Yanzhi Feng

My research focuses on advancing the immunotherapy of cancer and autoimmune diseases through antibody engineering, cell engineering, and gene perturbation. Using tools such as CRISPR screen, gene editing, and click chemistry, I work to identify new targets that enhance the efficacy of CAR-T / -NK, bispecific antibody, and iPSC-derived therapies, and fine-tune therapeutic design based on the biology of cancer cells, immune cells, and the tumor microenvironment. My long-term goal is to enable the translation of mechanistic understanding into innovative therapies that improve outcomes and meaningfully benefit patients.