Menon Lab

2026

Begin at the beginning: serum TNFa in brain dead donors as a biomarker for kidney transplant outcomes
Qian L, Heeger P, Menon M. Begin at the beginning: serum TNFa in brain dead donors as a biomarker for kidney transplant outcomes. American Journal Of Transplantation 2026 PMID: 41724434, DOI: 10.1016/j.ajt.2026.02.023.
Peer-Reviewed Original Research

2025

Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction
Reghuvaran, A., Kumar, A., Lin, Q. et al. Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction. Nat Commun (2025). https://doi.org/10.1038/s41467-025-67854-7
Peer-Reviewed Original Research
Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction
Reghuvaran A, Kumar A, Lin Q, Rajeevan N, Banu K, Sun Z, Shi H, Barsotti G, Tanvir E, Pell J, Perincheri S, Wei C, Bharathan B, Planoutene M, Eichmann A, Mas V, Zhang W, Cantley L, Xu L, Das B, He J, Menon M. Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction. Nature Communications 2025, 17: 1086. PMID: 41469391, PMCID: PMC12852734, DOI: 10.1038/s41467-025-67854-7.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Mechanisms of Podocyte Injury in Kidney Allografts
Barsotti, Gabriel C.1; Menon, Madhav C.1; Naik, Abhijit2; Rao, Arundati1,a. Mechanisms of Podocyte Injury in Kidney Allografts. Kidney360 ():10.34067/KID.0000001091, December 05, 2025. | DOI: 10.34067/KID.0000001091
Peer-Reviewed Original Research
Mechanisms of Podocyte Injury in Kidney Allografts.
Barsotti G, Menon M, Naik A, Rao A. Mechanisms of Podocyte Injury in Kidney Allografts. Kidney360 2025 PMID: 41348483, DOI: 10.34067/kid.0000001091.
Peer-Reviewed Original Research
Concepts
Design and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx
Design and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx Ashwani Kumar, Gabriel Caldato Barsotti, Zhengzi Yi, Zeguo Sun, Anand Reghuvaran, EM Tanvir, John Pell, Hongmei Shi, Sudhir Perincheri, Melissa Shaw, Candice Kent, Daris Javed, Petra Leite, Deepa Jayaram, Jeffrey Turner, Kristin Meliambro, Randy Luciano, John He, Dennis Moledina, Francis P Wilson, Weijia Zhang, Madhav C Menon medRxiv 2025.10.31.25338655; doi: https://doi.org/10.1101/2025.10.31.25338655
Peer-Reviewed Original Research
Design and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx.
Kumar A, Barsotti G, Yi Z, Sun Z, Reghuvaran A, Tanvir EM, Pell J, Shi H, Perincheri S, Shaw M, Kent C, Javed D, Leite P, Jayaram D, Turner J, Meliambro K, Luciano R, He JC, Moledina D, Wilson P, Zhang W, Menon MC. Design and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx. MedRxiv 2025 PMID: 41282816, DOI: 10.1101/2025.10.31.25338655.
Peer-Reviewed Original Research
APOL1 Variants Promote T Cell Excitation by Modulating Calcium (Ca2+) Signaling Downstream of T Cell Receptors (TCRs) in Graft Rejection
Pell J, Tanvir E, Sun Z, Azzi J, Murakami N, Reghuvaran A, Kumar A, Barsotti G, Ishibe S, Heeger P, Menon M. APOL1 Variants Promote T Cell Excitation by Modulating Calcium (Ca2+) Signaling Downstream of T Cell Receptors (TCRs) in Graft Rejection. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.2025kn5bktfx. DOI: 10.1681/asn.2025kn5bktfx.
Peer-Reviewed Original Research
Concepts
Predicting Risk of Acute Cellular Rejection After Belatacept Conversion
Qian L, Menon M, Cohen E, Belfield K, Wilson F, Kadhim B, Moledina D. Predicting Risk of Acute Cellular Rejection After Belatacept Conversion. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.2025tcxdcrvh. DOI: 10.1681/asn.2025tcxdcrvh.
Peer-Reviewed Original Research
Urine mRNA Assay to Measure Compartment-Specific Kidney Injury
Barsotti G, Kumar A, Yi Z, Pell J, Tanvir E, Moledina D, Luciano R, Reghuvaran A, Meliambro K, Perincheri S, Zhang W, He J, Menon M. Urine mRNA Assay to Measure Compartment-Specific Kidney Injury. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.2025c7mvzqgd. DOI: 10.1681/asn.2025c7mvzqgd.
Peer-Reviewed Original Research
Vincristine in FSGS: Rediscovering an Old Therapeutic for FSGS
Kumar A, Prasad P, Menon M. Vincristine in FSGS: Rediscovering an Old Therapeutic for FSGS. Kidney International Reports 2025, 10: 3727-3729. PMID: 41278331, PMCID: PMC12640027, DOI: 10.1016/j.ekir.2025.09.018.
Peer-Reviewed Original Research
A T Cell Intrinsic Role for APOL1 Risk Alleles in Allograft Rejection
Pell J, Tanvir E, Sun Z, Reghuvaran A, Guerra M, Mizuno H, Kumar A, Zhang W, Azzi J, Murakami N, Ishibe S, Heeger P, Menon M. A T Cell Intrinsic Role for APOL1 Risk Alleles in Allograft Rejection. American Journal Of Transplantation 2025, 25: s91-s92. DOI: 10.1016/j.ajt.2025.07.188.
Peer-Reviewed Original Research
Role of GCC2 in T Cell Mediated Allograft Rejection in Mice
Tanvir E, Pell J, Reghuvaran A, Kumar A, Qin L, Mandel-Brahm C, Tellides G, Menon M. Role of GCC2 in T Cell Mediated Allograft Rejection in Mice. American Journal Of Transplantation 2025, 25: s875-s876. DOI: 10.1016/j.ajt.2025.07.2079.
Peer-Reviewed Original Research
A T-cell intrinsic Role for APOL1 Risk Alleles in Allograft Rejection
A T-cell intrinsic Role for APOL1 Risk Alleles in Allograft Rejection John Pell, EM Tanvir, Zeguo Sun, Irene Chernova, Anand Reghuvaran, Soichiro Nagata, Mateus Guerra, John Choi, Soltan Al Chaar, Hiroki Mizuno, Ke Dong, Xin Tian, Reika Ishibe, Barbara Franchin, Paolo Cravedi, Ashwani Kumar, Gabriel Barsotti, Hongmei Shi, Bony De Kumar, Wenzhi Song, Cijiang He, Jordan S Pober, Stefan Somlo, Ian W Gibson, Waldemar Popik, Zhongyang Zhang, Joseph Craft, Jamil Azzi, Naoka Murakami, Shuta Ishibe, Peter Heeger, Madhav C Menon bioRxiv 2025.07.14.664793; doi: https://doi.org/10.1101/2025.07.14.664793
Peer-Reviewed Original Research
A T-cell intrinsic Role for APOL1 Risk Alleles in Allograft Rejection.
Pell J, Tanvir EM, Sun Z, Chernova I, Reghuvaran A, Nagata S, Guerra M, Choi J, Chaar SA, Mizuno H, Dong K, Tian X, Ishibe R, Franchin B, Cravedi P, Kumar A, Barsotti G, Shi H, Kumar B, Song W, He C, Pober JS, Somlo S, Gibson IW, Popik W, Zhang Z, Craft J, Azzi J, Murakami N, Ishibe S, Heeger P, Menon MC. A T-cell intrinsic Role for APOL1 Risk Alleles in Allograft Rejection. BioRxiv 2025 PMID: 40791557, DOI: 10.1101/2025.07.14.664793.
Peer-Reviewed Original Research
Diagnosis of Fibrosis with Magnetization-Prepared Golden-angle RAdial Sparse Parallel (MP-GRASP) T1Mapping in Renal Allografts
Bane O, Feng L, Xia D, Liu M, Bolger I, Calle S, Dyke J, Menon M, Seshan S, Salvatore S, Stillman I, Muthukumar T, Farouk S, Taouli B, Lewis S. Diagnosis of Fibrosis with Magnetization-Prepared Golden-angle RAdial Sparse Parallel (MP-GRASP) T1Mapping in Renal Allografts. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/4462.
Peer-Reviewed Original Research
Concepts
GALNT14 deficiency: connecting multiple links in the IgA nephropathy pathogenetic chain
Pell J, Menon M. GALNT14 deficiency: connecting multiple links in the IgA nephropathy pathogenetic chain. Journal Of Clinical Investigation 2025, 135: e192687. PMID: 40371648, PMCID: PMC12077885, DOI: 10.1172/jci192687.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
The Growth Hormone-IGF-1 axis is a risk factor for Long-Term Kidney Allograft Failure
Cusick M, Nair V, Fermin D, Hartman J, Beamish J, Sun Z, Zhang Z, Otto E, Menon R, Nadimidla S, Demchuk N, Shaffer K, Heeger P, Zhang W, Menon M, Kretzler M, Wiggins R, Naik A. The Growth Hormone-IGF-1 axis is a risk factor for Long-Term Kidney Allograft Failure. JCI Insight 2025, 10: e188485. PMID: 40327402, PMCID: PMC12220966, DOI: 10.1172/jci.insight.188485.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Author Correction: LILRB3 genetic variation is associated with kidney transplant failure in African American recipients
Sun Z, Yi Z, Wei C, Wang W, Ren T, Cravedi P, Tedla F, Ward S, Azeloglu E, Schrider D, Li Y, Khan A, Zanoni F, Fu J, Ali S, Liu S, Liang D, Liu T, Li H, Xi C, Vy T, Mosoyan G, Sun Q, Kumar A, Zhang Z, Farouk S, Campell K, Ochando J, Lee K, Coca S, Xiang J, Connolly P, Gallon L, O’Connell P, Colvin R, Menon M, Nadkarni G, He J, Kraft M, Jiang X, Zhang X, Kiryluk K, Cherukuri A, Lakkis F, Zhang W, Chen S, Heeger P, Zhang W. Author Correction: LILRB3 genetic variation is associated with kidney transplant failure in African American recipients. Nature Medicine 2025, 31: 1712-1712. PMID: 40234733, DOI: 10.1038/s41591-025-03706-7.
Peer-Reviewed Original Research
Concepts
Focus on a CKD-Associated Locus: SHROOM3 and Other Suspects
Qian L, Reghuvaran A, Menon M. Focus on a CKD-Associated Locus: SHROOM3 and Other Suspects. Kidney International Reports 2025, 10: 1329-1331. PMID: 40485672, PMCID: PMC12142795, DOI: 10.1016/j.ekir.2025.03.037.
Peer-Reviewed Original Research
LILRB3 genetic variation is associated with kidney transplant failure in African American recipients
Sun Z, Yi Z, Wei C, Wang W, Ren T, Cravedi P, Tedla F, Ward S, Azeloglu E, Schrider D, Li Y, Khan A, Zanoni F, Fu J, Ali S, Liu S, Liang D, Liu T, Li H, Xi C, Vy T, Mosoyan G, Sun Q, Kumar A, Zhang Z, Farouk S, Campell K, Ochando J, Lee K, Coca S, Xiang J, Connolly P, Gallon L, O’Connell P, Colvin R, Menon M, Nadkarni G, He J, Kraft M, Jiang X, Zhang X, Kiryluk K, Cherukuri A, Lakkis F, Zhang W, Chen S, Heeger P, Zhang W. LILRB3 genetic variation is associated with kidney transplant failure in African American recipients. Nature Medicine 2025, 31: 1677-1687. PMID: 40065170, PMCID: PMC12527113, DOI: 10.1038/s41591-025-03568-z.
Peer-Reviewed Original Research
Concepts

2024

Shroom3-Rock interaction and profibrotic function: Resolving mechanism of an intronic CKD risk allele
Reghuvaran A, Kumar A, Lin Q, Rajeevan N, Sun Z, Shi H, Barsotti G, Tanvir EM, Pell J, Perincheri S, Wei C, Planoutene M, Eichmann A, Mas V, Zhang W, Das B, Cantley L, Xu L, He CJ, Menon MC. Shroom3-Rock interaction and profibrotic function: Resolving mechanism of an intronic CKD risk allele. bioRxiv [Preprint]. 2024 Nov 23:2024.11.22.624409. doi: 10.1101/2024.11.22.624409. PMID: 39605692; PMCID: PMC11601673.
Peer-Reviewed Original Research In Press
Re-Evaluating the Transplant Glomerulopathy Lesion—Beyond Donor-Specific Antibodies
Chutani A, Guevara-Pineda D, Lerner G, Menon M. Re-Evaluating the Transplant Glomerulopathy Lesion—Beyond Donor-Specific Antibodies. Transplant International 2024, 37: 13365. PMID: 39640250, PMCID: PMC11617188, DOI: 10.3389/ti.2024.13365.
Peer-Reviewed Original Research
Concepts
Shroom3-Rock Interaction and Profibrotic Function: Resolving the Mechanism of a CKD Genome-Wide Association Study Risk Allele
Reghuvaran A, Kumar A, Barsotti G, Pell J, Tanvir E, He J, Menon M. Shroom3-Rock Interaction and Profibrotic Function: Resolving the Mechanism of a CKD Genome-Wide Association Study Risk Allele. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024qmq3drgr. DOI: 10.1681/asn.2024qmq3drgr.
Peer-Reviewed Original Research
Concepts
eGFR Variability in Heart Failure Patients with CardioMEMS Monitoring
Ullman L, Beaudry P, Barsotti G, Turner J. eGFR Variability in Heart Failure Patients with CardioMEMS Monitoring. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024wswzg8bh. DOI: 10.1681/asn.2024wswzg8bh.
Peer-Reviewed Original Research

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