Menon Lab

2026

APOL1-risk alleles modulate T-cell receptor signaling to promote allograft rejection
Pell J, Tanvir E, Sun Z, Chernova I, Reghuvaran A, Nagata S, Guerra M, Choi J, Al Chaar S, Mizuno H, Dong K, Tian X, Ishibe R, Franchin B, Cravedi P, Kumar A, Barsotti G, Shi H, De Kumar B, Smithson S, Song W, He J, Chong A, Pober J, Somlo S, Gibson I, Popik W, Zhang Z, Craft J, Azzi J, Murakami N, Ishibe S, Heeger P, Menon M. APOL1-risk alleles modulate T-cell receptor signaling to promote allograft rejection. Journal Of Clinical Investigation 2026 PMID: 42262888, DOI: 10.1172/jci193173.
Peer-Reviewed Original Research
Quantifying donor-recipient mismatches using recipient-derived sources of donor DNA
Quantifying donor-recipient mismatches using recipient-derived sources of donor DNA Nallakkandi Rajeevan, Gabriel Caldato Barsotti, Ashwani Kumar, Zeguo Sun, Anand Reghuvaran, Irina Tikhonova, E M Tanvir, Niketa Sareen, Ashley Swan, Richard Formica, Caleigh Mandel-Brehm, Arundati Rao, Whitney Besse, Maureen Miller, Laurine Bow, Bony De Kumar, Madhav C Menon medRxiv 2026.06.01.26354606; doi: https://doi.org/10.64898/2026.06.01.26354606
Peer-Reviewed Original Research
Concurrent Manifestation of Crescentic Anti-glomerular Basement Membrane Nephritis and Membranous Nephropathy
Vellaisamy G, Kumar A, Singh J, Nada R. Concurrent Manifestation of Crescentic Anti-glomerular Basement Membrane Nephritis and Membranous Nephropathy. Indian Journal Of Kidney Diseases 2026, 5: 123-126. DOI: 10.4103/ijkd.ijkd_6_26.
Peer-Reviewed Original Research
Begin at the beginning: serum TNFa in brain dead donors as a biomarker for kidney transplant outcomes
Qian L, Heeger P, Menon M. Begin at the beginning: serum TNFa in brain dead donors as a biomarker for kidney transplant outcomes. American Journal Of Transplantation 2026 PMID: 41724434, DOI: 10.1016/j.ajt.2026.02.023.
Commentaries, Editorials and Letters

2025

Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction
Reghuvaran, A., Kumar, A., Lin, Q. et al. Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction. Nat Commun (2025). https://doi.org/10.1038/s41467-025-67854-7
Peer-Reviewed Original Research
Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction
Reghuvaran A, Kumar A, Lin Q, Rajeevan N, Banu K, Sun Z, Shi H, Barsotti G, Tanvir E, Pell J, Perincheri S, Wei C, Bharathan B, Planoutene M, Eichmann A, Mas V, Zhang W, Cantley L, Xu L, Das B, He J, Menon M. Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction. Nature Communications 2025, 17: 1086. PMID: 41469391, PMCID: PMC12852734, DOI: 10.1038/s41467-025-67854-7.
Peer-Reviewed Original Research
MeSH Keywords
Mechanisms of Podocyte Injury in Kidney Allografts
Barsotti, Gabriel C.1; Menon, Madhav C.1; Naik, Abhijit2; Rao, Arundati1,a. Mechanisms of Podocyte Injury in Kidney Allografts. Kidney360 ():10.34067/KID.0000001091, December 05, 2025. | DOI: 10.34067/KID.0000001091
Peer-Reviewed Original Research
Mechanisms of Podocyte Injury in Kidney Allografts
Barsotti G, Menon M, Naik A, Rao A. Mechanisms of Podocyte Injury in Kidney Allografts. Kidney360 2025, 7: 1405-1415. PMID: 41348483, DOI: 10.34067/kid.0000001091.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Design and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx
Design and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx Ashwani Kumar, Gabriel Caldato Barsotti, Zhengzi Yi, Zeguo Sun, Anand Reghuvaran, EM Tanvir, John Pell, Hongmei Shi, Sudhir Perincheri, Melissa Shaw, Candice Kent, Daris Javed, Petra Leite, Deepa Jayaram, Jeffrey Turner, Kristin Meliambro, Randy Luciano, John He, Dennis Moledina, Francis P Wilson, Weijia Zhang, Madhav C Menon medRxiv 2025.10.31.25338655; doi: https://doi.org/10.1101/2025.10.31.25338655
Peer-Reviewed Original Research
Design and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx.
Kumar A, Barsotti G, Yi Z, Sun Z, Reghuvaran A, Tanvir EM, Pell J, Shi H, Perincheri S, Shaw M, Kent C, Javed D, Leite P, Jayaram D, Turner J, Meliambro K, Luciano R, He JC, Moledina D, Wilson P, Zhang W, Menon MC. Design and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx. MedRxiv 2025 PMID: 41282816, DOI: 10.1101/2025.10.31.25338655.
Peer-Reviewed Original Research
Immunotactoid Glomerulonephritis Unmasked From C3 Glomerulopathy: A Diagnostic Dilemma in Spectrum of MGRS
Vellaisamy G, Lad D, Ramachandran R, Kumar A, Nada R. Immunotactoid Glomerulonephritis Unmasked From C3 Glomerulopathy: A Diagnostic Dilemma in Spectrum of MGRS. Indian Journal Of Kidney Diseases 2025, 4: 149-151. DOI: 10.4103/ijkd.ijkd_29_25.
Peer-Reviewed Original Research
Vincristine in FSGS: Rediscovering an Old Therapeutic for FSGS
Kumar A, Prasad P, Menon M. Vincristine in FSGS: Rediscovering an Old Therapeutic for FSGS. Kidney International Reports 2025, 10: 3727-3729. PMID: 41278331, PMCID: PMC12640027, DOI: 10.1016/j.ekir.2025.09.018.
Commentaries, Editorials and Letters
A T-cell intrinsic Role for APOL1 Risk Alleles in Allograft Rejection
A T-cell intrinsic Role for APOL1 Risk Alleles in Allograft Rejection John Pell, EM Tanvir, Zeguo Sun, Irene Chernova, Anand Reghuvaran, Soichiro Nagata, Mateus Guerra, John Choi, Soltan Al Chaar, Hiroki Mizuno, Ke Dong, Xin Tian, Reika Ishibe, Barbara Franchin, Paolo Cravedi, Ashwani Kumar, Gabriel Barsotti, Hongmei Shi, Bony De Kumar, Wenzhi Song, Cijiang He, Jordan S Pober, Stefan Somlo, Ian W Gibson, Waldemar Popik, Zhongyang Zhang, Joseph Craft, Jamil Azzi, Naoka Murakami, Shuta Ishibe, Peter Heeger, Madhav C Menon bioRxiv 2025.07.14.664793; doi: https://doi.org/10.1101/2025.07.14.664793
Peer-Reviewed Original Research
A T-cell intrinsic Role for APOL1 Risk Alleles in Allograft Rejection.
Pell J, Tanvir EM, Sun Z, Chernova I, Reghuvaran A, Nagata S, Guerra M, Choi J, Chaar SA, Mizuno H, Dong K, Tian X, Ishibe R, Franchin B, Cravedi P, Kumar A, Barsotti G, Shi H, Kumar B, Song W, He C, Pober JS, Somlo S, Gibson IW, Popik W, Zhang Z, Craft J, Azzi J, Murakami N, Ishibe S, Heeger P, Menon MC. A T-cell intrinsic Role for APOL1 Risk Alleles in Allograft Rejection. BioRxiv 2025 PMID: 40791557, DOI: 10.1101/2025.07.14.664793.
Peer-Reviewed Original Research
Diagnosis of Fibrosis with Magnetization-Prepared Golden-angle RAdial Sparse Parallel (MP-GRASP) T1Mapping in Renal Allografts
Bane O, Feng L, Xia D, Liu M, Bolger I, Calle S, Dyke J, Menon M, Seshan S, Salvatore S, Stillman I, Muthukumar T, Farouk S, Taouli B, Lewis S. Diagnosis of Fibrosis with Magnetization-Prepared Golden-angle RAdial Sparse Parallel (MP-GRASP) T1Mapping in Renal Allografts. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/4462.
Peer-Reviewed Original Research
GALNT14 deficiency: connecting multiple links in the IgA nephropathy pathogenetic chain
Pell J, Menon M. GALNT14 deficiency: connecting multiple links in the IgA nephropathy pathogenetic chain. Journal Of Clinical Investigation 2025, 135: e192687. PMID: 40371648, PMCID: PMC12077885, DOI: 10.1172/jci192687.
Peer-Reviewed Original Research
MeSH Keywords
The Growth Hormone-IGF-1 axis is a risk factor for Long-Term Kidney Allograft Failure
Cusick M, Nair V, Fermin D, Hartman J, Beamish J, Sun Z, Zhang Z, Otto E, Menon R, Nadimidla S, Demchuk N, Shaffer K, Heeger P, Zhang W, Menon M, Kretzler M, Wiggins R, Naik A. The Growth Hormone-IGF-1 axis is a risk factor for Long-Term Kidney Allograft Failure. JCI Insight 2025, 10: e188485. PMID: 40327402, PMCID: PMC12220966, DOI: 10.1172/jci.insight.188485.
Peer-Reviewed Original Research
MeSH Keywords
Author Correction: LILRB3 genetic variation is associated with kidney transplant failure in African American recipients
Sun Z, Yi Z, Wei C, Wang W, Ren T, Cravedi P, Tedla F, Ward S, Azeloglu E, Schrider D, Li Y, Khan A, Zanoni F, Fu J, Ali S, Liu S, Liang D, Liu T, Li H, Xi C, Vy T, Mosoyan G, Sun Q, Kumar A, Zhang Z, Farouk S, Campell K, Ochando J, Lee K, Coca S, Xiang J, Connolly P, Gallon L, O’Connell P, Colvin R, Menon M, Nadkarni G, He J, Kraft M, Jiang X, Zhang X, Kiryluk K, Cherukuri A, Lakkis F, Zhang W, Chen S, Heeger P, Zhang W. Author Correction: LILRB3 genetic variation is associated with kidney transplant failure in African American recipients. Nature Medicine 2025, 31: 1712-1712. PMID: 40234733, DOI: 10.1038/s41591-025-03706-7.
Commentaries, Editorials and Letters
Focus on a CKD-Associated Locus: SHROOM3 and Other Suspects
Qian L, Reghuvaran A, Menon M. Focus on a CKD-Associated Locus: SHROOM3 and Other Suspects. Kidney International Reports 2025, 10: 1329-1331. PMID: 40485672, PMCID: PMC12142795, DOI: 10.1016/j.ekir.2025.03.037.
Commentaries, Editorials and Letters
LILRB3 genetic variation is associated with kidney transplant failure in African American recipients
Sun Z, Yi Z, Wei C, Wang W, Ren T, Cravedi P, Tedla F, Ward S, Azeloglu E, Schrider D, Li Y, Khan A, Zanoni F, Fu J, Ali S, Liu S, Liang D, Liu T, Li H, Xi C, Vy T, Mosoyan G, Sun Q, Kumar A, Zhang Z, Farouk S, Campell K, Ochando J, Lee K, Coca S, Xiang J, Connolly P, Gallon L, O’Connell P, Colvin R, Menon M, Nadkarni G, He J, Kraft M, Jiang X, Zhang X, Kiryluk K, Cherukuri A, Lakkis F, Zhang W, Chen S, Heeger P, Zhang W. LILRB3 genetic variation is associated with kidney transplant failure in African American recipients. Nature Medicine 2025, 31: 1677-1687. PMID: 40065170, PMCID: PMC12527113, DOI: 10.1038/s41591-025-03568-z.
Peer-Reviewed Original Research

2024

Shroom3-Rock interaction and profibrotic function: Resolving mechanism of an intronic CKD risk allele
Reghuvaran A, Kumar A, Lin Q, Rajeevan N, Sun Z, Shi H, Barsotti G, Tanvir EM, Pell J, Perincheri S, Wei C, Planoutene M, Eichmann A, Mas V, Zhang W, Das B, Cantley L, Xu L, He CJ, Menon MC. Shroom3-Rock interaction and profibrotic function: Resolving mechanism of an intronic CKD risk allele. bioRxiv [Preprint]. 2024 Nov 23:2024.11.22.624409. doi: 10.1101/2024.11.22.624409. PMID: 39605692; PMCID: PMC11601673.
Peer-Reviewed Original Research In Press
Re-Evaluating the Transplant Glomerulopathy Lesion—Beyond Donor-Specific Antibodies
Chutani A, Guevara-Pineda D, Lerner G, Menon M. Re-Evaluating the Transplant Glomerulopathy Lesion—Beyond Donor-Specific Antibodies. Transplant International 2024, 37: 13365. PMID: 39640250, PMCID: PMC11617188, DOI: 10.3389/ti.2024.13365.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Genetic ancestry, proportion of African ancestry, and apolipoprotein L1 risk variants in kidney recipients
Zhang Z, Sun Z, Heeger P, Menon M. Genetic ancestry, proportion of African ancestry, and apolipoprotein L1 risk variants in kidney recipients. American Journal Of Transplantation 2024, 24: 1710-1712. PMID: 38734416, PMCID: PMC12124478, DOI: 10.1016/j.ajt.2024.05.004.
Commentaries, Editorials and Letters
Clinical Characteristics and Outcomes of Neural Epidermal Growth Factor-like 1 Protein-Associated Membranous Nephropathy
Narayanasami S, Vijayakumar N, Trivedi M, Sekar A, Sulaiman S, Nayak S, Inamdar N, Sharma S, Parthasarathy R, Kadam V, Keskar V, Bagai S, Kumar A, Reen B, Kurien A, Sharma A, Khullar D, Hafeeq B, Krishnakumar A, Rahman Kv S, Na I, Nair S, Divyaveer S, Rathi M, Kohli H, Nada R, Ramachandran R. Clinical Characteristics and Outcomes of Neural Epidermal Growth Factor-like 1 Protein-Associated Membranous Nephropathy. Kidney International Reports 2024, 9: 1513-1516. PMID: 38707806, PMCID: PMC11068952, DOI: 10.1016/j.ekir.2024.02.1405.
Peer-Reviewed Original Research
Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis
Barsotti G, Luciano R, Kumar A, Meliambro K, Kakade V, Tokita J, Naik A, Fu J, Peck E, Pell J, Reghuvaran A, Tanvir E, Patel P, Zhang W, Li F, Moeckel G, Perincheri S, Cantley L, Moledina DG, Wilson F, He J, Menon M. Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis. Kidney International Reports 2024, 9: 1354-1368. PMID: 38707807, PMCID: PMC11068976, DOI: 10.1016/j.ekir.2024.02.006.
Peer-Reviewed Original Research

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