CCND3 is indispensable for the maintenance of B-cell acute lymphoblastic leukemia
Ketzer F, Abdelrasoul H, Vogel M, Marienfeld R, Müschen M, Jumaa H, Wirth T, Ushmorov A. CCND3 is indispensable for the maintenance of B-cell acute lymphoblastic leukemia. Oncogenesis 2022, 11: 1. PMID: 35013097, PMCID: PMC8748974, DOI: 10.1038/s41389-021-00377-0.Peer-Reviewed Original ResearchAnti-apoptotic effectsB-cell acute lymphoblastic leukemiaDriver mutationsCCND3 expressionAcute lymphoblastic leukemiaDifferent driver mutationsCDK4/6 kinase activityRole of FoxO1CDK4/6 inhibitionB-ALLDevelopment of resistanceLymphoblastic leukemiaCell cycle progressionMRNA levelsKinase activityPalbociclibCCND3Mutational backgroundD-type cyclinsFurther investigationCycle progressionGrowth arrestFOXO1CCND2Subsequent depletion