Publications

• Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans.Fischer IC, Na PJ, Nagamatsu ST, Jeste DV, Cabrera-Mendoza B, Montalvo-Ortiz JL, Krystal JH, Polimanti R, Gelernter J, Pietrzak RH. JAMA Psychiatry. 2024 Oct 30; 2024 Oct 30. PMID: 39476130.
• Mapping the epigenomic landscape of post-traumatic stress disorder in human cortical neurons.Núñez-Ríos DL, Nagamatsu ST, Martínez-Magaña JJ, Hurd Y, Rompala G, Krystal JH, Montalvo-Ortiz JL. medRxiv. 2024 Oct 16; 2024 Oct 16. PMID: 39484232.
• Multi-omics profiling of DNA methylation and gene expression alterations in human cocaine use disorder.Zillich E, Belschner H, Avetyan D, Andrade-Brito D, Martínez-Magaña JJ, Frank J, Mechawar N, Turecki G, Cabana-Domínguez J, Fernàndez-Castillo N, Cormand B, Montalvo-Ortiz JL, Nöthen MM, Hansson AC, Rietschel M, Spanagel R, Witt SH, Zillich L. Transl Psychiatry. 2024 Oct 9; 2024 Oct 9. PMID: 39384764.
• Epigenetic and Genetic Profiling of Comorbidity Patterns among Substance Dependence Diagnoses.Pathak GA, Pietrzak RH, Lacobelle A, Overstreet C, Wendt FR, Deak JD, Friligkou E, Nunez Y, Montalvo-Ortiz JL, Levey DF, Kranzler HR, Gelernter J, Polimanti R. medRxiv. 2024 Oct 8; 2024 Oct 8. PMID: 39417130.
• Towards a Novel Frontier in the Use of Epigenetic Clocks in Epidemiology.Martínez-Magaña JJ, Hurtado-Soriano J, Rivero-Segura NA, Montalvo-Ortiz JL, Garcia-delaTorre P, Becerril-Rojas K, Gomez-Verjan JC. Arch Med Res. 2024 Jul; 2024 Jul 1. PMID: 38955096.
• A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals.Jennings MV, Martínez-Magaña JJ, Courchesne-Krak NS, Cupertino RB, Vilar-Ribó L, Bianchi SB, Hatoum AS, Atkinson EG, Giusti-Rodriguez P, Montalvo-Ortiz JL, Gelernter J, Artigas MS, Elson SL, Edenberg HJ, Fontanillas P, Palmer AA, Sanchez-Roige S. EBioMedicine. 2024 May; 2024 Apr 4. PMID: 38580523.
• Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder.Andrade-Brito DE, Núñez-Ríos DL, Martínez-Magaña JJ, Nagamatsu ST, Rompala G, Zillich L, Witt SH, Clark SL, Lattig MC, Montalvo-Ortiz JL. Front Genet. 2024; 2024 Apr 3. PMID: 38633406.
• Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge.Tamman AJF, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Polimanti R, Pietrzak RH. Neuropsychopharmacology. 2024 Mar. PMID: 38182778.
• Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge.Tamman AJF, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Polimanti R, Pietrzak RH. Neuropsychopharmacology. 2024 Mar; 2023 Oct 17. PMID: 37848731.
• Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort study.Na P, Zhou H, Montalvo-Ortiz JL, Cabrera-Mendoza B, Petrakis IL, Krystal JH, Polimanti R, Gelernter J, Pietrzak RH. Psychol Med. 2023 Dec; 2023 Aug 29. PMID: 37642191.
• Neuronal-specific methylome and hydroxymethylome analysis reveal replicated and novel loci associated with alcohol use disorder.Andrade-Brito DE, Núñez-Ríos DL, Martínez-Magaña JJ, Nagamatsu ST, Rompala G, Zillich L, Witt SH, Clark SL, Latig MC, Montalvo-Ortiz JL. medRxiv. 2023 Nov 29; 2023 Nov 29. PMID: 38105948.
• Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex.Rompala G, Nagamatsu ST, Martínez-Magaña JJ, Nuñez-Ríos DL, Wang J, Girgenti MJ, Krystal JH, Gelernter J, Hurd YL, Montalvo-Ortiz JL. Nat Commun. 2023 Jul 28; 2023 Jul 28. PMID: 37507366.
• Decoding the role of transcriptomic clocks in the human prefrontal cortex.Martínez-Magaña JJ, Krystal JH, Girgenti MJ, Núnez-Ríos DL, Nagamatsu ST, Andrade-Brito DE, Montalvo-Ortiz JL. medRxiv. 2023 Apr 25; 2023 Apr 25. PMID: 37163025.
• Cross-Species Convergence of Brain Transcriptomic and Epigenomic Findings in Posttraumatic Stress Disorder: A Systematic Review.Núñez-Rios DL, Martínez-Magaña JJ, Nagamatsu ST, Krystal JH, Martínez-González KG, Giusti-Rodríguez P, Montalvo-Ortiz JL. Complex Psychiatry. 2023 Jan-Dec; 2023 Feb 3. PMID: 37404872.
• Psychosocial Factors Associated With Accelerated GrimAge in Male U.S. Military Veterans.Tamman AJF, Nagamatsu S, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Pietrzak RH. Am J Geriatr Psychiatry. 2023 Feb; 2022 Sep 10. PMID: 36210262.
• CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder.Nagamatsu ST, Rompala G, Hurd YL, Núñez-Rios DL, Montalvo-Ortiz JL. Front Psychiatry. 2022; 2023 Jan 19. PMID: 36745154.
• Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort.Nagamatsu ST, Pietrzak RH, Xu K, Krystal JH, Gelernter J, Montalvo-Ortiz JL. Addict Biol. 2023 Jan. PMID: 36577721.
• Cross-ancestry genomic research: time to close the gap.Atkinson EG, Bianchi SB, Ye GY, Martínez-Magaña JJ, Tietz GE, Montalvo-Ortiz JL, Giusti-Rodriguez P, Palmer AA, Sanchez-Roige S. Neuropsychopharmacology. 2022 Sep; 2022 Jun 23. PMID: 35739257.
• Association of Symptoms of Posttraumatic Stress Disorder and GrimAge, an Epigenetic Marker of Mortality Risk, in US Military Veterans.Na PJ, Montalvo-Ortiz JL, Nagamatsu ST, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. J Clin Psychiatry. 2022 Jul 6; 2022 Jul 6. PMID: 35802930.
• Central and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence.Núñez-Rios DL, Martínez-Magaña JJ, Nagamatsu ST, Andrade-Brito DE, Forero DA, Orozco-Castaño CA, Montalvo-Ortiz JL. Biomedicines. 2022 May 10; 2022 May 10. PMID: 35625844.
• Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veterans.Montalvo-Ortiz JL, Gelernter J, Cheng Z, Girgenti MJ, Xu K, Zhang X, Gopalan S, Zhou H, Duman RS, Southwick SM, Krystal JH, Pietrzak RH. Transl Psychiatry. 2022 Feb 17; 2022 Feb 17. PMID: 35177594.
• DNA methylation changes in African American women with a history of preterm birth from the InterGEN study.Barcelona V, Montalvo-Ortiz JL, Wright ML, Nagamatsu ST, Dreisbach C, Crusto CA, Sun YV, Taylor JY. BMC Genom Data. 2021 Sep 5; 2021 Sep 5. PMID: 34482817.
• Attachment Style Moderates Polygenic Risk for Posttraumatic Stress in United States Military Veterans: Results From the National Health and Resilience in Veterans Study.Tamman AJF, Wendt FR, Pathak GA, Krystal JH, Montalvo-Ortiz JL, Southwick SM, Sippel LM, Gelernter J, Polimanti R, Pietrzak RH. Biol Psychiatry. 2021 May 1; 2020 Sep 30. PMID: 33276944.
• Tubulin Polymerization Promoting Protein (TPPP) gene methylation and corpus callosum measures in maltreated children.de Araújo CM, Hudziak J, Crocetti D, Wymbs NF, Montalvo-Ortiz JL, Orr C, Albaugh MD, Althoff RR, O'Loughlin K, Holbrook H, Garavan H, Yang BZ, Mostofsky S, Jackowski A, Lee RS, Gelernter J, Kaufman J. Psychiatry Res Neuroimaging. 2020 Apr 30; 2020 Feb 22. PMID: 32120304.
• Advancing Alcohol Genetics Research: One Genome-wide Association Study at a Time and Beyond.Montalvo-Ortiz JL. Biol Psychiatry. 2020 Apr 1. PMID: 32164913.
• Social supports moderate the effects of child adversity on neural correlates of threat processing.Wymbs NF, Orr C, Albaugh MD, Althoff RR, O'Loughlin K, Holbrook H, Garavan H, Montalvo-Ortiz JL, Mostofsky S, Hudziak J, Kaufman J. Child Abuse Negl. 2020 Apr; 2020 Feb 14. PMID: 32065988.
• Author Correction: Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women.Montalvo-Ortiz JL, Cheng Z, Kranzler HR, Zhang H, Gelernter J. Sci Rep. 2019 Dec 5; 2019 Dec 5. PMID: 31801960.
• Epigenome-Wide DNA Methylation Association Analysis Identified Novel Loci in Peripheral Cells for Alcohol Consumption Among European American Male Veterans.Xu K, Montalvo-Ortiz JL, Zhang X, Southwick SM, Krystal JH, Pietrzak RH, Gelernter J. Alcohol Clin Exp Res. 2019 Oct; 2019 Aug 30. PMID: 31386212.
• Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study.Tamman AJF, Montalvo-Ortiz JL, Southwick SM, Krystal JH, Levy BR, Pietrzak RH. Am J Geriatr Psychiatry. 2019 May; 2019 Jan 7. PMID: 30792041.
• Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women.Montalvo-Ortiz JL, Cheng Z, Kranzler HR, Zhang H, Gelernter J. Sci Rep. 2019 Mar 15; 2019 Mar 15. PMID: 30874594.
• Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response.Montalvo-Ortiz JL, Zhou H, D'Andrea I, Maroteaux L, Lori A, Smith A, Ressler KJ, Nuñez YZ, Farrer LA, Zhao H, Kranzler HR, Gelernter J. Mol Psychiatry. 2018 Dec; 2018 Jun 6. PMID: 29875475.
• Adverse Childhood Experiences, Epigenetic Measures, and Obesity in Youth.Kaufman J, Montalvo-Ortiz JL, Holbrook H, O'Loughlin K, Orr C, Kearney C, Yang BZ, Wang T, Zhao H, Althoff R, Garavan H, Gelernter J, Hudziak J. J Pediatr. 2018 Nov; 2018 Aug 31. PMID: 30177354.
• Methylation in OTX2 and related genes, maltreatment, and depression in children.Kaufman J, Wymbs NF, Montalvo-Ortiz JL, Orr C, Albaugh MD, Althoff R, O'Loughlin K, Holbrook H, Garavan H, Kearney C, Yang BZ, Zhao H, Peña C, Nestler EJ, Lee RS, Mostofsky S, Gelernter J, Hudziak J. Neuropsychopharmacology. 2018 Oct; 2018 Jul 21. PMID: 30089883.
• Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment Analysis.Montalvo-Ortiz JL, Zhang H, Chen C, Liu C, Coccaro EF. Int J Neuropsychopharmacol. 2018 Jan 1. PMID: 29106553.
• A New Perspective on the Mechanisms of Neglect.Montalvo-Ortiz JL. Biol Psychiatry. 2017 Oct 1. PMID: 28870299.
• Histone deacetylase inhibitors reverse age-related increases in side effects of haloperidol in mice.Montalvo-Ortiz JL, Fisher DW, Rodríguez G, Fang D, Csernansky JG, Dong H. Psychopharmacology (Berl). 2017 Aug; 2017 Apr 18. PMID: 28421257.
• The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect.Montalvo-Ortiz JL, Bordner KA, Carlyle BC, Gelernter J, Simen AA, Kaufman J. Behav Brain Res. 2016 Dec 15; 2016 Aug 6. PMID: 27506655.
• RDoC and translational perspectives on the genetics of trauma-related psychiatric disorders.Montalvo-Ortiz JL, Gelernter J, Hudziak J, Kaufman J. Am J Med Genet B Neuropsychiatr Genet. 2016 Jan; 2015 Nov 22. PMID: 26592203.
• Early Life Stress as a Risk Factor for Substance use Disorders: Clinical and Neurobiological Substrates.Varghese SP, Montalvo-Ortiz JL, Csernansky JG, Eiger RI, Herrold AA, Koola MM, Dong H. Indian J Psychol Med. 2015 Jan-Mar. PMID: 25722510.
• HDAC inhibitors restore the capacity of aged mice to respond to haloperidol through modulation of histone acetylation.Montalvo-Ortiz JL, Keegan J, Gallardo C, Gerst N, Tetsuka K, Tucker C, Matsumoto M, Fang D, Csernansky JG, Dong H. Neuropsychopharmacology. 2014 May; 2013 Dec 24. PMID: 24366052.