Distinct polyfunctional CD4+ T cell responses to BCG, ESAT-6 and CFP-10 in tuberculous pleurisy
Li L, Qiao D, Li Q, Zhang X, Lao S, Wu C. Distinct polyfunctional CD4+ T cell responses to BCG, ESAT-6 and CFP-10 in tuberculous pleurisy. Tuberculosis 2011, 92: 63-71. PMID: 22154006, DOI: 10.1016/j.tube.2011.11.004.Peer-Reviewed Original ResearchConceptsPleural fluid cellsESAT-6T cellsMedian fluorescence intensityTuberculous pleurisyCFP-10IL-2Effector/effector memory phenotypeAntigen-specific T cellsFrequent extrapulmonary manifestationMtb-specific antigensEffector memory phenotypeT cell responsesCFP-10 peptidesExtrapulmonary manifestationsPolyfunctional CD4Th1 cytokinesTuberculosis infectionMemory phenotypeInflammatory cellsTh1 cellsSpecific antigenLocal controlCell responsesFollowing Stimulation