2008
Endothelial Expression of Beta‐1 Integrin Is Required for Embryonic Vascular Patterning and Postnatal Vascular Remodeling
lei L, Liu D, Huang Y, Jovin I, Shai S, Kyriakides T, Ross R, Giordano F. Endothelial Expression of Beta‐1 Integrin Is Required for Embryonic Vascular Patterning and Postnatal Vascular Remodeling. The FASEB Journal 2008, 22: 1122.11-1122.11. DOI: 10.1096/fasebj.22.1_supplement.1122.11.Peer-Reviewed Original ResearchVascular remodelingEndothelial expressionSevere fetal growth retardationFetal growth retardationCre/loxP techniqueAbnormal vascular remodelingSignificant clinical importancePostnatal vascular remodelingΒ1 subunit expressionΒ1 integrinBeta 1 integrinΒ1 integrin expressionBlood flowAdult miceClinical importanceSubunit expressionGlobal deletionPostnatal survivalGrowth retardationEndothelial cellsIntegrin expressionTime pointsHealing woundsSignificant functional effectsFunctional effects
2006
An engineered VEGF‐activating zinc finger protein transcription factor improves blood flow and limb salvage in advanced‐age mice
Yu J, Lei L, Liang Y, Hinh L, Hickey RP, Huang Y, Liu D, Yeh JL, Rebar E, Case C, Spratt K, Sessa WC, Giordano FJ. An engineered VEGF‐activating zinc finger protein transcription factor improves blood flow and limb salvage in advanced‐age mice. The FASEB Journal 2006, 20: 479-481. PMID: 16423874, DOI: 10.1096/fj.04-3670fje.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAgingAmino Acid SequenceAnimalsBlood Flow VelocityFeasibility StudiesGene Expression RegulationGenes, SyntheticGenetic TherapyGenetic VectorsHindlimbIschemiaLaser-Doppler FlowmetryMiceMice, Inbred C57BLMolecular Sequence DataNeovascularization, PhysiologicProtein EngineeringRecombinant ProteinsRNA, MessengerStructure-Activity RelationshipTranscription FactorsVascular Endothelial Growth Factor AZinc FingersConceptsLimb salvageBlood flowHindlimb ischemiaC57/BL6 micePeripheral vascular diseaseVascular endothelial growth factorPotential clinical utilityEndothelial growth factorExpression of VEGFABL6 miceIschemic limbsVascular diseaseIschemic hindlimbMurine modelClinical utilityVessel countProtein transcription factorsGrowth factorProtein levelsSalvage