Morphogenic gradients governing areal identity in the neorcortex
Graded expression patterns of several factors thought to be responsible for shaping the ultimate neocortical landscape that is highly partitioned and specialized. Supplement list to Figure 4 in Rakic P, Ayoub AE, Breunig JJ, Dominguez MH. Decision by division: making cortical maps. Trends Neurosci. 2009 May;32(5):291-301. Epub 2009 Apr 18. Review. PubMed PMID: 19380167.
| Image | Molecule | Repressses | Induces | Repressors | Inducers | References |
|---|---|---|---|---|---|---|
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BMPs (4,6,7; also 2,5) | Foxg1, FGF8 | Msx1 | FGF8, Noggin |
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PubMed |
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Cadherin-11 |
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PubMed |
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Cadherin-6 |
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FGFs |
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PubMed |
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Cadherin-8 |
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FGFs | PubMed |
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Clim1a |
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PubMed |
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COUP-TFI (Nr2f1) |
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FGF8 > FGF17 |
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PubMed |
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EGFs (TNFalpha, Nrg1, Nrg2, Nrg3) |
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Pax6 (required) | PubMed |
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Emx2 | FGFs, Pax6 | Reelin | FGF8 >>> FGF17, Pax6 | Wnts | PubMed |
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EphA2 |
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PubMed |
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EphA7 |
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PubMed |
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Ephrin-A5 |
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FGFs |
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PubMed |
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Etv1(Er81) |
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FGF8 | PubMed |
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FGF15 |
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PubMed |
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FGF17 |
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Sp8 |
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Sp8 | PubMed |
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FGF8 | BMP4, Wnts, COUP-TF1, Emx2, Otx2 | FGFs, Sp8, Nkx2.1, Ets Factors (Pea3, Erm, Etv1), Spry1 and Spry2 | Emx2 | Shh, Sp8 | PubMed |
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FGFR3 |
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FGF8 |
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PubMed |
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Foxg1 (BF1) | BMPs |
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BMP2, BMP4, Wnts |
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PubMed |
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Id2 |
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PubMed |
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Lhx2 | Wnts |
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PubMed |
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Lmo3 |
|
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PubMed |
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Lmo4 |
|
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PubMed |
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Nt3 |
|
|
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PubMed |
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Otx2 |
|
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FGF8 |
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PubMed |
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p75 |
|
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Emx2 | PubMed |
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Pax6 | Emx2 | sFrp2 | Emx2 |
|
PubMed |
|
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Pea3 |
|
|
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FGF8 | PubMed |
|
RORbeta |
|
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FGFs |
|
PubMed |
|
SCIP (Pou3f1) |
|
|
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PubMed |
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Sfrps (sFrp2) | Wnts |
|
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PubMed |
|
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Shh | Gli3 | FGF8, Gli3R |
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Nkx2.1 | PubMed |
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Sp5 |
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PubMed |
|
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Sp8 |
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FGF8 |
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FGFs | PubMed |
| Spry1 | Ets factors?? |
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|
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PubMed | |
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Tbr1 |
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FGF8 | PubMed |
|
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Wnts (Wnt3a,Wnt2b,Wnt5a,Wnt8b) |
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FGFs | NOT BMP | PubMed |