Publications
2024
- Nanoscale Surface Topography of Polyethylene Glycol-Coated Nanoparticles Composed of Bottlebrush Block Copolymers Prolongs Systemic Circulation and Enhances Tumor Uptake.Grundler J, Shin K, Suh HW, Whang CH, Fulgoni G, Pierce RW, Saltzman WM. ACS Nano. 2024 Jan 30; 2024 Jan 16. PMID: 38227820.
2023
- Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis.Chaube B, Citrin KM, Sahraei M, Singh AK, de Urturi DS, Ding W, Pierce RW, Raaisa R, Cardone R, Kibbey R, Fernández-Hernando C, Suárez Y. Nat Commun. 2023 Dec 12; 2023 Dec 12. PMID: 38086791.
- MicroRNA-1 protects the endothelium in acute lung injury.Korde A, Haslip M, Pednekar P, Khan A, Chioccioli M, Mehta S, Lopez-Giraldez F, Bermejo S, Rojas M, Dela Cruz C, Matthay MA, Pober JS, Pierce RW, Takyar SS. JCI Insight. 2023 Sep 22; 2023 Sep 22. PMID: 37737266.
- An AI-powered patient triage platform for future viral outbreaks using COVID-19 as a disease model.Charkoftaki G, Aalizadeh R, Santos-Neto A, Tan WY, Davidson EA, Nikolopoulou V, Wang Y, Thompson B, Furnary T, Chen Y, Wunder EA, Coppi A, Schulz W, Iwasaki A, Pierce RW, Cruz CSD, Desir GV, Kaminski N, Farhadian S, Veselkov K, Datta R, Campbell M, Thomaidis NS, Ko AI, Thompson DC, Vasiliou V. Hum Genomics. 2023 Aug 29; 2023 Aug 29. PMID: 37641126.
- Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis.Egozi A, Olaloye O, Werner L, Silva T, McCourt B, Pierce RW, An X, Wang F, Chen K, Pober JS, Shouval D, Itzkovitz S, Konnikova L. PLoS Biol. 2023 May; 2023 May 19. PMID: 37205711.
- Integrated Analysis of Tracheobronchial Fluid from Before and After Cardiopulmonary Bypass Reveals Activation of the Integrated Stress Response and Altered Pulmonary Microvascular Permeability.Habet V, Li N, Qi J, Peng G, Charkoftaki G, Vasiliou V, Sharma L, Pober JS, Dela Cruz C, Yan X, Pierce RW. Yale J Biol Med. 2023 Mar; 2023 Mar 31. PMID: 37009190.
2022
- ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leak.Khan A, Ni W, Baltazar T, Lopez-Giraldez F, Pober JS, Pierce RW. FASEB J. 2022 Apr. PMID: 35294066.
- Acute Liver Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.Squires JE, McKiernan PJ, Squires RH. Pediatrics. 2022 Jan 1. PMID: 34970684.
- Scoring Systems for Organ Dysfunction and Multiple Organ Dysfunction: The PODIUM Consensus Conference.Schlapbach LJ, Weiss SL, Bembea MM, Carcillo JA, Leclerc F, Leteurtre S, Tissieres P, Wynn JL, Zimmerman J, Lacroix J. Pediatrics. 2022 Jan 1. PMID: 34970683.
- Renal Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.Fitzgerald JC, Basu RK, Fuhrman DY, Gorga SM, Hassinger AB, Sanchez-Pinto LN, Selewski DT, Sutherland SM, Akcan-Arikan A. Pediatrics. 2022 Jan 1. PMID: 34970682.
- Acute Neurologic Dysfunction in Critically Ill Children: The PODIUM Consensus Conference.Wainwright MS, Guilliams K, Kannan S, Simon DW, Tasker RC, Traube C, Pineda J. Pediatrics. 2022 Jan 1. PMID: 34970681.
- Gastrointestinal Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.Typpo KV, Irving SY, Prince JM, Pathan N, Brown AM. Pediatrics. 2022 Jan 1. PMID: 34970680.
- Respiratory Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.Yehya N, Khemani RG, Erickson S, Smith LS, Rowan CM, Jouvet P, Willson DF, Cheifetz IM, Ward S, Thomas NJ. Pediatrics. 2022 Jan 1. PMID: 34970679.
- Patterns of Organ Dysfunction in Critically Ill Children Based on PODIUM Criteria.Sanchez-Pinto LN, Bembea MM, Farris RW, Hartman ME, Odetola FO, Spaeder MC, Watson RS, Zimmerman JJ, Bennett TD. Pediatrics. 2022 Jan 1. PMID: 34970678.
- Cardiovascular Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.Alexander PMA, Checchia PA, Ryerson LM, Bohn D, Eckerle M, Gaies M, Laussen P, Jeffries H, Thiagarajan RR, Shekerdemian L, Bembea MM, Zimmerman JJ, Kissoon N. Pediatrics. 2022 Jan 1. PMID: 34970677.
- Endothelial Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.Pierce RW, Giuliano JS, Whitney JE, Ouellette Y. Pediatrics. 2022 Jan 1. PMID: 34970676.
- Hematologic Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.Muszynski JA, Cholette JM, Steiner ME, Tucci M, Doctor A, Parker RI. Pediatrics. 2022 Jan 1. PMID: 34970675.
- Immune System Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.Hall MW, Carcillo JA, Cornell T. Pediatrics. 2022 Jan 1. PMID: 34970674.
- Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary.Bembea MM, Agus M, Akcan-Arikan A, Alexander P, Basu R, Bennett TD, Bohn D, Brandão LR, Brown AM, Carcillo JA, Checchia P, Cholette J, Cheifetz IM, Cornell T, Doctor A, Eckerle M, Erickson S, Farris RWD, Faustino EVS, Fitzgerald JC, Fuhrman DY, Giuliano JS, Guilliams K, Gaies M, Gorga SM, Hall M, Hanson SJ, Hartman M, Hassinger AB, Irving SY, Jeffries H, Jouvet P, Kannan S, Karam O, Khemani RG, Kissoon N, Lacroix J, Laussen P, Leclerc F, Lee JH, Leteurtre S, Lobner K, McKiernan PJ, Menon K, Monagle P, Muszynski JA, Odetola F, Parker R, Pathan N, Pierce RW, Pineda J, Prince JM, Robinson KA, Rowan CM, Ryerson LM, Sanchez-Pinto LN, Schlapbach LJ, Selewski DT, Shekerdemian LS, Simon D, Smith LS, Squires JE, Squires RH, Sutherland SM, Ouellette Y, Spaeder MC, Srinivasan V, Steiner ME, Tasker RC, Thiagarajan R, Thomas N, Tissieres P, Traube C, Tucci M, Typpo KV, Wainwright MS, Ward SL, Watson RS, Weiss S, Whitney J, Willson D, Wynn JL, Yehya N, Zimmerman JJ. Pediatrics. 2022 Jan 1. PMID: 34970673.
- Endocrine Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.Srinivasan V, Lee JH, Menon K, Zimmerman JJ, Bembea MM, Agus MSD. Pediatrics. 2022 Jan 1. PMID: 34970672.
- Refining the Pediatric Multiple Organ Dysfunction Syndrome.Weiss SL, Carcillo JA, Leclerc F, Leteurtre S, Schlapbach LJ, Tissieres P, Wynn JL, Lacroix J. Pediatrics. 2022 Jan 1. PMID: 34970671.
- Coagulation Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.Faustino EVS, Karam O, Parker RI, Hanson SJ, Brandão LR, Monagle P. Pediatrics. 2022 Jan 1. PMID: 34970670.
2021
- Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung.Schupp JC, Adams TS, Cosme C Jr, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe'er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Circulation. 2021 Jul 27; 2021 May 25. PMID: 34030460.
- Tumor necrosis factor-induced ArhGEF10 selectively activates RhoB contributing to human microvascular endothelial cell tight junction disruption.Khan A, Ni W, Lopez-Giraldez F, Kluger MS, Pober JS, Pierce RW. FASEB J. 2021 Jun. PMID: 33948992.
- Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children.Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. Immunity. 2021 May 11; 2021 Apr 13. PMID: 33891889.
- Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity.Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. medRxiv. 2021 Apr 3; 2021 Apr 3. PMID: 33300011.
- Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes.Ravindra NG, Alfajaro MM, Gasque V, Huston NC, Wan H, Szigeti-Buck K, Yasumoto Y, Greaney AM, Habet V, Chow RD, Chen JS, Wei J, Filler RB, Wang B, Wang G, Niklason LE, Montgomery RR, Eisenbarth SC, Chen S, Williams A, Iwasaki A, Horvath TL, Foxman EF, Pierce RW, Pyle AM, van Dijk D, Wilen CB. PLoS Biol. 2021 Mar; 2021 Mar 17. PMID: 33730024.
2020
- Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium.Ravindra NG, Alfajaro MM, Gasque V, Habet V, Wei J, Filler RB, Huston NC, Wan H, Szigeti-Buck K, Wang B, Wang G, Montgomery RR, Eisenbarth SC, Williams A, Pyle AM, Iwasaki A, Horvath TL, Foxman EF, Pierce RW, van Dijk D, Wilen CB. bioRxiv. 2020 Jul 13; 2020 Jul 13. PMID: 32511382.
- Methylene Blue for Refractory Shock in Children: A Systematic Review and Survey Practice Analysis.Otero Luna AV, Johnson R, Funaro M, Canarie MF, Pierce RW. Pediatr Crit Care Med. 2020 Jun. PMID: 32453920.
- Relevance of Microvascular Flow Assessments in Critically Ill Neonates and Children: A Systematic Review.Maitoza LA, Neeman E, Funaro M, Pierce RW. Pediatr Crit Care Med. 2020 Apr. PMID: 31834246.
- BMX Represses Thrombin-PAR1-Mediated Endothelial Permeability and Vascular Leakage During Early Sepsis.Li Z, Yin M, Zhang H, Ni W, Pierce RW, Zhou HJ, Min W. Circ Res. 2020 Feb 14; 2020 Jan 8. PMID: 31910739.
2019
- Progenitor-derived human endothelial cells evade alloimmunity by CRISPR/Cas9-mediated complete ablation of MHC expression.Merola J, Reschke M, Pierce RW, Qin L, Spindler S, Baltazar T, Manes TD, Lopez-Giraldez F, Li G, Bracaglia LG, Xie C, Kirkiles-Smith N, Saltzman WM, Tietjen GT, Tellides G, Pober JS. JCI Insight. 2019 Oct 17; 2019 Oct 17. PMID: 31527312.
- Letter in response to "Vascular endothelial cadherin shedding is more severe in sepsis patients with severe acute kidney injury".Pierce RW. Crit Care. 2019 May 14; 2019 May 14. PMID: 31088576.
- Angiopoietin Level Trajectories in Toddlers With Severe Sepsis and Septic Shock and Their Effect on Capillary Endothelium.Pierce RW, Shabanova V, Canarie M, Pinto M, da Silva YS, Bhandari V, Giuliano JS Jr. Shock. 2019 Mar. PMID: 30286031.
2018
- Tight junction structure, function, and assessment in the critically ill: a systematic review.Vermette D, Hu P, Canarie MF, Funaro M, Glover J, Pierce RW. Intensive Care Med Exp. 2018 Sep 26; 2018 Sep 26. PMID: 30259344.
- Rare and Low-Frequency Variant of ARHGEF17 Is Associated With Intracranial Aneurysms.He L, Pierce RW, Min W. Circ Genom Precis Med. 2018 Jul. PMID: 29997229.
- Sera From Children After Cardiopulmonary Bypass Reduces Permeability of Capillary Endothelial Cell Barriers.Pierce RW, Zahr RA, Kandil S, Faustino EVS, Pober JS. Pediatr Crit Care Med. 2018 Jul. PMID: 29652749.
- A Case of Succinyl-CoA:3-Oxoacid CoA Transferase Deficiency Presenting with Severe Acidosis in a 14-Month-Old Female: Evidence for Pathogenicity of a Point Mutation in the OXCT1 Gene.Zheng DJ, Hooper M, Spencer-Manzon M, Pierce RW. J Pediatr Intensive Care. 2018 Mar; 2017 Jul 19. PMID: 31073471.
2017
- A p190BRhoGAP mutation and prolonged RhoB activation in fatal systemic capillary leak syndrome.Pierce RW, Merola J, Lavik JP, Kluger MS, Huttner A, Khokha MK, Pober JS. J Exp Med. 2017 Dec 4; 2017 Nov 2. PMID: 29097442.
- Endothelial Cell Function and Dysfunction in Critically Ill Children.Pierce RW, Giuliano JS Jr, Pober JS. Pediatrics. 2017 Jul; 2017 Jun 1. PMID: 28759412.
2016
- IL-17 Promotes Neutrophil-Mediated Immunity by Activating Microvascular Pericytes and Not Endothelium.Liu R, Lauridsen HM, Amezquita RA, Pierce RW, Jane-Wit D, Fang C, Pellowe AS, Kirkiles-Smith NC, Gonzalez AL, Pober JS. J Immunol. 2016 Sep 15; 2016 Aug 17. PMID: 27534549.
2006
- Evolution of enzymatic activities in the enolase superfamily: L-fuconate dehydratase from Xanthomonas campestris.Yew WS, Fedorov AA, Fedorov EV, Rakus JF, Pierce RW, Almo SC, Gerlt JA. Biochemistry. 2006 Dec 12. PMID: 17144652.