Publications

• UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling.Harrison AG, Yang D, Cahoon JG, Geng T, Cao Z, Karginov TA, Hu Y, Li X, Chiari CC, Qyang Y, Vella AT, Fan Z, Vanaja SK, Rathinam VA, Witczak CA, Bogan JS, Wang P. Nat Immunol. 2024 Nov 20; 2024 Nov 20. PMID: 39567760.
• De Novo Elastin Assembly Alleviates Development of Supravalvular Aortic Stenosis-Brief Report.Ellis MW, Riaz M, Huang Y, Anderson CW, Hoareau M, Li X, Luo H, Lee S, Park J, Luo J, Batty LD, Huang Q, Lopez CA, Reinhardt DP, Tellides G, Qyang Y. Arterioscler Thromb Vasc Biol. 2024 Jul; 2024 May 16. PMID: 38752350.
• UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling.Wang P, Harrison A, Yang D, Cahoon J, Geng T, Cao Z, Karginov T, Chiari C, Li X, Qyang Y, Vella A, Fan Z, Vanaja SK, Rathinam V, Witczak C, Bogan J. Res Sq. 2024 Jun 4; 2024 Jun 4. PMID: 38883790.
• The relationship between elastin cross linking and alveolar wall rupture in human pulmonary emphysema.Fagiola M, Reznik S, Riaz M, Qyang Y, Lee S, Avella J, Turino G, Cantor J. Am J Physiol Lung Cell Mol Physiol. 2023 Jun 1; 2023 Apr 4. PMID: 37014816.
• Signaling network model of cardiomyocyte morphological changes in familial cardiomyopathy.Khalilimeybodi A, Riaz M, Campbell SG, Omens JH, McCulloch AD, Qyang Y, Saucerman JJ. J Mol Cell Cardiol. 2023 Jan; 2022 Nov 10. PMID: 36370475.
• Muscle LIM Protein Force-Sensing Mediates Sarcomeric Biomechanical Signaling in Human Familial Hypertrophic Cardiomyopathy.Riaz M, Park J, Sewanan LR, Ren Y, Schwan J, Das SK, Pomianowski PT, Huang Y, Ellis MW, Luo J, Liu J, Song L, Chen IP, Qiu C, Yazawa M, Tellides G, Hwa J, Young LH, Yang L, Marboe CC, Jacoby DL, Campbell SG, Qyang Y. Circulation. 2022 Apr 19; 2022 Apr 6. PMID: 35384713.
• Readily Available Tissue-Engineered Vascular Grafts Derived From Human Induced Pluripotent Stem Cells.Luo J, Qin L, Park J, Kural MH, Huang Y, Shi X, Riaz M, Wang J, Ellis MW, Anderson CW, Yuan Y, Ren Y, Yoder MC, Tellides G, Niklason LE, Qyang Y. Circ Res. 2022 Mar 18; 2022 Feb 22. PMID: 35189711.
• Epigallocatechin gallate facilitates extracellular elastin fiber formation in induced pluripotent stem cell derived vascular smooth muscle cells for tissue engineering.Ellis MW, Riaz M, Huang Y, Anderson CW, Luo J, Park J, Lopez CA, Batty LD, Gibson KH, Qyang Y. J Mol Cell Cardiol. 2022 Feb; 2021 Dec 31. PMID: 34979103.
• Methods for Differentiating hiPSCs into Vascular Smooth Muscle Cells.Li ML, Luo J, Ellis MW, Riaz M, Ajaj Y, Qyang Y. Methods Mol Biol. 2022. PMID: 34591296.
• Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation.Sewanan LR, Park J, Rynkiewicz MJ, Racca AW, Papoutsidakis N, Schwan J, Jacoby DL, Moore JR, Lehman W, Qyang Y, Campbell SG. J Gen Physiol. 2021 Sep 6; 2021 Jul 28. PMID: 34319370.
• An ex vivo physiologic and hyperplastic vessel culture model to study intra-arterial stent therapies.Wang J, Kural MH, Wu J, Leiby KL, Mishra V, Lysyy T, Li G, Luo J, Greaney A, Tellides G, Qyang Y, Huang N, Niklason LE. Biomaterials. 2021 Aug; 2021 May 29. PMID: 34087584.
• PECUU-ECM Patches: The Future of Ischemic Heart Disease Repair.Ajaj Y, Akingbesote ND, Qyang Y. JACC Basic Transl Sci. 2021 May; 2021 May 24. PMID: 34101774.
• Human-Induced Pluripotent Stem-Cell-Derived Smooth Muscle Cells Increase Angiogenesis to Treat Hindlimb Ischemia.Gao X, Gao M, Gorecka J, Langford J, Liu J, Luo J, Taniguchi R, Matsubara Y, Liu H, Guo L, Gu Y, Qyang Y, Dardik A. Cells. 2021 Apr 2; 2021 Apr 2. PMID: 33918299.
• Shortening Velocity Causes Myosin Isoform Shift in Human Engineered Heart Tissues.Ng R, Sewanan LR, Stankey P, Li X, Qyang Y, Campbell S. Circ Res. 2021 Jan 22; 2020 Nov 13. PMID: 33183160.
• Efficient Differentiation of Human Induced Pluripotent Stem Cells into Endothelial Cells under Xenogeneic-free Conditions for Vascular Tissue Engineering.Luo J, Shi X, Lin Y, Yuan Y, Kural MH, Wang J, Ellis MW, Anderson CW, Zhang SM, Riaz M, Niklason LE, Qyang Y. Acta Biomater. 2021 Jan 1; 2020 Nov 6. PMID: 33166710.
• Xenogeneic-free generation of vascular smooth muscle cells from human induced pluripotent stem cells for vascular tissue engineering.Luo J, Lin Y, Shi X, Li G, Kural MH, Anderson CW, Ellis MW, Riaz M, Tellides G, Niklason LE, Qyang Y. Acta Biomater. 2021 Jan 1; 2020 Oct 29. PMID: 33130306.
• Contractile work directly modulates mitochondrial protein levels in human engineered heart tissues.Ng R, Sewanan LR, Brill AL, Stankey P, Li X, Qyang Y, Ehrlich BE, Campbell SG. Am J Physiol Heart Circ Physiol. 2020 Jun 1; 2020 May 8. PMID: 32383992.
• Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human iPSCs.Luo J, Qin L, Zhao L, Gui L, Ellis MW, Huang Y, Kural MH, Clark JA, Ono S, Wang J, Yuan Y, Zhang SM, Cong X, Li G, Riaz M, Lopez C, Hotta A, Campbell S, Tellides G, Dardik A, Niklason LE, Qyang Y. Cell Stem Cell. 2020 Feb 6; 2020 Jan 16. PMID: 31956039.
• Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing.Gorecka J, Gao X, Fereydooni A, Dash BC, Luo J, Lee SR, Taniguchi R, Hsia HC, Qyang Y, Dardik A. Regen Med. 2020 Feb; 2020 Mar 31. PMID: 32228292.
• Modular design of a tissue engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes.Park J, Anderson CW, Sewanan LR, Kural MH, Huang Y, Luo J, Gui L, Riaz M, Lopez CA, Ng R, Das SK, Wang J, Niklason L, Campbell SG, Qyang Y. Acta Biomater. 2020 Jan 15; 2019 Oct 19. PMID: 31634626.
• Polydopamine and collagen coated micro-grated polydimethylsiloxane for human mesenchymal stem cell culture.Sharma D, Jia W, Long F, Pati S, Chen Q, Qyang Y, Lee B, Choi CK, Zhao F. Bioact Mater. 2019 Dec; 2019 Feb 21. PMID: 30873506.
• Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes.Sewanan LR, Schwan J, Kluger J, Park J, Jacoby DL, Qyang Y, Campbell SG. JACC Basic Transl Sci. 2019 Aug; 2019 Jul 24. PMID: 31468004.
• Patient mutations linked to arrhythmogenic cardiomyopathy enhance calpain-mediated desmoplakin degradation.Ng R, Manring H, Papoutsidakis N, Albertelli T, Tsai N, See CJ, Li X, Park J, Stevens TL, Bobbili PJ, Riaz M, Ren Y, Stoddard CE, Janssen PM, Bunch TJ, Hall SP, Lo YC, Jacoby DL, Qyang Y, Wright N, Ackermann MA, Campbell SG. JCI Insight. 2019 Jun 13; 2019 Jun 13. PMID: 31194698.
• Sarcomere-Directed Calcium Reporters in Cardiomyocytes.Campbell SG, Qyang Y, Hinson JT. Circ Res. 2019 Apr 12. PMID: 30973804.
• The potential and limitations of induced pluripotent stem cells to achieve wound healing.Gorecka J, Kostiuk V, Fereydooni A, Gonzalez L, Luo J, Dash B, Isaji T, Ono S, Liu S, Lee SR, Xu J, Liu J, Taniguchi R, Yastula B, Hsia HC, Qyang Y, Dardik A. Stem Cell Res Ther. 2019 Mar 12; 2019 Mar 12. PMID: 30867069.
• Modeling elastin-associated vasculopathy with patient induced pluripotent stem cells and tissue engineering.Ellis MW, Luo J, Qyang Y. Cell Mol Life Sci. 2019 Mar; 2018 Nov 20. PMID: 30460472.
• Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering.Luo J, Qin L, Kural MH, Schwan J, Li X, Bartulos O, Cong XQ, Ren Y, Gui L, Li G, Ellis MW, Li P, Kotton DN, Dardik A, Pober JS, Tellides G, Rolle M, Campbell S, Hawley RJ, Sachs DH, Niklason LE, Qyang Y. Biomaterials. 2017 Dec; 2017 Sep 19. PMID: 28942128.
• mTOR (Mechanistic Target of Rapamycin) Inhibition Decreases Mechanosignaling, Collagen Accumulation, and Stiffening of the Thoracic Aorta in Elastin-Deficient Mice.Jiao Y, Li G, Li Q, Ali R, Qin L, Li W, Qyang Y, Greif DM, Geirsson A, Humphrey JD, Tellides G. Arterioscler Thromb Vasc Biol. 2017 Sep; 2017 Jul 27. PMID: 28751568.
• Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.Sivarapatna A, Ghaedi M, Xiao Y, Han E, Aryal B, Zhou J, Fernandez-Hernando C, Qyang Y, Hirschi KK, Niklason LE. Cell Transplant. 2017 Aug. PMID: 28901188.
• Stem Cells in Cardiovascular Medicine: the Road to Regenerative Therapies.Anderson CW, Boardman N, Luo J, Park J, Qyang Y. Curr Cardiol Rep. 2017 Apr. PMID: 28324469.
• Alk2/ACVR1 and Alk3/BMPR1A Provide Essential Function for Bone Morphogenetic Protein-Induced Retinal Angiogenesis.Lee HW, Chong DC, Ola R, Dunworth WP, Meadows S, Ka J, Kaartinen VM, Qyang Y, Cleaver O, Bautch VL, Eichmann A, Jin SW. Arterioscler Thromb Vasc Biol. 2017 Apr; 2017 Feb 23. PMID: 28232325.
• Implantable tissue-engineered blood vessels from human induced pluripotent stem cells.Gui L, Dash BC, Luo J, Qin L, Zhao L, Yamamoto K, Hashimoto T, Wu H, Dardik A, Tellides G, Niklason LE, Qyang Y. Biomaterials. 2016 Sep; 2016 Jun 14. PMID: 27336184.
• Anisotropic engineered heart tissue made from laser-cut decellularized myocardium.Schwan J, Kwaczala AT, Ryan TJ, Bartulos O, Ren Y, Sewanan LR, Morris AH, Jacoby DL, Qyang Y, Campbell SG. Sci Rep. 2016 Aug 30; 2016 Aug 30. PMID: 27572147.
• Tissue-Engineered Vascular Rings from Human iPSC-Derived Smooth Muscle Cells.Dash BC, Levi K, Schwan J, Luo J, Bartulos O, Wu H, Qiu C, Yi T, Ren Y, Campbell S, Rolle MW, Qyang Y. Stem Cell Reports. 2016 Jul 12. PMID: 27411102.
• ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction.Bartulos O, Zhuang ZW, Huang Y, Mikush N, Suh C, Bregasi A, Wang L, Chang W, Krause DS, Young LH, Pober JS, Qyang Y. JCI Insight. 2016 Jul 7. PMID: 27525311.
• Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis.Misra A, Sheikh AQ, Kumar A, Luo J, Zhang J, Hinton RB, Smoot L, Kaplan P, Urban Z, Qyang Y, Tellides G, Greif DM. J Exp Med. 2016 Mar 7; 2016 Feb 8. PMID: 26858344.
• Efficient gene disruption in cultured primary human endothelial cells by CRISPR/Cas9.Abrahimi P, Chang WG, Kluger MS, Qyang Y, Tellides G, Saltzman WM, Pober JS. Circ Res. 2015 Jul 3; 2015 May 4. PMID: 25940550.
• Induced pluripotent stem cell-derived vascular smooth muscle cells: methods and application.Dash BC, Jiang Z, Suh C, Qyang Y. Biochem J. 2015 Jan 15. PMID: 25559088.
• Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor.Sivarapatna A, Ghaedi M, Le AV, Mendez JJ, Qyang Y, Niklason LE. Biomaterials. 2015; 2015 Mar 24. PMID: 25890758.
• Functional cardiomyocytes derived from Isl1 cardiac progenitors via Bmp4 stimulation.Cagavi E, Bartulos O, Suh CY, Sun B, Yue Z, Jiang Z, Yue L, Qyang Y. PLoS One. 2014; 2014 Dec 18. PMID: 25522363.
• Advancements in Induced Pluripotent Stem Cell Technology for Cardiac Regenerative Medicine.Suh CY, Wang Z, Bártulos O, Qyang Y. J Cardiovasc Pharmacol Ther. 2014 Jul; 2014 Mar 19. PMID: 24651517.
• Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos.Dunworth WP, Cardona-Costa J, Bozkulak EC, Kim JD, Meadows S, Fischer JC, Wang Y, Cleaver O, Qyang Y, Ober EA, Jin SW. Circ Res. 2014 Jan 3; 2013 Oct 11. PMID: 24122719.
• Rapamycin inhibits smooth muscle cell proliferation and obstructive arteriopathy attributable to elastin deficiency.Li W, Li Q, Qin L, Ali R, Qyang Y, Tassabehji M, Pober BR, Sessa WC, Giordano FJ, Tellides G. Arterioscler Thromb Vasc Biol. 2013 May; 2013 Mar 14. PMID: 23493289.
• Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells.Ge X, Ren Y, Bartulos O, Lee MY, Yue Z, Kim KY, Li W, Amos PJ, Bozkulak EC, Iyer A, Zheng W, Zhao H, Martin KA, Kotton DN, Tellides G, Park IH, Yue L, Qyang Y. Circulation. 2012 Oct 2; 2012 Aug 22. PMID: 22914687.
• Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2.Kim JD, Kang H, Larrivée B, Lee MY, Mettlen M, Schmid SL, Roman BL, Qyang Y, Eichmann A, Jin SW. Dev Cell. 2012 Aug 14. PMID: 22898784.
• Regenerating functional heart tissue for myocardial repair.Alcon A, Cagavi Bozkulak E, Qyang Y. Cell Mol Life Sci. 2012 Aug; 2012 Mar 3. PMID: 22388688.
• Evaluation of the use of an induced puripotent stem cell sheet for the construction of tissue-engineered vascular grafts.Hibino N, Duncan DR, Nalbandian A, Yi T, Qyang Y, Shinoka T, Breuer CK. J Thorac Cardiovasc Surg. 2012 Mar; 2012 Jan 12. PMID: 22244569.
• Derivation of functional ventricular cardiomyocytes using endogenous promoter sequence from murine embryonic stem cells.Lee MY, Sun B, Schliffke S, Yue Z, Ye M, Paavola J, Bozkulak EC, Amos PJ, Ren Y, Ju R, Jung YW, Ge X, Yue L, Ehrlich BE, Qyang Y. Stem Cell Res. 2012 Jan; 2011 Aug 22. PMID: 22099020.
• Methods of cell purification: a critical juncture for laboratory research and translational science.Amos PJ, Cagavi Bozkulak E, Qyang Y. Cells Tissues Organs. 2012; 2011 Oct 12. PMID: 21996576.
• High density cultures of embryoid bodies enhanced cardiac differentiation of murine embryonic stem cells.Lee MY, Cagavi Bozkulak E, Schliffke S, Amos PJ, Ren Y, Ge X, Ehrlich BE, Qyang Y. Biochem Biophys Res Commun. 2011 Dec 9; 2011 Nov 6. PMID: 22079290.
• Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells.Ren Y, Lee MY, Schliffke S, Paavola J, Amos PJ, Ge X, Ye M, Zhu S, Senyei G, Lum L, Ehrlich BE, Qyang Y. J Mol Cell Cardiol. 2011 Sep; 2011 May 4. PMID: 21569778.
• Regeneration of a heart cell.Qyang Y, Senyei G. Yale J Biol Med. 2009 Sep. PMID: 19774125.
• The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway.Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L, Jiang X, Lin L, Granger A, Moretti A, Caron L, Wu X, Clarke J, Taketo MM, Laugwitz KL, Moon RT, Gruber P, Evans SM, Ding S, Chien KR. Cell Stem Cell. 2007 Aug 16; 2007 Jun 14. PMID: 18371348.
• Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification.Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, Qyang Y, Bu L, Sasaki M, Martin-Puig S, Sun Y, Evans SM, Laugwitz KL, Chien KR. Cell. 2006 Dec 15; 2006 Nov 22. PMID: 17123592.
• Isl1Cre reveals a common Bmp pathway in heart and limb development.Yang L, Cai CL, Lin L, Qyang Y, Chung C, Monteiro RM, Mummery CL, Fishman GI, Cogen A, Evans S. Development. 2006 Apr. PMID: 16556916.
• T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis.Cai CL, Zhou W, Yang L, Bu L, Qyang Y, Zhang X, Li X, Rosenfeld MG, Chen J, Evans S. Development. 2005 May; 2005 Apr 20. PMID: 15843407.
• Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage.Qyang Y, Chambers SM, Wang P, Xia X, Chen X, Goodell MA, Zheng H. Biochemistry. 2004 May 11. PMID: 15122901.
• The novel Rho GTPase-activating protein family protein, Rga8, provides a potential link between Cdc42/p21-activated kinase and Rho signaling pathways in the fission yeast, Schizosaccharomyces pombe.Yang P, Qyang Y, Bartholomeusz G, Zhou X, Marcus S. J Biol Chem. 2003 Dec 5; 2003 Sep 23. PMID: 14506270.
• The p21-activated kinase, Shk1, is required for proper regulation of microtubule dynamics in the fission yeast, Schizosaccharomyces pombe.Qyang Y, Yang P, Du H, Lai H, Kim H, Marcus S. Mol Microbiol. 2002 Apr. PMID: 11972773.