SARS-CoV-2 Variants Increase Kinetic Stability of Open Spike Conformations as an Evolutionary Strategy
Yang Z, Han Y, Ding S, Shi W, Zhou T, Finzi A, Kwong PD, Mothes W, Lu M. SARS-CoV-2 Variants Increase Kinetic Stability of Open Spike Conformations as an Evolutionary Strategy. MBio 2022, 13: e03227-21. PMID: 35164561, PMCID: PMC8844933, DOI: 10.1128/mbio.03227-21.Peer-Reviewed Original ResearchMeSH KeywordsBiological EvolutionCOVID-19COVID-19 VaccinesHumansProtein BindingProtein ConformationReceptors, VirusSARS-CoV-2Spike Glycoprotein, CoronavirusConceptsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variantsAngiotensin-converting enzyme 2 receptorHuman angiotensin-converting enzyme 2 (ACE2) receptorVirus entryEnzyme 2 (ACE2) receptorTarget of antibodiesCOVID-19 vaccineSARS-CoV-2S variantsVirus particlesSARS-CoV-2 adaptationConvalescent patientsAntibody therapyAntibody responseImmune evasionE484KD614GSpike glycoproteinHarbor mutationsHuman hostVaccineS glycoproteinPrimary targetSoluble trimersHACE2