Brian B. Koo, MD

A graduate of the University of Pennsylvania (BA, 1995) and Tufts University School of Medicine (MD, 2001), Dr. Koo joined the Case Western Reserve School of Medicine faculty in 2008 and was subsequently recruited to Yale University in 2013. Dr. Koo’s primary clinical and research interest lies at the intersection between neurology and sleep medicine. Dr. Koo is particularly interested in the restless legs syndrome (RLS) and REM sleep behavior disorder and conducts patient-oriented clinical research to determine the underlying pathophysiology of these disorders. Dr. Koo is an international expert in the diagnosis, treatment, and investigation of restless legs syndrome and and treats patients with RLS from across the tri-state area. Currently, Dr. Koo's work focuses on assessing the role of the pro-opiomelanocortin-derived neuropeptides in RLS, and the role of autoimmunity in REM sleep behavior disorder. Other areas of research interest for Dr. Koo include the association between obstructive sleep apnea and wake-up stroke and the effects of cluster headache on quality of life.

Dr. Koo is director of the sleep laboratory at the Connecticut Veterans Affairs Healthcare System and the director of the Yale Center for Restless Legs Syndrome, an RLS Foundation sponsored Quality Care Center. Dr. Koo sees patients with sleep disorders at both Yale and the West Haven VA and is dedicated to the care of patients with both neurologic and sleep disorders.