Publications

Inducible cell lines producing replication-defective human immunodeficiency virus particles containing envelope glycoproteins stabilized in a pretriggered conformation.Ding H, Nguyen HT, Li W, Deshpande A, Zhang S, Jiang F, Zhang Z, Anang S, Mothes W, Sodroski J, Kappes JC. J Virol. 2024 Nov 7; 2024 Nov 7. PMID: 39508605.
The KT Jeang retrovirology prize 2024: Walther Mothes.Mothes W. Retrovirology. 2024 Oct 24; 2024 Oct 24. PMID: 39449025.
Beta Spike-Presenting SARS-CoV-2 Virus-like Particle Vaccine Confers Broad Protection against Other VOCs in Mice.Ullah I, Symmes K, Keita K, Zhu L, Grunst MW, Li W, Mothes W, Kumar P, Uchil PD. Vaccines (Basel). 2024 Sep 2; 2024 Sep 2. PMID: 39340037.
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC.Richard J, Grunst MW, Niu L, Díaz-Salinas MA, Tolbert WD, Marchitto L, Zhou F, Bourassa C, Yang D, Chiu TJ, Chen HC, Benlarbi M, Gottumukkala S, Li W, Dionne K, Bélanger É, Chatterjee D, Medjahed H, Hendrickson WA, Sodroski J, Lang ZC, Morton AJ, Huang RK, Matthies D, Smith AB 3rd, Mothes W, Munro JB, Pazgier M, Finzi A. bioRxiv. 2024 Aug 27; 2024 Aug 27. PMID: 39253431.
Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformation.Zhang P, Gorman J, Tsybovsky Y, Lu M, Liu Q, Gopan V, Singh M, Lin Y, Miao H, Seo Y, Kwon A, Olia AS, Chuang GY, Geng H, Lai YT, Zhou T, Mascola JR, Mothes W, Kwong PD, Lusso P. Cell Rep. 2024 Aug 27; 2024 Jul 18. PMID: 39028623.
Structure and inhibition of SARS-CoV-2 spike refolding in membranes.Grunst MW, Qin Z, Dodero-Rojas E, Ding S, Prévost J, Chen Y, Hu Y, Pazgier M, Wu S, Xie X, Finzi A, Onuchic JN, Whitford PC, Mothes W, Li W. Science. 2024 Aug 16; 2024 Aug 15. PMID: 39146425.
Proof-of-concept studies with a computationally designed M(pro) inhibitor as a synergistic combination regimen alternative to Paxlovid.Papini C, Ullah I, Ranjan AP, Zhang S, Wu Q, Spasov KA, Zhang C, Mothes W, Crawford JM, Lindenbach BD, Uchil PD, Kumar P, Jorgensen WL, Anderson KS. Proc Natl Acad Sci U S A. 2024 Apr 23; 2024 Apr 15. PMID: 38621119.
Bioorthogonal click labeling of an amber-free HIV-1 provirus for in-virus single molecule imaging.Ao Y, Grover JR, Gifford L, Han Y, Zhong G, Katte R, Li W, Bhattacharjee R, Zhang B, Sauve S, Qin W, Ghimire D, Haque MA, Arthos J, Moradi M, Mothes W, Lemke EA, Kwong PD, Melikyan GB, Lu M. Cell Chem Biol. 2024 Mar 21; 2024 Jan 16. PMID: 38232732.
Bioluminescence imaging reveals enhanced SARS-CoV-2 clearance in mice with combinatorial regimens.Ullah I, Escudie F, Scandale I, Gilani Z, Gendron-Lepage G, Gaudette F, Mowbray C, Fraisse L, Bazin R, Finzi A, Mothes W, Kumar P, Chatelain E, Uchil PD. iScience. 2024 Mar 15; 2024 Jan 30. PMID: 38361624.
Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy-Treated Individuals With Undetectable Viremia.Benlarbi M, Richard J, Bourassa C, Tolbert WD, Chartrand-Lefebvre C, Gendron-Lepage G, Sylla M, El-Far M, Messier-Peet M, Guertin C, Turcotte I, Fromentin R, Verly MM, Prévost J, Clark A, Mothes W, Kaufmann DE, Maldarelli F, Chomont N, Bégin P, Tremblay C, Baril JG, Trottier B, Trottier S, Duerr R, Pazgier M, Durand M, Finzi A. J Infect Dis. 2024 Mar 14. PMID: 38035854.
Epistatic pathways can drive HIV-1 escape from integrase strand transfer inhibitors.Hikichi Y, Grover JR, Schäfer A, Mothes W, Freed EO. Sci Adv. 2024 Mar; 2024 Mar 1. PMID: 38427738.
HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes.Li W, Qin Z, Nand E, Grunst MW, Grover JR, Bess JW Jr, Lifson JD, Zwick MB, Tagare HD, Uchil PD, Mothes W. Nature. 2023 Nov; 2023 Nov 22. PMID: 37993716.
Immunogenicity and Pre-Clinical Efficacy of an OMV-Based SARS-CoV-2 Vaccine.Grandi A, Tomasi M, Ullah I, Bertelli C, Vanzo T, Accordini S, Gagliardi A, Zanella I, Benedet M, Corbellari R, Di Lascio G, Tamburini S, Caproni E, Croia L, Ravà M, Fumagalli V, Di Lucia P, Marotta D, Sala E, Iannacone M, Kumar P, Mothes W, Uchil PD, Cherepanov P, Bolognesi M, Pizzato M, Grandi G. Vaccines (Basel). 2023 Sep 29; 2023 Sep 29. PMID: 37896949.
Plasmatic HIV-1 soluble gp120 is associated with immune dysfunction and inflammation in ART-treated individuals with undetectable viremia.Benlarbi M, Richard J, Bourassa C, Tolbert WD, Chartrand-Lefebvre C, Gendron-Lepage G, Sylla M, El-Far M, Messier-Peet M, Guertin C, Turcotte I, Fromentin R, Verly MM, Prévost J, Clark A, Mothes W, Kaufmann DE, Maldarelli F, Chomont N, Bégin P, Tremblay C, Baril JG, Trottier B, Trottier S, Duerr R, Pazgier M, Durand M, Finzi A. medRxiv. 2023 Aug 16; 2023 Aug 16. PMID: 37645879.
Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry.Leonhardt SA, Purdy MD, Grover JR, Yang Z, Poulos S, McIntire WE, Tatham EA, Erramilli SK, Nosol K, Lai KK, Ding S, Lu M, Uchil PD, Finzi A, Rein A, Kossiakoff AA, Mothes W, Yeager M. Nat Commun. 2023 Jul 20; 2023 Jul 20. PMID: 37474505.
PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection.Xu D, Jiang W, Wu L, Gaudet RG, Park ES, Su M, Cheppali SK, Cheemarla NR, Kumar P, Uchil PD, Grover JR, Foxman EF, Brown CM, Stansfeld PJ, Bewersdorf J, Mothes W, Karatekin E, Wilen CB, MacMicking JD. Nature. 2023 Jul; 2023 Jul 12. PMID: 37438530.
Combinatorial Regimens Augment Drug Monotherapy for SARS-CoV-2 Clearance in Mice.Ullah I, Escudie F, Scandale I, Gilani Z, Gendron-Lepage G, Gaudette F, Mowbray C, Fraisse L, Bazin R, Finzi A, Mothes W, Kumar P, Chatelain E, Uchil PD. bioRxiv. 2023 Jun 1; 2023 Jun 1. PMID: 37398307.
Immunogenicity and pre-clinical efficacy of an OMV-based SARS-CoV-2 vaccine.Grandi A, Tomasi M, Ullah I, Bertelli C, Vanzo T, Accordini S, Gagliardi A, Zanella I, Benedet M, Corbellari R, Lascio GD, Tamburini S, Caproni E, Croia L, Ravà M, Fumagalli V, Lucia PD, Marotta D, Sala E, Iannacone M, Kumar P, Mothes W, Uchil PD, Cherepanov P, Bolognesi M, Pizzato M, Grandi G. Res Sq. 2023 May 25; 2023 May 25. PMID: 37292970.
Vaccinia Virus Strain MVA Expressing a Prefusion-Stabilized SARS-CoV-2 Spike Glycoprotein Induces Robust Protection and Prevents Brain Infection in Mouse and Hamster Models.Lorenzo MM, Marín-López A, Chiem K, Jimenez-Cabello L, Ullah I, Utrilla-Trigo S, Calvo-Pinilla E, Lorenzo G, Moreno S, Ye C, Park JG, Matía A, Brun A, Sánchez-Puig JM, Nogales A, Mothes W, Uchil PD, Kumar P, Ortego J, Fikrig E, Martinez-Sobrido L, Blasco R. Vaccines (Basel). 2023 May 21; 2023 May 21. PMID: 37243110.
Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120.Richard J, Prévost J, Bourassa C, Brassard N, Boutin M, Benlarbi M, Goyette G, Medjahed H, Gendron-Lepage G, Gaudette F, Chen HC, Tolbert WD, Smith AB 3rd, Pazgier M, Dubé M, Clark A, Mothes W, Kaufmann DE, Finzi A. Cell Chem Biol. 2023 May 18; 2023 Mar 22. PMID: 36958337.
Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD.Chen Y, Prévost J, Ullah I, Romero H, Lisi V, Tolbert WD, Grover JR, Ding S, Gong SY, Beaudoin-Bussières G, Gasser R, Benlarbi M, Vézina D, Anand SP, Chatterjee D, Goyette G, Grunst MW, Yang Z, Bo Y, Zhou F, Béland K, Bai X, Zeher AR, Huang RK, Nguyen DN, Sherburn R, Wu D, Piszczek G, Paré B, Matthies D, Xia D, Richard J, Kumar P, Mothes W, Côté M, Uchil PD, Lavallée VP, Smith MA, Pazgier M, Haddad E, Finzi A. iScience. 2023 Jan 20; 2022 Dec 9. PMID: 36514310.
The Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice.Ullah I, Beaudoin-Bussières G, Symmes K, Cloutier M, Ducas E, Tauzin A, Laumaea A, Grunst MW, Dionne K, Richard J, Bégin P, Mothes W, Kumar P, Bazin R, Finzi A, Uchil PD. Cell Rep Med. 2023 Jan 17; 2022 Dec 29. PMID: 36584683.
Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities.Chen Y, Sun L, Ullah I, Beaudoin-Bussières G, Anand SP, Hederman AP, Tolbert WD, Sherburn R, Nguyen DN, Marchitto L, Ding S, Wu D, Luo Y, Gottumukkala S, Moran S, Kumar P, Piszczek G, Mothes W, Ackerman ME, Finzi A, Uchil PD, Gonzalez FJ, Pazgier M. Sci Adv. 2022 Jul 15; 2022 Jul 13. PMID: 35857504.
VE607 stabilizes SARS-CoV-2 Spike in the "RBD-up" conformation and inhibits viral entry.Ding S, Ullah I, Gong SY, Grover JR, Mohammadi M, Chen Y, Vézina D, Beaudoin-Bussières G, Verma VT, Goyette G, Gaudette F, Richard J, Yang D, Smith AB 3rd, Pazgier M, Côté M, Abrams C, Kumar P, Mothes W, Uchil PD, Finzi A, Baron C. iScience. 2022 Jul 15; 2022 Jun 3. PMID: 35677392.
Cancer Microbiology.DiMaio D, Emu B, Goodman AL, Mothes W, Justice A. J Natl Cancer Inst. 2022 May 9. PMID: 34850062.
Antigenic analysis of the HIV-1 envelope trimer implies small differences between structural states 1 and 2.Cale EM, Driscoll JI, Lee M, Gorman J, Zhou T, Lu M, Geng H, Lai YT, Chuang GY, Doria-Rose NA, Mothes W, Kwong PD, Mascola JR. J Biol Chem. 2022 Apr; 2022 Mar 10. PMID: 35283191.
VE607 Stabilizes SARS-CoV-2 Spike In the "RBD-up" Conformation and Inhibits Viral Entry.Ding S, Gong SY, Grover J, Mohammadi M, Chen Y, Vézina D, Beaudoin-Bussières G, Verma VT, Goyette G, Richard J, Yang D, Smith AB, Pazgier M, Côté M, Abrams C, Mothes W, Finzi A, Baron C. bioRxiv. 2022 Feb 22; 2022 Feb 22. PMID: 35233570.
A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection.Beaudoin-Bussières G, Chen Y, Ullah I, Prévost J, Tolbert WD, Symmes K, Ding S, Benlarbi M, Gong SY, Tauzin A, Gasser R, Chatterjee D, Vézina D, Goyette G, Richard J, Zhou F, Stamatatos L, McGuire AT, Charest H, Roger M, Pozharski E, Kumar P, Mothes W, Uchil PD, Pazgier M, Finzi A. Cell Rep. 2022 Feb 15; 2022 Jan 25. PMID: 35123652.
Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern.Li W, Chen Y, Prévost J, Ullah I, Lu M, Gong SY, Tauzin A, Gasser R, Vézina D, Anand SP, Goyette G, Chaterjee D, Ding S, Tolbert WD, Grunst MW, Bo Y, Zhang S, Richard J, Zhou F, Huang RK, Esser L, Zeher A, Côté M, Kumar P, Sodroski J, Xia D, Uchil PD, Pazgier M, Finzi A, Mothes W. Cell Rep. 2022 Jan 11; 2021 Dec 15. PMID: 34971573.
Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities.Chen Y, Sun L, Ullah I, Beaudoin-Bussières G, Anand SP, Hederman AP, Tolbert WD, Sherburn R, Nguyen DN, Marchitto L, Ding S, Wu D, Luo Y, Gottumukkala S, Moran S, Kumar P, Piszczek G, Mothes W, Ackerman ME, Finzi A, Uchil PD, Gonzalez FJ, Pazgier M. bioRxiv. 2021 Nov 24; 2021 Nov 24. PMID: 34845451.
Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2.Prévost J, Richard J, Gasser R, Ding S, Fage C, Anand SP, Adam D, Gupta Vergara N, Tauzin A, Benlarbi M, Gong SY, Goyette G, Privé A, Moreira S, Charest H, Roger M, Mothes W, Pazgier M, Brochiero E, Boivin G, Abrams CF, Schön A, Finzi A. J Biol Chem. 2021 Oct; 2021 Aug 31. PMID: 34478710.
Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy.Ullah I, Prévost J, Ladinsky MS, Stone H, Lu M, Anand SP, Beaudoin-Bussières G, Symmes K, Benlarbi M, Ding S, Gasser R, Fink C, Chen Y, Tauzin A, Goyette G, Bourassa C, Medjahed H, Mack M, Chung K, Wilen CB, Dekaban GA, Dikeakos JD, Bruce EA, Kaufmann DE, Stamatatos L, McGuire AT, Richard J, Pazgier M, Bjorkman PJ, Mothes W, Finzi A, Kumar P, Uchil PD. Immunity. 2021 Sep 14; 2021 Aug 18. PMID: 34453881.
Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern.Li W, Chen Y, Prévost J, Ullah I, Lu M, Gong SY, Tauzin A, Gasser R, Vézina D, Anand SP, Goyette G, Chaterjee D, Ding S, Tolbert WD, Grunst MW, Bo Y, Zhang S, Richard J, Zhou F, Huang RK, Esser L, Zeher A, Côté M, Kumar P, Sodroski J, Xia D, Uchil PD, Pazgier M, Finzi A, Mothes W. bioRxiv. 2021 Aug 3; 2021 Aug 3. PMID: 34373853.
A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses.Tauzin A, Nayrac M, Benlarbi M, Gong SY, Gasser R, Beaudoin-Bussières G, Brassard N, Laumaea A, Vézina D, Prévost J, Anand SP, Bourassa C, Gendron-Lepage G, Medjahed H, Goyette G, Niessl J, Tastet O, Gokool L, Morrisseau C, Arlotto P, Stamatatos L, McGuire AT, Larochelle C, Uchil P, Lu M, Mothes W, De Serres G, Moreira S, Roger M, Richard J, Martel-Laferrière V, Duerr R, Tremblay C, Kaufmann DE, Finzi A. Cell Host Microbe. 2021 Jul 14; 2021 Jun 4. PMID: 34133950.
Impact of temperature on the affinity of SARS-CoV-2 Spike for ACE2.Prévost J, Richard J, Gasser R, Ding S, Fage C, Anand SP, Adam D, Vergara NG, Tauzin A, Benlarbi M, Gong SY, Goyette G, Privé A, Moreira S, Charest H, Roger M, Mothes W, Pazgier M, Brochiero E, Boivin G, Abrams CF, Schön A, Finzi A. bioRxiv. 2021 Jul 9; 2021 Jul 9. PMID: 34268505.
In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission.Haugh KA, Ladinsky MS, Ullah I, Stone HM, Pi R, Gilardet A, Grunst MW, Kumar P, Bjorkman PJ, Mothes W, Uchil PD. Elife. 2021 Jul 5; 2021 Jul 5. PMID: 34223819.
Live Imaging of SARS-CoV-2 Infection in Mice Reveals Neutralizing Antibodies Require Fc Function for Optimal Efficacy.Ullah I, Prévost J, Ladinsky MS, Stone H, Lu M, Anand SP, Beaudoin-Bussières G, Symmes K, Benlarbi M, Ding S, Gasser R, Fink C, Chen Y, Tauzin A, Goyette G, Bourassa C, Medjahed H, Mack M, Chung K, Wilen CB, Dekaban GA, Dikeakos JD, Bruce EA, Kaufmann DE, Stamatatos L, McGuire AT, Richard J, Pazgier M, Bjorkman PJ, Mothes W, Finzi A, Kumar P, Uchil PD. bioRxiv. 2021 Jun 28; 2021 Jun 28. PMID: 33791699.
A single BNT162b2 mRNA dose elicits antibodies with Fc-mediated effector functions and boost pre-existing humoral and T cell responses.Tauzin A, Nayrac M, Benlarbi M, Gong SY, Gasser R, Beaudoin-Bussières G, Brassard N, Laumaea A, Vézina D, Prévost J, Anand SP, Bourassa C, Gendron-Lepage G, Medjahed H, Goyette G, Niessl J, Tastet O, Gokool L, Morrisseau C, Arlotto P, Stamatatos L, McGuire AT, Larochelle C, Uchil P, Lu M, Mothes W, Serres G, Moreira S, Roger M, Richard J, Martel-Laferrière V, Duerr R, Tremblay C, Kaufmann DE, Finzi A. bioRxiv. 2021 Mar 18; 2021 Mar 18. PMID: 33758857.
SARS-CoV-2 Variants Increase Kinetic Stability of Open Spike Conformations as an Evolutionary Strategy.Yang Z, Han Y, Ding S, Shi W, Zhou T, Finzi A, Kwong PD, Mothes W, Lu M. mBio. 2021 Feb 22; 2022 Feb 15. PMID: 35164561.
Real-Time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles.Lu M, Uchil PD, Li W, Zheng D, Terry DS, Gorman J, Shi W, Zhang B, Zhou T, Ding S, Gasser R, Prévost J, Beaudoin-Bussières G, Anand SP, Laumaea A, Grover JR, Liu L, Ho DD, Mascola JR, Finzi A, Kwong PD, Blanchard SC, Mothes W. Cell Host Microbe. 2020 Dec 9; 2020 Nov 13. PMID: 33242391.
Correction for Lu et al., "Shedding-Resistant HIV-1 Envelope Glycoproteins Adopt Downstream Conformations That Remain Responsive to Conformation-Preferring Ligands".Lu M, Ma X, Reichard N, Terry DS, Arthos J, Smith AB 3rd, Sodroski JG, Blanchard SC, Mothes W. J Virol. 2020 Oct 27; 2020 Oct 27. PMID: 33109770.
SV40 Polyomavirus Activates the Ras-MAPK Signaling Pathway for Vacuolization, Cell Death, and Virus Release.Motamedi N, Sewald X, Luo Y, Mothes W, DiMaio D. Viruses. 2020 Oct 5; 2020 Oct 5. PMID: 33028008.
Real-time conformational dynamics of SARS-CoV-2 spikes on virus particles.Lu M, Uchil PD, Li W, Zheng D, Terry DS, Gorman J, Shi W, Zhang B, Zhou T, Ding S, Gasser R, Prevost J, Beaudoin-Bussieres G, Anand SP, Laumaea A, Grover JR, Lihong L, Ho DD, Mascola J, Finzi A, Kwong PD, Blanchard SC, Mothes W. bioRxiv. 2020 Sep 13; 2020 Sep 13. PMID: 32935100.
Shedding-Resistant HIV-1 Envelope Glycoproteins Adopt Downstream Conformations That Remain Responsive to Conformation-Preferring Ligands.Lu M, Ma X, Reichard N, Terry DS, Arthos J, Smith AB 3rd, Sodroski JG, Blanchard SC, Mothes W. J Virol. 2020 Aug 17; 2020 Aug 17. PMID: 32522853.
Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles.Li Z, Li W, Lu M, Bess J Jr, Chao CW, Gorman J, Terry DS, Zhang B, Zhou T, Blanchard SC, Kwong PD, Lifson JD, Mothes W, Liu J. Nat Struct Mol Biol. 2020 Aug; 2020 Jun 29. PMID: 32601441.
Long-Acting BMS-378806 Analogues Stabilize the State-1 Conformation of the Human Immunodeficiency Virus Type 1 Envelope Glycoproteins.Zou S, Zhang S, Gaffney A, Ding H, Lu M, Grover JR, Farrell M, Nguyen HT, Zhao C, Anang S, Zhao M, Mohammadi M, Blanchard SC, Abrams C, Madani N, Mothes W, Kappes JC, Smith AB 3rd, Sodroski J. J Virol. 2020 May 4; 2020 May 4. PMID: 32161177.
Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements.Henderson R, Lu M, Zhou Y, Mu Z, Parks R, Han Q, Hsu AL, Carter E, Blanchard SC, Edwards RJ, Wiehe K, Saunders KO, Borgnia MJ, Bartesaghi A, Mothes W, Haynes BF, Acharya P, Munir Alam S. Nat Commun. 2020 Jan 24; 2020 Jan 24. PMID: 31980614.
Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice.Ventura JD, Beloor J, Allen E, Zhang T, Haugh KA, Uchil PD, Ochsenbauer C, Kieffer C, Kumar P, Hope TJ, Mothes W. PLoS Pathog. 2019 Dec; 2019 Dec 5. PMID: 31805155.
Murine Leukemia Virus Exploits Innate Sensing by Toll-Like Receptor 7 in B-1 Cells To Establish Infection and Locally Spread in Mice.Pi R, Iwasaki A, Sewald X, Mothes W, Uchil PD. J Virol. 2019 Nov 1; 2019 Oct 15. PMID: 31434732.
In Vivo Imaging-Driven Approaches to Study Virus Dissemination and Pathogenesis.Uchil PD, Haugh KA, Pi R, Mothes W. Annu Rev Virol. 2019 Sep 29; 2019 Jul 5. PMID: 31283440.
Antibody-Induced Internalization of HIV-1 Env Proteins Limits Surface Expression of the Closed Conformation of Env.Anand SP, Grover JR, Tolbert WD, Prévost J, Richard J, Ding S, Baril S, Medjahed H, Evans DT, Pazgier M, Mothes W, Finzi A. J Virol. 2019 Jun 1; 2019 May 15. PMID: 30894474.
An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity.Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, Das D, Anand SP, Prévost J, Tolbert WD, Lu H, Medjahed H, Gendron-Lepage G, Ortega Delgado GG, Kirk S, Melillo B, Mothes W, Sodroski J, Smith AB 3rd, Kaufmann DE, Wu X, Pazgier M, Rouiller I, Finzi A, Munro JB. Cell Host Microbe. 2019 Apr 10. PMID: 30974085.
Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.Lu M, Ma X, Castillo-Menendez LR, Gorman J, Alsahafi N, Ermel U, Terry DS, Chambers M, Peng D, Zhang B, Zhou T, Reichard N, Wang K, Grover JR, Carman BP, Gardner MR, Nikić-Spiegel I, Sugawara A, Arthos J, Lemke EA, Smith AB 3rd, Farzan M, Abrams C, Munro JB, McDermott AB, Finzi A, Kwong PD, Blanchard SC, Sodroski JG, Mothes W. Nature. 2019 Apr; 2019 Apr 10. PMID: 30971821.
A Protective Role for the Lectin CD169/Siglec-1 against a Pathogenic Murine Retrovirus.Uchil PD, Pi R, Haugh KA, Ladinsky MS, Ventura JD, Barrett BS, Santiago ML, Bjorkman PJ, Kassiotis G, Sewald X, Mothes W. Cell Host Microbe. 2019 Jan 9; 2018 Dec 27. PMID: 30595553.
Illuminating the virus life cycle with single-molecule FRET imaging.Lu M, Ma X, Mothes W. Adv Virus Res. 2019; 2019 Aug 20. PMID: 31522706.
HIV-1-Infected CD4+ T Cells Facilitate Latent Infection of Resting CD4+ T Cells through Cell-Cell Contact.Agosto LM, Herring MB, Mothes W, Henderson AJ. Cell Rep. 2018 Aug 21. PMID: 30134170.
HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations.Ma X, Lu M, Gorman J, Terry DS, Hong X, Zhou Z, Zhao H, Altman RB, Arthos J, Blanchard SC, Kwong PD, Munro JB, Mothes W. Elife. 2018 Mar 21; 2018 Mar 21. PMID: 29561264.
NF-κB-Chromatin Interactions Drive Diverse Phenotypes by Modulating Transcriptional Noise.Wong VC, Bass VL, Bullock ME, Chavali AK, Lee REC, Mothes W, Gaudet S, Miller-Jensen K. Cell Rep. 2018 Jan 16. PMID: 29346759.
Publisher Correction: The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.Herschhorn A, Gu C, Moraca F, Ma X, Farrell M, Smith AB 3rd, Pancera M, Kwong PD, Schön A, Freire E, Abrams C, Blanchard SC, Mothes W, Sodroski JG. Nat Commun. 2018 Jan 8; 2018 Jan 8. PMID: 29311557.
Mutation of the Putative Immunosuppressive Domain of the Retroviral Envelope Glycoprotein Compromises Infectivity.Eksmond U, Jenkins B, Merkenschlager J, Mothes W, Stoye JP, Kassiotis G. J Virol. 2017 Nov 1; 2017 Oct 13. PMID: 28814524.
The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.Herschhorn A, Gu C, Moraca F, Ma X, Farrell M, Smith AB 3rd, Pancera M, Kwong PD, Schön A, Freire E, Abrams C, Blanchard SC, Mothes W, Sodroski JG. Nat Commun. 2017 Oct 19; 2017 Oct 19. PMID: 29051495.
Native structure of a retroviral envelope protein and its conformational change upon interaction with the target cell.Riedel C, Vasishtan D, Siebert CA, Whittle C, Lehmann MJ, Mothes W, Grünewald K. J Struct Biol. 2017 Feb; 2016 Jun 23. PMID: 27345930.
Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins.Herschhorn A, Ma X, Gu C, Ventura JD, Castillo-Menendez L, Melillo B, Terry DS, Smith AB 3rd, Blanchard SC, Munro JB, Mothes W, Finzi A, Sodroski J. mBio. 2016 Oct 25; 2016 Oct 25. PMID: 27795397.
Viruses exploit the tissue physiology of the host to spread in vivo.Sewald X, Motamedi N, Mothes W. Curr Opin Cell Biol. 2016 Aug; 2016 May 3. PMID: 27149407.
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.Kong R, Xu K, Zhou T, Acharya P, Lemmin T, Liu K, Ozorowski G, Soto C, Taft JD, Bailer RT, Cale EM, Chen L, Choi CW, Chuang GY, Doria-Rose NA, Druz A, Georgiev IS, Gorman J, Huang J, Joyce MG, Louder MK, Ma X, McKee K, O'Dell S, Pancera M, Yang Y, Blanchard SC, Mothes W, Burton DR, Koff WC, Connors M, Ward AB, Kwong PD, Mascola JR. Science. 2016 May 13. PMID: 27174988.
TRIM5 Retroviral Restriction Activity Correlates with the Ability To Induce Innate Immune Signaling.Lascano J, Uchil PD, Mothes W, Luban J. J Virol. 2016 Jan 1; 2015 Oct 14. PMID: 26468522.
Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.Sewald X, Ladinsky MS, Uchil PD, Beloor J, Pi R, Herrmann C, Motamedi N, Murooka TT, Brehm MA, Greiner DL, Shultz LD, Mempel TR, Bjorkman PJ, Kumar P, Mothes W. Science. 2015 Oct 30; 2015 Oct 1. PMID: 26429886.
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env.Kwon YD, Pancera M, Acharya P, Georgiev IS, Crooks ET, Gorman J, Joyce MG, Guttman M, Ma X, Narpala S, Soto C, Terry DS, Yang Y, Zhou T, Ahlsen G, Bailer RT, Chambers M, Chuang GY, Doria-Rose NA, Druz A, Hallen MA, Harned A, Kirys T, Louder MK, O'Dell S, Ofek G, Osawa K, Prabhakaran M, Sastry M, Stewart-Jones GB, Stuckey J, Thomas PV, Tittley T, Williams C, Zhang B, Zhao H, Zhou Z, Donald BR, Lee LK, Zolla-Pazner S, Baxa U, Schön A, Freire E, Shapiro L, Lee KK, Arthos J, Munro JB, Blanchard SC, Mothes W, Binley JM, McDermott AB, Mascola JR, Kwong PD. Nat Struct Mol Biol. 2015 Jul; 2015 Jun 22. PMID: 26098315.
Structure and Dynamics of the Native HIV-1 Env Trimer.Munro JB, Mothes W. J Virol. 2015 Jun; 2015 Mar 11. PMID: 25762739.
HIV cell-to-cell transmission: effects on pathogenesis and antiretroviral therapy.Agosto LM, Uchil PD, Mothes W. Trends Microbiol. 2015 May; 2015 Mar 9. PMID: 25766144.
Attachment of cell-binding ligands to arginine-rich cell-penetrating peptides enables cytosolic translocation of complexed siRNA.Zeller S, Choi CS, Uchil PD, Ban HS, Siefert A, Fahmy TM, Mothes W, Lee SK, Kumar P. Chem Biol. 2015 Jan 22; 2014 Dec 24. PMID: 25544044.
Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions.Munro JB, Gorman J, Ma X, Zhou Z, Arthos J, Burton DR, Koff WC, Courter JR, Smith AB 3rd, Kwong PD, Blanchard SC, Mothes W. Science. 2014 Nov 7; 2014 Oct 8. PMID: 25298114.
Structure and immune recognition of trimeric pre-fusion HIV-1 Env.Pancera M, Zhou T, Druz A, Georgiev IS, Soto C, Gorman J, Huang J, Acharya P, Chuang GY, Ofek G, Stewart-Jones GB, Stuckey J, Bailer RT, Joyce MG, Louder MK, Tumba N, Yang Y, Zhang B, Cohen MS, Haynes BF, Mascola JR, Morris L, Munro JB, Blanchard SC, Mothes W, Connors M, Kwong PD. Nature. 2014 Oct 23; 2014 Oct 8. PMID: 25296255.
TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly.Uchil PD, Pawliczek T, Reynolds TD, Ding S, Hinz A, Munro JB, Huang F, Floyd RW, Yang H, Hamilton WL, Bewersdorf J, Xiong Y, Calderwood DA, Mothes W. J Cell Sci. 2014 Sep 15; 2014 Jul 11. PMID: 25015296.
Murine leukemia virus Gag localizes to the uropod of migrating primary lymphocytes.Li F, Sewald X, Jin J, Sherer NM, Mothes W. J Virol. 2014 Sep; 2014 Jun 25. PMID: 24965475.
The HIV-1 Env trimer in HD.Munro JB, Mothes W. Structure. 2014 Jul 8. PMID: 25007222.
A conformational transition observed in single HIV-1 Gag molecules during in vitro assembly of virus-like particles.Munro JB, Nath A, Färber M, Datta SA, Rein A, Rhoades E, Mothes W. J Virol. 2014 Mar; 2014 Jan 8. PMID: 24403576.
Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission.Agosto LM, Zhong P, Munro J, Mothes W. PLoS Pathog. 2014 Feb; 2014 Feb 27. PMID: 24586176.
Functional characterization of the putative hepatitis B virus core protein late domain using retrovirus chimeras.Garcia ML, Reynolds TD, Mothes W, Robek MD. PLoS One. 2013; 2013 Aug 29. PMID: 24009707.
Video-rate nanoscopy using sCMOS camera-specific single-molecule localization algorithms.Huang F, Hartwich TM, Rivera-Molina FE, Lin Y, Duim WC, Long JJ, Uchil PD, Myers JR, Baird MA, Mothes W, Davidson MW, Toomre D, Bewersdorf J. Nat Methods. 2013 Jul; 2013 May 26. PMID: 23708387.
Basic residues in the matrix domain and multimerization target murine leukemia virus Gag to the virological synapse.Li F, Jin J, Herrmann C, Mothes W. J Virol. 2013 Jun; 2013 Apr 24. PMID: 23616653.
Cell-to-cell transmission of viruses.Zhong P, Agosto LM, Munro JB, Mothes W. Curr Opin Virol. 2013 Feb; 2012 Dec 5. PMID: 23219376.
Cell-to-cell transmission can overcome multiple donor and target cell barriers imposed on cell-free HIV.Zhong P, Agosto LM, Ilinskaya A, Dorjbal B, Truong R, Derse D, Uchil PD, Heidecker G, Mothes W. PLoS One. 2013; 2013 Jan 7. PMID: 23308151.
TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.Uchil PD, Hinz A, Siegel S, Coenen-Stass A, Pertel T, Luban J, Mothes W. J Virol. 2013 Jan; 2012 Oct 17. PMID: 23077300.
In vivo imaging of virological synapses.Sewald X, Gonzalez DG, Haberman AM, Mothes W. Nat Commun. 2012. PMID: 23271654.
Viral determinants of polarized assembly for the murine leukemia virus.Jin J, Li F, Mothes W. J Virol. 2011 Aug; 2011 May 18. PMID: 21593177.
TRIM22 inhibits HIV-1 transcription independently of its E3 ubiquitin ligase activity, Tat, and NF-kappaB-responsive long terminal repeat elements.Kajaste-Rudnitski A, Marelli SS, Pultrone C, Pertel T, Uchil PD, Mechti N, Mothes W, Poli G, Luban J, Vicenzi E. J Virol. 2011 May; 2011 Feb 23. PMID: 21345949.
TRIM5 is an innate immune sensor for the retrovirus capsid lattice.Pertel T, Hausmann S, Morger D, Züger S, Guerra J, Lascano J, Reinhard C, Santoni FA, Uchil PD, Chatel L, Bisiaux A, Albert ML, Strambio-De-Castillia C, Mothes W, Pizzato M, Grütter MG, Luban J. Nature. 2011 Apr 21. PMID: 21512573.
Virus cell-to-cell transmission.Mothes W, Sherer NM, Jin J, Zhong P. J Virol. 2010 Sep; 2010 Apr 7. PMID: 20375157.
Directional spread of surface-associated retroviruses regulated by differential virus-cell interactions.Sherer NM, Jin J, Mothes W. J Virol. 2010 Apr; 2010 Jan 20. PMID: 20089647.
Surface Transmission or Polarized Egress? Lessons Learned from HTLV Cell-to-Cell Transmission.Jin J, Sherer N, Mothes W. Viruses. 2010 Feb; 2010 Feb 10. PMID: 21994650.
HIV-1 matrix dependent membrane targeting is regulated by Gag mRNA trafficking.Jin J, Sturgeon T, Weisz OA, Mothes W, Montelaro RC. PLoS One. 2009 Aug 7; 2009 Aug 7. PMID: 19662089.
Assembly of the murine leukemia virus is directed towards sites of cell-cell contact.Jin J, Sherer NM, Heidecker G, Derse D, Mothes W. PLoS Biol. 2009 Jul; 2009 Jul 28. PMID: 19636361.
HIV Entry Revisited.Uchil PD, Mothes W. Cell. 2009 May 1. PMID: 19410537.
Human TRIM gene expression in response to interferons.Carthagena L, Bergamaschi A, Luna JM, David A, Uchil PD, Margottin-Goguet F, Mothes W, Hazan U, Transy C, Pancino G, Nisole S. PLoS One. 2009; 2009 Mar 17. PMID: 19290053.
The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection.Roan NR, Münch J, Arhel N, Mothes W, Neidleman J, Kobayashi A, Smith-McCune K, Kirchhoff F, Greene WC. J Virol. 2009 Jan; 2008 Oct 22. PMID: 18945786.
Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides.Chan R, Uchil PD, Jin J, Shui G, Ott DE, Mothes W, Wenk MR. J Virol. 2008 Nov; 2008 Sep 17. PMID: 18799574.
Cytonemes and tunneling nanotubules in cell-cell communication and viral pathogenesis.Sherer NM, Mothes W. Trends Cell Biol. 2008 Sep; 2008 Aug 14. PMID: 18703335.
Murine leukemia virus spreading in mice impaired in the biogenesis of secretory lysosomes and Ca2+-regulated exocytosis.Chan WT, Sherer NM, Uchil PD, Novak EK, Swank RT, Mothes W. PLoS One. 2008 Jul 16; 2008 Jul 16. PMID: 18629000.
TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.Uchil PD, Quinlan BD, Chan WT, Luna JM, Mothes W. PLoS Pathog. 2008 Feb 8. PMID: 18248090.