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International symposium on lymphatic circulation begins on Friday

April 29, 2013

Yale School of Medicine and the North American Vascular Biology Organization are pleased to present a special symposium, “Lymphatic Circulation in Health and Disease,” on Friday, May 3, and Saturday, May 4, at the Omni Hotel in New Haven.

Highlights of the two-day event include a keynote address by Kari Alitalo, M.D., of the University of Helsinki and a featured lecture on new technology by Derek Toomre, Ph.D., of Yale School of Medicine. The program includes 22 lectures by experts in lymphatics, lymphangiogenesis, and signaling and development as they relate to lymphatic circulation and biology. Also on the program are a poster session and reception promoting networking and initiating new collaborations.

Keynote speaker Alitalo is a leading scientist in the field of angiogenesis and lymphangiogenesis. He was appointed director of the Wihuri Research Institute in Helskinki in January. His major research focus is on signaling mechanisms that establish and maintain blood and lymphatic vascular systems. He has pioneered the work on vascular endothelial growth factors and their receptors, which regulate the blood and lymphatic vasculatures, thus providing targets for the treatment of numerous vascular diseases.

To register for this premiere event in lymphatic research, visit

Friday May 3
7:30-8:30 a.m.
Registration & breakfast
Session I: Specification of lymphatic fate and early development. 
Chair: Anne Eichmann
8:30-9 a.m.
Carrie Shawber, Columbia
Early lymphatic specification
9-9:30 a.m.
Michael Simons, Yale
ERK signaling and lymphatic fate determination
9:30-10 a.m.
Guillermo Oliver, St Jude
PROX1 and early lymphangiogenesis
10-10:30 a.m. Coffee Break
Session II: Signaling in lymphatic development
Chair: Michael Simons
10:30-11 a.m.
Kristina Bostrom, UCLA
BMP signaling: an introduction
11-11:30 a.m.
Suk-Won Jin, Yale
BMP determination of venous fate
11:30-12 p.m.
Anne Eichmann, Yale
BMP determination of lymphatic fate
12-12:30 p.m.
Yosuke Mukoyama, NIH
Patterning of tubular networks
12:30-1:30 p.m.
Lunch Break
1:30-2:30 p.m.
Plenary Lecture: Kari Alitalo, Helsinki 
New Growth Factor Mechanisms in Lymphangiogenesis
Sponsored by the Lymphatics Research Foundation
Session III: New frontiers in lymphatics biology
Chair: Jan Kitajewski
2:30-3 p.m.
Tim Hla, Cornell
miRs and HuR (and MIGs)
3-3:30 p.m.
Jeffrey Bender, Yale
HuR regulation of VEGF-C
3:30-4 p.m.
Kathleen Caron, UNC
Adrenomedullin and lymphangiogenesis
4-4:30 p.m.
Bill Sessa, Yale
Akt signaling in lymphangiogenesis
4:30-6:30 p.m.
Posters & Reception
6:30-7:15 p.m.
New Technology: Derek Toomre, Yale
Super resolution imaging
Saturday May 4
Session I: A word from the fishes
Chair: Suk-Won Jin
8:30-9 a.m.
Brant Weinstein, NIH
Some cool stuff from my lab
9-9:30 a.m.
Nathan Lawson, U Mass
Even more cool stuff from my lab
9:30-10 a.m.
Vicki Bautch, UNC
Some fishy stuff from my lab
10-10:30 a.m. Coffee Break
Session II: Mechanosensing, lymphatics and valves
Chair: Tim Hla
10:30-11 a.m.
Martin Schwartz, Yale
Mechanosensing: an overview
11-11:30 a.m.
Mark Kahn, U Penn
Mechanosensing in lymphatics
11:30-12 p.m.
Jan Kitajewski, Columbia
Role of Notch in lymphatic development and valves
12-12:30 p.m.
Minhong Yan, Genentech
EphB4/EphrinB2 signaling in lymphatic valve morphogenesis
12:30-1:30 Lunch Break
Session III: Lymphatics and Disease
Chair: Bill Sessa
1:30-2 p.m.
Wang Min, Yale
Inflammatory lymphangiogenesis
2-2:30 p.m.
Nancy Ruddle, Yale
Inflammatory lymphangiogenesis
2:30-3 p.m.
Mihaela Skobe, MSSM
Lymphatics and cancer
3-3:30 p.m.
Jens Titze, Vanderbilt
Lymphatics control of blood pressure
3:30-6 p.m.
Poster session and guided tours of the Yale CINEMA Super Resolution Microscopy Facility.
Submitted by Michael Fitzsousa on April 29, 2013