC: NgBR is essential for endothelial cell glycosylation and vascular development. EMBO Rep. 2016 Feb; 2016 Jan 11. PMID: 26755743

Kraehling JR, Hao Z, Lee MY, Vinyard DJ, Velazquez H, Liu X, Stan RV, Brudvig GW, Sessa WC: Uncoupling Caveolae From Intracellular Signaling In Vivo. Circ Res. 2016 Jan 8; 2015 Nov 24. PMID: 26602865

Chamorro-Jorganes A, Lee MY, Araldi E, Landskroner-Eiger S, Fernández-Fuertes M, Sahraei M, Quiles Del Rey M, van Solingen C, Yu J, Fernández-Hernando C, Sessa WC, Suárez Y: VEGF-Induced Expression of miR-17-92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates Angiogenesis. Circ Res. 2016 Jan 8; 2015 Oct 15. PMID: 26472816

Landskroner-Eiger S, Qiu C, Perrotta P, Siragusa M, Lee MY, Ulrich V, Luciano AK, Zhuang ZW, Corti F, Simons M, Montgomery RL, Wu D, Yu J, Sessa WC: Endothelial miR-17∼92 cluster negatively regulates arteriogenesis via miRNA-19 repression of WNT signaling. Proc Natl Acad Sci U S A. 2015 Oct 13; 2015 Sep 28. PMID: 26417068

Siragusa M, Fröhlich F, Park EJ, Schleicher M, Walther TC, Sessa WC: Stromal cell-derived factor 2 is critical for Hsp90-dependent eNOS activation. Sci Signal. 2015 Aug 18; 2015 Aug 18. PMID: 26286023

Patrick J, Dillaha L, Armas D, Sessa WC: A randomized trial to assess the pharmacodynamics and pharmacokinetics of a single dose of an extended-release aspirin formulation. Postgrad Med. 2015 Aug; 2015 May 22. PMID: 25998572

Kraehling JR, Sessa WC: Enhanced eNOS Activation as the Fountain of Youth for Vascular Disease: Is BPIFB4 What Ponce de León Was Looking For? Circ Res. 2015 Jul 31. PMID: 26227874

Rotllan N, Wanschel AC, Fernández-Hernando A, Salerno AG, Offermanns S, Sessa WC, Fernández-Hernando C: Genetic Evidence Supports a Major Role for Akt1 in VSMCs During Atherogenesis. Circ Res. 2015 May 22; 2015 Apr 13. PMID: 25868464

Xie Y, Jin Y, Merenick BL, Ding M, Fetalvero KM, Wagner RJ, Mai A, Gleim S, Tucker DF, Birnbaum MJ, Ballif BA, Luciano AK, Sessa WC, Rzucidlo EM, Powell RJ, Hou L, Zhao H, Hwa J, Yu J, Martin KA: Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition. Sci Signal. 2015 May 12; 2015 May 12. PMID: 25969542

Goodwin JE, Zhang X, Rotllan N, Feng Y, Zhou H, Fernández-Hernando C, Yu J, Sessa WC: Endothelial glucocorticoid receptor suppresses atherogenesis--brief report. Arterioscler Thromb Vasc Biol. 2015 Apr; 2015 Feb 19. PMID: 25810297

Rotllan N, Chamorro-Jorganes A, Araldi E, Wanschel AC, Aryal B, Aranda JF, Goedeke L, Salerno AG, Ramírez CM, Sessa WC, Suárez Y, Fernández-Hernando C: Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis. FASEB J. 2015 Feb; 2014 Nov 12. PMID: 25392271

Bancroft T, Bouaouina M, Roberts S, Lee M, Calderwood DA, Schwartz M, Simons M, Sessa WC, Kyriakides TR: Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function. J Biol Chem. 2015 Jan 2; 2014 Nov 11. PMID: 25389299

Pober JS, Sessa WC: Inflammation and the blood microvascular system. Cold Spring Harb Perspect Biol. 2014 Oct 23; 2014 Oct 23. PMID: 25384307

Goodwin JE, Feng Y, Velazquez H, Zhou H, Sessa WC: Loss of the endothelial glucocorticoid receptor prevents the therapeutic protection afforded by dexamethasone after LPS. PLoS One. 2014; 2014 Oct 9. PMID: 25299055

Park EJ, Grabińska KA, Guan Z, Stránecký V, Hartmannová H, Hodaňová K, Barešová V, Sovová J, Jozsef L, Ondrušková N, Hansíková H, Honzík T, Zeman J, Hůlková H, Wen R, Kmoch S, Sessa WC: Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation. Cell Metab. 2014 Sep 2; 2014 Jul 24. PMID: 25066056

Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, Morales-Ruiz M, Sessa WC: Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates. Proc Natl Acad Sci U S A. 2014 Sep 2; 2014 Aug 18. PMID: 25136137

Mehra VC, Jackson E, Zhang XM, Jiang XC, Dobrucki LW, Yu J, Bernatchez P, Sinusas AJ, Shulman GI, Sessa WC, Yarovinsky TO, Bender JR: Ceramide-activated phosphatase mediates fatty acid-induced endothelial VEGF resistance and impaired angiogenesis. Am J Pathol. 2014 May; 2014 Mar 5. PMID: 24606881

Lee MY, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano AK, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood DA, Ferguson SM, De Camilli P, Sessa WC: Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis. Development. 2014 Apr; 2014 Mar 5. PMID: 24598168

Jozsef L, Tashiro K, Kuo A, Park EJ, Skoura A, Albinsson S, Rivera-Molina F, Harrison KD, Iwakiri Y, Toomre D, Sessa WC: Reticulon 4 is necessary for endoplasmic reticulum tubulation, STIM1-Orai1 coupling, and store-operated calcium entry. J Biol Chem. 2014 Mar 28; 2014 Feb 20. PMID: 24558039

Ju R, Zhuang ZW, Zhang J, Lanahan AA, Kyriakides T, Sessa WC, Simons M: Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways. J Biol Chem. 2014 Jan 3; 2013 Nov 14. PMID: 24235146

Di Lorenzo A, Lin MI, Murata T, Landskroner-Eiger S, Schleicher M, Kothiya M, Iwakiri Y, Yu J, Huang PL, Sessa WC: eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases. J Cell Sci. 2013 Dec 15; 2013 Sep 17. PMID: 24046447

Kondo Y, Jadlowiec CC, Muto A, Yi T, Protack C, Collins MJ, Tellides G, Sessa WC, Dardik A: The Nogo-B-PirB axis controls macrophage-mediated vascular remodeling. PLoS One. 2013; 2013 Nov 20. PMID: 24278366

Li Q, Atochin D, Kashiwagi S, Earle J, Wang A, Mandeville E, Hayakawa K, d'Uscio LV, Lo EH, Katusic Z, Sessa W, Huang PL: Deficient eNOS phosphorylation is a mechanism for diabetic vascular dysfunction contributing to increased stroke size. Stroke. 2013 Nov; 2013 Aug 29. PMID: 23988642

Reese C, Dyer S, Perry B, Bonner M, Oates J, Hofbauer A, Sessa W, Bernatchez P, Visconti RP, Zhang J, Hatfield CM, Silver RM, Hoffman S, Tourkina E: Differential regulation of cell functions by CSD peptide subdomains. Respir Res. 2013 Sep 8; 2013 Sep 8. PMID: 24011378

Huang Y, Di Lorenzo A, Jiang W, Cantalupo A, Sessa WC, Giordano FJ: Hypoxia-inducible factor-1α in vascular smooth muscle regulates blood pressure homeostasis through a peroxisome proliferator-activated receptor-γ-angiotensin II receptor type 1 axis. Hypertension. 2013 Sep; 2013 Aug 5. PMID: 23918749

Zhang P, Huang B, Xu X, Sessa WC: Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a. Biochem Biophys Res Commun. 2013 Aug 2; 2013 Jun 29. PMID: 23820384

Siragusa M, Sessa WC: Telmisartan exerts pleiotropic effects in endothelial cells and promotes endothelial cell quiescence and survival. Arterioscler Thromb Vasc Biol. 2013 Aug; 2013 May 23. PMID: 23702662

Li W, Li Q, Qin L, Ali R, Qyang Y, Tassabehji M, Pober BR, Sessa WC, Giordano FJ, Tellides G: Rapamycin inhibits smooth muscle cell proliferation and obstructive arteriopathy attributable to elastin deficiency. Arterioscler Thromb Vasc Biol. 2013 May; 2013 Mar 14. PMID: 23493289

Jaba IM, Zhuang ZW, Li N, Jiang Y, Martin KA, Sinusas AJ, Papademetris X, Simons M, Sessa WC, Young LH, Tirziu D: NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth. J Clin Invest. 2013 Apr. PMID: 23454748

Kashiwagi S, Atochin DN, Li Q, Schleicher M, Pong T, Sessa WC, Huang PL: eNOS phosphorylation on serine 1176 affects insulin sensitivity and adiposity. Biochem Biophys Res Commun. 2013 Feb 8; 2013 Jan 3. PMID: 23291238

Landskroner-Eiger S, Moneke I, Sessa WC: miRNAs as modulators of angiogenesis. Cold Spring Harb Perspect Med. 2013 Feb 1; 2013 Feb 1. PMID: 23169571

Cho WK, Lee CM, Kang MJ, Huang Y, Giordano FJ, Lee PJ, Trow TK, Homer RJ, Sessa WC, Elias JA, Lee CG: IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2013 Jan 15; 2012 Nov 2. PMID: 23125252

Goodwin JE, Feng Y, Velazquez H, Sessa WC: Endothelial glucocorticoid receptor is required for protection against sepsis. Proc Natl Acad Sci U S A. 2013 Jan 2; 2012 Dec 17. PMID: 23248291

Chick HE, Nowrouzi A, Fronza R, McDonald RA, Kane NM, Alba R, Delles C, Sessa WC, Schmidt M, Thrasher AJ, Baker AH: Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk. Hum Gene Ther. 2012 Dec; 2012 Oct 26. PMID: 22931362

Zhang P, Huang A, Morales-Ruiz M, Starcher BC, Huang Y, Sessa WC, Niklason LE, Giordano FJ: Engineered zinc-finger proteins can compensate genetic haploinsufficiency by transcriptional activation of the wild-type allele: application to Willams-Beuren syndrome and supravalvular aortic stenosis. Hum Gene Ther. 2012 Nov. PMID: 22891920

Sessa WC: A new approach to weight loss: just activate endothelial NO synthase! Circ Res. 2012 Oct 12. PMID: 23065339

Marin EP, Derakhshan B, Lam TT, Davalos A, Sessa WC: Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases. Circ Res. 2012 May 11; 2012 Apr 10. PMID: 22496122

Zhang J, Modi Y, Yarovinsky T, Yu J, Collinge M, Kyriakides T, Zhu Y, Sessa WC, Pardi R, Bender JR: Macrophage β2 integrin-mediated, HuR-dependent stabilization of angiogenic factor-encoding mRNAs in inflammatory angiogenesis. Am J Pathol. 2012 Apr; 2012 Feb 7. PMID: 22322302

Förstermann U, Sessa WC: Nitric oxide synthases: regulation and function. Eur Heart J. 2012 Apr; 2011 Sep 1. PMID: 21890489

Zhang P, Huang A, Ferruzzi J, Mecham RP, Starcher BC, Tellides G, Humphrey JD, Giordano FJ, Niklason LE, Sessa WC: Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report. Arterioscler Thromb Vasc Biol. 2012 Mar; 2011 Nov 17. PMID: 22095981

Yi T, Fogal B, Hao Z, Tobiasova Z, Wang C, Rao DA, Al-Lamki RS, Kirkiles-Smith NC, Kulkarni S, Bradley JR, Bothwell AL, Sessa WC, Tellides G, Pober JS: Reperfusion injury intensifies the adaptive human T cell alloresponse in a human-mouse chimeric artery model. Arterioscler Thromb Vasc Biol. 2012 Feb; 2011 Nov 3. PMID: 22053072

Tkachenko E, Tse D, Sideleva O, Deharvengt SJ, Luciano MR, Xu Y, McGarry CL, Chidlow J, Pilch PF, Sessa WC, Toomre DK, Stan RV: Caveolae, fenestrae and transendothelial channels retain PV1 on the surface of endothelial cells. PLoS One. 2012; 2012 Mar 5. PMID: 22403691

Sangwung P, Greco TM, Wang Y, Ischiropoulos H, Sessa WC, Iwakiri Y: Proteomic identification of S-nitrosylated Golgi proteins: new insights into endothelial cell regulation by eNOS-derived NO. PLoS One. 2012; 2012 Feb 21. PMID: 22363674

Yu J, Zhang Y, Zhang X, Rudic RD, Bauer PM, Altieri DC, Sessa WC: Endothelium derived nitric oxide synthase negatively regulates the PDGF-survivin pathway during flow-dependent vascular remodeling. PLoS One. 2012; 2012 Feb 15. PMID: 22355372

MacLauchlan S, Yu J, Parrish M, Asoulin TA, Schleicher M, Krady MM, Zeng J, Huang PL, Sessa WC, Kyriakides TR: Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2. Proc Natl Acad Sci U S A. 2011 Nov 15; 2011 Sep 26. PMID: 21949402

Sessa WC: MicroRNA regulation of cardiovascular functions. Arterioscler Thromb Vasc Biol. 2011 Nov. PMID: 22011748

Karuppiah K, Druhan LJ, Chen CA, Smith T, Zweier JL, Sessa WC, Cardounel AJ: Suppression of eNOS-derived superoxide by caveolin-1: a biopterin-dependent mechanism. Am J Physiol Heart Circ Physiol. 2011 Sep; 2011 Jul 1. PMID: 21724868

Bernatchez P, Sharma A, Bauer PM, Marin E, Sessa WC: A noninhibitory mutant of the caveolin-1 scaffolding domain enhances eNOS-derived NO synthesis and vasodilation in mice. J Clin Invest. 2011 Sep; 2011 Aug 1. PMID: 21804187

Sutendra G, Dromparis P, Wright P, Bonnet S, Haromy A, Hao Z, McMurtry MS, Michalak M, Vance JE, Sessa WC, Michelakis ED: The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension. Sci Transl Med. 2011 Jun 22. PMID: 21697531

Wilson KA, Colavito SA, Schulz V, Wakefield PH, Sessa W, Tuck D, Stern DF: NFBD1/MDC1 regulates Cav1 and Cav2 independently of DNA damage and p53. Mol Cancer Res. 2011 Jun; 2011 May 6. PMID: 21551225

Harrison KD, Park EJ, Gao N, Kuo A, Rush JS, Waechter CJ, Lehrman MA, Sessa WC: Nogo-B receptor is necessary for cellular dolichol biosynthesis and protein N-glycosylation. EMBO J. 2011 May 13; 2011 May 13. PMID: 21572394

Albinsson S, Sessa WC: Can microRNAs control vascular smooth muscle phenotypic modulation and the response to injury? Physiol Genomics. 2011 May 1; 2010 Sep 14. PMID: 20841497

Albinsson S, Skoura A, Yu J, DiLorenzo A, Fernández-Hernando C, Offermanns S, Miano JM, Sessa WC: Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function. PLoS One. 2011 Apr 22; 2011 Apr 22. PMID: 21526127

Zhang D, Utsumi T, Huang HC, Gao L, Sangwung P, Chung C, Shibao K, Okamoto K, Yamaguchi K, Groszmann RJ, Jozsef L, Hao Z, Sessa WC, Iwakiri Y: Reticulon 4B (Nogo-B) is a novel regulator of hepatic fibrosis. Hepatology. 2011 Apr. PMID: 21480333

Muto A, Yi T, Harrison KD, Dávalos A, Fancher TT, Ziegler KR, Feigel A, Kondo Y, Nishibe T, Sessa WC, Dardik A: Eph-B4 prevents venous adaptive remodeling in the adult arterial environment. J Exp Med. 2011 Mar 14; 2011 Feb 21. PMID: 21339325

Di Lorenzo A, Manes TD, Davalos A, Wright PL, Sessa WC: Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation. Blood. 2011 Feb 17; 2010 Dec 23. PMID: 21183689

Briand N, Le Lay S, Sessa WC, Ferré P, Dugail I: Distinct roles of endothelial and adipocyte caveolin-1 in macrophage infiltration and adipose tissue metabolic activity. Diabetes. 2011 Feb. PMID: 21270257

Marin EP, Moeckel G, Al-Lamki R, Bradley J, Yan Q, Wang T, Wright PL, Yu J, Sessa WC: Identification and regulation of reticulon 4B (Nogo-B) in renal tubular epithelial cells. Am J Pathol. 2010 Dec; 2010 Oct 22. PMID: 20971739

Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC: Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. J Exp Med. 2010 Nov 22; 2010 Oct 25. PMID: 20975041

Terasaka N, Westerterp M, Koetsveld J, Fernández-Hernando C, Yvan-Charvet L, Wang N, Sessa WC, Tall AR: ATP-binding cassette transporter G1 and high-density lipoprotein promote endothelial NO synthesis through a decrease in the interaction of caveolin-1 and endothelial NO synthase. Arterioscler Thromb Vasc Biol. 2010 Nov; 2010 Aug 26. PMID: 20798376

Krieger MH, Di Lorenzo A, Teutsch C, Kauser K, Sessa WC: Telmisartan regresses left ventricular hypertrophy in caveolin-1-deficient mice. Lab Invest. 2010 Nov; 2010 Jun 28. PMID: 20585312

Dávalos A, Fernández-Hernando C, Sowa G, Derakhshan B, Lin MI, Lee JY, Zhao H, Luo R, Colangelo C, Sessa WC: Quantitative proteomics of caveolin-1-regulated proteins: characterization of polymerase i and transcript release factor/CAVIN-1 IN endothelial cells. Mol Cell Proteomics. 2010 Oct; 2010 Jun 28. PMID: 20585024

Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B: Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells. Mol Cell. 2010 Aug 13. PMID: 20705244

Sessa WC: A new way to lower blood pressure: pass the chili peppers please! Cell Metab. 2010 Aug 4. PMID: 20674855

Fernández-Hernando C, Yu J, Dávalos A, Prendergast J, Sessa WC: Endothelial-specific overexpression of caveolin-1 accelerates atherosclerosis in apolipoprotein E-deficient mice. Am J Pathol. 2010 Aug; 2010 Jun 25. PMID: 20581061

Zheng X, Xu C, Di Lorenzo A, Kleaveland B, Zou Z, Seiler C, Chen M, Cheng L, Xiao J, He J, Pack MA, Sessa WC, Kahn ML: CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. J Clin Invest. 2010 Aug; 2010 Jul 1. PMID: 20592472

Albinsson S, Suarez Y, Skoura A, Offermanns S, Miano JM, Sessa WC: MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function. Arterioscler Thromb Vasc Biol. 2010 Jun; 2010 Apr 8. PMID: 20378849

Sanchez-Madrid F, Sessa WC: Spotlight on mechanisms of vascular inflammation. Cardiovasc Res. 2010 May 1; 2010 Mar 13. PMID: 20228399

Chidlow JH Jr, Sessa WC: Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation. Cardiovasc Res. 2010 May 1; 2010 Mar 3. PMID: 20202978

Fernández-Hernando C, József L, Jenkins D, Di Lorenzo A, Sessa WC: Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis. Arterioscler Thromb Vasc Biol. 2009 Dec; 2009 Sep 17. PMID: 19762778

Luo R, Colangelo CM, Sessa WC, Zhao H: Bayesian Analysis of iTRAQ Data with Nonrandom Missingness: Identification of Differentially Expressed Proteins. Stat Biosci. 2009 Nov. PMID: 21927625

Yu J, Fernández-Hernando C, Suarez Y, Schleicher M, Hao Z, Wright PL, DiLorenzo A, Kyriakides TR, Sessa WC: Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. Proc Natl Acad Sci U S A. 2009 Oct 13; 2009 Sep 25. PMID: 19805174

Bernatchez PN, Sharma A, Kodaman P, Sessa WC: Myoferlin is critical for endocytosis in endothelial cells. Am J Physiol Cell Physiol. 2009 Sep; 2009 Jun 3. PMID: 19494235

Harrison KD, Miao RQ, Fernandez-Hernándo C, Suárez Y, Dávalos A, Sessa WC: Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking. Cell Metab. 2009 Sep. PMID: 19723497

Di Lorenzo A, Fernández-Hernando C, Cirino G, Sessa WC: Akt1 is critical for acute inflammation and histamine-mediated vascular leakage. Proc Natl Acad Sci U S A. 2009 Aug 25; 2009 Jul 21. PMID: 19622728

Schleicher M, Yu J, Murata T, Derakhshan B, Atochin D, Qian L, Kashiwagi S, Di Lorenzo A, Harrison KD, Huang PL, Sessa WC: The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. Sci Signal. 2009 Aug 4; 2009 Aug 4. PMID: 19654415

Dobrucki LW, Dione DP, Kalinowski L, Dione D, Mendizabal M, Yu J, Papademetris X, Sessa WC, Sinusas AJ: Serial noninvasive targeted imaging of peripheral angiogenesis: validation and application of a semiautomated quantitative approach. J Nucl Med. 2009 Aug; 2009 Jul 17. PMID: 19617325

Fernández-Hernando C, Yu J, Suárez Y, Rahner C, Dávalos A, Lasunción MA, Sessa WC: Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis. Cell Metab. 2009 Jul. PMID: 19583953

Sessa WC: Molecular control of blood flow and angiogenesis: role of nitric oxide. J Thromb Haemost. 2009 Jul. PMID: 19630764

Suárez Y, Sessa WC: MicroRNAs as novel regulators of angiogenesis. Circ Res. 2009 Feb 27. PMID: 19246688

Chidlow JH Jr, Greer JJ, Anthoni C, Bernatchez P, Fernandez-Hernando C, Bruce M, Abdelbaqi M, Shukla D, Granger DN, Sessa WC, Kevil CG: Endothelial caveolin-1 regulates pathologic angiogenesis in a mouse model of colitis. Gastroenterology. 2009 Feb; 2008 Nov 7. PMID: 19111727

Tang PC, Qin L, Zielonka J, Zhou J, Matte-Martone C, Bergaya S, van Rooijen N, Shlomchik WD, Min W, Sessa WC, Pober JS, Tellides G: MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries. J Exp Med. 2008 Dec 22; 2008 Dec 8. PMID: 19064699

Murata T, Lin MI, Aritake K, Matsumoto S, Narumiya S, Ozaki H, Urade Y, Hori M, Sessa WC: Role of prostaglandin D2 receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo. Proc Natl Acad Sci U S A. 2008 Dec 16; 2008 Dec 5. PMID: 19060214

Zhang H, He Y, Dai S, Xu Z, Luo Y, Wan T, Luo D, Jones D, Tang S, Chen H, Sessa WC, Min W: AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. J Clin Invest. 2008 Dec; 2008 Nov 3. PMID: 19033661

Kritz AB, Yu J, Wright PL, Wan S, George SJ, Halliday C, Kang N, Sessa WC, Baker AH: In vivo modulation of Nogo-B attenuates neointima formation. Mol Ther. 2008 Nov; 2008 Sep 9. PMID: 18781142

Suárez Y, Fernández-Hernando C, Yu J, Gerber SA, Harrison KD, Pober JS, Iruela-Arispe ML, Merkenschlager M, Sessa WC: Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci U S A. 2008 Sep 16; 2008 Sep 8. PMID: 18779589

Krady MM, Zeng J, Yu J, MacLauchlan S, Skokos EA, Tian W, Bornstein P, Sessa WC, Kyriakides TR: Thrombospondin-2 modulates extracellular matrix remodeling during physiological angiogenesis. Am J Pathol. 2008 Sep; 2008 Aug 7. PMID: 18688033

Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E: The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J. 2008 Jul 23; 2008 Jun 19. PMID: 18566586

Rodriguez-Feo JA, Hellings WE, Moll FL, De Vries JP, van Middelaar BJ, Algra A, Sluijter J, Velema E, van den Broek T, Sessa WC, De Kleijn DP, Pasterkamp G: Caveolin-1 influences vascular protease activity and is a potential stabilizing factor in human atherosclerotic disease. PLoS One. 2008 Jul 2; 2008 Jul 2. PMID: 18596970

Schleicher M, Sessa WC: Are the mechanisms for NO-dependent vascular remodeling different from vasorelaxation in vivo? Arterioscler Thromb Vasc Biol. 2008 Jul. PMID: 18565841

Tourkina E, Richard M, Gööz P, Bonner M, Pannu J, Harley R, Bernatchez PN, Sessa WC, Silver RM, Hoffman S: Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol. 2008 May; 2008 Jan 18. PMID: 18203815

Kashiwagi S, Tsukada K, Xu L, Miyazaki J, Kozin SV, Tyrrell JA, Sessa WC, Gerweck LE, Jain RK, Fukumura D: Perivascular nitric oxide gradients normalize tumor vasculature. Nat Med. 2008 Mar; 2008 Feb 17. PMID: 18278052

Schleicher M, Shepherd BR, Suarez Y, Fernandez-Hernando C, Yu J, Pan Y, Acevedo LM, Shadel GS, Sessa WC: Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. J Cell Biol. 2008 Jan 14. PMID: 18195103

Sowa G, Xie L, Xu L, Sessa WC: Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells. Biochemistry. 2008 Jan 8; 2007 Dec 15. PMID: 18081315

Miao RQ, Fontana J, Fulton D, Lin MI, Harrison KD, Sessa WC: Dominant-negative Hsp90 reduces VEGF-stimulated nitric oxide release and migration in endothelial cells. Arterioscler Thromb Vasc Biol. 2008 Jan; 2007 Nov 1. PMID: 17975117

Derakhshan B, Harrison KD, Miao QR, Sessa WC: Approaches for studying angiogenesis-related signal transduction. Methods Enzymol. 2008. PMID: 18772008

Fernández-Hernando C, Ackah E, Yu J, Suárez Y, Murata T, Iwakiri Y, Prendergast J, Miao RQ, Birnbaum MJ, Sessa WC: Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metab. 2007 Dec. PMID: 18054314

Bernatchez PN, Acevedo L, Fernandez-Hernando C, Murata T, Chalouni C, Kim J, Erdjument-Bromage H, Shah V, Gratton JP, McNally EM, Tempst P, Sessa WC: Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function. J Biol Chem. 2007 Oct 19; 2007 Aug 16. PMID: 17702744

Li L, Hisamoto K, Kim KH, Haynes MP, Bauer PM, Sanjay A, Collinge M, Baron R, Sessa WC, Bender JR: Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation. Proc Natl Acad Sci U S A. 2007 Oct 16; 2007 Oct 5. PMID: 17921256

Murata T, Lin MI, Huang Y, Yu J, Bauer PM, Giordano FJ, Sessa WC: Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice. J Exp Med. 2007 Oct 1; 2007 Sep 24. PMID: 17893196

Pober JS, Sessa WC: Evolving functions of endothelial cells in inflammation. Nat Rev Immunol. 2007 Oct. PMID: 17893694

Kudo FA, Muto A, Maloney SP, Pimiento JM, Bergaya S, Fitzgerald TN, Westvik TS, Frattini JC, Breuer CK, Cha CH, Nishibe T, Tellides G, Sessa WC, Dardik A: Venous identity is lost but arterial identity is not gained during vein graft adaptation. Arterioscler Thromb Vasc Biol. 2007 Jul; 2007 Apr 26. PMID: 17463332

Atochin DN, Wang A, Liu VW, Critchlow JD, Dantas AP, Looft-Wilson R, Murata T, Salomone S, Shin HK, Ayata C, Moskowitz MA, Michel T, Sessa WC, Huang PL: The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. J Clin Invest. 2007 Jul. PMID: 17557122

Rodriguez-Feo JA, Hellings WE, Verhoeven BA, Moll FL, de Kleijn DP, Prendergast J, Gao Y, van der Graaf Y, Tellides G, Sessa WC, Pasterkamp G: Low levels of Nogo-B in human carotid atherosclerotic plaques are associated with an atheromatous phenotype, restenosis, and stenosis severity. Arterioscler Thromb Vasc Biol. 2007 Jun; 2007 Apr 5. PMID: 17413036

Murata T, Lin MI, Stan RV, Bauer PM, Yu J, Sessa WC: Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells. J Biol Chem. 2007 Jun 1; 2007 Apr 6. PMID: 17416589

Hooper WC, Catravas JD, Heistad DD, Sessa WC, Mensah GA: Vascular endothelium summary statement I: Health promotion and chronic disease prevention. Vascul Pharmacol. 2007 May; 2006 Nov 22. PMID: 17197248

Suárez Y, Fernández-Hernando C, Pober JS, Sessa WC: Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells. Circ Res. 2007 Apr 27; 2007 Mar 22. PMID: 17379831

Morales-Ruiz M, Fondevila C, Muñoz-Luque J, Tugues S, Rodríguez-Laiz G, Cejudo-Martín P, Romero JM, Navasa M, Fuster J, Arroyo V, Sessa WC, García-Valdecasas JC, Jiménez W: Gene transduction of an active mutant of akt exerts cytoprotection and reduces graft injury after liver transplantation. Am J Transplant. 2007 Apr. PMID: 17391122

Pyriochou A, Zhou Z, Koika V, Petrou C, Cordopatis P, Sessa WC, Papapetropoulos A: The phosphodiesterase 5 inhibitor sildenafil stimulates angiogenesis through a protein kinase G/MAPK pathway. J Cell Physiol. 2007 Apr. PMID: 17226792

Paszkowiak JJ, Maloney SP, Kudo FA, Muto A, Teso D, Rutland RC, Westvik TS, Pimiento JM, Tellides G, Sessa WC, Dardik A: Evidence supporting changes in Nogo-B levels as a marker of neointimal expansion but not adaptive arterial remodeling. Vascul Pharmacol. 2007 Apr; 2006 Nov 18. PMID: 17207665

Lin MI, Yu J, Murata T, Sessa WC: Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Cancer Res. 2007 Mar 15. PMID: 17363608

Zhang H, Luo Y, Zhang W, He Y, Dai S, Zhang R, Huang Y, Bernatchez P, Giordano FJ, Shadel G, Sessa WC, Min W: Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions. Am J Pathol. 2007 Mar. PMID: 17322393

Marin E, Sessa WC: Role of endothelial-derived nitric oxide in hypertension and renal disease. Curr Opin Nephrol Hypertens. 2007 Mar. PMID: 17293684

Sessa WC: Nitric oxide synthase inhibition and cancer. Lancet Oncol. 2007 Feb. PMID: 17267319

Iwakiri Y, Satoh A, Chatterjee S, Toomre DK, Chalouni CM, Fulton D, Groszmann RJ, Shah VH, Sessa WC: Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking. Proc Natl Acad Sci U S A. 2006 Dec 26; 2006 Dec 14. PMID: 17170139

Luo D, Luo Y, He Y, Zhang H, Zhang R, Li X, Dobrucki WL, Sinusas AJ, Sessa WC, Min W: Differential functions of tumor necrosis factor receptor 1 and 2 signaling in ischemia-mediated arteriogenesis and angiogenesis. Am J Pathol. 2006 Nov. PMID: 17071609

Lin MI, Sessa WC: Vascular endothelial growth factor signaling to endothelial nitric oxide synthase: more than a FLeeTing moment. Circ Res. 2006 Sep 29. PMID: 17008595

Qian HS, Liu P, Huw LY, Orme A, Halks-Miller M, Hill SM, Jin F, Kretschmer P, Blasko E, Cashion L, Szymanski P, Vergona R, Harkins R, Yu J, Sessa WC, Dole WP, Rubanyi GM, Kauser K: Effective treatment of vascular endothelial growth factor refractory hindlimb ischemia by a mutant endothelial nitric oxide synthase gene. Gene Ther. 2006 Sep; 2006 Apr 27. PMID: 16642030

He Y, Luo Y, Tang S, Rajantie I, Salven P, Heil M, Zhang R, Luo D, Li X, Chi H, Yu J, Carmeliet P, Schaper W, Sinusas AJ, Sessa WC, Alitalo K, Min W: Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. J Clin Invest. 2006 Sep; 2006 Aug 24. PMID: 16932810

Phung TL, Ziv K, Dabydeen D, Eyiah-Mensah G, Riveros M, Perruzzi C, Sun J, Monahan-Earley RA, Shiojima I, Nagy JA, Lin MI, Walsh K, Dvorak AM, Briscoe DM, Neeman M, Sessa WC, Dvorak HF, Benjamin LE: Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. Cancer Cell. 2006 Aug. PMID: 16904613

Fernández-Hernando C, Fukata M, Bernatchez PN, Fukata Y, Lin MI, Bredt DS, Sessa WC: Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. J Cell Biol. 2006 Jul 31; 2006 Jul 24. PMID: 16864653

Miao RQ, Gao Y, Harrison KD, Prendergast J, Acevedo LM, Yu J, Hu F, Strittmatter SM, Sessa WC: Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. Proc Natl Acad Sci U S A. 2006 Jul 18; 2006 Jul 11. PMID: 16835300

Bhandari V, Choo-Wing R, Chapoval SP, Lee CG, Tang C, Kim YK, Ma B, Baluk P, Lin MI, McDonald DM, Homer RJ, Sessa WC, Elias JA: Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proc Natl Acad Sci U S A. 2006 Jul 18; 2006 Jul 10. PMID: 16832062

Boo YC, Kim HJ, Song H, Fulton D, Sessa W, Jo H: Coordinated regulation of endothelial nitric oxide synthase activity by phosphorylation and subcellular localization. Free Radic Biol Med. 2006 Jul 1; 2006 Apr 5. PMID: 16781462

Hatakeyama T, Pappas PJ, Hobson RW 2nd, Boric MP, Sessa WC, Durán WN: Endothelial nitric oxide synthase regulates microvascular hyperpermeability in vivo. J Physiol. 2006 Jul 1; 2006 May 4. PMID: 16675496

Abraldes JG, Iwakiri Y, Loureiro-Silva M, Haq O, Sessa WC, Groszmann RJ: Mild increases in portal pressure upregulate vascular endothelial growth factor and endothelial nitric oxide synthase in the intestinal microcirculatory bed, leading to a hyperdynamic state. Am J Physiol Gastrointest Liver Physiol. 2006 May. PMID: 16603731

Zhang Q, Church JE, Jagnandan D, Catravas JD, Sessa WC, Fulton D: Functional relevance of Golgi- and plasma membrane-localized endothelial NO synthase in reconstituted endothelial cells. Arterioscler Thromb Vasc Biol. 2006 May; 2006 Mar 2. PMID: 16514082

Yu J, Bergaya S, Murata T, Alp IF, Bauer MP, Lin MI, Drab M, Kurzchalia TV, Stan RV, Sessa WC: Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels. J Clin Invest. 2006 May. PMID: 16670769

Yu J, Lei L, Liang Y, Hinh L, Hickey RP, Huang Y, Liu D, Yeh JL, Rebar E, Case C, Spratt K, Sessa WC, Giordano FJ: An engineered VEGF-activating zinc finger protein transcription factor improves blood flow and limb salvage in advanced-age mice. FASEB J. 2006 Mar; 2006 Jan 19. PMID: 16423874

Jagnandan D, Sessa WC, Fulton D: Intracellular location regulates calcium-calmodulin-dependent activation of organelle-restricted eNOS. Am J Physiol Cell Physiol. 2005 Oct; 2005 May 25. PMID: 15917301

Papapetropoulos A, Zhou Z, Gerassimou C, Yetik G, Venema RC, Roussos C, Sessa WC, Catravas JD: Interaction between the 90-kDa heat shock protein and soluble guanylyl cyclase: physiological significance and mapping of the domains mediating binding. Mol Pharmacol. 2005 Oct; 2005 Jul 15. PMID: 16024662

Partovian C, Zhuang Z, Moodie K, Lin M, Ouchi N, Sessa WC, Walsh K, Simons M: PKCalpha activates eNOS and increases arterial blood flow in vivo. Circ Res. 2005 Sep 2; 2005 Aug 4. PMID: 16081872

Yu J, deMuinck ED, Zhuang Z, Drinane M, Kauser K, Rubanyi GM, Qian HS, Murata T, Escalante B, Sessa WC: Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve. Proc Natl Acad Sci U S A. 2005 Aug 2; 2005 Jul 25. PMID: 16043715

Ackah E, Yu J, Zoellner S, Iwakiri Y, Skurk C, Shibata R, Ouchi N, Easton RM, Galasso G, Birnbaum MJ, Walsh K, Sessa WC: Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. J Clin Invest. 2005 Aug. PMID: 16075056

Zhang R, Luo D, Miao R, Bai L, Ge Q, Sessa WC, Min W: Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis. Oncogene. 2005 Jun 2. PMID: 15782121

Sessa WC: Regulation of endothelial derived nitric oxide in health and disease. Mem Inst Oswaldo Cruz. 2005 Mar; 2005 Jun 14. PMID: 15962093

Bucci M, Roviezzo F, Posadas I, Yu J, Parente L, Sessa WC, Ignarro LJ, Cirino G: Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo. Proc Natl Acad Sci U S A. 2005 Jan 18; 2005 Jan 7. PMID: 15640348

Bernatchez PN, Bauer PM, Yu J, Prendergast JS, He P, Sessa WC: Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides. Proc Natl Acad Sci U S A. 2005 Jan 18; 2005 Jan 6. PMID: 15637154

Bauer PM, Yu J, Chen Y, Hickey R, Bernatchez PN, Looft-Wilson R, Huang Y, Giordano F, Stan RV, Sessa WC: Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis. Proc Natl Acad Sci U S A. 2005 Jan 4; 2004 Dec 22. PMID: 15615855

Sorenson J, Santhanam AV, Smith LA, Akiyama M, Sessa WC, Katusic ZS: Expression and function of recombinant S1179D endothelial NO synthase in human pial arteries. Stroke. 2005 Jan; 2004 Nov 29. PMID: 15569867

Lin MI, Sessa WC: Antiangiogenic therapy: creating a unique "window" of opportunity. Cancer Cell. 2004 Dec. PMID: 15607955

Koh KP, Wang Y, Yi T, Shiao SL, Lorber MI, Sessa WC, Tellides G, Pober JS: T cell-mediated vascular dysfunction of human allografts results from IFN-gamma dysregulation of NO synthase. J Clin Invest. 2004 Sep. PMID: 15372109

Hagendoorn J, Padera TP, Kashiwagi S, Isaka N, Noda F, Lin MI, Huang PL, Sessa WC, Fukumura D, Jain RK: Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics. Circ Res. 2004 Jul 23; 2004 Jun 10. PMID: 15192027

Fulton D, Babbitt R, Zoellner S, Fontana J, Acevedo L, McCabe TJ, Iwakiri Y, Sessa WC: Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release. J Biol Chem. 2004 Jul 16; 2004 May 10. PMID: 15136572

Gratton JP, Bernatchez P, Sessa WC: Caveolae and caveolins in the cardiovascular system. Circ Res. 2004 Jun 11. PMID: 15192036

Sessa WC: eNOS at a glance. J Cell Sci. 2004 May 15. PMID: 15159447

Kuhlencordt PJ, Rosel E, Gerszten RE, Morales-Ruiz M, Dombkowski D, Atkinson WJ, Han F, Preffer F, Rosenzweig A, Sessa WC, Gimbrone MA Jr, Ertl G, Huang PL: Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells. Am J Physiol Cell Physiol. 2004 May; 2004 Jan 28. PMID: 15075219

Bucci M, Roviezzo F, Brancaleone V, Lin MI, Di Lorenzo A, Cicala C, Pinto A, Sessa WC, Farneti S, Fiorucci S, Cirino G: Diabetic mouse angiopathy is linked to progressive sympathetic receptor deletion coupled to an enhanced caveolin-1 expression. Arterioscler Thromb Vasc Biol. 2004 Apr; 2004 Feb 12. PMID: 14962949

Acevedo L, Yu J, Erdjument-Bromage H, Miao RQ, Kim JE, Fulton D, Tempst P, Strittmatter SM, Sessa WC: A new role for Nogo as a regulator of vascular remodeling. Nat Med. 2004 Apr; 2004 Mar 21. PMID: 15034570

Wang Y, Burns WR, Tang PC, Yi T, Schechner JS, Zerwes HG, Sessa WC, Lorber MI, Pober JS, Tellides G: Interferon-gamma plays a nonredundant role in mediating T cell-dependent outward vascular remodeling of allogeneic human coronary arteries. FASEB J. 2004 Mar; 2004 Jan 20. PMID: 14734640

Ou J, Fontana JT, Ou Z, Jones DW, Ackerman AW, Oldham KT, Yu J, Sessa WC, Pritchard KA Jr: Heat shock protein 90 and tyrosine kinase regulate eNOS NO* generation but not NO* bioactivity. Am J Physiol Heart Circ Physiol. 2004 Feb; 2003 Oct 9. PMID: 14551044

Payne GW, Madri JA, Sessa WC, Segal SS: Histamine inhibits conducted vasodilation through endothelium-derived NO production in arterioles of mouse skeletal muscle. FASEB J. 2004 Feb. PMID: 14769822

Papapetropoulos A, Fulton D, Lin MI, Fontana J, McCabe TJ, Zoellner S, García-Cardeña G, Zhou Z, Gratton JP, Sessa WC: Vanadate is a potent activator of endothelial nitric-oxide synthase: evidence for the role of the serine/threonine kinase Akt and the 90-kDa heat shock protein. Mol Pharmacol. 2004 Feb. PMID: 14742683

Sessa WC: Atheroprotection in the abence of "caves": is it the fat, the vessels, or both? Arterioscler Thromb Vasc Biol. 2004 Jan. PMID: 14707034

Jiang J, Cyr D, Babbitt RW, Sessa WC, Patterson C: Chaperone-dependent regulation of endothelial nitric-oxide synthase intracellular trafficking by the co-chaperone/ubiquitin ligase CHIP. J Biol Chem. 2003 Dec 5; 2003 Sep 24. PMID: 14507928

Minshall RD, Sessa WC, Stan RV, Anderson RG, Malik AB: Caveolin regulation of endothelial function. Am J Physiol Lung Cell Mol Physiol. 2003 Dec. PMID: 14604847

Fortugno P, Beltrami E, Plescia J, Fontana J, Pradhan D, Marchisio PC, Sessa WC, Altieri DC: Regulation of survivin function by Hsp90. Proc Natl Acad Sci U S A. 2003 Nov 25; 2003 Nov 12. PMID: 14614132

Lin MI, Fulton D, Babbitt R, Fleming I, Busse R, Pritchard KA Jr, Sessa WC: Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production. J Biol Chem. 2003 Nov 7; 2003 Sep 2. PMID: 12952971

Tsai MH, Iwakiri Y, Cadelina G, Sessa WC, Groszmann RJ: Mesenteric vasoconstriction triggers nitric oxide overproduction in the superior mesenteric artery of portal hypertensive rats. Gastroenterology. 2003 Nov. PMID: 14598261

Boo YC, Sorescu GP, Bauer PM, Fulton D, Kemp BE, Harrison DG, Sessa WC, Jo H: Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increase. Free Radic Biol Med. 2003 Oct 1. PMID: 14583337

Post H, Kajstura J, Lei B, Sessa WC, Byrne B, Anversa P, Hintze TH, Recchia FA: Adeno-associated virus mediated gene delivery into coronary microvessels of chronically instrumented dogs. J Appl Physiol (1985). 2003 Oct; 2003 Jul 3. PMID: 12844500

Hendrickson H, Chatterjee S, Cao S, Morales Ruiz M, Sessa WC, Shah V: Influence of caveolin on constitutively activated recombinant eNOS: insights into eNOS dysfunction in BDL rat liver. Am J Physiol Gastrointest Liver Physiol. 2003 Sep; 2003 Jun 26. PMID: 12829439

Peterson TE, Guicciardi ME, Gulati R, Kleppe LS, Mueske CS, Mookadam M, Sowa G, Gores GJ, Sessa WC, Simari RD: Caveolin-1 can regulate vascular smooth muscle cell fate by switching platelet-derived growth factor signaling from a proliferative to an apoptotic pathway. Arterioscler Thromb Vasc Biol. 2003 Sep 1; 2003 Jun 19. PMID: 12816877

Payne GW, Madri JA, Sessa WC, Segal SS: Abolition of arteriolar dilation but not constriction to histamine in cremaster muscle of eNOS-/- mice. Am J Physiol Heart Circ Physiol. 2003 Aug; 2003 Apr 10. PMID: 12689855

Morales-Ruiz M, Cejudo-Martín P, Fernández-Varo G, Tugues S, Ros J, Angeli P, Rivera F, Arroyo V, Rodés J, Sessa WC, Jiménez W: Transduction of the liver with activated Akt normalizes portal pressure in cirrhotic rats. Gastroenterology. 2003 Aug. PMID: 12891555

Gratton JP, Lin MI, Yu J, Weiss ED, Jiang ZL, Fairchild TA, Iwakiri Y, Groszmann R, Claffey KP, Cheng YC, Sessa WC: Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice. Cancer Cell. 2003 Jul. PMID: 12892711

Sowa G, Pypaert M, Fulton D, Sessa WC: The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation. Proc Natl Acad Sci U S A. 2003 May 27; 2003 May 12. PMID: 12743374

Bauer PM, Fulton D, Boo YC, Sorescu GP, Kemp BE, Jo H, Sessa WC: Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase. J Biol Chem. 2003 Apr 25; 2003 Feb 18. PMID: 12591925

Gratton JP, Yu J, Griffith JW, Babbitt RW, Scotland RS, Hickey R, Giordano FJ, Sessa WC: Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo. Nat Med. 2003 Mar; 2003 Feb 24. PMID: 12598894

Cirino G, Fiorucci S, Sessa WC: Endothelial nitric oxide synthase: the Cinderella of inflammation? Trends Pharmacol Sci. 2003 Feb. PMID: 12559774

Haynes MP, Li L, Sinha D, Russell KS, Hisamoto K, Baron R, Collinge M, Sessa WC, Bender JR: Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen. J Biol Chem. 2003 Jan 24; 2002 Nov 12. PMID: 12431978

Nedvetsky PI, Sessa WC, Schmidt HH: There's NO binding like NOS binding: protein-protein interactions in NO/cGMP signaling. Proc Natl Acad Sci U S A. 2002 Dec 24; 2002 Dec 16. PMID: 12486234

Iwakiri Y, Cadelina G, Sessa WC, Groszmann RJ: Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension. Am J Physiol Gastrointest Liver Physiol. 2002 Nov. PMID: 12381520

Napoli C, Ackah E, De Nigris F, Del Soldato P, D'Armiento FP, Crimi E, Condorelli M, Sessa WC: Chronic treatment with nitric oxide-releasing aspirin reduces plasma low-density lipoprotein oxidation and oxidative stress, arterial oxidation-specific epitopes, and atherogenesis in hypercholesterolemic mice. Proc Natl Acad Sci U S A. 2002 Sep 17; 2002 Sep 3. PMID: 12209007

Blanc-Brude OP, Yu J, Simosa H, Conte MS, Sessa WC, Altieri DC: Inhibitor of apoptosis protein survivin regulates vascular injury. Nat Med. 2002 Sep; 2002 Aug 12. PMID: 12172543

Pritchard KA, Ackerman AW, Ou J, Curtis M, Smalley DM, Fontana JT, Stemerman MB, Sessa WC: Native low-density lipoprotein induces endothelial nitric oxide synthase dysfunction: role of heat shock protein 90 and caveolin-1. Free Radic Biol Med. 2002 Jul 1. PMID: 12086682

Yu J, Rudic RD, Sessa WC: Nitric oxide-releasing aspirin decreases vascular injury by reducing inflammation and promoting apoptosis. Lab Invest. 2002 Jul. PMID: 12118084

Iwakiri Y, Tsai MH, McCabe TJ, Gratton JP, Fulton D, Groszmann RJ, Sessa WC: Phosphorylation of eNOS initiates excessive NO production in early phases of portal hypertension. Am J Physiol Heart Circ Physiol. 2002 Jun. PMID: 12003815

Scotland RS, Morales-Ruiz M, Chen Y, Yu J, Rudic RD, Fulton D, Gratton JP, Sessa WC: Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion. Circ Res. 2002 May 3. PMID: 11988492

Fontana J, Fulton D, Chen Y, Fairchild TA, McCabe TJ, Fujita N, Tsuruo T, Sessa WC: Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release. Circ Res. 2002 May 3. PMID: 11988487

Akiyama M, Eguchi D, Weiler D, O'Brien T, Kovesdi I, Scotland RS, Sessa WC, Katusic ZS: Expression and function of recombinant S1179D endothelial nitric oxide synthase in canine cerebral arteries. Stroke. 2002 Apr. PMID: 11935063

Fulton D, Fontana J, Sowa G, Gratton JP, Lin M, Li KX, Michell B, Kemp BE, Rodman D, Sessa WC: Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme. J Biol Chem. 2002 Feb 8; 2001 Nov 29. PMID: 11729179

Kim I, Oh JL, Ryu YS, So JN, Sessa WC, Walsh K, Koh GY: Angiopoietin-1 negatively regulates expression and activity of tissue factor in endothelial cells. FASEB J. 2002 Jan; 2001 Nov 29. PMID: 11729102

Fulton D, Gratton JP, Sessa WC: Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough? J Pharmacol Exp Ther. 2001 Dec. PMID: 11714864

Sowa G, Pypaert M, Sessa WC: Distinction between signaling mechanisms in lipid rafts vs. caveolae. Proc Natl Acad Sci U S A. 2001 Nov 20; 2001 Nov 13. PMID: 11707586

Paxinou E, Weisse M, Chen Q, Souza JM, Hertkorn C, Selak M, Daikhin E, Yudkoff M, Sowa G, Sessa WC, Ischiropoulos H: Dynamic regulation of metabolism and respiration by endogenously produced nitric oxide protects against oxidative stress. Proc Natl Acad Sci U S A. 2001 Sep 25; 2001 Sep 18. PMID: 11562476

Lee MJ, Thangada S, Paik JH, Sapkota GP, Ancellin N, Chae SS, Wu M, Morales-Ruiz M, Sessa WC, Alessi DR, Hla T: Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Mol Cell. 2001 Sep. PMID: 11583630

Gratton JP, Morales-Ruiz M, Kureishi Y, Fulton D, Walsh K, Sessa WC: Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells. J Biol Chem. 2001 Aug 10; 2001 May 31. PMID: 11387313

Fairchild TA, Fulton D, Fontana JT, Gratton JP, McCabe TJ, Sessa WC: Acidic hydrolysis as a mechanism for the cleavage of the Glu(298)-->Asp variant of human endothelial nitric-oxide synthase. J Biol Chem. 2001 Jul 13; 2001 Apr 30. PMID: 11331296

Karpen HE, Bukowski JT, Hughes T, Gratton JP, Sessa WC, Gailani MR: The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane. J Biol Chem. 2001 Jun 1; 2001 Mar 1. PMID: 11278759

Morales-Ruiz M, Lee MJ, Zöllner S, Gratton JP, Scotland R, Shiojima I, Walsh K, Hla T, Sessa WC: Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. J Biol Chem. 2001 Jun 1; 2001 Mar 6. PMID: 11278592

Pritchard KA Jr, Ackerman AW, Gross ER, Stepp DW, Shi Y, Fontana JT, Baker JE, Sessa WC: Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase. J Biol Chem. 2001 May 25; 2001 Mar 16. PMID: 11278264

Mesri M, Morales-Ruiz M, Ackermann EJ, Bennett CF, Pober JS, Sessa WC, Altieri DC: Suppression of vascular endothelial growth factor-mediated endothelial cell protection by survivin targeting. Am J Pathol. 2001 May. PMID: 11337373

Sessa WC: Can modulation of endothelial nitric oxide synthase explain the vasculoprotective actions of statins? Trends Mol Med. 2001 May. PMID: 11325618

Cao S, Yao J, McCabe TJ, Yao Q, Katusic ZS, Sessa WC, Shah V: Direct interaction between endothelial nitric-oxide synthase and dynamin-2. Implications for nitric-oxide synthase function. J Biol Chem. 2001 Apr 27; 2000 Dec 18. PMID: 11120737

Mital S, Zhang X, Zhao G, Bernstein RD, Smith CJ, Fulton DL, Sessa WC, Liao JK, Hintze TH: Simvastatin upregulates coronary vascular endothelial nitric oxide production in conscious dogs. Am J Physiol Heart Circ Physiol. 2000 Dec. PMID: 11087217

Bucci M, Gratton JP, Rudic RD, Acevedo L, Roviezzo F, Cirino G, Sessa WC: In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation. Nat Med. 2000 Dec. PMID: 11100121

Haynes MP, Sinha D, Russell KS, Collinge M, Fulton D, Morales-Ruiz M, Sessa WC, Bender JR: Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells. Circ Res. 2000 Oct 13. PMID: 11029403

Bucci M, Roviezzo F, Cicala C, Sessa WC, Cirino G: Geldanamycin, an inhibitor of heat shock protein 90 (Hsp90) mediated signal transduction has anti-inflammatory effects and interacts with glucocorticoid receptor in vivo. Br J Pharmacol. 2000 Sep. PMID: 10960063

Kureishi Y, Luo Z, Shiojima I, Bialik A, Fulton D, Lefer DJ, Sessa WC, Walsh K: The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med. 2000 Sep. PMID: 10973320

Luo Z, Fujio Y, Kureishi Y, Rudic RD, Daumerie G, Fulton D, Sessa WC, Walsh K: Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo. J Clin Invest. 2000 Aug. PMID: 10953024

Gratton JP, Fontana J, O'Connor DS, Garcia-Cardena G, McCabe TJ, Sessa WC: Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1. J Biol Chem. 2000 Jul 21. PMID: 10781589

Rudic RD, Bucci M, Fulton D, Segal SS, Sessa WC: Temporal events underlying arterial remodeling after chronic flow reduction in mice: correlation of structural changes with a deficit in basal nitric oxide synthesis. Circ Res. 2000 Jun 9. PMID: 10850968

Morales-Ruiz M, Fulton D, Sowa G, Languino LR, Fujio Y, Walsh K, Sessa WC: Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt. Circ Res. 2000 Apr 28. PMID: 10785512

Papapetropoulos A, Fulton D, Mahboubi K, Kalb RG, O'Connor DS, Li F, Altieri DC, Sessa WC: Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway. J Biol Chem. 2000 Mar 31. PMID: 10734041

McCabe TJ, Fulton D, Roman LJ, Sessa WC: Enhanced electron flux and reduced calmodulin dissociation may explain "calcium-independent" eNOS activation by phosphorylation. J Biol Chem. 2000 Mar 3. PMID: 10692402

Russell KS, Haynes MP, Caulin-Glaser T, Rosneck J, Sessa WC, Bender JR: Estrogen stimulates heat shock protein 90 binding to endothelial nitric oxide synthase in human vascular endothelial cells. Effects on calcium sensitivity and NO release. J Biol Chem. 2000 Feb 18. PMID: 10671543

Fulton D, Papapetropoulos A, Zhang X, Catravas JD, Hintze TH, Sessa WC: Quantification of eNOS mRNA in the canine cardiac vasculature by competitive PCR. Am J Physiol Heart Circ Physiol. 2000 Feb. PMID: 10666099

Hungerford JE, Sessa WC, Segal SS: Vasomotor control in arterioles of the mouse cremaster muscle. FASEB J. 2000 Jan. PMID: 10627294

Shah V, Toruner M, Haddad F, Cadelina G, Papapetropoulos A, Choo K, Sessa WC, Groszmann RJ: Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat. Gastroenterology. 1999 Nov. PMID: 10535886

Smart EJ, Graf GA, McNiven MA, Sessa WC, Engelman JA, Scherer PE, Okamoto T, Lisanti MP: Caveolins, liquid-ordered domains, and signal transduction. Mol Cell Biol. 1999 Nov. PMID: 10523618

Segal SS, Brett SE, Sessa WC: Codistribution of NOS and caveolin throughout peripheral vasculature and skeletal muscle of hamsters. Am J Physiol. 1999 Sep. PMID: 10484439

Papapetropoulos A, Rudic RD, Sessa WC: Molecular control of nitric oxide synthases in the cardiovascular system. Cardiovasc Res. 1999 Aug 15. PMID: 10690323

Sowa G, Liu J, Papapetropoulos A, Rex-Haffner M, Hughes TE, Sessa WC: Trafficking of endothelial nitric-oxide synthase in living cells. Quantitative evidence supporting the role of palmitoylation as a kinetic trapping mechanism limiting membrane diffusion. J Biol Chem. 1999 Aug 6. PMID: 10428829

Shah V, Wiest R, Garcia-Cardena G, Cadelina G, Groszmann RJ, Sessa WC: Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension. Am J Physiol. 1999 Aug. PMID: 10444461

Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC: Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. 1999 Jun 10. PMID: 10376602

Wiest R, Shah V, Sessa WC, Groszmann RJ: NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats. Am J Physiol. 1999 Apr. PMID: 10198349

Rudic RD, Sessa WC: Nitric oxide in endothelial dysfunction and vascular remodeling: clinical correlates and experimental links. Am J Hum Genet. 1999 Mar. PMID: 10052999

Guillot PV, Guan J, Liu L, Kuivenhoven JA, Rosenberg RD, Sessa WC, Aird WC: A vascular bed-specific pathway. J Clin Invest. 1999 Mar. PMID: 10079100

Papapetropoulos A, García-Cardeña G, Dengler TJ, Maisonpierre PC, Yancopoulos GD, Sessa WC: Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors. Lab Invest. 1999 Feb. PMID: 10068209

Malek AM, Jiang L, Lee I, Sessa WC, Izumo S, Alper SL: Induction of nitric oxide synthase mRNA by shear stress requires intracellular calcium and G-protein signals and is modulated by PI 3 kinase. Biochem Biophys Res Commun. 1999 Jan 8. PMID: 9920763

Sierra-Honigmann MR, Nath AK, Murakami C, García-Cardeña G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ, Flores-Riveros JR: Biological action of leptin as an angiogenic factor. Science. 1998 Sep 11. PMID: 9733517

Wang X, Lu M, Gao Y, Papapetropoulos A, Sessa WC, Wang W: Neuronal nitric oxide synthase is expressed in principal cell of collecting duct. Am J Physiol. 1998 Sep. PMID: 9729512

García-Cardeña G, Fan R, Shah V, Sorrentino R, Cirino G, Papapetropoulos A, Sessa WC: Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature. 1998 Apr 23. PMID: 9580552

Papapetropoulos A, Piccardoni P, Cirino G, Bucci M, Sorrentino R, Cicala C, Johnson K, Zachariou V, Sessa WC, Altieri DC: Hypotension and inflammatory cytokine gene expression triggered by factor Xa-nitric oxide signaling. Proc Natl Acad Sci U S A. 1998 Apr 14. PMID: 9539808

Olsson LE, Wheeler MA, Sessa WC, Weiss RM: Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder. J Pharmacol Exp Ther. 1998 Mar. PMID: 9495884

Rudic RD, Shesely EG, Maeda N, Smithies O, Segal SS, Sessa WC: Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J Clin Invest. 1998 Feb 15. PMID: 9466966

Woodard AS, García-Cardeña G, Leong M, Madri JA, Sessa WC, Languino LR: The synergistic activity of alphavbeta3 integrin and PDGF receptor increases cell migration. J Cell Sci. 1998 Feb. PMID: 9443896

Shah V, García-Cardeña G, Sessa WC, Groszmann RJ: The hepatic circulation in health and disease: report of a single-topic symposium. Hepatology. 1998 Jan. PMID: 9425948

Papapetropoulos A, García-Cardeña G, Madri JA, Sessa WC: Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest. 1997 Dec 15. PMID: 9399960

Shah V, Haddad FG, Garcia-Cardena G, Frangos JA, Mennone A, Groszmann RJ, Sessa WC: Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids. J Clin Invest. 1997 Dec 1. PMID: 9389760

Caulin-Glaser T, García-Cardeña G, Sarrel P, Sessa WC, Bender JR: 17 beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization. Circ Res. 1997 Nov. PMID: 9351464

García-Cardeña G, Martasek P, Masters BS, Skidd PM, Couet J, Li S, Lisanti MP, Sessa WC: Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo. J Biol Chem. 1997 Oct 10. PMID: 9325253

Liu J, Hughes TE, Sessa WC: The first 35 amino acids and fatty acylation sites determine the molecular targeting of endothelial nitric oxide synthase into the Golgi region of cells: a green fluorescent protein study. J Cell Biol. 1997 Jun 30. PMID: 9199168

Papapetropoulos A, Desai KM, Rudic RD, Mayer B, Zhang R, Ruiz-Torres MP, García-Cardeña G, Madri JA, Sessa WC: Nitric oxide synthase inhibitors attenuate transforming-growth-factor-beta 1-stimulated capillary organization in vitro. Am J Pathol. 1997 May. PMID: 9137106

Trauner M, Nathanson MH, Rydberg SA, Koeppel TA, Gartung C, Sessa WC, Boyer JL: Endotoxin impairs biliary glutathione and HCO3- excretion and blocks the choleretic effect of nitric oxide in rat liver. Hepatology. 1997 May. PMID: 9141437

List BM, Klösch B, Völker C, Gorren AC, Sessa WC, Werner ER, Kukovetz WR, Schmidt K, Mayer B: Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization. Biochem J. 1997 Apr 1. PMID: 9173876

Presta A, Liu J, Sessa WC, Stuehr DJ: Substrate binding and calmodulin binding to endothelial nitric oxide synthase coregulate its enzymatic activity. Nitric Oxide. 1997 Feb. PMID: 9701047

Wheeler MA, Smith SD, García-Cardeña G, Nathan CF, Weiss RM, Sessa WC: Bacterial infection induces nitric oxide synthase in human neutrophils. J Clin Invest. 1997 Jan 1. PMID: 9011564

Atucha NM, Shah V, García-Cardeña G, Sessa WE, Groszmann RJ: Role of endothelium in the abnormal response of mesenteric vessels in rats with portal hypertension and liver cirrhosis. Gastroenterology. 1996 Dec. PMID: 8942743

Smith SD, Wheeler MA, Zhang R, Weiss ED, Lorber MI, Sessa WC, Weiss RM: Nitric oxide synthase induction with renal transplant rejection or infection. Kidney Int. 1996 Dec. PMID: 8943494

Shesely EG, Maeda N, Kim HS, Desai KM, Krege JH, Laubach VE, Sherman PA, Sessa WC, Smithies O: Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 1996 Nov 12. PMID: 8917564

García-Cardeña G, Fan R, Stern DF, Liu J, Sessa WC: Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1. J Biol Chem. 1996 Nov 1. PMID: 8910295

Liu J, García-Cardeña G, Sessa WC: Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: implications for caveolae localization. Biochemistry. 1996 Oct 15. PMID: 8873592

Reid SN, Daw NW, Czepita D, Flavin HJ, Sessa WC: Inhibition of nitric oxide synthase does not alter ocular dominance shifts in kitten visual cortex. J Physiol. 1996 Jul 15. PMID: 8842008

García-Cardeña G, Oh P, Liu J, Schnitzer JE, Sessa WC: Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. Proc Natl Acad Sci U S A. 1996 Jun 25. PMID: 8692835

Martasek P, Liu Q, Liu J, Roman LJ, Gross SS, Sessa WC, Masters BS: Characterization of bovine endothelial nitric oxide synthase expressed in E. coli. Biochem Biophys Res Commun. 1996 Feb 15. PMID: 8604992

Smith CJ, Sun D, Hoegler C, Roth BS, Zhang X, Zhao G, Xu XB, Kobari Y, Pritchard K Jr, Sessa WC, Hintze TH: Reduced gene expression of vascular endothelial NO synthase and cyclooxygenase-1 in heart failure. Circ Res. 1996 Jan. PMID: 8603506

Liu J, García-Cardeña G, Sessa WC: Biosynthesis and palmitoylation of endothelial nitric oxide synthase: mutagenesis of palmitoylation sites, cysteines-15 and/or -26, argues against depalmitoylation-induced translocation of the enzyme. Biochemistry. 1995 Sep 26. PMID: 7547976

Pritchard KA Jr, Groszek L, Smalley DM, Sessa WC, Wu M, Villalon P, Wolin MS, Stemerman MB: Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. Circ Res. 1995 Sep. PMID: 7543827

Awolesi MA, Sessa WC, Sumpio BE: Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells. J Clin Invest. 1995 Sep. PMID: 7544806

Shen W, Zhang X, Zhao G, Wolin MS, Sessa W, Hintze TH: Nitric oxide production and NO synthase gene expression contribute to vascular regulation during exercise. Med Sci Sports Exerc. 1995 Aug. PMID: 7476056

Sessa WC, García-Cardeña G, Liu J, Keh A, Pollock JS, Bradley J, Thiru S, Braverman IM, Desai KM: The Golgi association of endothelial nitric oxide synthase is necessary for the efficient synthesis of nitric oxide. J Biol Chem. 1995 Jul 28. PMID: 7543089

Zhang R, Min W, Sessa WC: Functional analysis of the human endothelial nitric oxide synthase promoter. Sp1 and GATA factors are necessary for basal transcription in endothelial cells. J Biol Chem. 1995 Jun 23. PMID: 7541039

Awolesi MA, Widmann MD, Sessa WC, Sumpio BE: Cyclic strain increases endothelial nitric oxide synthase activity. Surgery. 1994 Aug. PMID: 7519368

Rosenkranz-Weiss P, Sessa WC, Milstien S, Kaufman S, Watson CA, Pober JS: Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity. J Clin Invest. 1994 May. PMID: 7514193

Sessa WC: The nitric oxide synthase family of proteins. J Vasc Res. 1994 May-Jun. PMID: 7511942

Liu J, Sessa WC: Identification of covalently bound amino-terminal myristic acid in endothelial nitric oxide synthase. J Biol Chem. 1994 Apr 22. PMID: 7512951

Sessa WC, Pritchard K, Seyedi N, Wang J, Hintze TH: Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res. 1994 Feb. PMID: 7507417

Sessa WC, Harrison JK, Luthin DR, Pollock JS, Lynch KR: Genomic analysis and expression patterns reveal distinct genes for endothelial and brain nitric oxide synthase. Hypertension. 1993 Jun. PMID: 7685005

Escalante B, Omata K, Sessa W, Lee SG, Falck JR, Schwartzman ML: 20-hydroxyeicosatetraenoic acid is an endothelium-dependent vasoconstrictor in rabbit arteries. Eur J Pharmacol. 1993 Apr 22. PMID: 8519270

Sessa WC, Barber CM, Lynch KR: Mutation of N-myristoylation site converts endothelial cell nitric oxide synthase from a membrane to a cytosolic protein. Circ Res. 1993 Apr. PMID: 7680289

Sessa WC, Harrison JK, Barber CM, Zeng D, Durieux ME, D'Angelo DD, Lynch KR, Peach MJ: Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase. J Biol Chem. 1992 Aug 5. PMID: 1379225

Hecker M, Siegle I, Macarthur H, Sessa WC, Vane JR: Role of intracellular thiols in release of EDRF from cultured endothelial cells. Am J Physiol. 1992 Mar. PMID: 1558197

Murch SH, Braegger CP, Sessa WC, MacDonald TT: High endothelin-1 immunoreactivity in Crohn's disease and ulcerative colitis. Lancet. 1992 Feb 15. PMID: 1346658

Desai KM, Zembowicz A, Sessa WC, Vane JR: Nitroxergic nerves mediate vagally induced relaxation in the isolated stomach of the guinea pig. Proc Natl Acad Sci U S A. 1991 Dec 15. PMID: 1684865

Zembowicz A, Hecker M, Macarthur H, Sessa WC, Vane JR: Nitric oxide and another potent vasodilator are formed from NG-hydroxy-L-arginine by cultured endothelial cells. Proc Natl Acad Sci U S A. 1991 Dec 15. PMID: 1662386

Mollace V, Salvemini D, Sessa WC, Vane JR: Inhibition of human platelet aggregation by endothelium-derived relaxing factor, sodium nitroprusside or iloprost is potentiated by captopril and reduced thiols. J Pharmacol Exp Ther. 1991 Sep. PMID: 1716310

Pagano PJ, Lin L, Sessa WC, Nasjletti A: Arachidonic acid elicits endothelium-dependent release from the rabbit aorta of a constrictor prostanoid resembling prostaglandin endoperoxides. Circ Res. 1991 Aug. PMID: 1907227

Desai KM, Sessa WC, Vane JR: Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid. Nature. 1991 Jun 6. PMID: 1675430

Sessa WC, Kaw S, Hecker M, Vane JR: The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes. Biochem Biophys Res Commun. 1991 Jan 31. PMID: 1993057

Sessa WC, Kaw S, Zembowicz A, Anggård E, Hecker M, Vane JR: Human polymorphonuclear leukocytes generate and degrade endothelin-1 by two distinct neutral proteases. J Cardiovasc Pharmacol. 1991. PMID: 1725374

Sessa WC, Halushka PV, Okwu A, Nasjletti A: Characterization of the vascular thromboxane A2/prostaglandin endoperoxide receptor in rabbit aorta. Regulation by dexamethasone. Circ Res. 1990 Dec. PMID: 2147131

Hecker M, Sessa WC, Harris HJ, Anggård EE, Vane JR: The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine. Proc Natl Acad Sci U S A. 1990 Nov. PMID: 2236071

Sessa WC, Hecker M, Mitchell JA, Vane JR: The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: L-glutamine inhibits the generation of L-arginine by cultured endothelial cells. Proc Natl Acad Sci U S A. 1990 Nov. PMID: 1978327

Swierkosz TA, Mitchell JA, Sessa WC, Hecker M, Vane JR: L-glutamine inhibits the release of endothelium-derived relaxing factor from the rabbit aorta. Biochem Biophys Res Commun. 1990 Oct 15. PMID: 2222463

Hecker M, Mitchell JA, Swierkosz TA, Sessa WC, Vane JR: Inhibition by L-glutamine of the release of endothelium-derived relaxing factor from cultured endothelial cells. Br J Pharmacol. 1990 Oct. PMID: 2257431

Escalante B, Sessa WC, Falck JR, Yadagiri P, Schwartzman ML: Cytochrome P450-dependent arachidonic acid metabolites, 19- and 20-hydroxyeicosatetraenoic acids, enhance sodium-potassium ATPase activity in vascular smooth muscle. J Cardiovasc Pharmacol. 1990 Sep. PMID: 1700215

Sessa WC, Mullane KM: Release of a neutrophil-derived vasoconstrictor agent which augments platelet-induced contractions of blood vessels in vitro. Br J Pharmacol. 1990 Mar. PMID: 2110018

Sessa WC, Nasjletti A: Dexamethasone selectively attenuates prostanoid-induced vasoconstrictor responses in vitro. Circ Res. 1990 Feb. PMID: 2297809

Sessa WC, Lin L, Nasjletti A: Reciprocal effects of dexamethasone on vasodilatory responses to arachidonic acid and prostanoids in the isolated perfused rabbit kidney. Hypertension. 1990 Feb. PMID: 2105268

Mariani MJ, Sessa WC Jr, Chichester CO, Rodgers RL: STZ-induced diabetes in SHR and renovascular hypertensive rats: dissociation between changes in arterial pressure and vascular collagen synthesis. Clin Exp Hypertens A. 1990. PMID: 2245511

Sessa WC, Abraham NG, Escalante B, Schwartzman ML: Manipulation of cytochrome P-450 dependent renal thromboxane synthase activity in spontaneously hypertensive rats. J Hypertens. 1989 Jan. PMID: 2708811

Escalante B, Sessa WC, Falck JR, Yadagiri P, Schwartzman ML: Vasoactivity of 20-hydroxyeicosatetraenoic acid is dependent on metabolism by cyclooxygenase. J Pharmacol Exp Ther. 1989 Jan. PMID: 2492340

Mullane K, Hatala MA, Kraemer R, Sessa W, Westlin W: Myocardial salvage induced by REV-5901: an inhibitor and antagonist of the leukotrienes. J Cardiovasc Pharmacol. 1987 Oct. PMID: 2444792