ORF33 and ORF38 of Kaposi's Sarcoma-Associated Herpesvirus Interact and Are Required for Optimal Production of Infectious Progeny Viruses
Wu J, Avey D, Li W, Gillen J, Fu B, Miley W, Whitby D, Zhu F. ORF33 and ORF38 of Kaposi's Sarcoma-Associated Herpesvirus Interact and Are Required for Optimal Production of Infectious Progeny Viruses. Journal Of Virology 2015, 90: 1741-1756. PMID: 26637455, PMCID: PMC4734004, DOI: 10.1128/jvi.02738-15.Peer-Reviewed Original ResearchMeSH KeywordsCapsid ProteinsGene DeletionGene Expression ProfilingHerpesvirus 8, HumanHumansProtein BindingVirus ReplicationConceptsProgeny virionsCytoplasmic vesiclesKaposi's Sarcoma-Associated Herpesvirus InteractsDouble null mutantsEarly endosome membraneVirion-containing vesiclesMembranes of vesiclesLytic replicationViral gene expressionProgeny virion productionViral lytic replicationEndosome membraneHerpesvirus assemblyGolgi membranesComponent proteinsIdentical phenotypesGene expressionDelicate regulationVirion proteinsVirus assemblyVirus propagationExact functionInfectious progeny virusMature virionsViral assemblyA Survey of the Interactome of Kaposi's Sarcoma-Associated Herpesvirus ORF45 Revealed Its Binding to Viral ORF33 and Cellular USP7, Resulting in Stabilization of ORF33 That Is Required for Production of Progeny Viruses
Gillen J, Li W, Liang Q, Avey D, Wu J, Wu F, Myoung J, Zhu F. A Survey of the Interactome of Kaposi's Sarcoma-Associated Herpesvirus ORF45 Revealed Its Binding to Viral ORF33 and Cellular USP7, Resulting in Stabilization of ORF33 That Is Required for Production of Progeny Viruses. Journal Of Virology 2015, 89: 4918-4931. PMID: 25694600, PMCID: PMC4403494, DOI: 10.1128/jvi.02925-14.Peer-Reviewed Original ResearchConceptsUbiquitin-specific protease 7Kaposi's sarcoma-associated herpesvirusSarcoma-associated herpesvirusKSHV lytic replicationORF45 proteinKaposi's Sarcoma-Associated Herpesvirus ORF45Lytic replicationCarboxyl-terminal 19 amino acidsKSHV ORF45Copurified proteinsConsensus motifMultifunctional proteinKinase proteinInteractomeCarboxyl terminusKSHV genomeORF45Tegument proteinsWeight complexesProtein accumulationORF33Progeny virionsAmino acidsHuman cancersProtein