T cell receptors for antigen on intraepithelial cytolytic T lymphocytes in celiac disease engage enterocyte HLA-E and HLA-B
Johnson J, Agrawal K, Al-Lamki R, Zhang F, Wang X, Tobiasova Z, Taleb S, Liburd S, Rodriguez L, Martins A, Flavell R, Robert M, Sefik E, Pober J. T cell receptors for antigen on intraepithelial cytolytic T lymphocytes in celiac disease engage enterocyte HLA-E and HLA-B. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2525433123. PMID: 41642982, PMCID: PMC12890992, DOI: 10.1073/pnas.2525433123.Peer-Reviewed Original Research
ConceptsCytotoxic T lymphocytesT cell receptorHLA-ET lymphocytesProximity ligation assayClass II HLA moleculesT cell receptor for antigenHLA-B mRNACytolytic T lymphocytesT cell subsetsCeliac diseaseReceptor for antigenActive celiac diseaseLigation assayCTL activityHLA-E.T cellsAntigen presentationFrequent bindingHLA moleculesDuodenal biopsiesHLA-BSingle-cell RNA sequencingNormal controlsHLA-B.