Funding

Qyang (PI) - 07/01/2022 – 06/30/2026

NIH/NHLBI

Modulation of heart function by Muscle LIM protein-mediated mechanotransduction

The goal of this research proposal is to elucidate the molecular mechanisms that mediate the repression of calcineurin/NFAT by MLP as well as MLP protein degradation by stretch-sensing in familial hypertrophic cardiomyopathy caused by sarcomeric mutations.

Qyang (PI) - 07/01/2021 – 06/30/2025

NIH/NHLBI

Development of HLA engineered universal vascular grafts from human iPSCs

This proposal is aimed at investigating the interactions between a hypoimmunogenic, universal endothelium derived from human pluripotent stem cells and a mechanically robust, cell-produced extracellular matrix scaffold in order to produce endothelialized, small diameter (2-4 mm) tissue-engineered vascular grafts.

Qyang (PI) - 07/01/2020 – 06/30/2024

NIH/NHLBI

Readily Available Stem Cell-Based Vascular Grafts for Emergent Surgical Care

The goal of this project is to develop readily available tissue-engineered vascular grafts using vascular cells derived from wild type pluripotent stem cells for testing in immune deficient rats and immune-suppressed pigs, setting the stage for treating patients with urgent need for endothelialized small caliber vascular grafts.

Qyang (PI) - 08/15/2019 – 08/14/2023

Department of Defense

Human Tissue Engineered Pulsatile Conduits for Treatment of Single Ventricle Congenital Heart Defect

This proposal is aimed at producing a tissue engineered pulsatile conduit (TEPC) for the Fontan procedure, which is used as a clinical intervention for children born with single ventricle congenital heart defect (SVCHD).

Campbell (PI; Qyang co-I) - 07/01/2017 – 03/31/2023

NIH/NHLBI

Revealing Pathomechanisms of Mutant TPM1 Through a Hybrid Computational-Experimental Approach We will develop new multiscale models that predict the impact of tropomyosin (TPM1) mutations on cardiac cell hypertrophy.

Park (Qyang Faculty Sponsor) - 01/1/2020 – 12/31/2022

Department of Defense

High-Throughput Screening for Novel Drug Discovery Using Patient-Specific Induced Pluripotent Stem Cells for Familial Hypertrophic Cardiomyopathy

The goal of this project is to discover new drugs to treat familiar hypertrophy cardiomyopathy using the FDA-approved small molecule libraries.