Selected Publications

• Mechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis.Kural MH, Djakbarova U, Cakir B, Tanaka Y, Chan ET, Arteaga Muniz VI, Madraki Y, Qian H, Park J, Sewanan LR, Park IH, Niklason LE, Kural C. Cell Death Dis. 2024 Jun 22; 2024 Jun 22. PMID: 38909035.
• Identifying an Early Neuropathological Mechanism in Schizophrenia With Brain Organoids.Kim J, Park IH. Biol Psychiatry. 2024 Apr 1. PMID: 38479977.
• Diencephalic organoids - A key to unraveling development, connectivity, and pathology of the human diencephalon.Kiral FR, Choe M, Park IH. Front Cell Neurosci. 2023; 2023 Dec 7. PMID: 38130869.
• Scalable production of tissue-like vascularized liver organoids from human PSCs.Harrison SP, Siller R, Tanaka Y, Chollet ME, de la Morena-Barrio ME, Xiang Y, Patterson B, Andersen E, Bravo-Pérez C, Kempf H, Åsrud KS, Lunov O, Dejneka A, Mowinckel MC, Stavik B, Sandset PM, Melum E, Baumgarten S, Bonanini F, Kurek D, Mathapati S, Almaas R, Sharma K, Wilson SR, Skottvoll FS, Boger IC, Bogen IL, Nyman TA, Wu JJ, Bezrouk A, Cizkova D, Corral J, Mokry J, Zweigerdt R, Park IH, Sullivan GJ. Exp Mol Med. 2023 Sep; 2023 Sep 1. PMID: 37653039.
• Female naïve human pluripotent stem cells carry X chromosomes with Xa-like and Xi-like folding conformations.Patterson B, Yang B, Tanaka Y, Kim KY, Cakir B, Xiang Y, Kim J, Wang S, Park IH. Sci Adv. 2023 Aug 4; 2023 Aug 4. PMID: 37540754.
• Generation of ventralized human thalamic organoids with thalamic reticular nucleus.Kiral FR, Cakir B, Tanaka Y, Kim J, Yang WS, Wehbe F, Kang YJ, Zhong M, Sancer G, Lee SH, Xiang Y, Park IH. Cell Stem Cell. 2023 May 4; 2023 Apr 4. PMID: 37019105.
• Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation.Sun J, Osenberg S, Irwin A, Ma LH, Lee N, Xiang Y, Li F, Wan YW, Park IH, Maletic-Savatic M, Ballas N. Cell Rep. 2023 Jan 31; 2023 Jan 5. PMID: 36640327.
• Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas.Zhang H, Li B, Huang Q, López-Giráldez F, Tanaka Y, Lin Q, Mehta S, Wang G, Graham M, Liu X, Park IH, Eichmann A, Min W, Zhou JH. Nat Commun. 2022 Dec 10; 2022 Dec 10. PMID: 36496409.
• Advanced in vitro models: Microglia in action.Cakir B, Kiral FR, Park IH. Neuron. 2022 Nov 2. PMID: 36327894.
• A nomenclature consensus for nervous system organoids and assembloids.Pașca SP, Arlotta P, Bateup HS, Camp JG, Cappello S, Gage FH, Knoblich JA, Kriegstein AR, Lancaster MA, Ming GL, Muotri AR, Park IH, Reiner O, Song H, Studer L, Temple S, Testa G, Treutlein B, Vaccarino FM. Nature. 2022 Sep; 2022 Sep 28. PMID: 36171373.
• Dyslexia associated gene KIAA0319 regulates cell cycle during human neuroepithelial cell development.Paniagua S, Cakir B, Hu Y, Kiral FR, Tanaka Y, Xiang Y, Patterson B, Gruen JR, Park IH. Front Cell Dev Biol. 2022; 2022 Aug 9. PMID: 36016658.
• Human Down syndrome microglia are up for a synaptic feast.Kiral FR, Park IH. Cell Stem Cell. 2022 Jul 7. PMID: 35803219.
• Live isolation of naïve ESCs via distinct glucose metabolism and stored glycogen.Kim KT, Oh JY, Park S, Kim SM, Benjamin P, Park IH, Chun KH, Chang YT, Cha HJ. Metab Eng. 2022 Jul; 2022 Mar 10. PMID: 35283260.
• Getting the right cells.Cakir B, Park IH. Elife. 2022 Jun 30; 2022 Jun 30. PMID: 35770899.
• Region Specific Brain Organoids to Study Neurodevelopmental Disorders.Susaimanickam PJ, Kiral FR, Park IH. Int J Stem Cells. 2022 Feb 28. PMID: 35220290.
• Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids.Cakir B, Tanaka Y, Kiral FR, Xiang Y, Dagliyan O, Wang J, Lee M, Greaney AM, Yang WS, duBoulay C, Kural MH, Patterson B, Zhong M, Kim J, Bai Y, Min W, Niklason LE, Patra P, Park IH. Nat Commun. 2022 Jan 20; 2022 Jan 20. PMID: 35058453.
• Exploration of alcohol use disorder-associated brain miRNA-mRNA regulatory networks.Lim Y, Beane-Ebel JE, Tanaka Y, Ning B, Husted CR, Henderson DC, Xiang Y, Park IH, Farrer LA, Zhang H. Transl Psychiatry. 2021 Oct 2; 2021 Oct 2. PMID: 34601489.
• Regeneration of infarcted mouse hearts by cardiovascular tissue formed via the direct reprogramming of mouse fibroblasts.Cho J, Kim S, Lee H, Rah W, Cho HC, Kim NK, Bae S, Shin DH, Lee MG, Park IH, Tanaka Y, Shin E, Yi H, Han JW, Hwang PTJ, Jun HW, Park HJ, Cho K, Lee SW, Jung JK, Levit RD, Sussman MA, Harvey RP, Yoon YS. Nat Biomed Eng. 2021 Aug; 2021 Aug 23. PMID: 34426676.
• Vulnerability of cholecystokinin-expressing GABAergic interneurons in the unilateral intrahippocampal kainate mouse model of temporal lobe epilepsy.Kang YJ, Clement EM, Park IH, Greenfield LJ Jr, Smith BN, Lee SH. Exp Neurol. 2021 Aug; 2021 Apr 26. PMID: 33915166.
• Regional specification and complementation with non-neuroectodermal cells in human brain organoids.Tanaka Y, Park IH. J Mol Med (Berl). 2021 Apr; 2021 Mar 2. PMID: 33651139.
• Deconstructing and reconstructing the human brain with regionally specified brain organoids.Xiang Y, Cakir B, Park IH. Semin Cell Dev Biol. 2021 Mar; 2020 Jun 15. PMID: 32553582.
• How well do brain organoids capture your brain?Kim J, Sullivan GJ, Park IH. iScience. 2021 Feb 19; 2021 Jan 19. PMID: 33554067.
• Genes causing congenital hydrocephalus: Their chromosomal characteristics of telomere proximity and DNA compositions.McKnight I, Hart C, Park IH, Shim JW. Exp Neurol. 2021 Jan; 2020 Nov 4. PMID: 33157092.
• Reprogramming progressive cells display low CAG promoter activity.Hu X, Wu Q, Zhang J, Kim J, Chen X, Hartman AA, Eastman AE, Park IH, Guo S. Stem Cells. 2021 Jan; 2020 Nov 4. PMID: 33075202.
• Intracerebral Transplants of GMP-Grade Human Umbilical Cord-Derived Mesenchymal Stromal Cells Effectively Treat Subacute-Phase Ischemic Stroke in a Rodent Model.Noh JE, Oh SH, Park IH, Song J. Front Cell Neurosci. 2020; 2020 Sep 25. PMID: 33100972.
• Mural Cell-Specific Deletion of Cerebral Cavernous Malformation 3 in the Brain Induces Cerebral Cavernous Malformations.Wang K, Zhang H, He Y, Jiang Q, Tanaka Y, Park IH, Pober JS, Min W, Zhou HJ. Arterioscler Thromb Vasc Biol. 2020 Sep; 2020 Jul 9. PMID: 32640906.
• Implantation of the clinical-grade human neural stem cell line, CTX0E03, rescues the behavioral and pathological deficits in the quinolinic acid-lesioned rodent model of Huntington's disease.Yoon Y, Kim HS, Jeon I, Noh JE, Park HJ, Lee S, Park IH, Stevanato L, Hicks C, Corteling R, Barker RA, Sinden JD, Song J. Stem Cells. 2020 Aug; 2020 May 6. PMID: 32374064.
• Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons.Xiang Y, Tanaka Y, Patterson B, Hwang SM, Hysolli E, Cakir B, Kim KY, Wang W, Kang YJ, Clement EM, Zhong M, Lee SH, Cho YS, Patra P, Sullivan GJ, Weissman SM, Park IH. Mol Cell. 2020 Jul 2; 2020 Jun 10. PMID: 32526163.
• Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development.Xiang Y, Cakir B, Park IH. STAR Protoc. 2020 Jun 19; 2020 Jun 4. PMID: 33103124.
• Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain.Tanaka Y, Cakir B, Xiang Y, Sullivan GJ, Park IH. Cell Rep. 2020 Feb 11. PMID: 32049002.
• The critical role of persistent sodium current in hippocampal gamma oscillations.Kang YJ, Clement EM, Sumsky SL, Xiang Y, Park IH, Santaniello S, Greenfield LJ Jr, Garcia-Rill E, Smith BN, Lee SH. Neuropharmacology. 2020 Jan 1; 2019 Sep 21. PMID: 31550457.
• Engineering of human brain organoids with a functional vascular-like system.Cakir B, Xiang Y, Tanaka Y, Kural MH, Parent M, Kang YJ, Chapeton K, Patterson B, Yuan Y, He CS, Raredon MSB, Dengelegi J, Kim KY, Sun P, Zhong M, Lee S, Patra P, Hyder F, Niklason LE, Lee SH, Yoon YS, Park IH. Nat Methods. 2019 Nov; 2019 Oct 7. PMID: 31591580.
• The RNA exosome nuclease complex regulates human embryonic stem cell differentiation.Belair C, Sim S, Kim KY, Tanaka Y, Park IH, Wolin SL. J Cell Biol. 2019 Aug 5; 2019 Jul 15. PMID: 31308215.
• hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids.Xiang Y, Tanaka Y, Cakir B, Patterson B, Kim KY, Sun P, Kang YJ, Zhong M, Liu X, Patra P, Lee SH, Weissman SM, Park IH. Cell Stem Cell. 2019 Mar 7; 2019 Feb 21. PMID: 30799279.
• Generation and Fusion of Human Cortical and Medial Ganglionic Eminence Brain Organoids.Xiang Y, Yoshiaki T, Patterson B, Cakir B, Kim KY, Cho YS, Park IH. Curr Protoc Stem Cell Biol. 2018 Nov; 2018 Sep 11. PMID: 30854156.
• Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a.Kim KY, Tanaka Y, Su J, Cakir B, Xiang Y, Patterson B, Ding J, Jung YW, Kim JH, Hysolli E, Lee H, Dajani R, Kim J, Zhong M, Lee JH, Skalnik D, Lim JM, Sullivan GJ, Wang J, Park IH. Nat Commun. 2018 Jul 3; 2018 Jul 3. PMID: 29968706.
• Correction to: New Advances in Human X Chromosome Status from a Developmental and Stem Cell Biology.Patterson B, Tanaka Y, Park IH. Tissue Eng Regen Med. 2018 Feb; 2018 Jan 19. PMID: 30603540.
• New Advances in Human X chromosome status from a Developmental and Stem Cell Biology.Patterson B, Tanaka Y, Park IH. Tissue Eng Regen Med. 2017 Dec; 2017 Nov 22. PMID: 29276809.
• Enhanced Therapeutic and Long-Term Dynamic Vascularization Effects of Human Pluripotent Stem Cell-Derived Endothelial Cells Encapsulated in a Nanomatrix Gel.Lee SJ, Sohn YD, Andukuri A, Kim S, Byun J, Han JW, Park IH, Jun HW, Yoon YS. Circulation. 2017 Nov 14; 2017 Sep 29. PMID: 28972000.
• Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration.Xiang Y, Tanaka Y, Patterson B, Kang YJ, Govindaiah G, Roselaar N, Cakir B, Kim KY, Lombroso AP, Hwang SM, Zhong M, Stanley EG, Elefanty AG, Naegele JR, Lee SH, Weissman SM, Park IH. Cell Stem Cell. 2017 Sep 7; 2017 Jul 27. PMID: 28757360.
• Bisulfite-independent analysis of CpG island methylation enables genome-scale stratification of single cells.Han L, Wu HJ, Zhu H, Kim KY, Marjani SL, Riester M, Euskirchen G, Zi X, Yang J, Han J, Snyder M, Park IH, Irizarry R, Weissman SM, Michor F, Fan R, Pan X. Nucleic Acids Res. 2017 Jun 2. PMID: 28126923.
• Development of an inducible platform for intercellular protein delivery.Siller R, Dufour E, Lycke M, Wilmut I, Jung YW, Park IH, Sullivan GJ. Int J Pharm. 2017 Apr 30; 2017 Feb 28. PMID: 28254654.
• Direct Reprogramming of Human Dermal Fibroblasts Into Endothelial Cells Using ER71/ETV2.Lee S, Park C, Han JW, Kim JY, Cho K, Kim EJ, Kim S, Lee SJ, Oh SY, Tanaka Y, Park IH, An HJ, Shin CM, Sharma S, Yoon YS. Circ Res. 2017 Mar 3; 2016 Dec 21. PMID: 28003219.
• Single cell transcriptomics reveals unanticipated features of early hematopoietic precursors.Yang J, Tanaka Y, Seay M, Li Z, Jin J, Garmire LX, Zhu X, Taylor A, Li W, Euskirchen G, Halene S, Kluger Y, Snyder MP, Park IH, Pan X, Weissman SM. Nucleic Acids Res. 2017 Feb 17. PMID: 28003475.
• Modeling and correction of structural variations in patient-derived iPSCs using CRISPR/Cas9.Park CY, Sung JJ, Choi SH, Lee DR, Park IH, Kim DW. Nat Protoc. 2016 Nov; 2016 Oct 6. PMID: 27711053.
• Dnmt1 regulates the myogenic lineage specification of muscle stem cells.Liu R, Kim KY, Jung YW, Park IH. Sci Rep. 2016 Oct 18; 2016 Oct 18. PMID: 27752090.
• Regulation of the DNA Methylation Landscape in Human Somatic Cell Reprogramming by the miR-29 Family.Hysolli E, Tanaka Y, Su J, Kim KY, Zhong T, Janknecht R, Zhou XL, Geng L, Qiu C, Pan X, Jung YW, Cheng J, Lu J, Zhong M, Weissman SM, Park IH. Stem Cell Reports. 2016 Jul 12; 2016 Jun 30. PMID: 27373925.
• Neural Stem Cells Restore Hair Growth Through Activation of the Hair Follicle Niche.Hwang I, Choi KA, Park HS, Jeong H, Kim JO, Seol KC, Kwon HJ, Park IH, Hong S. Cell Transplant. 2016; 2016 Apr 22. PMID: 27110030.
• Histone Deacetylases Positively Regulate Transcription through the Elongation Machinery.Greer CB, Tanaka Y, Kim YJ, Xie P, Zhang MQ, Park IH, Kim TH. Cell Rep. 2015 Nov 17; 2015 Nov 5. PMID: 26549458.
• Tgif1 Counterbalances the Activity of Core Pluripotency Factors in Mouse Embryonic Stem Cells.Lee BK, Shen W, Lee J, Rhee C, Chung H, Kim KY, Park IH, Kim J. Cell Rep. 2015 Oct 6; 2015 Sep 24. PMID: 26411691.
• Transplantation of Macaca cynomolgus iPS-derived hematopoietic cells in NSG immunodeficient mice.Abed S, Tubsuwan A, Chaichompoo P, Park IH, Pailleret A, Benyoucef A, Tosca L, De Dreuzy E, Paulard A, Granger-Locatelli M, Relouzat F, Prost S, Tachdjian G, Fucharoen S, Daley GQ, Payen E, Chrétien S, Leboulch P, Maouche-Chrétien L. Haematologica. 2015 Oct; 2015 Jun 18. PMID: 26088930.
• Ethanol upregulates NMDA receptor subunit gene expression in human embryonic stem cell-derived cortical neurons.Xiang Y, Kim KY, Gelernter J, Park IH, Zhang H. PLoS One. 2015; 2015 Aug 12. PMID: 26266540.
• Role of Zscan4 in secondary murine iPSC derivation mediated by protein extracts of ESC or iPSC.Kwon YW, Paek JS, Cho HJ, Lee CS, Lee HJ, Park IH, Roh TY, Kang CM, Yang HM, Park YB, Kim HS. Biomaterials. 2015 Aug; 2015 May 15. PMID: 25956855.
• Transcriptome Signature and Regulation in Human Somatic Cell Reprogramming.Tanaka Y, Hysolli E, Su J, Xiang Y, Kim KY, Zhong M, Li Y, Heydari K, Euskirchen G, Snyder MP, Pan X, Weissman SM, Park IH. Stem Cell Reports. 2015 Jun 9; 2015 May 21. PMID: 26004630.
• Correction: Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice.Tucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, Redenti S, Daley GQ, Young MJ. PLoS One. 2015; 2015 May 7. PMID: 25950705.
• X Chromosome of female cells shows dynamic changes in status during human somatic cell reprogramming.Kim KY, Hysolli E, Tanaka Y, Wang B, Jung YW, Pan X, Weissman SM, Park IH. Stem Cell Reports. 2014 Jun 3; 2014 May 15. PMID: 24936474.
• In Vivo Roles of a Patient-Derived Induced Pluripotent Stem Cell Line (HD72-iPSC) in the YAC128 Model of Huntington's Disease.Jeon I, Choi C, Lee N, Im W, Kim M, Oh SH, Park IH, Kim HS, Song J. Int J Stem Cells. 2014 May. PMID: 24921027.
• Transcriptional regulation in pluripotent stem cells by methyl CpG-binding protein 2 (MeCP2).Tanaka Y, Kim KY, Zhong M, Pan X, Weissman SM, Park IH. Hum Mol Genet. 2014 Feb 15; 2013 Oct 15. PMID: 24129406.
• Trivalent chromatin marks the way in.Hysolli E, Park IH. Cell Stem Cell. 2013 Nov 7. PMID: 24209756.
• Investigation of Rett syndrome using pluripotent stem cells.Dajani R, Koo SE, Sullivan GJ, Park IH. J Cell Biochem. 2013 Nov. PMID: 23744605.
• An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis.Cheng J, Guo S, Chen S, Mastriano SJ, Liu C, D'Alessio AC, Hysolli E, Guo Y, Yao H, Megyola CM, Li D, Liu J, Pan W, Roden CA, Zhou XL, Heydari K, Chen J, Park IH, Ding Y, Zhang Y, Lu J. Cell Rep. 2013 Oct 31; 2013 Oct 10. PMID: 24120864.
• Development of a novel two-dimensional directed differentiation system for generation of cardiomyocytes from human pluripotent stem cells.Moon SH, Ban K, Kim C, Kim SS, Byun J, Song MK, Park IH, Yu SP, Yoon YS. Int J Cardiol. 2013 Sep 20; 2012 Oct 6. PMID: 23044428.
• Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cells.Lee JB, Werbowetski-Ogilvie TE, Lee JH, McIntyre BA, Schnerch A, Hong SH, Park IH, Daley GQ, Bernstein ID, Bhatia M. Blood. 2013 Aug 15; 2013 Jun 3. PMID: 23733337.
• Transformation of somatic cells into stem cell-like cells under a stromal niche.Lee ST, Gong SP, Yum KE, Lee EJ, Lee CH, Choi JH, Kim DY, Han H, Kim KS, Hysolli E, Ahn JY, Park IH, Han JY, Jeong JW, Lim JM. FASEB J. 2013 Jul; 2013 Apr 11. PMID: 23580613.
• Pluripotent stem cell models of Shwachman-Diamond syndrome reveal a common mechanism for pancreatic and hematopoietic dysfunction.Tulpule A, Kelley JM, Lensch MW, McPherson J, Park IH, Hartung O, Nakamura T, Schlaeger TM, Shimamura A, Daley GQ. Cell Stem Cell. 2013 Jun 6; 2013 Apr 18. PMID: 23602541.
• Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, Wilmut I, Finkbeiner S, Maniatis T, Shaw CE, Chandran S. Sci Transl Med. 2013 Jun 5. PMID: 23740897.
• MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons.Larimore J, Ryder PV, Kim KY, Ambrose LA, Chapleau C, Calfa G, Gross C, Bassell GJ, Pozzo-Miller L, Smith Y, Talbot K, Park IH, Faundez V. PLoS One. 2013; 2013 Jun 4. PMID: 23750231.
• Modelling human disease with pluripotent stem cells.Siller R, Greenhough S, Park IH, Sullivan GJ. Curr Gene Ther. 2013 Apr. PMID: 23444871.
• Two methods for full-length RNA sequencing for low quantities of cells and single cells.Pan X, Durrett RE, Zhu H, Tanaka Y, Li Y, Zi X, Marjani SL, Euskirchen G, Ma C, Lamotte RH, Park IH, Snyder MP, Mason CE, Weissman SM. Proc Natl Acad Sci U S A. 2013 Jan 8; 2012 Dec 24. PMID: 23267071.
• Therapeutic potential of human induced pluripotent stem cells in experimental stroke.Chang DJ, Lee N, Park IH, Choi C, Jeon I, Kwon J, Oh SH, Shin DA, Do JT, Lee DR, Lee H, Moon H, Hong KS, Daley GQ, Song J. Cell Transplant. 2013; 2012 Oct 3. PMID: 23044029.
• Impact of retrotransposons in pluripotent stem cells.Tanaka Y, Chung L, Park IH. Mol Cells. 2012 Dec; 2012 Nov 6. PMID: 23135636.
• Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells.Maclean GA, Menne TF, Guo G, Sanchez DJ, Park IH, Daley GQ, Orkin SH. Proc Natl Acad Sci U S A. 2012 Oct 23; 2012 Oct 8. PMID: 23045682.
• Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells.Ge X, Ren Y, Bartulos O, Lee MY, Yue Z, Kim KY, Li W, Amos PJ, Bozkulak EC, Iyer A, Zheng W, Zhao H, Martin KA, Kotton DN, Tellides G, Park IH, Yue L, Qyang Y. Circulation. 2012 Oct 2; 2012 Aug 22. PMID: 22914687.
• Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient.Chae JI, Kim DW, Lee N, Jeon YJ, Jeon I, Kwon J, Kim J, Soh Y, Lee DS, Seo KS, Choi NJ, Park BC, Kang SH, Ryu J, Oh SH, Shin DA, Lee DR, Do JT, Park IH, Daley GQ, Song J. Biochem J. 2012 Sep 15. PMID: 22694310.
• Neuronal properties, in vivo effects, and pathology of a Huntington's disease patient-derived induced pluripotent stem cells.Jeon I, Lee N, Li JY, Park IH, Park KS, Moon J, Shim SH, Choi C, Chang DJ, Kwon J, Oh SH, Shin DA, Kim HS, Do JT, Lee DR, Kim M, Kang KS, Daley GQ, Brundin P, Song J. Stem Cells. 2012 Sep. PMID: 22628015.
• Cellular reprogramming: a novel tool for investigating autism spectrum disorders.Kim KY, Jung YW, Sullivan GJ, Chung L, Park IH. Trends Mol Med. 2012 Aug; 2012 Jul 6. PMID: 22771169.
• Pancreatic differentiation.Nostro MC, Sarangi F, Ogawa S, Holtzinger A, Corneo B, Li X, Micallef SJ, Park IH, Basford C, Wheeler MB, Daley GQ, Elefanty AG, Stanley EG, Keller G. 2008. PMID: 23658992.
• Overcoming reprogramming resistance of Fanconi anemia cells.Müller LU, Milsom MD, Harris CE, Vyas R, Brumme KM, Parmar K, Moreau LA, Schambach A, Park IH, London WB, Strait K, Schlaeger T, Devine AL, Grassman E, D'Andrea A, Daley GQ, Williams DA. Blood. 2012 Jun 7; 2012 Feb 27. PMID: 22371882.
• Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability.Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, Wilmut I, Finkbeiner S, Maniatis T, Shaw CE, Chandran S. Proc Natl Acad Sci U S A. 2012 Apr 10; 2012 Mar 26. PMID: 22451909.
• Reprogramming human somatic cells into induced pluripotent stem cells (iPSCs) using retroviral vector with GFP.Kim KY, Hysolli E, Park IH. J Vis Exp. 2012 Apr 3; 2012 Apr 3. PMID: 22491226.
• Human induced pluripotent stem cells and neurodegenerative disease: prospects for novel therapies.Jung YW, Hysolli E, Kim KY, Tanaka Y, Park IH. Curr Opin Neurol. 2012 Apr. PMID: 22357218.
• Humanized murine model for HBV and HCV using human induced pluripotent stem cells.Zhou XL, Sullivan GJ, Sun P, Park IH. Arch Pharm Res. 2012 Feb; 2012 Feb 28. PMID: 22370780.
• The lesser known story of X chromosome reactivation: a closer look into the reprogramming of the inactive X chromosome.Hysolli E, Jung YW, Tanaka Y, Kim KY, Park IH. Cell Cycle. 2012 Jan 15; 2012 Jan 15. PMID: 22234239.
• Excision of a viral reprogramming cassette by delivery of synthetic Cre mRNA.Loh YH, Yang JC, De Los Angeles A, Guo C, Cherry A, Rossi DJ, Park IH, Daley GQ. Curr Protoc Stem Cell Biol. 2012. PMID: 22605648.
• Cell cycle adaptations of embryonic stem cells.Ballabeni A, Park IH, Zhao R, Wang W, Lerou PH, Daley GQ, Kirschner MW. Proc Natl Acad Sci U S A. 2011 Nov 29; 2011 Nov 14. PMID: 22084091.
• Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J, Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC, Bosman A, Brena RM, Brison D, Caisander G, Camarasa MV, Chen J, Chiao E, Choi YM, Choo AB, Collins D, Colman A, Crook JM, Daley GQ, Dalton A, De Sousa PA, Denning C, Downie J, Dvorak P, Montgomery KD, Feki A, Ford A, Fox V, Fraga AM, Frumkin T, Ge L, Gokhale PJ, Golan-Lev T, Gourabi H, Gropp M, Lu G, Hampl A, Harron K, Healy L, Herath W, Holm F, Hovatta O, Hyllner J, Inamdar MS, Irwanto AK, Ishii T, Jaconi M, Jin Y, Kimber S, Kiselev S, Knowles BB, Kopper O, Kukharenko V, Kuliev A, Lagarkova MA, Laird PW, Lako M, Laslett AL, Lavon N, Lee DR, Lee JE, Li C, Lim LS, Ludwig TE, Ma Y, Maltby E, Mateizel I, Mayshar Y, Mileikovsky M, Minger SL, Miyazaki T, Moon SY, Moore H, Mummery C, Nagy A, Nakatsuji N, Narwani K, Oh SK, Oh SK, Olson C, Otonkoski T, Pan F, Park IH, Pells S, Pera MF, Pereira LV, Qi O, Raj GS, Reubinoff B, Robins A, Robson P, Rossant J, Salekdeh GH, Schulz TC, Sermon K, Sheik Mohamed J, Shen H, Sherrer E, Sidhu K, Sivarajah S, Skottman H, Spits C, Stacey GN, Strehl R, Strelchenko N, Suemori H, Sun B, Suuronen R, Takahashi K, Tuuri T, Venu P, Verlinsky Y, Ward-van Oostwaard D, Weisenberger DJ, Wu Y, Yamanaka S, Young L, Zhou Q. Nat Biotechnol. 2011 Nov 27; 2011 Nov 27. PMID: 22119741.
• Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients.Jang J, Kang HC, Kim HS, Kim JY, Huh YJ, Kim DS, Yoo JE, Lee JA, Lim B, Lee J, Yoon TM, Park IH, Hwang DY, Daley GQ, Kim DW. Ann Neurol. 2011 Sep; 2011 Jun 30. PMID: 21721033.
• Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome.Kim KY, Hysolli E, Park IH. Proc Natl Acad Sci U S A. 2011 Aug 23; 2011 Aug 1. PMID: 21807996.
• Induced pluripotent stem cells for neural tissue engineering.Wang A, Tang Z, Park IH, Zhu Y, Patel S, Daley GQ, Li S. Biomaterials. 2011 Aug; 2011 Apr 22. PMID: 21514663.
• Induced pluripotent stem cells: a novel frontier in the study of human primary immunodeficiencies.Pessach IM, Ordovas-Montanes J, Zhang SY, Casanova JL, Giliani S, Gennery AR, Al-Herz W, Manos PD, Schlaeger TM, Park IH, Rucci F, Agarwal S, Mostoslavsky G, Daley GQ, Notarangelo LD. J Allergy Clin Immunol. 2011 Jun; 2010 Dec 24. PMID: 21185069.
• Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice.Tucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, Redenti S, Daley GQ, Young MJ. PLoS One. 2011 Apr 29; 2011 Apr 29. PMID: 21559507.
• Analysis of differential proteomes of induced pluripotent stem cells by protein-based reprogramming of fibroblasts.Jin J, Kwon YW, Paek JS, Cho HJ, Yu J, Lee JY, Chu IS, Park IH, Park YB, Kim HS, Kim Y. J Proteome Res. 2011 Mar 4; 2011 Feb 4. PMID: 21175196.
• Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells.Nostro MC, Sarangi F, Ogawa S, Holtzinger A, Corneo B, Li X, Micallef SJ, Park IH, Basford C, Wheeler MB, Daley GQ, Elefanty AG, Stanley EG, Keller G. Development. 2011 Mar; 2011 Jan 26. PMID: 21270052.
• Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome).Tolar J, Park IH, Xia L, Lees CJ, Peacock B, Webber B, McElmurry RT, Eide CR, Orchard PJ, Kyba M, Osborn MJ, Lund TC, Wagner JE, Daley GQ, Blazar BR. Blood. 2011 Jan 20; 2010 Oct 29. PMID: 21037085.
• Human pluripotent stem cells produce natural killer cells that mediate anti-HIV-1 activity by utilizing diverse cellular mechanisms.Ni Z, Knorr DA, Clouser CL, Hexum MK, Southern P, Mansky LM, Park IH, Kaufman DS. J Virol. 2011 Jan; 2010 Oct 20. PMID: 20962093.
• MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states.Neveu P, Kye MJ, Qi S, Buchholz DE, Clegg DO, Sahin M, Park IH, Kim KS, Daley GQ, Kornblum HI, Shraiman BI, Kosik KS. Cell Stem Cell. 2010 Dec 3. PMID: 21112562.
• Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.Loewer S, Cabili MN, Guttman M, Loh YH, Thomas K, Park IH, Garber M, Curran M, Onder T, Agarwal S, Manos PD, Datta S, Lander ES, Schlaeger TM, Daley GQ, Rinn JL. Nat Genet. 2010 Dec; 2010 Nov 7. PMID: 21057500.
• Five classic articles in somatic cell reprogramming.Park IH. Yale J Biol Med. 2010 Sep. PMID: 20885901.
• Reprogramming of T cells from human peripheral blood.Loh YH, Hartung O, Li H, Guo C, Sahalie JM, Manos PD, Urbach A, Heffner GC, Grskovic M, Vigneault F, Lensch MW, Park IH, Agarwal S, Church GM, Collins JJ, Irion S, Daley GQ. Cell Stem Cell. 2010 Jul 2. PMID: 20621044.
• Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity.Kim DS, Lee JS, Leem JW, Huh YJ, Kim JY, Kim HS, Park IH, Daley GQ, Hwang DY, Kim DW. Stem Cell Rev Rep. 2010 Jun. PMID: 20376579.