Publications (PubMed)

2024

A Noncanonical CD56dimCD16dim/- NK Cell Subset Indicative of Prior Cytotoxic Activity Is Elevated in Patients with Autoantibody-Mediated Neurologic Diseases.Yandamuri SS, Filipek B, Lele N, Cohen I, Bennett JL, Nowak RJ, Sotirchos ES, Longbrake EE, Mace EM, O'Connor KC. J Immunol. 2024 Mar 1. PMID: 38251887.

2023

Unveiling the autoreactome: Proteome-wide immunological fingerprints reveal the promise of plasma cell depleting therapy.Bodansky A, Yu DJ, Rallistan A, Kalaycioglu M, Boonyaratanakornkit J, Green DJ, Gauthier J, Turtle CJ, Zorn K, O'Donovan B, Mandel-Brehm C, Asaki J, Kortbawi H, Kung AF, Rackaityte E, Wang CY, Saxena A, de Dios K, Masi G, Nowak RJ, O'Connor KC, Li H, Diaz VE, Casaletto KB, Gontrum EQ, Chan B, Kramer JH, Wilson MR, Utz PJ, Hill JA, Jackson SW, Anderson MS, DeRisi JL. medRxiv. 2023 Dec 20; 2023 Dec 20. PMID: 38196603.
Remission of severe myasthenia gravis after autologous stem cell transplantation.Schlatter MI, Yandamuri SS, O'Connor KC, Nowak RJ, Pham MC, Obaid AH, Redman C, Provost M, McSweeney PA, Pearlman ML, Tees MT, Bowen JD, Nash RA, Georges GE. Ann Clin Transl Neurol. 2023 Nov; 2023 Sep 19. PMID: 37726935.
From drab to Fab; PLP1's fit is redressed for MS.Bayer AC, O'Connor KC. Sci Immunol. 2023 Oct 13; 2023 Oct 6. PMID: 37801515.
Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells.Oh S, Mao X, Manfredo-Vieira S, Lee J, Patel D, Choi EJ, Alvarado A, Cottman-Thomas E, Maseda D, Tsao PY, Ellebrecht CT, Khella SL, Richman DP, O'Connor KC, Herzberg U, Binder GK, Milone MC, Basu S, Payne AS. Nat Biotechnol. 2023 Sep; 2023 Jan 19. PMID: 36658341.
Toddler's T cells are taught in muco-school.Khani-Habibabadi F, O'Connor KC. Sci Immunol. 2023 Aug 4; 2023 Aug 4. PMID: 37540737.
Individual myasthenia gravis autoantibody clones can efficiently mediate multiple mechanisms of pathology.Pham MC, Masi G, Patzina R, Obaid AH, Oxendine SR, Oh S, Payne AS, Nowak RJ, O'Connor KC. Acta Neuropathol. 2023 Aug; 2023 Jun 21. PMID: 37344701.
MOGAD patient autoantibodies induce complement, phagocytosis, and cellular cytotoxicity.Yandamuri SS, Filipek B, Obaid AH, Lele N, Thurman JM, Makhani N, Nowak RJ, Guo Y, Lucchinetti CF, Flanagan EP, Longbrake EE, O'Connor KC. JCI Insight. 2023 Jun 8; 2023 Jun 8. PMID: 37097758.
The Plasma Cell Infiltrate Populating the Muscle Tissue of Patients with Inclusion Body Myositis Features Distinct B Cell Receptor Repertoire Properties.Jiang R, Roy B, Wu Q, Mohanty S, Nowak RJ, Shaw AC, Kleinstein SH, O'Connor KC. Immunohorizons. 2023 May 1. PMID: 37171806.
Clinicoserological insights into patients with immune checkpoint inhibitor-induced myasthenia gravis.Masi G, Pham MC, Karatz T, Oh S, Payne AS, Nowak RJ, Howard JF Jr, Guptill JT, Juel VC, O'Connor KC. Ann Clin Transl Neurol. 2023 May; 2023 Mar 16. PMID: 36924454.
Plasmablasts from the past: Nostalgic B cells can't let go.Ohashi SN, O'Connor KC. Sci Immunol. 2023 Mar 10; 2023 Mar 3. PMID: 36867677.
SAkuraBONSAI: Protocol design of a novel, prospective study to explore clinical, imaging, and biomarker outcomes in patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorder receiving open-label satralizumab.Bennett JL, Fujihara K, Kim HJ, Marignier R, O'Connor KC, Sergott RC, Traboulsee A, Wiendl H, Wuerfel J, Zamvil SS, Anania VG, Buffels R, Künzel T, Lekkerkerker AN, Lennon-Chrimes S, Pittock SJ. Front Neurol. 2023; 2023 Feb 17. PMID: 36873431.

2022

Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapy.Fichtner ML, Hoehn KB, Ford EE, Mane-Damas M, Oh S, Waters P, Payne AS, Smith ML, Watson CT, Losen M, Martinez-Martinez P, Nowak RJ, Kleinstein SH, O'Connor KC. Acta Neuropathol Commun. 2022 Oct 28; 2022 Oct 28. PMID: 36307868.
EBVerified TCRs and multiple sclerosis.Sefik E, O'Connor KC. Sci Immunol. 2022 Oct 14; 2022 Oct 7. PMID: 36206354.
Novel pathophysiological insights in autoimmune myasthenia gravis.Masi G, O'Connor KC. Curr Opin Neurol. 2022 Oct 1; 2022 Aug 4. PMID: 35942663.
Inflammatory Responses After Ischemic Stroke.DeLong JH, Ohashi SN, O'Connor KC, Sansing LH. Semin Immunopathol. 2022 Sep; 2022 Jun 29. PMID: 35767089.
Heterogeneity of Acetylcholine Receptor Autoantibody-Mediated Complement Activity in Patients With Myasthenia Gravis.Obaid AH, Zografou C, Vadysirisack DD, Munro-Sheldon B, Fichtner ML, Roy B, Philbrick WM, Bennett JL, Nowak RJ, O'Connor KC. Neurol Neuroimmunol Neuroinflamm. 2022 Jul; 2022 Apr 26. PMID: 35473886.
The clinical need for clustered AChR cell-based assay testing of seronegative MG.Masi G, Li Y, Karatz T, Pham MC, Oxendine SR, Nowak RJ, Guptill JT, O'Connor KC. J Neuroimmunol. 2022 Jun 15; 2022 Mar 25. PMID: 35366559.
Reliability of patient self-reports to clinician-assigned functional scores of inclusion body myositis.Roy B, Zubair A, Petschke K, O'Connor KC, Paltiel AD, Nowak RJ. J Neurol Sci. 2022 May 15; 2022 Mar 15. PMID: 35344793.
Myasthenia gravis complement activity is independent of autoantibody titer and disease severity.Fichtner ML, Hoarty MD, Vadysirisack DD, Munro-Sheldon B, Nowak RJ, O'Connor KC. PLoS One. 2022; 2022 Mar 15. PMID: 35290370.
Phase 2 Trial of Rituximab in Acetylcholine Receptor Antibody-Positive Generalized Myasthenia Gravis: The BeatMG Study.Nowak RJ, Coffey CS, Goldstein JM, Dimachkie MM, Benatar M, Kissel JT, Wolfe GI, Burns TM, Freimer ML, Nations S, Granit V, Smith AG, Richman DP, Ciafaloni E, Al-Lozi MT, Sams LA, Quan D, Ubogu E, Pearson B, Sharma A, Yankey JW, Uribe L, Shy M, Amato AA, Conwit R, O'Connor KC, Hafler DA, Cudkowicz ME, Barohn RJ. Neurology. 2022 Jan 25; 2022 Jan 25. PMID: 34857535.
COVID-19 Vaccination Reactogenicity in Persons With Multiple Sclerosis.Briggs FBS, Mateen FJ, Schmidt H, Currie KM, Siefers HM, Crouthamel S, Bebo BF, Fiol J, Racke MK, O'Connor KC, Kolaczkowski LG, Klein P, Loud S, McBurney RN. Neurol Neuroimmunol Neuroinflamm. 2022 Jan; 2021 Nov 9. PMID: 34753828.

2021

GABA-cadabra: autoantibodies trick neurotransmitter receptors and induce seizures.Masi G, O'Connor KC. Sci Immunol. 2021 Dec 3; 2021 Dec 3. PMID: 34860582.
Elevated N-Linked Glycosylation of IgG V Regions in Myasthenia Gravis Disease Subtypes.Mandel-Brehm C, Fichtner ML, Jiang R, Winton VJ, Vazquez SE, Pham MC, Hoehn KB, Kelleher NL, Nowak RJ, Kleinstein SH, Wilson MR, DeRisi JL, O'Connor KC. J Immunol. 2021 Oct 15; 2021 Sep 20. PMID: 34544801.
Lost in post-translational modification-Dengue virus writes its own sequel.Yandamuri SS, O'Connor KC. Sci Immunol. 2021 Jul 2. PMID: 34215681.
Brain tumor T cells inhibited by their natural KLR(B1) instinct.Oxendine S, O'Connor KC. Sci Immunol. 2021 Apr 2. PMID: 33811061.
CD4+ follicular regulatory T cells optimize the influenza virus-specific B cell response.Lu Y, Jiang R, Freyn AW, Wang J, Strohmeier S, Lederer K, Locci M, Zhao H, Angeletti D, O'Connor KC, Kleinstein SH, Nachbagauer R, Craft J. J Exp Med. 2021 Mar 1. PMID: 33326020.

2020

Affinity maturation is required for pathogenic monovalent IgG4 autoantibody development in myasthenia gravis.Fichtner ML, Vieni C, Redler RL, Kolich L, Jiang R, Takata K, Stathopoulos P, Suarez PA, Nowak RJ, Burden SJ, Ekiert DC, O'Connor KC. J Exp Med. 2020 Dec 7. PMID: 32820331.
Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis.Jiang R, Hoehn KB, Lee CS, Pham MC, Homer RJ, Detterbeck FC, Aban I, Jacobson L, Vincent A, Nowak RJ, Kaminski HJ, Kleinstein SH, O'Connor KC. Proc Natl Acad Sci U S A. 2020 Dec 1; 2020 Nov 16. PMID: 33199596.
Two mAbs take a stab at influenza's NActive site.Pham MC, O'Connor KC. Sci Immunol. 2020 Nov 6. PMID: 33158977.

Publications (bioRX)

2020

Fichtner, M.L, C. Vieni, Redler, R.L., Kolich L., Jiang, R., Takata, P. Stathopoulos, P. Suarez, R.J. Nowak, S.J. Burden, D.C. Ekiert and K.C. O'Connor (2020). Self-antigen driven affinity maturation is required for pathogenic monovalent IgG4 autoantibody development. BioRxiv doi: https://doi.org/10.1101/2020.03.14.988758
Jiang, R., M.L. Fichtner, K.B. Hoehn, P. Stathopoulos, R.J. Nowak, S.H. Kleinstein, K.C. O'Connor (2020). Single-cell repertoire tracing identifies rituximab refractory B cells during myasthenia gravis relapses. BioRxiv doi: https://doi.org/10.1101/840389
Fichtner, M.L., Jiang R., Bourke, A., Nowak R.J. and K.C. O'Connor (2020). Autoimmune pathology in myasthenia gravis disease subtypes are governed by divergent mechanisms of immunopathology. Provisionally accepted https://www.frontiersin.org/articles/10.3389/fimmu.2020.00776/abstract