Raffaella Morotti, MD
Professor of Pathology and PediatricsCards
About
Research
Publications
2024
Expanding the spectrum of progressive familial intrahepatic cholestasis: A report of 3 cases
Jiao J, Morotti R, Shafizadeh N, Jain D. Expanding the spectrum of progressive familial intrahepatic cholestasis: A report of 3 cases. American Journal Of Clinical Pathology 2024, aqae123. PMID: 39333837, DOI: 10.1093/ajcp/aqae123.Peer-Reviewed Original ResearchProgressive familial intrahepatic cholestasisATP-binding cassette subfamily B member 4Whole-exome sequencingFamilial intrahepatic cholestasisIntrahepatic cholestasisDiagnostic challengeGroup of autosomal recessive disordersAbnormal liver function testsHomozygous splice site variantDrug-induced liver injuryHeterozygous frameshift mutationHeterozygous missense mutationLiver function testsAged 2 monthsAutosomal recessive disorderSplice site variantHistory of alcoholismABCB4 mutationsPediatric ageLiver biopsyClinical historyRecessive disorderLiver injuryMolecular testingHeterogeneous presentationPlacental Vascular Anastamoses and Associated Pathologies in Dichorionic Twin Gestations
Dave E, Bahtiyar M, Campbell W, Morotti R, Kohari K. Placental Vascular Anastamoses and Associated Pathologies in Dichorionic Twin Gestations. Twin Research And Human Genetics 2024, 27: 251-255. PMID: 39508257, DOI: 10.1017/thg.2024.35.Peer-Reviewed Original ResearchTwin-to-twin transfusion syndromeTwin anemia-polycythemia sequenceDichorionic twin gestationsVascular anastamosesTwin gestationsDichorionic twin pregnanciesTwin transfusion syndromePlacental vascular anastomosesDichorionic gestationsMonochorionic pregnanciesPrenatal surveillanceTransfusion syndromeTwin pregnanciesGestationMitigate morbidityVascular anastomosisAssociated pathologyPregnancyAnastamosesPathologyDichorionicityMorbidityPathophysiologySyndromeWhen lungs and weights tell different stories
Godse S, Brumer E, Kizilirmak T, Canapari C, Silva C, Morotti R, Jiang Y, Jeffries L, Chen L, Panacherry S. When lungs and weights tell different stories. Pediatric Pulmonology 2024, 59: 1047-1059. PMID: 38353400, DOI: 10.1002/ppul.26832.Peer-Reviewed Original ResearchMolecular Genetics Augment Cytopathologic Evaluation and Surgical Planning of Pediatric Thyroid Nodules
Spaulding S, Maayah M, Dinauer C, Prasad M, Darbinyan A, Morotti R, Christison-Lagay E. Molecular Genetics Augment Cytopathologic Evaluation and Surgical Planning of Pediatric Thyroid Nodules. Journal Of Pediatric Surgery 2024, 59: 975-980. PMID: 38246817, DOI: 10.1016/j.jpedsurg.2024.01.001.Peer-Reviewed Original ResearchFine-needle aspiration biopsyPediatric thyroid nodulesMolecular genetic testingBethesda IV nodulesPrediction of malignancyDICER1 mutationsThyroid nodulesGenetic testingNRAS mutationsMethods Retrospective chart reviewRetrospective chart reviewTime of surgeryBRAF V600E testingMutations/fusionsBethesda III nodulesChart reviewSurgical resectionFinal histopathologyThyroid resectionPediatric dataHistologic classificationSurgical specimensBRAF mutationsAspiration biopsyCytopathologic evaluation
2022
Isolated Terminal Ileitis in Children
Alper A, Bennett A, Rottmann D, Morotti R, Escalera S, Phatak U, Pashankar D. Isolated Terminal Ileitis in Children. Journal Of Pediatric Gastroenterology And Nutrition 2022, 76: 338-342. PMID: 36729703, DOI: 10.1097/mpg.0000000000003679.Peer-Reviewed Original ResearchConceptsCrohn's diseaseTerminal ileitisAbnormal C-reactive protein levelsC-reactive protein levelsBowel wall thickeningLong-term outcomesRadiological evidenceRadiological featuresSevere inflammationPediatric literatureHigh prevalenceIleitisWall thickeningProtein levelsChildrenPrevalenceAdultsColonoscopyInflammationEndoscopicHistologicDiseaseMonths
2020
Motility Disorders of the Gastrointestinal Tract
Morotti R, Jain D. Motility Disorders of the Gastrointestinal Tract. Practical Anatomic Pathology 2020, 313-337. DOI: 10.1007/978-3-030-51268-2_13.Peer-Reviewed Original ResearchMotility disordersGastrointestinal tractRole of immunohistochemistryVisceral myopathyVisceral neuropathyClinical correlatesHirschsprung's diseaseHistologic characteristicsCommon disorderAdverse effectsDisordersHistochemical stainsMotility functionTractNeuropathyMedicationsImmunohistochemistryWorkupMyopathyDiseaseDiagnosisPediatric unilobar resection in primary ciliary dyskinesia.
Sendon C, Cowles R, Worhunsky D, Hodson D, Morotti R, Bazzy-Asaad A, Esquibies A. Pediatric unilobar resection in primary ciliary dyskinesia. Minerva Pediatrica 2020, 74: 593-599. PMID: 32731729, DOI: 10.23736/s2724-5276.20.05802-8.Peer-Reviewed Original ResearchConceptsPrimary ciliary dyskinesiaSevere lung diseasePulmonary functionLung diseaseCiliary dyskinesiaAggressive medical managementSelective surgical removalQuality of lifeProgressive bronchiectasisUnilobar diseaseProphylactic antibioticsLung resectionAggressive administrationAirway clearanceMedical managementChronic bronchiectasisTherapy optionsLocalized bronchiectasisSurgical removalChronic infectionBronchiectasisRare caseAlternative treatmentNutritional statusNecrotic areas
2018
29 Intrahepatic Cholestasis
Saxena R, Ghabril M, Morotti R, Saxena R. 29 Intrahepatic Cholestasis. 2018, 445-464. DOI: 10.1016/b978-0-323-42873-6.00029-9.Peer-Reviewed Original Research
2017
OR51 Correlation of class II antibody development with acute cellular rejection and fibrosis in pediatric liver transplantation
Bow L, Ekong U, Morotti R, Antala S, Emre S. OR51 Correlation of class II antibody development with acute cellular rejection and fibrosis in pediatric liver transplantation. Human Immunology 2017, 78: 47. DOI: 10.1016/j.humimm.2017.06.057.Peer-Reviewed Original ResearchAcute cellular rejectionClass II DSAPediatric liver transplantationLiver transplantationCellular rejectionHLA antibodiesFibrosis scoreDe novo HLA antibodiesNovo HLA antibodiesSided p valueDiagnosis of antibodyWilcoxon rank sumContinuous variablesGraft dysfunctionMean fibrosisSinusoidal fibrosisGraft functionPost transplantRejection gradeAvailable biopsiesLiver dysfunctionPatient characteristicsAntibody levelsDSA developmentSpecificity of antibodies
2016
CONGENITAL CYSTIC LUNG LESIONS: EVOLUTION FROM IN-UTERO TO PATHOLOGY DIAGNOSIS - A MULTIDISCIPLINARY APPROACH
Hardee S, Tuzovic L, Silva C, Cowles R, Copel J, Morotti R. CONGENITAL CYSTIC LUNG LESIONS: EVOLUTION FROM IN-UTERO TO PATHOLOGY DIAGNOSIS - A MULTIDISCIPLINARY APPROACH. Pediatric And Developmental Pathology 2016 DOI: 10.2350/16-05-1815-oa.1.Peer-Reviewed Original ResearchCongenital cystic lung lesionsCongenital pulmonary airway malformationBronchopulmonary sequestrationPrenatal ultrasoundSingle tertiary care centerCystic lung lesionsPulmonary airway malformationTertiary care centerFinal pathologic diagnosisCorrelate imagingCPAM lesionsAirway malformationExcellent prognosisPathological findingsPostnatal imagingRetrospective reviewPathology databaseSurgical interventionRare pathologyBronchial atresiaLung lesionsPathologic diagnosisPrenatal coursePathology examinationCare center
Clinical Care
Overview
Raffaella Morotti, MD, is a specialist in pediatric pathology, a subspecialty dedicated to the diagnosis of diseases that affect children. She serves as director of pediatric pathology and associate director of the autopsy service for Yale Medicine.
Dr. Morotti’s work encompasses the diagnosis of malignant tumors in children, particularly blastomas and sarcomas, types of cancer that originate in the body in different ways. It also includes diagnosis of diseases of the gastrointestinal tract and liver. Dr. Morotti has a specific passion for and expertise in cholestatic diseases in infants and children—diseases that result when the flow of bile from the liver is reduced or blocked.
In addition, she is a perinatal pathologist with rare expertise in a unique field dealing with fetal malformations, placenta pathology, and perinatal autopsy.
Dr. Morotti says she is guided by the knowledge that children’s bodies are different than adult bodies. “The philosophy that guides pediatric pathology is the same one that guides the pediatric specialty in general and relies on the understanding that children are not little adults,” Dr. Morotti says. “They have specific diseases that call for dedicated physicians with specific training.”
Clinical Specialties
Pathology; Anatomic Pathology; Neonatal - Perinatal Medicine
Fact Sheets
Pediatric Crohn's Disease
Learn More on Yale MedicinePediatric Ulcerative Colitis
Learn More on Yale MedicineDiagnosing Pediatric Sarcomas
Learn More on Yale Medicine
Board Certifications
Pediatric Pathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 1999
Anatomic Pathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 1997