Lais Osmani, MD, MHS
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Biography
Lais grew up in Newton, MA. He graduated from Boston University in 2010. After college, he worked on the COMBREX (Computational Bridges to Experiments) project which sought to accelerate microbial genome annotation through collaboration between computational and experimental biologists. He then attended the University of Illinois College of Medicine and graduated in 2015. He completed a Pathology residency at Johns Hopkins Hospital, during which time he was involved in identifying the antigen specificity of the monoclonal immunoglobulin in patients with Schnitzler syndrome. He most recently completed a second residency in Internal Medicine at Dartmouth-Hitchcock Medical Center. During this time, he investigated the role of neutrophils in lupus nephritis. He is interested in leveraging omics data to study the pathogenesis and heterogeneity of autoimmune diseases and to identify potential therapeutic targets.
Last Updated on January 14, 2023.
Appointments
Rheumatology
InstructorPrimary
Other Departments & Organizations
- Internal Medicine
- Rheumatology
- Rheumatology, Allergy, & Immunology
- Yale Medicine
- Yale New Haven Health System
Education & Training
- Fellowship
- Yale University (2024)
- MHS
- Yale School of Medicine (2024)
- Resident
- Dartmouth-Hitchcock Medical Center (2021)
- Residency
- Johns Hopkins Hospital (2018)
- MD
- University of Illinois College of Medicine (2015)
Research
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Lais Osmani's published research.
Publications Timeline
A big-picture view of Lais Osmani's research output by year.
Insoo Kang, MD
Lin Leng
Former YSMMarta Piecychna
Richard Bucala, MD, PhD
Gabriela Sanchez-Zuno
Harriet Kluger, MD
11Publications
914Citations
Publications
2026
Identification of Lupus Immune Complex-Driven Pathogenic Pro-inflammatory Monocytes and Macrophages in Systemic Lupus Erythematosus.
Osmani L, Shin M, Lee SJ, Cai H, Seong WJ, Kim H, Yoo J, Kim M, Bracamonte W, Felix M, Ahn JG, Park HJ, Shin JJ, Unlu S, Par-Young J, Doherty E, Chen J, Dong MX, Koumpouras F, Gomez JL, Kaminski N, Bucala R, You S, Kang I. Identification of Lupus Immune Complex-Driven Pathogenic Pro-inflammatory Monocytes and Macrophages in Systemic Lupus Erythematosus. BioRxiv 2026 PMID: 41648138, DOI: 10.64898/2026.01.21.700902.Peer-Reviewed Original ResearchPathogenic role of MIF receptor (CD74) expressing T cells in inflammatory arthritis
Doherty E, Osmani L, Bilsborrow J, Par-Young J, Choi S, Tilstam P, Shin M, Piecychna M, Cai H, Leng L, Kim W, Kang I, Bucala R. Pathogenic role of MIF receptor (CD74) expressing T cells in inflammatory arthritis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2509156123. PMID: 41505516, PMCID: PMC12799170, DOI: 10.1073/pnas.2509156123.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMacrophage migration inhibitory factorT cell-dependent modelCollagen-induced arthritisT cellsImpact of gene deletionPathogenic roleMIF's roleCollagen-induced arthritis developmentEffector memory phenotypeRheumatoid arthritisMacrophage migration inhibitory factor inhibitionExperimental models of arthritisModel of collagen-induced arthritisT cell subpopulationsArthritogenic T cellsT cell activationExperimental modelHigh-expression alleleT lineage cellsAutoimmune inflammatory diseaseJoint synoviumMigration inhibitory factorModels of arthritisExpressed alleleMemory phenotype
2025
Improving immunotherapy responses by dual inhibition of macrophage migration inhibitory factor and PD-1
Tran T, Sánchez-Zuno G, Osmani L, Caulfield J, Valdez C, Piecychna M, Leng L, Armstrong M, Donnelly S, Bifulco C, Clister T, Kulkarni R, Zhang L, Sznol M, Jilaveanu L, Kluger H, Kang I, Bucala R. Improving immunotherapy responses by dual inhibition of macrophage migration inhibitory factor and PD-1. JCI Insight 2025, 10: e191539. PMID: 41122966, PMCID: PMC12581657, DOI: 10.1172/jci.insight.191539.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAnti-PD-1Macrophage migration inhibitory factorAnti-MIFMigration inhibitory factorTumor growthTherapeutic efficacyAnti-programmed cell death 1Intratumoral immune cell populationsAssociated with advanced diseaseHigh-expression MIF allelesCell death 1Inhibitory factorTh1 cytokine levelsInhibition of macrophage migration inhibitory factorDual inhibitionMurine tumor modelsColorectal cancer modelImmune cell populationsTumor-bearing animalsClinical trial developmentMultiple cancer typesAntitumor responseDeath-1PD-1Tumor burden
2023
Investigating the functional heterogeneity of Monocytes and Macrophages in Systemic Lupus Erythematosus
Osmani L, Shin MS, Cai H, Lee SJ, Kim H, Yoo J, You S, Li C, Dong MX, Gomez-Villalobos J, Bucala R, Kang I. Investigating the functional heterogeneity of Monocytes and Macrophages in Systemic Lupus Erythematosus. Single Cell Analyses conference at Cold Spring Harbor Laboratory. Nov 2023. Cold Spring Harbor, NY.Peer-Reviewed Original Research
2019
Ultrasound-Guided Transthoracic Fine-Needle Aspiration: A Reliable Tool in Diagnosis and Molecular Profiling of Lung Masses
Rodriguez EF, Pastorello R, Osmani L, Hopkins M, Kryatova M, Kawamoto S, Maleki Z. Ultrasound-Guided Transthoracic Fine-Needle Aspiration: A Reliable Tool in Diagnosis and Molecular Profiling of Lung Masses. Acta Cytologica 2019, 64: 208-215. PMID: 31362293, DOI: 10.1159/000501421.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsLung massPulmonary adenocarcinomaMedical recordsTransthoracic fine needle aspirationConcurrent core biopsyAdvanced stage diseaseInstitutional review board approvalMajority of patientsTransthoracic needle aspirationCarcinoma/adenocarcinomaPatients' medical recordsFine-needle aspirationReview board approvalStage diseaseCommon diagnosisMean agePulmonary lesionsCore biopsyMalignant diagnosisNeedle aspirationPrior historyCytologic diagnosisInvasive proceduresBoard approvalCytology specimens
2017
Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy
Osmani L, Askin F, Gabrielson E, Li QK. Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy. Seminars In Cancer Biology 2017, 52: 103-109. PMID: 29183778, PMCID: PMC5970946, DOI: 10.1016/j.semcancer.2017.11.019.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsNon-small cell lung carcinomaCell lung carcinomaLung cancerWorld Health OrganizationLung carcinomaSignificant prognostic impactLung cancer patientsRecent large-scale genomic studiesSmall biopsy specimensDriver gene mutationsPrognostic impactCancer patientsBiopsy specimensTargeted therapyOncologic practiceAccurate subclassificationIHC biomarkersImmunohistochemical markersPatient careAccurate diagnosisImmunotherapyTherapyCancerSubclassificationCritical roleCurrent insight in the localized insulin-derived amyloidosis (LIDA): clinico-pathological characteristics and differential diagnosis
Ansari AM, Osmani L, Matsangos AE, Li QK. Current insight in the localized insulin-derived amyloidosis (LIDA): clinico-pathological characteristics and differential diagnosis. Pathology - Research And Practice 2017, 213: 1237-1241. PMID: 28935176, DOI: 10.1016/j.prp.2017.08.013.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsInsulin-derived amyloidosisSystemic amyloidosisDiabetic patientsGlycemic controlDifferential diagnosisAccurate diagnosisAggressive systemic therapyBlood glycemic controlCommon side effectsCase series studyClinico-pathological characteristicsNon-surgical approachSubcutaneous insulin injectionsPrimary cutaneous amyloidosisAnti-insulin antibodiesAutonomic neuropathyInsulin requirementsClinical suspicionKey diagnostic featuresRare complicationSystemic therapySurgical excisionSurgical interventionCase reportInsulin injectionsBiomarkers in the accurate subclassification of non-small-cell lung carcinoma for targeted therapy: issues and prospects
Osmani L, Li QK. Biomarkers in the accurate subclassification of non-small-cell lung carcinoma for targeted therapy: issues and prospects. Biomarkers In Medicine 2017, 11: 405-407. PMID: 28621614, DOI: 10.2217/bmm-2017-0059.Commentaries, Editorials and LettersCitationsAltmetric
2013
The COMBREX Project: Design, Methodology, and Initial Results
Anton BP, Chang YC, Brown P, Choi HP, Faller LL, Guleria J, Hu Z, Klitgord N, Levy-Moonshine A, Maksad A, Mazumdar V, McGettrick M, Osmani L, Pokrzywa R, Rachlin J, Swaminathan R, Allen B, Housman G, Monahan C, Rochussen K, Tao K, Bhagwat AS, Brenner SE, Columbus L, de Crécy-Lagard V, Ferguson D, Fomenkov A, Gadda G, Morgan RD, Osterman AL, Rodionov DA, Rodionova IA, Rudd KE, Söll D, Spain J, Xu SY, Bateman A, Blumenthal RM, Bollinger JM, Chang WS, Ferrer M, Friedberg I, Galperin MY, Gobeill J, Haft D, Hunt J, Karp P, Klimke W, Krebs C, Macelis D, Madupu R, Martin MJ, Miller JH, O'Donovan C, Palsson B, Ruch P, Setterdahl A, Sutton G, Tate J, Yakunin A, Tchigvintsev D, Plata G, Hu J, Greiner R, Horn D, Sjölander K, Salzberg SL, Vitkup D, Letovsky S, Segrè D, DeLisi C, Roberts RJ, Steffen M, Kasif S. The COMBREX Project: Design, Methodology, and Initial Results. PLOS Biology 2013, 11: e1001638. PMID: 24013487, PMCID: PMC3754883, DOI: 10.1371/journal.pbio.1001638.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords
2012
Thousands of missed genes found in bacterial genomes and their analysis with COMBREX
Wood DE, Lin H, Levy-Moonshine A, Swaminathan R, Chang YC, Anton BP, Osmani L, Steffen M, Kasif S, Salzberg SL. Thousands of missed genes found in bacterial genomes and their analysis with COMBREX. Biology Direct 2012, 7: 37. PMID: 23111013, PMCID: PMC3534567, DOI: 10.1186/1745-6150-7-37.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsProtein-coding genesProkaryotic genome annotationCost of sequencingGenome annotationHypothetical proteinsBacterial genomesProkaryotic genomesShort genesArcady MushegianLikely geneGenesPhenotype informationGenomeHomologPotential targetPathogenic organismsAnnotationSequencingProteinFunction databaseAnnotation methodDramatic reductionGenBankOrganismsPharmaceutical research
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Overview
Lais Osmani, MD, is a rheumatologist who specializes in the diagnosis and treatment of autoimmune diseases. He focuses on conditions such as lupus nephritis and other disorders affecting the immune system.
As an instructor at Yale School of Medicine, Dr. Osmani conducts research on the pathogenesis and heterogeneity of autoimmune diseases. He is particularly interested in using biological data to identify potential therapeutic targets, which could lead to more effective treatments.
Dr. Osmani received his medical training from the University of Illinois College of Medicine. He completed a residency in anatomical and clinical pathology at Johns Hopkins Hospital, followed by a residency in internal medicine at Dartmouth-Hitchcock Medical Center and a fellowship in rheumatology at Yale School of Medicine.
Clinical Specialties
Rheumatology
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- January 08, 2026
New Yale Study Reveals Mechanism Behind Persistent Autoimmune Joint Destruction
- September 11, 2025
Finding Patterns in Genetic Uncertainty: Clues for Inborn Errors of Immunity
- October 16, 2024
Welcome New Staff, Faculty, Postdocs & Postgrads (October 2024)
- September 16, 2024
Introducing the New Yale Rheumatology, Allergy and Immunology Faculty
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Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.