Publications
2024
- Mechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis.Kural MH, Djakbarova U, Cakir B, Tanaka Y, Chan ET, Arteaga Muniz VI, Madraki Y, Qian H, Park J, Sewanan LR, Park IH, Niklason LE, Kural C. Cell Death Dis. 2024 Jun 22; 2024 Jun 22. PMID: 38909035.
- Organ Boundary Circuits Regulate Sox9+ Alveolar Tuft Cells During Post-Pneumonectomy Lung Regeneration.Obata T, Mizoguchi S, Greaney AM, Adams T, Yuan Y, Edelstein S, Leiby KL, Rivero R, Wang N, Kim H, Yang J, Schupp JC, Stitelman D, Tsuchiya T, Levchenko A, Kaminski N, Niklason LE, Brickman Raredon MS. bioRxiv. 2024 Jan 8; 2024 Jan 8. PMID: 38260691.
2023
- Evaluation of vascular repair by tissue-engineered human acellular vessels or expanded polytetrafluoroethylene grafts in a porcine model of limb ischemia and reperfusion.Kirkton RD, Watson JDB, Houston R 4th, Prichard HL, Niklason LE, Rasmussen TE. J Trauma Acute Care Surg. 2023 Aug 1; 2023 Mar 22. PMID: 36943014.
- Biological mechanisms of infection resistance in tissue engineered blood vessels compared to synthetic expanded polytetrafluoroethylene grafts.Wang J, Blalock SKF, Levitan GS, Prichard HL, Niklason LE, Kirkton RD. JVS Vasc Sci. 2023; 2023 Jul 14. PMID: 37662589.
- Use of bioengineered human acellular vessels to treat traumatic injuries in the Ukraine-Russia conflict.Sokolov O, Shaprynskyi V, Skupyy O, Stanko O, Yurets S, Yurkova Y, Niklason LE. Lancet Reg Health Eur. 2023 Jun; 2023 May 6. PMID: 37213923.
- Rational engineering of lung alveolar epithelium.Leiby KL, Yuan Y, Ng R, Raredon MSB, Adams TS, Baevova P, Greaney AM, Hirschi KK, Campbell SG, Kaminski N, Herzog EL, Niklason LE. NPJ Regen Med. 2023 Apr 28; 2023 Apr 28. PMID: 37117221.
- A Multi-omic Analysis of the Human Lung Reveals Distinct Cell Specific Aging and Senescence Molecular Programs.De Man R, McDonough JE, Adams TS, Manning EP, Myers G, Vos R, Ceulemans L, Dupont L, Vanaudenaerde BM, Wuyts WA, Rosas IO, Hagood JS, Ambalavanan N, Niklason L, Hansen KC, Yan X, Kaminski N. bioRxiv. 2023 Apr 19; 2023 Apr 19. PMID: 37131739.
- SARS-CoV-2 leverages airway epithelial protective mechanism for viral infection.Greaney AM, Raredon MSB, Kochugaeva MP, Niklason LE, Levchenko A. iScience. 2023 Mar 17; 2023 Feb 10. PMID: 36788793.
- Decellularization compromises mechanical and structural properties of the native trachea.Greaney AM, Ramachandra AB, Yuan Y, Korneva A, Humphrey JD, Niklason LE. Biomater Biosyst. 2023 Mar; 2023 Feb 3. PMID: 36967724.
- Six-year outcomes of a phase II study of human-tissue engineered blood vessels for peripheral arterial bypass.Gutowski P, Guziewicz M, Ilzecki M, Kazimierczak A, Lawson JH, Prichard HL, Przywara S, Samad R, Tente W, Turek J, Witkiewicz W, Zapotoczny N, Zubilewicz T, Niklason LE. JVS Vasc Sci. 2023; 2022 Dec 1. PMID: 36874956.
- Comprehensive visualization of cell-cell interactions in single-cell and spatial transcriptomics with NICHES.Raredon MSB, Yang J, Kothapalli N, Lewis W, Kaminski N, Niklason LE, Kluger Y. Bioinformatics. 2023 Jan 1. PMID: 36458905.
2022
- Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer.Sinha S, Sparks HD, Labit E, Robbins HN, Gowing K, Jaffer A, Kutluberk E, Arora R, Raredon MSB, Cao L, Swanson S, Jiang P, Hee O, Pope H, Workentine M, Todkar K, Sharma N, Bharadia S, Chockalingam K, de Almeida LGN, Adam M, Niklason L, Potter SS, Seifert AW, Dufour A, Gabriel V, Rosin NL, Stewart R, Muench G, McCorkell R, Matyas J, Biernaskie J. Cell. 2022 Dec 8. PMID: 36493752.
- Lung Tissue Engineering: Toward a More Deliberate Approach.Leiby KL, Niklason LE. ACS Biomater Sci Eng. 2022 Nov 14; 2022 Jan 24. PMID: 35073058.
- Bioengineering Human Tissues and the Future of Vascular Replacement.Naegeli KM, Kural MH, Li Y, Wang J, Hugentobler EA, Niklason LE. Circ Res. 2022 Jun 24; 2022 Jun 23. PMID: 35737757.
- Pressure-Regulated Ventilator Splitting for Disaster Relief: Design, Testing, and Clinical Experience.Raredon MSB, Fisher C, Heerdt PM, Schonberger RB, Nargi A, Nivison S, Fajardo E, Deshpande R, Akhtar S, Greaney AM, Belter J, Raredon T, Zinter J, McKee A, Michalski M, Baevova P, Niklason LE. Anesth Analg. 2022 May 1. PMID: 34928890.
- Readily Available Tissue-Engineered Vascular Grafts Derived From Human Induced Pluripotent Stem Cells.Luo J, Qin L, Park J, Kural MH, Huang Y, Shi X, Riaz M, Wang J, Ellis MW, Anderson CW, Yuan Y, Ren Y, Yoder MC, Tellides G, Niklason LE, Qyang Y. Circ Res. 2022 Mar 18; 2022 Feb 22. PMID: 35189711.
- Computation and visualization of cell-cell signaling topologies in single-cell systems data using Connectome.Raredon MSB, Yang J, Garritano J, Wang M, Kushnir D, Schupp JC, Adams TS, Greaney AM, Leiby KL, Kaminski N, Kluger Y, Levchenko A, Niklason LE. Sci Rep. 2022 Mar 9; 2022 Mar 9. PMID: 35264704.
- SARS-CoV-2 leverages airway epithelial protective mechanism for viral infection.Greaney AM, Raredon MSB, Kochugaeva MP, Niklason LE, Levchenko A. bioRxiv. 2022 Jan 31; 2022 Jan 31. PMID: 35132420.
- Characterization of the COPD alveolar niche using single-cell RNA sequencing.Sauler M, McDonough JE, Adams TS, Kothapalli N, Barnthaler T, Werder RB, Schupp JC, Nouws J, Robertson MJ, Coarfa C, Yang T, Chioccioli M, Omote N, Cosme C Jr, Poli S, Ayaub EA, Chu SG, Jensen KH, Gomez JL, Britto CJ, Raredon MSB, Niklason LE, Wilson AA, Timshel PN, Kaminski N, Rosas IO. Nat Commun. 2022 Jan 25; 2022 Jan 25. PMID: 35078977.
- Engineered Lung Tissues Prepared from Decellularized Lung Slices.Leiby KL, Ng R, Campbell SG, Niklason LE. J Vis Exp. 2022 Jan 21; 2022 Jan 21. PMID: 35129166.
- Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19.Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C Jr, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K, Niklason LE, Ko AI, Montgomery RR, Farhadian SF, Iwasaki A, Shaw AC, van Dijk D, Zhao H, Kleinstein SH, Hafler DA, Kaminski N, Dela Cruz CS. Nat Commun. 2022 Jan 21; 2022 Jan 21. PMID: 35064122.
- Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids.Cakir B, Tanaka Y, Kiral FR, Xiang Y, Dagliyan O, Wang J, Lee M, Greaney AM, Yang WS, duBoulay C, Kural MH, Patterson B, Zhong M, Kim J, Bai Y, Min W, Niklason LE, Patra P, Park IH. Nat Commun. 2022 Jan 20; 2022 Jan 20. PMID: 35058453.
- Five Year Outcomes in Patients with End Stage Renal Disease Who Received a Bioengineered Human Acellular Vessel for Dialysis Access.Jakimowicz T, Przywara S, Turek J, Pilgrim A, Macech M, Zapotoczny N, Zubilewicz T, Lawson JH, Niklason LE. EJVES Vasc Forum. 2022; 2022 Jan 10. PMID: 35243473.
2021
- A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds.Yuan Y, Leiby KL, Greaney AM, Raredon MSB, Qian H, Schupp JC, Engler AJ, Baevova P, Adams TS, Kural MH, Wang J, Obata T, Yoder MC, Kaminski N, Niklason LE. Front Bioeng Biotechnol. 2021; 2021 Nov 19. PMID: 34869270.
- Microvascular fluid flow in ex vivo and engineered lungs.Raredon MSB, Engler AJ, Yuan Y, Greaney AM, Niklason LE. J Appl Physiol (1985). 2021 Nov 1; 2021 Sep 23. PMID: 34554016.
- An ex vivo physiologic and hyperplastic vessel culture model to study intra-arterial stent therapies.Wang J, Kural MH, Wu J, Leiby KL, Mishra V, Lysyy T, Li G, Luo J, Greaney A, Tellides G, Qyang Y, Huang N, Niklason LE. Biomaterials. 2021 Aug; 2021 May 29. PMID: 34087584.
- Critical Considerations for Regeneration of Vascularized Composite Tissues.Shah Mohammadi M, Buchen JT, Pasquina PF, Niklason LE, Alvarez LM, Jariwala SH. Tissue Eng Part B Rev. 2021 Aug; 2020 Dec 3. PMID: 33115331.
- The History of Engineered Tracheal Replacements: Interpreting the Past and Guiding the Future.Greaney AM, Niklason LE. Tissue Eng Part B Rev. 2021 Aug; 2020 Nov 9. PMID: 33045942.
- A therapeutic vascular conduit to support in vivo cell-secreted therapy.Han EX, Qian H, Jiang B, Figetakis M, Kosyakova N, Tellides G, Niklason LE, Chang WG. NPJ Regen Med. 2021 Jul 29; 2021 Jul 29. PMID: 34326344.
- Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung.Schupp JC, Adams TS, Cosme C Jr, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe'er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Circulation. 2021 Jul 27; 2021 May 25. PMID: 34030460.
- Development of a Bioartificial Vascular Pancreas.Han EX, Wang J, Kural M, Jiang B, Leiby KL, Chowdhury N, Tellides G, Kibbey RG, Lawson JH, Niklason LE. J Tissue Eng. 2021 Jan-Dec; 2021 Jun 28. PMID: 34262686.
- Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes.Ravindra NG, Alfajaro MM, Gasque V, Huston NC, Wan H, Szigeti-Buck K, Yasumoto Y, Greaney AM, Habet V, Chow RD, Chen JS, Wei J, Filler RB, Wang B, Wang G, Niklason LE, Montgomery RR, Eisenbarth SC, Chen S, Williams A, Iwasaki A, Horvath TL, Foxman EF, Pierce RW, Pyle AM, van Dijk D, Wilen CB. PLoS Biol. 2021 Mar; 2021 Mar 17. PMID: 33730024.
- Efficient Differentiation of Human Induced Pluripotent Stem Cells into Endothelial Cells under Xenogeneic-free Conditions for Vascular Tissue Engineering.Luo J, Shi X, Lin Y, Yuan Y, Kural MH, Wang J, Ellis MW, Anderson CW, Zhang SM, Riaz M, Niklason LE, Qyang Y. Acta Biomater. 2021 Jan 1; 2020 Nov 6. PMID: 33166710.
- Xenogeneic-free generation of vascular smooth muscle cells from human induced pluripotent stem cells for vascular tissue engineering.Luo J, Lin Y, Shi X, Li G, Kural MH, Anderson CW, Ellis MW, Riaz M, Tellides G, Niklason LE, Qyang Y. Acta Biomater. 2021 Jan 1; 2020 Oct 29. PMID: 33130306.
2020
- Patency of ePTFE Arteriovenous Graft Placements in Hemodialysis Patients: Systematic Literature Review and Meta-Analysis.Halbert RJ, Nicholson G, Nordyke RJ, Pilgrim A, Niklason L. Kidney360. 2020 Dec 31; 2020 Oct 15. PMID: 35372887.
- Bioengineered human blood vessels.Niklason LE, Lawson JH. Science. 2020 Oct 9. PMID: 33033191.
- Challenges and novel therapies for vascular access in haemodialysis.Lawson JH, Niklason LE, Roy-Chaudhury P. Nat Rev Nephrol. 2020 Oct; 2020 Aug 24. PMID: 32839580.
- Arterial reconstruction with human bioengineered acellular blood vessels in patients with peripheral arterial disease.Gutowski P, Gage SM, Guziewicz M, Ilzecki M, Kazimierczak A, Kirkton RD, Niklason LE, Pilgrim A, Prichard HL, Przywara S, Samad R, Tente B, Turek J, Witkiewicz W, Zapotoczny N, Zubilewicz T, Lawson JH. J Vasc Surg. 2020 Oct; 2020 Feb 21. PMID: 32093913.
- Reduced patency in left-sided arteriovenous grafts in a porcine model.Liu S, Wang T, Wang J, Isaji T, Ono S, Fereydooni A, Taniguchi R, Matsubara Y, Niklason LE, Dardik A. J Vasc Surg. 2020 Jul; 2019 Nov 4. PMID: 31699515.
- Microvessel Network Formation and Interactions with Pancreatic Islets in Three-Dimensional Chip Cultures.Rambøl MH, Han E, Niklason LE. Tissue Eng Part A. 2020 May; 2020 Jan 20. PMID: 31724494.
- Platform Effects on Regeneration by Pulmonary Basal Cells as Evaluated by Single-Cell RNA Sequencing.Greaney AM, Adams TS, Brickman Raredon MS, Gubbins E, Schupp JC, Engler AJ, Ghaedi M, Yuan Y, Kaminski N, Niklason LE. Cell Rep. 2020 Mar 24. PMID: 32209482.
- Bioengineering the Blood-gas Barrier.Leiby KL, Raredon MSB, Niklason LE. Compr Physiol. 2020 Mar 12; 2020 Mar 12. PMID: 32163210.
- Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human iPSCs.Luo J, Qin L, Zhao L, Gui L, Ellis MW, Huang Y, Kural MH, Clark JA, Ono S, Wang J, Yuan Y, Zhang SM, Cong X, Li G, Riaz M, Lopez C, Hotta A, Campbell S, Tellides G, Dardik A, Niklason LE, Qyang Y. Cell Stem Cell. 2020 Feb 6; 2020 Jan 16. PMID: 31956039.
- Modular design of a tissue engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes.Park J, Anderson CW, Sewanan LR, Kural MH, Huang Y, Luo J, Gui L, Riaz M, Lopez CA, Ng R, Das SK, Wang J, Niklason L, Campbell SG, Qyang Y. Acta Biomater. 2020 Jan 15; 2019 Oct 19. PMID: 31634626.
2019
- Single-cell connectomic analysis of adult mammalian lungs.Raredon MSB, Adams TS, Suhail Y, Schupp JC, Poli S, Neumark N, Leiby KL, Greaney AM, Yuan Y, Horien C, Linderman G, Engler AJ, Boffa DJ, Kluger Y, Rosas IO, Levchenko A, Kaminski N, Niklason LE. Sci Adv. 2019 Dec; 2019 Dec 4. PMID: 31840053.
- Engineering of human brain organoids with a functional vascular-like system.Cakir B, Xiang Y, Tanaka Y, Kural MH, Parent M, Kang YJ, Chapeton K, Patterson B, Yuan Y, He CS, Raredon MSB, Dengelegi J, Kim KY, Sun P, Zhong M, Lee S, Patra P, Hyder F, Niklason LE, Lee SH, Yoon YS, Park IH. Nat Methods. 2019 Nov; 2019 Oct 7. PMID: 31591580.
- Non-invasive and real-time measurement of microvascular barrier in intact lungs.Engler AJ, Raredon MSB, Le AV, Yuan Y, Oczkowicz YA, Kan EL, Baevova P, Niklason LE. Biomaterials. 2019 Oct; 2019 Jun 30. PMID: 31280072.
- Utilization of Natural Detergent Potassium Laurate for Decellularization in Lung Bioengineering.Obata T, Tsuchiya T, Akita S, Kawahara T, Matsumoto K, Miyazaki T, Masumoto H, Kobayashi E, Niklason LE, Nagayasu T. Tissue Eng Part C Methods. 2019 Aug. PMID: 31317819.
- Fas ligand and nitric oxide combination to control smooth muscle growth while sparing endothelium.Kural MH, Wang J, Gui L, Yuan Y, Li G, Leiby KL, Quijano E, Tellides G, Saltzman WM, Niklason LE. Biomaterials. 2019 Aug; 2019 May 7. PMID: 31102854.
- Epac agonist improves barrier function in iPSC-derived endothelial colony forming cells for whole organ tissue engineering.Yuan Y, Engler AJ, Raredon MS, Le A, Baevova P, Yoder MC, Niklason LE. Biomaterials. 2019 Apr; 2019 Feb 7. PMID: 30754017.
- Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation.Kirkton RD, Santiago-Maysonet M, Lawson JH, Tente WE, Dahl SLM, Niklason LE, Prichard HL. Sci Transl Med. 2019 Mar 27. PMID: 30918113.
- Human Pluripotent Stem Cells (iPSC) Generation, Culture, and Differentiation to Lung Progenitor Cells.Ghaedi M, Niklason LE. Methods Mol Biol. 2019. PMID: 27628133.
2018
- Extracellular matrix in lung development, homeostasis and disease.Zhou Y, Horowitz JC, Naba A, Ambalavanan N, Atabai K, Balestrini J, Bitterman PB, Corley RA, Ding BS, Engler AJ, Hansen KC, Hagood JS, Kheradmand F, Lin QS, Neptune E, Niklason L, Ortiz LA, Parks WC, Tschumperlin DJ, White ES, Chapman HA, Thannickal VJ. Matrix Biol. 2018 Nov; 2018 Mar 8. PMID: 29524630.
- An Ex Vivo Vessel Injury Model to Study Remodeling.Kural MH, Dai G, Niklason LE, Gui L. Cell Transplant. 2018 Sep; 2018 Aug 10. PMID: 30095004.
- Vascularization of Natural and Synthetic Bone Scaffolds.Liu X, Jakus AE, Kural M, Qian H, Engler A, Ghaedi M, Shah R, Steinbacher DM, Niklason LE. Cell Transplant. 2018 Aug; 2018 Jul 16. PMID: 30008231.
- Arterial Venous Differentiation for Vascular Bioengineering.Niklason L, Dai G. Annu Rev Biomed Eng. 2018 Jun 4; 2018 Apr 11. PMID: 29641908.
- Flow Preservation of Umbilical Vein for Autologous Shunt and Cardiovascular Reconstruction.Hoganson DM, Cooper DA, Rich KN, Piekarski BL, Gui L, Gaut JP, Mayer JE, Aikawa E, Niklason LE, Emani SM. Ann Thorac Surg. 2018 Jun; 2018 Mar 3. PMID: 29510094.
- Neuropilin-1 Mediated Arterial Differentiation of Murine Pluripotent Stem Cells.Kim D, Lee V, Dorsey TB, Niklason LE, Gui L, Dai G. Stem Cells Dev. 2018 Apr 1; 2018 Mar 13. PMID: 29415620.
- Understanding the Extracellular Matrix to Enhance Stem Cell-Based Tissue Regeneration.Niklason LE. Cell Stem Cell. 2018 Mar 1. PMID: 29499149.
- Bioengineered lungs generated from human iPSCs-derived epithelial cells on native extracellular matrix.Ghaedi M, Le AV, Hatachi G, Beloiartsev A, Rocco K, Sivarapatna A, Mendez JJ, Baevova P, Dyal RN, Leiby KL, White ES, Niklason LE. J Tissue Eng Regen Med. 2018 Mar; 2017 Nov 28. PMID: 29024475.
- Historical Perspective and Future Direction of Blood Vessel Developments.Dimitrievska S, Niklason LE. Cold Spring Harb Perspect Med. 2018 Feb 1; 2018 Feb 1. PMID: 28348177.
- Susceptibility of ePTFE vascular grafts and bioengineered human acellular vessels to infection.Kirkton RD, Prichard HL, Santiago-Maysonet M, Niklason LE, Lawson JH, Dahl SLM. J Surg Res. 2018 Jan; 2017 Sep 19. PMID: 29229120.
- Controlled gas exchange in whole lung bioreactors.Engler AJ, Le AV, Baevova P, Niklason LE. J Tissue Eng Regen Med. 2018 Jan; 2017 Jun 15. PMID: 28083925.
2017
- Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering.Luo J, Qin L, Kural MH, Schwan J, Li X, Bartulos O, Cong XQ, Ren Y, Gui L, Li G, Ellis MW, Li P, Kotton DN, Dardik A, Pober JS, Tellides G, Rolle M, Campbell S, Hawley RJ, Sachs DH, Niklason LE, Qyang Y. Biomaterials. 2017 Dec; 2017 Sep 19. PMID: 28942128.
- Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix.Kristofik NJ, Qin L, Calabro NE, Dimitrievska S, Li G, Tellides G, Niklason LE, Kyriakides TR. Biomaterials. 2017 Oct; 2017 Jun 22. PMID: 28667900.
- Efficient and Functional Endothelial Repopulation of Whole Lung Organ Scaffolds.Le AV, Hatachi G, Beloiartsev A, Ghaedi M, Engler AJ, Baevova P, Niklason LE, Calle EA. ACS Biomater Sci Eng. 2017 Sep 11; 2017 Jun 30. PMID: 33440555.
- Transplantation of bioengineered rat lungs recellularized with endothelial and adipose-derived stromal cells.Doi R, Tsuchiya T, Mitsutake N, Nishimura S, Matsuu-Matsuyama M, Nakazawa Y, Ogi T, Akita S, Yukawa H, Baba Y, Yamasaki N, Matsumoto K, Miyazaki T, Kamohara R, Hatachi G, Sengyoku H, Watanabe H, Obata T, Niklason LE, Nagayasu T. Sci Rep. 2017 Aug 16; 2017 Aug 16. PMID: 28814761.
- Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.Sivarapatna A, Ghaedi M, Xiao Y, Han E, Aryal B, Zhou J, Fernandez-Hernando C, Qyang Y, Hirschi KK, Niklason LE. Cell Transplant. 2017 Aug. PMID: 28901188.
- Lung regeneration: steps toward clinical implementation and use.Calle EA, Leiby KL, Raredon MB, Niklason LE. Curr Opin Anaesthesiol. 2017 Feb. PMID: 27922848.
- A short discourse on vascular tissue engineering.Chang WG, Niklason LE. NPJ Regen Med. 2017; 2017 Mar 27. PMID: 29057097.
2016
- Targeted proteomics effectively quantifies differences between native lung and detergent-decellularized lung extracellular matrices.Calle EA, Hill RC, Leiby KL, Le AV, Gard AL, Madri JA, Hansen KC, Niklason LE. Acta Biomater. 2016 Dec; 2016 Sep 29. PMID: 27693690.
- Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice.Kristofik N, Calabro NE, Tian W, Meng A, MacLauchlan S, Wang Y, Breuer CK, Tellides G, Niklason LE, Kyriakides TR. Blood. 2016 Sep 22; 2016 Jul 28. PMID: 27471233.
- Engineered Tissue-Stent Biocomposites as Tracheal Replacements.Zhao L, Sundaram S, Le AV, Huang AH, Zhang J, Hatachi G, Beloiartsev A, Caty MG, Yi T, Leiby K, Gard A, Kural MH, Gui L, Rocco KA, Sivarapatna A, Calle E, Greaney A, Urbani L, Maghsoudlou P, Burns A, DeCoppi P, Niklason LE. Tissue Eng Part A. 2016 Sep. PMID: 27520928.
- New Functional Tools for Antithrombogenic Activity Assessment of Live Surface Glycocalyx.Dimitrievska S, Gui L, Weyers A, Lin T, Cai C, Wu W, Tuggle CT, Sundaram S, Balestrini JL, Slattery D, Tchouta L, Kyriakides TR, Tarbell JM, Linhardt RJ, Niklason LE. Arterioscler Thromb Vasc Biol. 2016 Sep; 2016 Jul 7. PMID: 27386939.
- Comparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicine.Balestrini JL, Gard AL, Gerhold KA, Wilcox EC, Liu A, Schwan J, Le AV, Baevova P, Dimitrievska S, Zhao L, Sundaram S, Sun H, Rittié L, Dyal R, Broekelmann TJ, Mecham RP, Schwartz MA, Niklason LE, White ES. Biomaterials. 2016 Sep; 2016 Jun 16. PMID: 27344365.
- Implantable tissue-engineered blood vessels from human induced pluripotent stem cells.Gui L, Dash BC, Luo J, Qin L, Zhao L, Yamamoto K, Hashimoto T, Wu H, Dardik A, Tellides G, Niklason LE, Qyang Y. Biomaterials. 2016 Sep; 2016 Jun 14. PMID: 27336184.
- Biaxial Stretch Improves Elastic Fiber Maturation, Collagen Arrangement, and Mechanical Properties in Engineered Arteries.Huang AH, Balestrini JL, Udelsman BV, Zhou KC, Zhao L, Ferruzzi J, Starcher BC, Levene MJ, Humphrey JD, Niklason LE. Tissue Eng Part C Methods. 2016 Jun. PMID: 27108525.
- Bioengineered human acellular vessels for dialysis access in patients with end-stage renal disease: two phase 2 single-arm trials.Lawson JH, Glickman MH, Ilzecki M, Jakimowicz T, Jaroszynski A, Peden EK, Pilgrim AJ, Prichard HL, Guziewicz M, Przywara S, Szmidt J, Turek J, Witkiewicz W, Zapotoczny N, Zubilewicz T, Niklason LE. Lancet. 2016 May 14. PMID: 27203778.
- Ventilation-Based Decellularization System of the Lung.Tsuchiya T, Mendez J, Calle EA, Hatachi G, Doi R, Zhao L, Suematsu T, Nagayasu T, Niklason LE. Biores Open Access. 2016; 2016 May 1. PMID: 27186445.
- Netrin-1 Regulates Fibrocyte Accumulation in the Decellularized Fibrotic Sclerodermatous Lung Microenvironment and in Bleomycin-Induced Pulmonary Fibrosis.Sun H, Zhu Y, Pan H, Chen X, Balestrini JL, Lam TT, Kanyo JE, Eichmann A, Gulati M, Fares WH, Bai H, Feghali-Bostwick CA, Gan Y, Peng X, Moore MW, White ES, Sava P, Gonzalez AL, Cheng Y, Niklason LE, Herzog EL. Arthritis Rheumatol. 2016 May. PMID: 26749424.
- Biomimetic Culture Reactor for Whole-Lung Engineering.Raredon MS, Rocco KA, Gheorghe CP, Sivarapatna A, Ghaedi M, Balestrini JL, Raredon TL, Calle EA, Niklason LE. Biores Open Access. 2016; 2016 Apr 1. PMID: 27088061.
- Sterilization of Lung Matrices by Supercritical Carbon Dioxide.Balestrini JL, Liu A, Gard AL, Huie J, Blatt KM, Schwan J, Zhao L, Broekelmann TJ, Mecham RP, Wilcox EC, Niklason LE. Tissue Eng Part C Methods. 2016 Mar; 2016 Jan 29. PMID: 26697757.
2015
- Production of decellularized porcine lung scaffolds for use in tissue engineering.Balestrini JL, Gard AL, Liu A, Leiby KL, Schwan J, Kunkemoeller B, Calle EA, Sivarapatna A, Lin T, Dimitrievska S, Cambpell SG, Niklason LE. Integr Biol (Camb). 2015 Dec; 2015 Oct 1. PMID: 26426090.
- Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli.Chang WG, Fornoni A, Tietjen G, Mendez JJ, Niklason LE, Saltzman WM, Pober JS. Tissue Eng Part A. 2015 Nov; 2015 Oct 1. PMID: 26414101.
- A Rotating Bioreactor for Scalable Culture and Differentiation of Respiratory Epithelium.Raredon MS, Ghaedi M, Calle EA, Niklason LE. Cell Med. 2015 Oct 1; 2014 Dec 12. PMID: 26858899.
- Bmk-1 regulates lifespan in Caenorhabditis elegans by activating hsp-16.Qian H, Xu X, Niklason LE. Oncotarget. 2015 Aug 7. PMID: 26299918.
- Design and Use of a Novel Bioreactor for Regeneration of Biaxially Stretched Tissue-Engineered Vessels.Huang AH, Lee YU, Calle EA, Boyle M, Starcher BC, Humphrey JD, Niklason LE. Tissue Eng Part C Methods. 2015 Aug; 2015 Mar 20. PMID: 25669988.
- Fate of distal lung epithelium cultured in a decellularized lung extracellular matrix.Calle EA, Mendez JJ, Ghaedi M, Leiby KL, Bove PF, Herzog EL, Sundaram S, Niklason LE. Tissue Eng Part A. 2015 Jun; 2015 May 4. PMID: 25789725.
- Osteogenic performance of donor-matched human adipose and bone marrow mesenchymal cells under dynamic culture.Wu W, Le AV, Mendez JJ, Chang J, Niklason LE, Steinbacher DM. Tissue Eng Part A. 2015 May. PMID: 25668104.
- Quantification of extracellular matrix proteins from a rat lung scaffold to provide a molecular readout for tissue engineering.Hill RC, Calle EA, Dzieciatkowska M, Niklason LE, Hansen KC. Mol Cell Proteomics. 2015 Apr; 2015 Feb 8. PMID: 25660013.
- Development of Lung Epithelium from Induced Pluripotent Stem Cells.Ghaedi M, Niklason LE, Williams J. Curr Transplant Rep. 2015 Mar 1. PMID: 26052480.
- Extracellular matrix as a driver for lung regeneration.Balestrini JL, Niklason LE. Ann Biomed Eng. 2015 Mar; 2014 Oct 25. PMID: 25344351.
- Click-coated, heparinized, decellularized vascular grafts.Dimitrievska S, Cai C, Weyers A, Balestrini JL, Lin T, Sundaram S, Hatachi G, Spiegel DA, Kyriakides TR, Miao J, Li G, Niklason LE, Linhardt RJ. Acta Biomater. 2015 Feb; 2014 Nov 20. PMID: 25463496.
- Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo.Mendez JJ, Ghaedi M, Sivarapatna A, Dimitrievska S, Shao Z, Osuji CO, Steinbacher DM, Leffell DJ, Niklason LE. Biomaterials. 2015 Feb; 2014 Nov 26. PMID: 25433608.
- Efficient intratracheal delivery of airway epithelial cells in mice and pigs.Gui L, Qian H, Rocco KA, Grecu L, Niklason LE. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15. PMID: 25416381.
- Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor.Sivarapatna A, Ghaedi M, Le AV, Mendez JJ, Qyang Y, Niklason LE. Biomaterials. 2015; 2015 Mar 24. PMID: 25890758.
- PCH-2 regulates Caenorhabditis elegans lifespan.Qian H, Xu X, Niklason LE. Aging (Albany NY). 2015 Jan. PMID: 25635513.
2014
- Tissue-engineered vascular grafts created from human induced pluripotent stem cells.Sundaram S, One J, Siewert J, Teodosescu S, Zhao L, Dimitrievska S, Qian H, Huang AH, Niklason L. Stem Cells Transl Med. 2014 Dec; 2014 Nov 5. PMID: 25378654.
- Influence of pH on extracellular matrix preservation during lung decellularization.Tsuchiya T, Balestrini JL, Mendez J, Calle EA, Zhao L, Niklason LE. Tissue Eng Part C Methods. 2014 Dec; 2014 Jun 3. PMID: 24735501.
- Arterial shear stress reduces eph-b4 expression in adult human veins.Model LS, Hall MR, Wong DJ, Muto A, Kondo Y, Ziegler KR, Feigel A, Quint C, Niklason L, Dardik A. Yale J Biol Med. 2014 Sep; 2014 Sep 3. PMID: 25191151.