Publications (PubMed)

• Autoimmune mechanisms elucidated through muscle acetylcholine receptor structures.Li H, Pham MC, Teng J, O'Connor KC, Noviello CM, Hibbs RE. Cell. 2025 May 1; 2025 Apr 8. PMID: 40203823.
• MuSK is a substrate for CaMK2β but this interaction is dispensable for MuSK activation in vivo.Prömer JJ, Wolske S, Castets P, van Woerden GM, Barresi C, O'Connor KC, Herbst R. Sci Rep. 2025 Apr 28; 2025 Apr 28. PMID: 40295530.
• Permissive central tolerance plus defective peripheral checkpoints license pathogenic memory B cells in CASPR2-antibody encephalitis.Sun B, Fernandes D, Soltys J, Kienzler AK, Paneva S, Harrison R, Ramanathan S, Harrison AL, Makuch M, Fichtner ML, Donat RF, Akdeniz D, Bayuangga H, Im MG, Williams R, Vasconcelos A, Thomsen S, Fower A, Sun R, Fox H, Mgbachi V, Davies A, Tseng M, Handel A, Kelly M, Zhao M, Bancroft J, Bashford-Rogers R, Pluvinage JV, Dandekar R, Alvarenga BD, Dustin LB, Rinaldi S, Owens R, Anthony D, Bennett DL, Waters P, Davis SJ, Wilson MR, O'Connor KC, Carvalho AL, Irani SR. Sci Adv. 2025 Apr 18; 2025 Apr 16. PMID: 40238887.
• Luck gone cold: A trifecta of B cell mutations associates with cryoglobulinemia.Chen K, O'Connor KC. Sci Immunol. 2025 Apr 4; 2025 Apr 4. PMID: 40184441.
• Does thymectomy in adults have long-term health consequences?Detterbeck FC, Kaminski HJ, Blasberg JD, O'Connor KC. J Thorac Cardiovasc Surg. 2025 Mar; 2024 Dec 6. PMID: 39641701.
• Composition and function of AChR chimeric autoantibody receptor T cells for antigen-specific B cell depletion in myasthenia gravis.Oh S, Khani-Habibabadi F, O'Connor KC, Payne AS. Sci Adv. 2025 Feb 28; 2025 Feb 28. PMID: 40020066.
• Permissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis.Sun B, Fernandes D, Kienzler AK, Paneva S, Harrison R, Ramanathan S, Harrison AL, Makuch M, Fichtner ML, Donat RF, Akdeniz D, Bayuangga H, Im MG, Williams R, Vasconcelos A, Thomsen S, Fower A, Sun R, Fox H, Mgbachi V, Davies A, Tseng M, Handel A, Kelly M, Zhao M, Bancroft J, Bashford-Rogers R, Pluvinage JV, Dandekar R, Alvarenga BD, Dustin L, Rinaldi S, Owens R, Anthony D, Bennett DL, Waters P, Davis SJ, Wilson MR, O'Connor KC, Soltys J, Carvalho AL, Irani SR. bioRxiv. 2025 Jan 14; 2025 Jan 14. PMID: 39868113.
• Author Correction: Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells.Oh S, Mao X, Manfredo-Vieira S, Lee J, Patel D, Choi EJ, Alvarado A, Cottman-Thomas E, Maseda D, Tsao PY, Ellebrecht CT, Khella SL, Richman DP, O'Connor KC, Herzberg U, Binder GK, Milone MC, Basu S, Payne AS. Nat Biotechnol. 2024 Dec. PMID: 39543316.
• Fluorescence-detection size-exclusion chromatography specifically detects autoantibodies targeting the ganglionic acetylcholine receptor in patients with autoimmune autonomic ganglionopathy.Baxter L, Hopkins S, O'Connor KC, Pham MC, Nowak RJ, Monson NL, Blackburn K, Hibbs RE, Vernino S, Noviello CM. J Neuroimmunol. 2024 Nov 15; 2024 Sep 8. PMID: 39277987.
• Tricky Ts play possum to propagate autoimmune disease.Panicker AJ, O'Connor KC. Sci Immunol. 2024 Oct 4; 2024 Oct 4. PMID: 39365872.
• B cell and aquaporin-4 antibody relationships with neuromyelitis optica spectrum disorder activity.Bennett JL, Pittock SJ, Paul F, Kim HJ, Irani SR, O'Connor KC, Patterson KR, Smith MA, Gunsior M, Mittereder N, Rees WA, Cimbora D, Cree BAC. Ann Clin Transl Neurol. 2024 Oct; 2024 Sep 2. PMID: 39222408.
• Hide-&-Go-PhiP-Seq: Finding an elusive predictive MS biomarker.Wallace A, O'Connor KC. Sci Immunol. 2024 Jun 7; 2024 Jun 7. PMID: 38848339.
• Unveiling the proteome-wide autoreactome enables enhanced evaluation of emerging CAR T cell therapies in autoimmunity.Bodansky A, Yu DJ, Rallistan A, Kalaycioglu M, Boonyaratanakornkit J, Green DJ, Gauthier J, Turtle CJ, Zorn K, O'Donovan B, Mandel-Brehm C, Asaki J, Kortbawi H, Kung AF, Rackaityte E, Wang CY, Saxena A, de Dios K, Masi G, Nowak RJ, O'Connor KC, Li H, Diaz VE, Saloner R, Casaletto KB, Gontrum EQ, Chan B, Kramer JH, Wilson MR, Utz PJ, Hill JA, Jackson SW, Anderson MS, DeRisi JL. J Clin Invest. 2024 May 16; 2024 May 16. PMID: 38753445.
• A Noncanonical CD56dimCD16dim/- NK Cell Subset Indicative of Prior Cytotoxic Activity Is Elevated in Patients with Autoantibody-Mediated Neurologic Diseases.Yandamuri SS, Filipek B, Lele N, Cohen I, Bennett JL, Nowak RJ, Sotirchos ES, Longbrake EE, Mace EM, O'Connor KC. J Immunol. 2024 Mar 1. PMID: 38251887.
• Unveiling the autoreactome: Proteome-wide immunological fingerprints reveal the promise of plasma cell depleting therapy.Bodansky A, Yu DJ, Rallistan A, Kalaycioglu M, Boonyaratanakornkit J, Green DJ, Gauthier J, Turtle CJ, Zorn K, O'Donovan B, Mandel-Brehm C, Asaki J, Kortbawi H, Kung AF, Rackaityte E, Wang CY, Saxena A, de Dios K, Masi G, Nowak RJ, O'Connor KC, Li H, Diaz VE, Casaletto KB, Gontrum EQ, Chan B, Kramer JH, Wilson MR, Utz PJ, Hill JA, Jackson SW, Anderson MS, DeRisi JL. medRxiv. 2023 Dec 20; 2023 Dec 20. PMID: 38196603.
• Remission of severe myasthenia gravis after autologous stem cell transplantation.Schlatter MI, Yandamuri SS, O'Connor KC, Nowak RJ, Pham MC, Obaid AH, Redman C, Provost M, McSweeney PA, Pearlman ML, Tees MT, Bowen JD, Nash RA, Georges GE. Ann Clin Transl Neurol. 2023 Nov; 2023 Sep 19. PMID: 37726935.
• From drab to Fab; PLP1's fit is redressed for MS.Bayer AC, O'Connor KC. Sci Immunol. 2023 Oct 13; 2023 Oct 6. PMID: 37801515.
• Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells.Oh S, Mao X, Manfredo-Vieira S, Lee J, Patel D, Choi EJ, Alvarado A, Cottman-Thomas E, Maseda D, Tsao PY, Ellebrecht CT, Khella SL, Richman DP, O'Connor KC, Herzberg U, Binder GK, Milone MC, Basu S, Payne AS. Nat Biotechnol. 2023 Sep; 2023 Jan 19. PMID: 36658341.
• Toddler's T cells are taught in muco-school.Khani-Habibabadi F, O'Connor KC. Sci Immunol. 2023 Aug 4; 2023 Aug 4. PMID: 37540737.
• Individual myasthenia gravis autoantibody clones can efficiently mediate multiple mechanisms of pathology.Pham MC, Masi G, Patzina R, Obaid AH, Oxendine SR, Oh S, Payne AS, Nowak RJ, O'Connor KC. Acta Neuropathol. 2023 Aug; 2023 Jun 21. PMID: 37344701.
• MOGAD patient autoantibodies induce complement, phagocytosis, and cellular cytotoxicity.Yandamuri SS, Filipek B, Obaid AH, Lele N, Thurman JM, Makhani N, Nowak RJ, Guo Y, Lucchinetti CF, Flanagan EP, Longbrake EE, O'Connor KC. JCI Insight. 2023 Jun 8; 2023 Jun 8. PMID: 37097758.
• The Plasma Cell Infiltrate Populating the Muscle Tissue of Patients with Inclusion Body Myositis Features Distinct B Cell Receptor Repertoire Properties.Jiang R, Roy B, Wu Q, Mohanty S, Nowak RJ, Shaw AC, Kleinstein SH, O'Connor KC. Immunohorizons. 2023 May 1. PMID: 37171806.
• Clinicoserological insights into patients with immune checkpoint inhibitor-induced myasthenia gravis.Masi G, Pham MC, Karatz T, Oh S, Payne AS, Nowak RJ, Howard JF Jr, Guptill JT, Juel VC, O'Connor KC. Ann Clin Transl Neurol. 2023 May; 2023 Mar 16. PMID: 36924454.
• Plasmablasts from the past: Nostalgic B cells can't let go.Ohashi SN, O'Connor KC. Sci Immunol. 2023 Mar 10; 2023 Mar 3. PMID: 36867677.
• SAkuraBONSAI: Protocol design of a novel, prospective study to explore clinical, imaging, and biomarker outcomes in patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorder receiving open-label satralizumab.Bennett JL, Fujihara K, Kim HJ, Marignier R, O'Connor KC, Sergott RC, Traboulsee A, Wiendl H, Wuerfel J, Zamvil SS, Anania VG, Buffels R, Künzel T, Lekkerkerker AN, Lennon-Chrimes S, Pittock SJ. Front Neurol. 2023; 2023 Feb 17. PMID: 36873431.
• Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapy.Fichtner ML, Hoehn KB, Ford EE, Mane-Damas M, Oh S, Waters P, Payne AS, Smith ML, Watson CT, Losen M, Martinez-Martinez P, Nowak RJ, Kleinstein SH, O'Connor KC. Acta Neuropathol Commun. 2022 Oct 28; 2022 Oct 28. PMID: 36307868.
• EBVerified TCRs and multiple sclerosis.Sefik E, O'Connor KC. Sci Immunol. 2022 Oct 14; 2022 Oct 7. PMID: 36206354.
• Novel pathophysiological insights in autoimmune myasthenia gravis.Masi G, O'Connor KC. Curr Opin Neurol. 2022 Oct 1; 2022 Aug 4. PMID: 35942663.
• Inflammatory Responses After Ischemic Stroke.DeLong JH, Ohashi SN, O'Connor KC, Sansing LH. Semin Immunopathol. 2022 Sep; 2022 Jun 29. PMID: 35767089.
• Heterogeneity of Acetylcholine Receptor Autoantibody-Mediated Complement Activity in Patients With Myasthenia Gravis.Obaid AH, Zografou C, Vadysirisack DD, Munro-Sheldon B, Fichtner ML, Roy B, Philbrick WM, Bennett JL, Nowak RJ, O'Connor KC. Neurol Neuroimmunol Neuroinflamm. 2022 Jul; 2022 Apr 26. PMID: 35473886.
• The clinical need for clustered AChR cell-based assay testing of seronegative MG.Masi G, Li Y, Karatz T, Pham MC, Oxendine SR, Nowak RJ, Guptill JT, O'Connor KC. J Neuroimmunol. 2022 Jun 15; 2022 Mar 25. PMID: 35366559.
• Reliability of patient self-reports to clinician-assigned functional scores of inclusion body myositis.Roy B, Zubair A, Petschke K, O'Connor KC, Paltiel AD, Nowak RJ. J Neurol Sci. 2022 May 15; 2022 Mar 15. PMID: 35344793.
• Myasthenia gravis complement activity is independent of autoantibody titer and disease severity.Fichtner ML, Hoarty MD, Vadysirisack DD, Munro-Sheldon B, Nowak RJ, O'Connor KC. PLoS One. 2022; 2022 Mar 15. PMID: 35290370.
• Phase 2 Trial of Rituximab in Acetylcholine Receptor Antibody-Positive Generalized Myasthenia Gravis: The BeatMG Study.Nowak RJ, Coffey CS, Goldstein JM, Dimachkie MM, Benatar M, Kissel JT, Wolfe GI, Burns TM, Freimer ML, Nations S, Granit V, Smith AG, Richman DP, Ciafaloni E, Al-Lozi MT, Sams LA, Quan D, Ubogu E, Pearson B, Sharma A, Yankey JW, Uribe L, Shy M, Amato AA, Conwit R, O'Connor KC, Hafler DA, Cudkowicz ME, Barohn RJ. Neurology. 2022 Jan 25; 2022 Jan 25. PMID: 34857535.
• COVID-19 Vaccination Reactogenicity in Persons With Multiple Sclerosis.Briggs FBS, Mateen FJ, Schmidt H, Currie KM, Siefers HM, Crouthamel S, Bebo BF, Fiol J, Racke MK, O'Connor KC, Kolaczkowski LG, Klein P, Loud S, McBurney RN. Neurol Neuroimmunol Neuroinflamm. 2022 Jan; 2021 Nov 9. PMID: 34753828.
• GABA-cadabra: autoantibodies trick neurotransmitter receptors and induce seizures.Masi G, O'Connor KC. Sci Immunol. 2021 Dec 3; 2021 Dec 3. PMID: 34860582.
• Elevated N-Linked Glycosylation of IgG V Regions in Myasthenia Gravis Disease Subtypes.Mandel-Brehm C, Fichtner ML, Jiang R, Winton VJ, Vazquez SE, Pham MC, Hoehn KB, Kelleher NL, Nowak RJ, Kleinstein SH, Wilson MR, DeRisi JL, O'Connor KC. J Immunol. 2021 Oct 15; 2021 Sep 20. PMID: 34544801.
• Lost in post-translational modification-Dengue virus writes its own sequel.Yandamuri SS, O'Connor KC. Sci Immunol. 2021 Jul 2. PMID: 34215681.
• Brain tumor T cells inhibited by their natural KLR(B1) instinct.Oxendine S, O'Connor KC. Sci Immunol. 2021 Apr 2. PMID: 33811061.
• CD4+ follicular regulatory T cells optimize the influenza virus-specific B cell response.Lu Y, Jiang R, Freyn AW, Wang J, Strohmeier S, Lederer K, Locci M, Zhao H, Angeletti D, O'Connor KC, Kleinstein SH, Nachbagauer R, Craft J. J Exp Med. 2021 Mar 1. PMID: 33326020.
• Affinity maturation is required for pathogenic monovalent IgG4 autoantibody development in myasthenia gravis.Fichtner ML, Vieni C, Redler RL, Kolich L, Jiang R, Takata K, Stathopoulos P, Suarez PA, Nowak RJ, Burden SJ, Ekiert DC, O'Connor KC. J Exp Med. 2020 Dec 7. PMID: 32820331.
• Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis.Jiang R, Hoehn KB, Lee CS, Pham MC, Homer RJ, Detterbeck FC, Aban I, Jacobson L, Vincent A, Nowak RJ, Kaminski HJ, Kleinstein SH, O'Connor KC. Proc Natl Acad Sci U S A. 2020 Dec 1; 2020 Nov 16. PMID: 33199596.
• Two mAbs take a stab at influenza's NActive site.Pham MC, O'Connor KC. Sci Immunol. 2020 Nov 6. PMID: 33158977.
• High-throughput investigation of molecular and cellular biomarkers in NMOSD.Yandamuri SS, Jiang R, Sharma A, Cotzomi E, Zografou C, Ma AK, Alvey JS, Cook LJ, Smith TJ, Yeaman MR, O'Connor KC. Neurol Neuroimmunol Neuroinflamm. 2020 Sep; 2020 Aug 4. PMID: 32753407.
• The B cell immunobiology that underlies CNS autoantibody-mediated diseases.Sun B, Ramberger M, O'Connor KC, Bashford-Rogers RJM, Irani SR. Nat Rev Neurol. 2020 Sep; 2020 Jul 28. PMID: 32724223.
• Single-cell repertoire tracing identifies rituximab-resistant B cells during myasthenia gravis relapses.Jiang R, Fichtner ML, Hoehn KB, Pham MC, Stathopoulos P, Nowak RJ, Kleinstein SH, O'Connor KC. JCI Insight. 2020 Jul 23; 2020 Jul 23. PMID: 32573488.
• Exploring outcomes and characteristics of myasthenia gravis: Rationale, aims and design of registry - The EXPLORE-MG registry.Anil R, Kumar A, Alaparthi S, Sharma A, Nye JL, Roy B, O'Connor KC, Nowak RJ. J Neurol Sci. 2020 Jul 15; 2020 Apr 16. PMID: 32388060.
• Sweet and low-autoantibodies deny oligodendrocytes their sugar fix.Hernandez AL, O'Connor KC. Sci Immunol. 2020 Jun 5. PMID: 32503879.
• Autoimmune Pathology in Myasthenia Gravis Disease Subtypes Is Governed by Divergent Mechanisms of Immunopathology.Fichtner ML, Jiang R, Bourke A, Nowak RJ, O'Connor KC. Front Immunol. 2020; 2020 May 27. PMID: 32547535.
• Impaired B-cell tolerance checkpoints promote the development of autoimmune diseases and pathogenic autoantibodies.Meffre E, O'Connor KC. Immunol Rev. 2019 Nov; 2019 Nov 12. PMID: 31721234.
• Phenotypic and Ig Repertoire Analyses Indicate a Common Origin of IgD(-)CD27(-) Double Negative B Cells in Healthy Individuals and Multiple Sclerosis Patients.Fraussen J, Marquez S, Takata K, Beckers L, Montes Diaz G, Zografou C, Van Wijmeersch B, Villar LM, O'Connor KC, Kleinstein SH, Somers V. J Immunol. 2019 Sep 15; 2019 Aug 7. PMID: 31391234.
• Characterization of pathogenic monoclonal autoantibodies derived from muscle-specific kinase myasthenia gravis patients.Takata K, Stathopoulos P, Cao M, Mané-Damas M, Fichtner ML, Benotti ES, Jacobson L, Waters P, Irani SR, Martinez-Martinez P, Beeson D, Losen M, Vincent A, Nowak RJ, O'Connor KC. JCI Insight. 2019 Jun 20; 2019 Jun 20. PMID: 31217355.
• Early B cell tolerance defects in neuromyelitis optica favour anti-AQP4 autoantibody production.Cotzomi E, Stathopoulos P, Lee CS, Ritchie AM, Soltys JN, Delmotte FR, Oe T, Sng J, Jiang R, Ma AK, Vander Heiden JA, Kleinstein SH, Levy M, Bennett JL, Meffre E, O'Connor KC. Brain. 2019 Jun 1. PMID: 31056665.
• Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity.Stathopoulos P, Chastre A, Waters P, Irani S, Fichtner ML, Benotti ES, Guthridge JM, Seifert J, Nowak RJ, Buckner JH, Holers VM, James JA, Hafler DA, O'Connor KC. J Immunol. 2019 Apr 15; 2019 Mar 1. PMID: 30824481.
• Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients.James JA, Chen H, Young KA, Bemis EA, Seifert J, Bourn RL, Deane KD, Demoruelle MK, Feser M, O'Dell JR, Weisman MH, Keating RM, Gaffney PM, Kelly JA, Langefeld CD, Harley JB, Robinson W, Hafler DA, O'Connor KC, Buckner J, Guthridge JM, Norris JM, Holers VM. EBioMedicine. 2019 Apr; 2019 Apr 3. PMID: 30952617.
• Identification of Subject-Specific Immunoglobulin Alleles From Expressed Repertoire Sequencing Data.Gadala-Maria D, Gidoni M, Marquez S, Vander Heiden JA, Kos JT, Watson CT, O'Connor KC, Yaari G, Kleinstein SH. Front Immunol. 2019; 2019 Feb 13. PMID: 30814994.
• Belly-born B cells bathe the brain.Stathopoulos PA, O'Connor KC. Sci Immunol. 2019 Feb 1. PMID: 30709846.
• B cells drive auto-T cells to the brain.Pappalardo JL, O'Connor KC. Sci Immunol. 2018 Oct 5. PMID: 30291134.
• Bats are "blind" to the deadly effects of viruses.O'Connor KC. Sci Immunol. 2018 Jun 1. PMID: 29858289.
• B cells in the pathophysiology of myasthenia gravis.Yi JS, Guptill JT, Stathopoulos P, Nowak RJ, O'Connor KC. Muscle Nerve. 2018 Feb; 2017 Sep 30. PMID: 28940642.
• Mechanisms underlying B cell immune dysregulation and autoantibody production in MuSK myasthenia gravis.Stathopoulos P, Kumar A, Heiden JAV, Pascual-Goñi E, Nowak RJ, O'Connor KC. Ann N Y Acad Sci. 2018 Jan. PMID: 29381221.
• In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence.Hillmer AT, Sandiego CM, Hannestad J, Angarita GA, Kumar A, McGovern EM, Huang Y, O'Connor KC, Carson RE, O'Malley SS, Cosgrove KP. Mol Psychiatry. 2017 Dec; 2017 Feb 28. PMID: 28242869.
• Autoantibody-producing plasmablasts after B cell depletion identified in muscle-specific kinase myasthenia gravis.Stathopoulos P, Kumar A, Nowak RJ, O'Connor KC. JCI Insight. 2017 Sep 7; 2017 Sep 7. PMID: 28878127.
• Dysregulation of B Cell Repertoire Formation in Myasthenia Gravis Patients Revealed through Deep Sequencing.Vander Heiden JA, Stathopoulos P, Zhou JQ, Chen L, Gilbert TJ, Bolen CR, Barohn RJ, Dimachkie MM, Ciafaloni E, Broering TJ, Vigneault F, Nowak RJ, Kleinstein SH, O'Connor KC. J Immunol. 2017 Feb 15; 2017 Jan 13. PMID: 28087666.
• Durability of the Rituximab Response in Acetylcholine Receptor Autoantibody-Positive Myasthenia Gravis.Robeson KR, Kumar A, Keung B, DiCapua DB, Grodinsky E, Patwa HS, Stathopoulos PA, Goldstein JM, O'Connor KC, Nowak RJ. JAMA Neurol. 2017 Jan 1. PMID: 27893014.
• A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data.Cui A, Di Niro R, Vander Heiden JA, Briggs AW, Adams K, Gilbert T, O'Connor KC, Vigneault F, Shlomchik MJ, Kleinstein SH. J Immunol. 2016 Nov 1; 2016 Oct 5. PMID: 27707999.
• Compromised fidelity of B-cell tolerance checkpoints in AChR and MuSK myasthenia gravis.Lee JY, Stathopoulos P, Gupta S, Bannock JM, Barohn RJ, Cotzomi E, Dimachkie MM, Jacobson L, Lee CS, Morbach H, Querol L, Shan JL, Vander Heiden JA, Waters P, Vincent A, Nowak RJ, O'Connor KC. Ann Clin Transl Neurol. 2016 Jun; 2016 Apr 27. PMID: 27547772.
• Evaluation of KIR4.1 as an Immune Target in Multiple Sclerosis.Chastre A, Hafler DA, O'Connor KC. N Engl J Med. 2016 Apr 14. PMID: 27074083.
• Autoreactive T Cells from Patients with Myasthenia Gravis Are Characterized by Elevated IL-17, IFN-γ, and GM-CSF and Diminished IL-10 Production.Cao Y, Amezquita RA, Kleinstein SH, Stathopoulos P, Nowak RJ, O'Connor KC. J Immunol. 2016 Mar 1; 2016 Jan 29. PMID: 26826242.
• Current and future immunotherapy targets in autoimmune neurology.Hu MY, Stathopoulos P, O'connor KC, Pittock SJ, Nowak RJ. Handb Clin Neurol. 2016. PMID: 27112694.
• Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived Immunoglobulins.Willis SN, Stathopoulos P, Chastre A, Compton SD, Hafler DA, O'Connor KC. Front Immunol. 2015; 2015 Nov 25. PMID: 26648933.
• Imaging robust microglial activation after lipopolysaccharide administration in humans with PET.Sandiego CM, Gallezot JD, Pittman B, Nabulsi N, Lim K, Lin SF, Matuskey D, Lee JY, O'Connor KC, Huang Y, Carson RE, Hannestad J, Cosgrove KP. Proc Natl Acad Sci U S A. 2015 Oct 6; 2015 Sep 18. PMID: 26385967.
• Demographic and clinical features of inclusion body myositis in North America.Paltiel AD, Ingvarsson E, Lee DK, Leff RL, Nowak RJ, Petschke KD, Richards-Shubik S, Zhou A, Shubik M, O'Connor KC. Muscle Nerve. 2015 Oct; 2015 Feb 17. PMID: 25557419.
• Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome.Xu GJ, Kula T, Xu Q, Li MZ, Vernon SD, Ndung'u T, Ruxrungtham K, Sanchez J, Brander C, Chung RT, O'Connor KC, Walker B, Larman HB, Elledge SJ. Science. 2015 Jun 5. PMID: 26045439.
• B lymphocytes in neuromyelitis optica.Bennett JL, O'Connor KC, Bar-Or A, Zamvil SS, Hemmer B, Tedder TF, von Büdingen HC, Stuve O, Yeaman MR, Smith TJ, Stadelmann C. Neurol Neuroimmunol Neuroinflamm. 2015 Jun; 2015 May 7. PMID: 25977932.
• (11)C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas.Park E, Gallezot JD, Delgadillo A, Liu S, Planeta B, Lin SF, O'Connor KC, Lim K, Lee JY, Chastre A, Chen MK, Seneca N, Leppert D, Huang Y, Carson RE, Pelletier D. Eur J Nucl Med Mol Imaging. 2015 Jun; 2015 Apr 2. PMID: 25833352.
• MOG cell-based assay detects non-MS patients with inflammatory neurologic disease.Waters P, Woodhall M, O'Connor KC, Reindl M, Lang B, Sato DK, Juryńczyk M, Tackley G, Rocha J, Takahashi T, Misu T, Nakashima I, Palace J, Fujihara K, Leite MI, Vincent A. Neurol Neuroimmunol Neuroinflamm. 2015 Jun; 2015 Mar 19. PMID: 25821844.
• Interleukin-10+ regulatory B cells arise within antigen-experienced CD40+ B cells to maintain tolerance to islet autoantigens.Kleffel S, Vergani A, Tezza S, Ben Nasr M, Niewczas MA, Wong S, Bassi R, D'Addio F, Schatton T, Abdi R, Atkinson M, Sayegh MH, Wen L, Wasserfall CH, O'Connor KC, Fiorina P. Diabetes. 2015 Jan; 2014 Sep 3. PMID: 25187361.
• B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes.Stern JN, Yaari G, Vander Heiden JA, Church G, Donahue WF, Hintzen RQ, Huttner AJ, Laman JD, Nagra RM, Nylander A, Pitt D, Ramanan S, Siddiqui BA, Vigneault F, Kleinstein SH, Hafler DA, O'Connor KC. Sci Transl Med. 2014 Aug 6. PMID: 25100741.
• pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires.Vander Heiden JA, Yaari G, Uduman M, Stern JN, O'Connor KC, Hafler DA, Vigneault F, Kleinstein SH. Bioinformatics. 2014 Jul 1; 2014 Mar 10. PMID: 24618469.
• A molecular view of multiple sclerosis and experimental autoimmune encephalitis: what can we learn from the epitope data?Vaughan K, Peters B, O'Connor KC, Martin R, Sette A. J Neuroimmunol. 2014 Feb 15; 2013 Dec 12. PMID: 24365494.
• Long-term benefit of rituximab in MuSK autoantibody myasthenia gravis patients.Keung B, Robeson KR, DiCapua DB, Rosen JB, O'Connor KC, Goldstein JM, Nowak RJ. J Neurol Neurosurg Psychiatry. 2013 Dec; 2013 Jun 12. PMID: 23761915.
• Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data.Yaari G, Vander Heiden JA, Uduman M, Gadala-Maria D, Gupta N, Stern JN, O'Connor KC, Hafler DA, Laserson U, Vigneault F, Kleinstein SH. Front Immunol. 2013; 2013 Nov 15. PMID: 24298272.
• The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells.Fang L, Lowther DE, Meizlish ML, Anderson RC, Bruce JN, Devine L, Huttner AJ, Kleinstein SH, Lee JY, Stern JN, Yaari G, Lovato L, Cronk KM, O'Connor KC. Neuro Oncol. 2013 Nov; 2013 Aug 26. PMID: 23978377.
• Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing-remitting multiple sclerosis.Van Haren K, Tomooka BH, Kidd BA, Banwell B, Bar-Or A, Chitnis T, Tenembaum SN, Pohl D, Rostasy K, Dale RC, O'Connor KC, Hafler DA, Steinman L, Robinson WH. Mult Scler. 2013 Nov; 2013 Apr 23. PMID: 23612879.
• The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: a [¹¹C]PBR28 PET study.Hannestad J, DellaGioia N, Gallezot JD, Lim K, Nabulsi N, Esterlis I, Pittman B, Lee JY, O'Connor KC, Pelletier D, Carson RE. Brain Behav Immun. 2013 Oct; 2013 Jul 9. PMID: 23850810.
• Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis.Querol L, Clark PL, Bailey MA, Cotsapas C, Cross AH, Hafler DA, Kleinstein SH, Lee JY, Yaari G, Willis SN, O'Connor KC. Neurology. 2013 Sep 10; 2013 Aug 6. PMID: 23921886.
• Specific peripheral B cell tolerance defects in patients with multiple sclerosis.Kinnunen T, Chamberlain N, Morbach H, Cantaert T, Lynch M, Preston-Hurlburt P, Herold KC, Hafler DA, O'Connor KC, Meffre E. J Clin Invest. 2013 Jun; 2013 May 15. PMID: 23676463.
• PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis.Larman HB, Laserson U, Querol L, Verhaeghen K, Solimini NL, Xu GJ, Klarenbeek PL, Church GM, Hafler DA, Plenge RM, Nigrovic PA, De Jager PL, Weets I, Martens GA, O'Connor KC, Elledge SJ. J Autoimmun. 2013 Jun; 2013 Mar 13. PMID: 23497938.
• Autoantibodies produced at the site of tissue damage provide evidence of humoral autoimmunity in inclusion body myositis.Ray A, Amato AA, Bradshaw EM, Felice KJ, DiCapua DB, Goldstein JM, Lundberg IE, Nowak RJ, Ploegh HL, Spooner E, Wu Q, Willis SN, O'Connor KC. PLoS One. 2012; 2012 Oct 5. PMID: 23071619.
• Cortical injury in multiple sclerosis; the role of the immune system.Walker CA, Huttner AJ, O'Connor KC. BMC Neurol. 2011 Dec 6; 2011 Dec 6. PMID: 22145746.
• Acute demyelinating disease after oral therapy with herbal extracts.Kostianovsky A, Maskin P, Noriega MM, Soler C, Bonelli I, Riley CS, O'Connor KC, Saubidet CN, Alvarez PA. Case Rep Neurol. 2011 May; 2011 Jun 25. PMID: 21738505.
• Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin.Obermeier B, Lovato L, Mentele R, Brück W, Forne I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O'Connor KC, Dornmair K. J Neuroimmunol. 2011 Apr; 2011 Feb 24. PMID: 21353315.
• Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis.Lovato L, Willis SN, Rodig SJ, Caron T, Almendinger SE, Howell OW, Reynolds R, O'Connor KC, Hafler DA. Brain. 2011 Feb; 2011 Jan 7. PMID: 21216828.
• A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis.Ligocki AJ, Lovato L, Xiang D, Guidry P, Scheuermann RH, Willis SN, Almendinger S, Racke MK, Frohman EM, Hafler DA, O'Connor KC, Monson NL. J Neuroimmunol. 2010 Sep 14; 2010 Jul 23. PMID: 20655601.
• Elevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis.Klawiter EC, Piccio L, Lyons JA, Mikesell R, O'Connor KC, Cross AH. Arch Neurol. 2010 Sep. PMID: 20837855.
• Anti-myelin antibodies modulate clinical expression of childhood multiple sclerosis.O'Connor KC, Lopez-Amaya C, Gagne D, Lovato L, Moore-Odom NH, Kennedy J, Krupp L, Tenembaum S, Ness J, Belman A, Boyko A, Bykova O, Mah JK, Stoian CA, Waubant E, Kremenchutzky M, Ruggieri M, Bardini MR, Rensel M, Hahn J, Weinstock-Guttman B, Yeh EA, Farrell K, Freedman MS, Iivanainen M, Bhan V, Dilenge M, Hancock MA, Gano D, Fattahie R, Kopel L, Fournier AE, Moscarello M, Banwell B, Bar-Or A. J Neuroimmunol. 2010 Jun; 2010 Apr 8. PMID: 20381173.
• Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain.Willis SN, Stadelmann C, Rodig SJ, Caron T, Gattenloehner S, Mallozzi SS, Roughan JE, Almendinger SE, Blewett MM, Brück W, Hafler DA, O'Connor KC. Brain. 2009 Dec. PMID: 19638446.
• Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis.McLaughlin KA, Chitnis T, Newcombe J, Franz B, Kennedy J, McArdel S, Kuhle J, Kappos L, Rostasy K, Pohl D, Gagne D, Ness JM, Tenembaum S, O'Connor KC, Viglietta V, Wong SJ, Tavakoli NP, de Seze J, Idrissova Z, Khoury SJ, Bar-Or A, Hafler DA, Banwell B, Wucherpfennig KW. J Immunol. 2009 Sep 15; 2009 Aug 17. PMID: 19687098.
• Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid.Owens GP, Bennett JL, Lassmann H, O'Connor KC, Ritchie AM, Shearer A, Lam C, Yu X, Birlea M, DuPree C, Williamson RA, Hafler DA, Burgoon MP, Gilden D. Ann Neurol. 2009 Jun. PMID: 19557869.