Miguel López de Rodas Gregorio, MD
Cards
About
Research
Publications
2022
Role of tumor infiltrating lymphocytes and spatial immune heterogeneity in sensitivity to PD-1 axis blockers in non-small cell lung cancer
de Rodas M, Nagineni V, Ravi A, Datar IJ, Mino-Kenudson M, Corredor G, Barrera C, Behlman L, Rimm DL, Herbst RS, Madabhushi A, Riess JW, Velcheti V, Hellmann MD, Gainor J, Schalper KA. Role of tumor infiltrating lymphocytes and spatial immune heterogeneity in sensitivity to PD-1 axis blockers in non-small cell lung cancer. Journal For ImmunoTherapy Of Cancer 2022, 10: e004440. PMID: 35649657, PMCID: PMC9161072, DOI: 10.1136/jitc-2021-004440.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerImmune checkpoint inhibitorsT-cell immunoglobulin mucin-3Cell lung cancerCytotoxic T cellsT cellsImmune heterogeneityLung cancerT cell exhaustion marker expressionPD-L1 positive patientsT cell exhaustion markersAdaptive antitumor immune responsesCell death protein 1Baseline tumor samplesExhaustion marker expressionIndependent NSCLC cohortsTumor immune heterogeneityT-cell densityAntitumor immune responseT cell infiltrationDeath protein 1Multi-institutional cohortActivation gene-3Helper T cellsRole of tumor
2021
Tumour antigen-induced T cell exhaustion — the archenemy of immune-hot malignancies
Lopez de Rodas M, Schalper KA. Tumour antigen-induced T cell exhaustion — the archenemy of immune-hot malignancies. Nature Reviews Clinical Oncology 2021, 18: 749-750. PMID: 34556846, PMCID: PMC9235859, DOI: 10.1038/s41571-021-00562-5.Peer-Reviewed Original ResearchConceptsT cell exhaustionCell exhaustionTumor antigen-specific effector T cellsAntigen-specific effector T cellsTissue-resident memory phenotypeT-cell alterationsEffector T cellsCell-specific antigensMemory phenotypeLung carcinomaClinical significanceT cellsHuman melanomaTumor microenvironmentCell alterationsSingle-cell strategyRecent studiesCD8CarcinomaMalignancyMelanomaExhaustionAntigenTargeting the Atf7ip–Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity
Hu H, Khodadadi-Jamayran A, Dolgalev I, Cho H, Badri S, Chiriboga LA, Zeck B, De Rodas Gregorio M, Dowling CM, Labbe K, Deng J, Chen T, Zhang H, Zappile P, Chen Z, Ueberheide B, Karatza A, Han H, Ranieri M, Tang S, Jour G, Osman I, Sucker A, Schadendorf D, Tsirigos A, Schalper KA, Velcheti V, Huang HY, Jin Y, Ji H, Poirier JT, Li F, Wong KK. Targeting the Atf7ip–Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity. Cancer Immunology Research 2021, 9: 1298-1315. PMID: 34462284, PMCID: PMC9414288, DOI: 10.1158/2326-6066.cir-21-0543.Peer-Reviewed Original ResearchConceptsHistone lysine methyltransferase 1Common adaptive mechanismSuppressor screenChromatin modifiersIntron retentionSET domainEpigenetic regulatorsEpigenetic modificationsEpigenetic modifiersType I interferon responseMethyltransferase 1I interferon responseHuman cancersTranscription factor 7Immune invasionInterferon responseAdaptive mechanismsFactor 7GenesCritical roleExpressionImmune evasionRejection of cellsAntigen processingAntigen expression
2018
Functional transcriptomic annotation and protein-protein interaction analysis identify EZH2 and UBE2C as key upregulated proteins in ovarian cancer.
Martínez-Canales S, López de Rodas M, Nuncia-Cantarero M, Páez R, Amir E, Győrffy B, Pandiella A, Galán-Moya EM, Ocaña A. Functional transcriptomic annotation and protein-protein interaction analysis identify EZH2 and UBE2C as key upregulated proteins in ovarian cancer. Cancer Medicine 2018, 7: 1896-1907. PMID: 29575713, PMCID: PMC5943485, DOI: 10.1002/cam4.1406.Peer-Reviewed Original Research
2017
Transcriptomic immunologic signature associated with favorable clinical outcome in basal-like breast tumors.
Martínez-Canales S, Cifuentes F, López De Rodas Gregorio M, Serrano-Oviedo L, Galán-Moya EM, Amir E, Pandiella A, Győrffy B, Ocaña A. Transcriptomic immunologic signature associated with favorable clinical outcome in basal-like breast tumors. PloS One 2017, 12: e0175128. PMID: 28472085, PMCID: PMC5417488, DOI: 10.1371/journal.pone.0175128.Peer-Reviewed Original Research