Publications

2026

Brief Report: Is once daily enough? Assessing the impact of timing of methadone dose on pain sensitivity via quantitative sensory testing in persons with opioid use disorder
Costa G, Riggione C, Meyerovich J, Barry D, De Aquino J. Brief Report: Is once daily enough? Assessing the impact of timing of methadone dose on pain sensitivity via quantitative sensory testing in persons with opioid use disorder. American Journal On Addictions 2026 PMID: 42046174, PMCID: PMC13132031, DOI: 10.1111/ajad.70162.
Peer-Reviewed Original Research
Modulating the endocannabinoid system in alcohol use disorder: A translational systematic review and meta-analysis of preclinical and human studies
Costa G, Cerezo-Matias M, Funaro M, Bagdas D, Kaye A, Krystal J, Petrakis I, De Aquino J. Modulating the endocannabinoid system in alcohol use disorder: A translational systematic review and meta-analysis of preclinical and human studies. Molecular Psychiatry 2026, 31: 3849-3871. PMID: 41760917, PMCID: PMC13269127, DOI: 10.1038/s41380-026-03523-5.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
This study investigates targeting the endocannabinoid system for alcohol use disorder, finding promising preclinical results for cannabidiol and CB1 receptor modulators, but inconsistent human trial outcomes highlight the need for better-designed clinical studies.
Full Summary
Psychedelic‐assisted therapy for substance use disorders: Between urgency and uncertainty
De Aquino J. Psychedelic‐assisted therapy for substance use disorders: Between urgency and uncertainty. American Journal On Addictions 2026, 35: 317-318. PMID: 41742736, DOI: 10.1111/ajad.70128.
Peer-Reviewed Original Research
Characteristics of United States Food and Drug Administration Drug Recalls Involving Opioid Medications, 2002–2025
Nunes J, Costa G, De Aquino J. Characteristics of United States Food and Drug Administration Drug Recalls Involving Opioid Medications, 2002–2025. Pharmacoepidemiology And Drug Safety 2026, 35: e70341. PMID: 41725568, DOI: 10.1002/pds.70341.
Peer-Reviewed Original Research
MeSH Keywords
Addiction research and national resilience: Protecting surveillance, treatment development, and integrated care
Nunes J, De Aquino J. Addiction research and national resilience: Protecting surveillance, treatment development, and integrated care. Drug And Alcohol Dependence 2026, 279: 113002. DOI: 10.1016/j.drugalcdep.2025.113002.
Peer-Reviewed Original Research

2025

Exploring the effects of cannabidiol on pain sensitivity using quantitative sensory testing among individuals receiving methadone or buprenorphine for opioid use disorder: an open-label, proof-of-concept study
Costa G, Suh R, Sofuoglu M, De Aquino J. Exploring the effects of cannabidiol on pain sensitivity using quantitative sensory testing among individuals receiving methadone or buprenorphine for opioid use disorder: an open-label, proof-of-concept study. Addictive Behaviors Reports 2025, 23: 100654. PMID: 41496743, PMCID: PMC12767834, DOI: 10.1016/j.abrep.2025.100654.
Peer-Reviewed Original Research
Differences in diagnosis and treatment across racial–ethnic groups with co-occurring chronic pain and opioid use disorder: a scoping review
Nunes J, Costa G, Cerezo-Matias M, Funaro M, Campbell C, De Aquino J. Differences in diagnosis and treatment across racial–ethnic groups with co-occurring chronic pain and opioid use disorder: a scoping review. Pain Medicine 2025, 27: 613-626. PMID: 41358971, DOI: 10.1093/pm/pnaf173.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Expanding Access to Buprenorphine and Methadone: Global Perspectives and Policy Recommendations
Nunes J, Costa G, De Aquino J, Adinoff B. Expanding Access to Buprenorphine and Methadone: Global Perspectives and Policy Recommendations. Substance Use & Addiction Journal 2025, 47: 595-610. PMID: 41317155, DOI: 10.1177/29767342251392342.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Tobacco use Disorder and Chronic Pain: a Narrative Review of Integrated Treatment Approaches, Underlying Mechanisms, and Future Research Directions
da Rocha L, Costa G, Sofuoglu M, Castaldelli-Maia J, De Aquino J. Tobacco use Disorder and Chronic Pain: a Narrative Review of Integrated Treatment Approaches, Underlying Mechanisms, and Future Research Directions. Current Addiction Reports 2025, 12: 75. DOI: 10.1007/s40429-025-00687-y.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Tobacco–cannabis co‐use in adults ≥50: Trends, medical marijuana laws, and cessation implications—Letter to the Editor
Costa G, Asnes S, De Aquino J. Tobacco–cannabis co‐use in adults ≥50: Trends, medical marijuana laws, and cessation implications—Letter to the Editor. American Journal On Addictions 2025, 34: 682-683. PMID: 41025258, DOI: 10.1111/ajad.70088.
Commentaries, Editorials and Letters
Quantitative sensory testing of pain in persons with opioid use disorder on opioid agonist treatment: a scoping review
Oliveira D, Costa G, Fontenele R, Córdoba-Delgado M, Funaro M, Campbell C, Fiellin D, Angarita G, De Aquino J. Quantitative sensory testing of pain in persons with opioid use disorder on opioid agonist treatment: a scoping review. Pain Medicine 2025, 27: 243-253. PMID: 40990827, PMCID: PMC13017201, DOI: 10.1093/pm/pnaf132.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Cannabis use frequency is associated with emotion dysregulation among persons receiving long-term opioid therapy for chronic pain: A psychophysiological study
De Aquino J, Costa G, Nunes J, Hudak J, Odette M, Garland E. Cannabis use frequency is associated with emotion dysregulation among persons receiving long-term opioid therapy for chronic pain: A psychophysiological study. Drug And Alcohol Dependence 2025, 275: 112812. PMID: 40779835, PMCID: PMC12396927, DOI: 10.1016/j.drugalcdep.2025.112812.
Peer-Reviewed Original Research
MeSH Keywords
The Role of Childhood Trauma in Chronic Pain and Substance Use Among Individuals Receiving Methadone Treatment for Opioid Use Disorder
Costa G, Ra J, Meyerovich J, Pittman B, Nunes J, De Aquino J. The Role of Childhood Trauma in Chronic Pain and Substance Use Among Individuals Receiving Methadone Treatment for Opioid Use Disorder. Journal Of Addiction Medicine 2025, 20: 351-358. PMID: 40728216, PMCID: PMC13166079, DOI: 10.1097/adm.0000000000001553.
Peer-Reviewed Original Research
Psychedelic drugs for the treatment of substance use disorders
Sofuoglu M, De Aquino J, MacLean R. Psychedelic drugs for the treatment of substance use disorders. Expert Review Of Clinical Pharmacology 2025, 18: 437-439. PMID: 40726066, DOI: 10.1080/17512433.2025.2541103.
Commentaries, Editorials and Letters
Pain interference, alcohol use, and metabolic health: Insights from a nationally representative study
Costa G, Suh R, Nunes J, Pittman B, Sofuoglu M, Petrakis I, De Aquino J. Pain interference, alcohol use, and metabolic health: Insights from a nationally representative study. Alcohol Clinical And Experimental Research 2025, 49: 1768-1777. PMID: 40568749, DOI: 10.1111/acer.70108.
Peer-Reviewed Original Research
MeSH Keywords
Letter to the Editor: Effect of Nicotine Replacement Therapy on Perioperative Pain Management and Opioid Requirement in Abstinent Tobacco Smokers Undergoing Spinal Fusion: A Double-Blind Randomized Controlled Trial
Costa G, De Aquino J. Letter to the Editor: Effect of Nicotine Replacement Therapy on Perioperative Pain Management and Opioid Requirement in Abstinent Tobacco Smokers Undergoing Spinal Fusion: A Double-Blind Randomized Controlled Trial. Journal Of Neurosurgical Anesthesiology 2025, 37: 418-419. PMID: 40325556, DOI: 10.1097/ana.0000000000001041.
Commentaries, Editorials and Letters
Exploring the Addictive Potential of Tranylcypromine
de Lima L, Berto L, Spitz V, De Aquino J, Damiano R. Exploring the Addictive Potential of Tranylcypromine. Journal Of Clinical Psychopharmacology 2025, 45: 404-406. PMID: 40184518, DOI: 10.1097/jcp.0000000000001998.
Peer-Reviewed Original Research
Response to the letter to the editor
Hickey T, Avila-Quintero V, De Aquino J. Response to the letter to the editor. Regional Anesthesia & Pain Medicine 2025, rapm-2025-106481. PMID: 39929637, DOI: 10.1136/rapm-2025-106481.
Commentaries, Editorials and Letters
The bidirectional relationship between pain and tobacco use: Insights from the longitudinal Population Assessment of Tobacco and Health (PATH) study
Costa G, Nunes J, Suh R, Sofuoglu M, De Aquino J. The bidirectional relationship between pain and tobacco use: Insights from the longitudinal Population Assessment of Tobacco and Health (PATH) study. Drug And Alcohol Dependence 2025, 268: 112552. PMID: 39848133, PMCID: PMC11832315, DOI: 10.1016/j.drugalcdep.2025.112552.
Peer-Reviewed Original Research
MeSH Keywords
Buprenorphine versus full agonist opioids for acute postoperative pain management: an infographic
Hickey T, Costa G, Avila-Quintero V, De Aquino J. Buprenorphine versus full agonist opioids for acute postoperative pain management: an infographic. Regional Anesthesia & Pain Medicine 2025, 51: 594-595. PMID: 39793993, PMCID: PMC13151492, DOI: 10.1136/rapm-2024-106304.
Peer-Reviewed Original Research
Buprenorphine versus full agonist opioids for acute postoperative pain management: a systematic review and meta-analysis of randomized controlled trials
Hickey T, Costa G, Oliveira D, Podosek A, Abelleira A, Avila-Quintero V, De Aquino J. Buprenorphine versus full agonist opioids for acute postoperative pain management: a systematic review and meta-analysis of randomized controlled trials. Regional Anesthesia & Pain Medicine 2025, 51: 1-16. PMID: 39753290, DOI: 10.1136/rapm-2024-106014.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

2024

Navigating new norms: Addiction specialists' perspectives on opioid use disorder treatments and policy challenges in the fentanyl era
Weleff J, Christian N, Wang J, Singh M, De Aquino J, Saxon A, Vassallo G. Navigating new norms: Addiction specialists' perspectives on opioid use disorder treatments and policy challenges in the fentanyl era. American Journal On Addictions 2024, 34: 85-92. PMID: 39364597, PMCID: PMC11673400, DOI: 10.1111/ajad.13653.
Peer-Reviewed Original Research
Editorial for the themed issue: Addressing the dual challenges of opioid use disorder and chronic pain in the context of the opioid crisis
Sofuoglu M, MacLean R, De Aquino J. Editorial for the themed issue: Addressing the dual challenges of opioid use disorder and chronic pain in the context of the opioid crisis. British Journal Of Clinical Pharmacology 2024, 90: 2960-2961. PMID: 39340184, PMCID: PMC11604519, DOI: 10.1111/bcp.16273.
Commentaries, Editorials and Letters
The Impact of High-Potency Synthetic Opioids on Pharmacotherapies for Opioid Use Disorder: A Scoping Review
Jegede O, De Aquino J, Hsaio C, Caldwell E, Funaro M, Petrakis I, Muvvala S. The Impact of High-Potency Synthetic Opioids on Pharmacotherapies for Opioid Use Disorder: A Scoping Review. Journal Of Addiction Medicine 2024, 18: 499-510. PMID: 39356620, PMCID: PMC11449257, DOI: 10.1097/adm.0000000000001356.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
We Need to Rethink Our Strategy on Cannabis in the Overdose Crisis
Joao P. De Aquino and Gabriel P. A. Costa. Cannabis Needs Rethinking As a Strategy in the Overdose Crisis. Scientific American. Available at:
Publications for non-academic audiences

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