Jonghun Kim
Associate Research Scientist in GeneticsAbout
Research
Publications
2026
Establishing Area-Specific Brain Organoids Through Transcription Factor-Mediated Patterning
Kim J, Jang Y, Lee M, Choi N, Jung Y, Lim J, Kwak T. Establishing Area-Specific Brain Organoids Through Transcription Factor-Mediated Patterning. Biology 2026, 15: 488. PMID: 41892247, PMCID: PMC13024533, DOI: 10.3390/biology15060488.Peer-Reviewed Original ResearchTranscription factorsPatterns of spontaneous neural activityControlled generationHuman cerebral organoidsSingle-cell RNA sequencing datasetsOverexpression of transcription factorsRNA sequencing datasetsSpontaneous neural activitySequencing datasetsTranscriptomic datasetsExpressed genesInducible mannerHuman brain organoid modelsHuman cortical regionsRegional diversityOverexpressionRegion-specific mechanisms
2025
Generation of human pineal gland organoids with melatonin production for disease modeling
Kiral F, Yang W, Iyilikci O, Lu X, Kim J, Choe M, Lo C, Zhong M, Kim K, Jiang Y, Park I. Generation of human pineal gland organoids with melatonin production for disease modeling. Cell Stem Cell 2025, 33: 91-107.e9. PMID: 41475351, PMCID: PMC12925488, DOI: 10.1016/j.stem.2025.12.004.Peer-Reviewed Original ResearchConceptsSingle-cell RNA sequencingAngelman syndromePineal developmentCell therapy approachesPatient-derived iPSCsRNA sequencingTranscriptome profilingPluripotent stem cellsSleep-related disordersCircadian regulationPineal glandMelatonin productionAdrenergic receptorsPinealectomized micePhysiological regulationHuman studiesTissue accessStem cellsDevelopmental pathologyMelatonin synthesisDisease modelsDisease-related impairmentMelatoninCircadian rhythmRegulationKIAA0319 plays a critical role in cortical neuronal maturation and synaptic development through a dyslexia-associated gene network
Scandura M, Choe M, Kiral F, Lo C, Kim J, Yang W, Qiu C, Ma Y, Gruen J, Park I. KIAA0319 plays a critical role in cortical neuronal maturation and synaptic development through a dyslexia-associated gene network. Biological Psychiatry 2025 PMID: 41115623, DOI: 10.1016/j.biopsych.2025.10.014.Peer-Reviewed Original ResearchHuman cortical organoidsNeuronal maturationScRNA-seqHuman embryonic stem cellsImpaired neuronal maturationPrimary cilia formationSingle-cell RNA sequencingNeural progenitor cellsDyslexia-associated genesEmbryonic stem cellsDisrupted neurogenesisRegulatory networksGene networksProgenitor cellsCalcium imagingCilia formationTranscriptome analysisRNA sequencingTranscriptomic changesStem cellsSynaptic developmentCortical organoidsMolecular basisKIAA0319Morphological abnormalitiesRadiofrequency regulates the BET-mediated pathways in radial glia differentiation in human cortical development
Cakir B, Tanaka Y, Choe M, Kiral F, Kim J, Micali N, Kang Y, Dharmadhikari B, Patterson B, Yang W, Cho Y, Xiang Y, Zhong M, Lee S, Patra P, Rakic P, Park I. Radiofrequency regulates the BET-mediated pathways in radial glia differentiation in human cortical development. Cell Reports 2025, 44: 116238. PMID: 40997800, PMCID: PMC12959456, DOI: 10.1016/j.celrep.2025.116238.Peer-Reviewed Original ResearchConceptsHuman cortical organoidsHuman embryonic stem cellsExpression of human endogenous retrovirusesBrain developmentStem Cell Self-RenewalRadial glia progenitorsNeural Stem Cell Self-RenewalCell Self-RenewalHuman cortical developmentHuman endogenous retrovirusesEmbryonic stem cellsStem cell identityCortical developmentGlia progenitorsPrenatal stressSelf-RenewalStem cellsCortical organoidsNon-genetic factorsGlia differentiationDevelopmental defectsEndogenous retrovirusesBrainRadiofrequencyDelayed differentiation
2024
Identifying an Early Neuropathological Mechanism in Schizophrenia With Brain Organoids
Kim J, Park I. Identifying an Early Neuropathological Mechanism in Schizophrenia With Brain Organoids. Biological Psychiatry 2024, 95: 608-610. PMID: 38479977, DOI: 10.1016/j.biopsych.2024.01.015.Peer-Reviewed Original Research
2023
3D hepatic organoid production from human pluripotent stem cells
Jin Z, Xu K, Kim J, Guo H, Yao X, Xu Y, Li Y, Ryu D, Kim K, Hong K, Kim Y, Wang L, Cao Q, Kim K, Kim N, Han D. 3D hepatic organoid production from human pluripotent stem cells. Differentiation 2023, 135: 100742. PMID: 38104501, DOI: 10.1016/j.diff.2023.100742.Peer-Reviewed Original ResearchPluripotent stem cellsHuman pluripotent stem cellsHepatic organoidsStem cellsNovel platformOrganoid productionClinical translationHepatic functionalityToxicity screeningDifferentiation procedureOrganoid technologySpontaneous formationProtocolTechnologyOptimal concentrationFunctionalityPlatformIndustrial settingsOrganoidsProductionPSC
2022
Non-coding de novo mutations in chromatin interactions are implicated in autism spectrum disorder
Kim I, Lee T, Lee J, Kim J, Lee S, Koh I, Kim J, An J, Lee H, Kim W, Ju Y, Cho Y, Yu S, Kim S, Oh M, Han D, Kim E, Choi J, Yoo H, Lee J. Non-coding de novo mutations in chromatin interactions are implicated in autism spectrum disorder. Molecular Psychiatry 2022, 27: 4680-4694. PMID: 35840799, DOI: 10.1038/s41380-022-01697-2.Peer-Reviewed Original ResearchConceptsASD probandsChromatin interactionsTarget genesSimons Simplex CollectionNon-coding de novo mutationsThree-dimensional chromatin interactionsWhole-genome sequencingExpression of target genesWhole genomeHistone modificationsChromatinASD familiesSimplex familiesBiological pathwaysGene expressionEarly neural developmentGenesReplication cohortNeural developmentAutism spectrum disorder riskASD riskProbandsPluripotent stem cellsMutationsDNM
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