Endothelial MHC expression is required to initiate T cell–mediated rejection of 3D-printed skin grafts
Tobiasova Z, Sefik E, Qin L, McNiff J, Davis G, Flavell R, Saltzman W, Pober J. Endothelial MHC expression is required to initiate T cell–mediated rejection of 3D-printed skin grafts. JCI Insight 2026, 11: e201946. PMID: 42018655, PMCID: PMC13135413, DOI: 10.1172/jci.insight.201946.Peer-Reviewed Original Research
ConceptsHuman hematopoietic stem cellsCD8+ T cellsT cell-mediated rejectionT cellsWT-ECMinimal infiltrationCD4+ T cellsHuman CD4+ T cellsAdult human hematopoietic stem cellsGrafted cell typeEndothelial cellsHematopoietic stem cellsT cell clonesEvidence of rejectionMHC molecule expressionCD4+Dendritic cellsImmunodeficient miceMHC expressionLymphoid cellsMolecule expressionHuman PBMCsSkin graftsMHC moleculesStem cells