Welcome to the Schalper Lab

My research is focused on understanding the immunobiology of human solid tumors and develop molecular biomarkers for prediction of response or resistance to therapies. In particular, my group has been actively evaluating the role of specific tumor antigens and immune evasion pathways used by human lung malignancies including immune co-inhibitory/stimulatory ligands and receptors, tolerogenic enzymes, immune suppressive cells, antigen presenting/processing machinery, metabolic alterations in the tumor microenvironment and oncogenic intracellular signaling. More recent and future scientific interests include the evaluation and clinical impact of tumor immune heterogeneity and editing.