Live Observation of Two Parallel Membrane Degradation Pathways at Axon Terminals
Jin E, Kiral F, Ozel M, Burchardt L, Osterland M, Epstein D, Wolfenberg H, Prohaska S, Hiesinger P. Live Observation of Two Parallel Membrane Degradation Pathways at Axon Terminals. Current Biology 2018, 28: 1027-1038.e4. PMID: 29551411, PMCID: PMC5944365, DOI: 10.1016/j.cub.2018.02.032.Peer-Reviewed Original ResearchConceptsSynaptic vesicle proteinsMembrane proteinsVesicle proteinsLive-imaging approachesPlasma membrane proteinsMembrane protein degradationIntact Drosophila brainsProtein degradation mechanismsMembrane cargoDegradative compartmentsNeuronal synaptobrevinProtein degradationDrosophila brainContinuous turnoverCell bodiesProteinDegradation pathwayLive observationDistinct classesSortingCargoCompartmentsSynaptobrevinDegradationRab7