People

Bridging the Gap from Acute Stroke to Brain Stewardship The Mission I am a vascular neurologist and researcher dedicated to a single, urgent goal: ensuring that a stroke survivor’s journey does not end with "survival," but continues into a life of neurological health and cognitive resilience. Over the past two decades, my work has spanned the globe—from India and Europe to my current home at Yale School of Medicine and the West Haven VA. A Legacy of Impact My early research focused on breaking down unnecessary barriers to acute care. I led the pivotal studies (published in The BMJ and Neurology) that challenged age-based and several other exclusions for thrombolysis, findings that were eventually integrated into the AHA/ASA National Stroke Guidelines. Today, my scholarly work is cited nearly 3,000 times, serving as a foundation for evidence-based stroke protocols worldwide. The Current Frontier: IPSERC and Brain Recovery At Yale, I have pivoted to the "next frontier" of stroke: long-term recovery. Preventing Epilepsy: I co-founded and lead the International Post Stroke Epilepsy Research Consortium (IPSERC). Our recent leadership in JAMA Neurology and Stroke is uncovering the genomic and clinical "signatures" that predict post-stroke seizures, moving us closer to the first generation of preventative anti-epileptogenic therapies. As a stroke specialist, my service on the American Epilepsy Society Scientific Program Committee serves as a strategic bridge for interdisciplinary scholarship. In this role, I lead the development of scientific programming that integrates stroke and epilepsy research, directly advancing my primary research agenda in post-stroke epilepsy.Cognitive Resilience: I am investigating how cultural and linguistic assets, such as bilingualism, act as a "cognitive reserve" that shields the brain from post-stroke decline. My vision is to develop cost-effective, community-based interventions that protect the cognitive identity of every patient. For Future Collaborators and Trainees I am a "traditional" neurologist at heart. Whether at the bedside at the VA or in the teachin session at Yale, I believe in the power of clinical storytelling and meticulous semiology. To Trainees: My lab is a global pipeline. I have had the privilege of mentoring students who have won AAN awards, matched into top-tier residencies, and serving as professor internationally. I provide a mentorship experience that balances high-level scientific rigor with personalized professional growth.To Collaborators: I believe in "convening power." Through IPSERC (co-convened with Patrick Kwan, MD, Monash University), I foster an environment where multidisciplinary experts from genomics, neurology, and neuro-critical care work together to solve the field’s most complex recovery challenges. Vision for the Future I am working toward a world where post-stroke epilepsy is preventable and where a patient's cultural background is leveraged as a medical tool for recovery. I invite you to join me in this mission to protect the brain, one patient and one discovery at a time.

Dr. Misra is a Postdoctoral Associate in the Department of Neurology at Yale University School of Medicine. He is a clinical researcher with an avid interest in biomarker discovery and outcomes research in neurological disorders. He is serving as a member of the COVID-19 global forum in the Brain Health Unit of the World Health Organization. He is also the Guest Editor at Frontiers in Neurology, where he is leading a research collection on omics-based approaches in stroke research. His long-term goal is to become an independent investigator and build a career in clinical biomarker discovery and data sciences. Dr. Misra obtained his Ph.D. in Neurology from the All India Institute of Medical Sciences, New Delhi, India. His thesis was aimed at determining diagnostic and prognostic biomarkers of stroke using high-throughput proteomics and machine learning approaches. He received the prestigious DST-INSPIRE Fellowship from the Department of Science and Technology, Government of India, for pursuing his doctoral studies. He completed his B. Tech and M. Tech degrees in Biotechnology from Amity University, Noida, India, and had the distinction of being the University Gold Medalist. Dr. Misra has co-authored over 50 peer-reviewed research publications, including first-author articles in leading journals such as JAMA Neurology, Neurology, the European Journal of Neurology, and the International Journal of Stroke. His work has been cited more than 1,000 times. He took a 2-hour lecture on "Proteomics data analysis in R" at the peer-to-peer teaching sessions organized by the Bioinformatics Support Hub in the Cushing/Whitney Medical Library at Yale School of Medicine. Dr. Misra is a recipient of the Young Investigator Award from the World Stroke Organization for his contributions to the field of stroke research. He is open to research collaborations on research topics, including: Biomarker research in strokeProteomics data analysisEvidence synthesis through systematic reviews and meta-analysesClinical trials in stroke For research collaborations, reach out to Dr. Misra at shubham.misra@yale.edu. For more details regarding his academic interests, please visit his website at https://sites.google.com/view/shubham-misra.