Menon Lab

2025

Mechanisms of Podocyte Injury in Kidney Allografts
Barsotti, Gabriel C.1; Menon, Madhav C.1; Naik, Abhijit2; Rao, Arundati1,a. Mechanisms of Podocyte Injury in Kidney Allografts. Kidney360 ():10.34067/KID.0000001091, December 05, 2025. | DOI: 10.34067/KID.0000001091
Peer-Reviewed Original Research
Design and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx
Design and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx Ashwani Kumar, Gabriel Caldato Barsotti, Zhengzi Yi, Zeguo Sun, Anand Reghuvaran, EM Tanvir, John Pell, Hongmei Shi, Sudhir Perincheri, Melissa Shaw, Candice Kent, Daris Javed, Petra Leite, Deepa Jayaram, Jeffrey Turner, Kristin Meliambro, Randy Luciano, John He, Dennis Moledina, Francis P Wilson, Weijia Zhang, Madhav C Menon medRxiv 2025.10.31.25338655; doi: https://doi.org/10.1101/2025.10.31.25338655
Peer-Reviewed Original Research
Vincristine in FSGS: rediscovering an old therapeutic for FSGS
Kumar A, Prasad P, Menon M. Vincristine in FSGS: rediscovering an old therapeutic for FSGS. Kidney International Reports 2025 DOI: 10.1016/j.ekir.2025.09.018.
Peer-Reviewed Original Research
A T Cell Intrinsic Role for APOL1 Risk Alleles in Allograft Rejection
Pell J, Tanvir E, Sun Z, Reghuvaran A, Guerra M, Mizuno H, Kumar A, Zhang W, Azzi J, Murakami N, Ishibe S, Heeger P, Menon M. A T Cell Intrinsic Role for APOL1 Risk Alleles in Allograft Rejection. American Journal Of Transplantation 2025, 25: s91-s92. DOI: 10.1016/j.ajt.2025.07.188.
Peer-Reviewed Original Research
Role of GCC2 in T Cell Mediated Allograft Rejection in Mice
Tanvir E, Pell J, Reghuvaran A, Kumar A, Qin L, Mandel-Brahm C, Tellides G, Menon M. Role of GCC2 in T Cell Mediated Allograft Rejection in Mice. American Journal Of Transplantation 2025, 25: s875-s876. DOI: 10.1016/j.ajt.2025.07.2079.
Peer-Reviewed Original Research
A T-cell intrinsic Role for APOL1 Risk Alleles in Allograft Rejection
A T-cell intrinsic Role for APOL1 Risk Alleles in Allograft Rejection John Pell, EM Tanvir, Zeguo Sun, Irene Chernova, Anand Reghuvaran, Soichiro Nagata, Mateus Guerra, John Choi, Soltan Al Chaar, Hiroki Mizuno, Ke Dong, Xin Tian, Reika Ishibe, Barbara Franchin, Paolo Cravedi, Ashwani Kumar, Gabriel Barsotti, Hongmei Shi, Bony De Kumar, Wenzhi Song, Cijiang He, Jordan S Pober, Stefan Somlo, Ian W Gibson, Waldemar Popik, Zhongyang Zhang, Joseph Craft, Jamil Azzi, Naoka Murakami, Shuta Ishibe, Peter Heeger, Madhav C Menon bioRxiv 2025.07.14.664793; doi: https://doi.org/10.1101/2025.07.14.664793
Peer-Reviewed Original Research
Diagnosis of Fibrosis with Magnetization-Prepared Golden-angle RAdial Sparse Parallel (MP-GRASP) T1Mapping in Renal Allografts
Bane O, Feng L, Xia D, Liu M, Bolger I, Calle S, Dyke J, Menon M, Seshan S, Salvatore S, Stillman I, Muthukumar T, Farouk S, Taouli B, Lewis S. Diagnosis of Fibrosis with Magnetization-Prepared Golden-angle RAdial Sparse Parallel (MP-GRASP) T1Mapping in Renal Allografts. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/4462.
Peer-Reviewed Original Research
Concepts
GALNT14 deficiency: connecting multiple links in the IgA nephropathy pathogenetic chain
Pell J, Menon M. GALNT14 deficiency: connecting multiple links in the IgA nephropathy pathogenetic chain. Journal Of Clinical Investigation 2025, 135: e192687. PMID: 40371648, PMCID: PMC12077885, DOI: 10.1172/jci192687.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
The Growth Hormone-IGF-1 axis is a risk factor for Long-Term Kidney Allograft Failure
Cusick M, Nair V, Fermin D, Hartman J, Beamish J, Sun Z, Zhang Z, Otto E, Menon R, Nadimidla S, Demchuk N, Shaffer K, Heeger P, Zhang W, Menon M, Kretzler M, Wiggins R, Naik A. The Growth Hormone-IGF-1 axis is a risk factor for Long-Term Kidney Allograft Failure. JCI Insight 2025, 10: e188485. PMID: 40327402, PMCID: PMC12220966, DOI: 10.1172/jci.insight.188485.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Author Correction: LILRB3 genetic variation is associated with kidney transplant failure in African American recipients
Sun Z, Yi Z, Wei C, Wang W, Ren T, Cravedi P, Tedla F, Ward S, Azeloglu E, Schrider D, Li Y, Khan A, Zanoni F, Fu J, Ali S, Liu S, Liang D, Liu T, Li H, Xi C, Vy T, Mosoyan G, Sun Q, Kumar A, Zhang Z, Farouk S, Campell K, Ochando J, Lee K, Coca S, Xiang J, Connolly P, Gallon L, O’Connell P, Colvin R, Menon M, Nadkarni G, He J, Kraft M, Jiang X, Zhang X, Kiryluk K, Cherukuri A, Lakkis F, Zhang W, Chen S, Heeger P, Zhang W. Author Correction: LILRB3 genetic variation is associated with kidney transplant failure in African American recipients. Nature Medicine 2025, 31: 1712-1712. PMID: 40234733, DOI: 10.1038/s41591-025-03706-7.
Peer-Reviewed Original Research
Concepts
Focus on a CKD-Associated Locus: SHROOM3 and Other Suspects
Qian L, Reghuvaran A, Menon M. Focus on a CKD-Associated Locus: SHROOM3 and Other Suspects. Kidney International Reports 2025, 10: 1329-1331. PMID: 40485672, PMCID: PMC12142795, DOI: 10.1016/j.ekir.2025.03.037.
Peer-Reviewed Original Research
LILRB3 genetic variation is associated with kidney transplant failure in African American recipients
Sun Z, Yi Z, Wei C, Wang W, Ren T, Cravedi P, Tedla F, Ward S, Azeloglu E, Schrider D, Li Y, Khan A, Zanoni F, Fu J, Ali S, Liu S, Liang D, Liu T, Li H, Xi C, Vy T, Mosoyan G, Sun Q, Kumar A, Zhang Z, Farouk S, Campell K, Ochando J, Lee K, Coca S, Xiang J, Connolly P, Gallon L, O’Connell P, Colvin R, Menon M, Nadkarni G, He J, Kraft M, Jiang X, Zhang X, Kiryluk K, Cherukuri A, Lakkis F, Zhang W, Chen S, Heeger P, Zhang W. LILRB3 genetic variation is associated with kidney transplant failure in African American recipients. Nature Medicine 2025, 31: 1677-1687. PMID: 40065170, DOI: 10.1038/s41591-025-03568-z.
Peer-Reviewed Original Research
Concepts

2024

Shroom3-Rock interaction and profibrotic function: Resolving mechanism of an intronic CKD risk allele
Reghuvaran A, Kumar A, Lin Q, Rajeevan N, Sun Z, Shi H, Barsotti G, Tanvir EM, Pell J, Perincheri S, Wei C, Planoutene M, Eichmann A, Mas V, Zhang W, Das B, Cantley L, Xu L, He CJ, Menon MC. Shroom3-Rock interaction and profibrotic function: Resolving mechanism of an intronic CKD risk allele. bioRxiv [Preprint]. 2024 Nov 23:2024.11.22.624409. doi: 10.1101/2024.11.22.624409. PMID: 39605692; PMCID: PMC11601673.
Peer-Reviewed Original Research In Press
Re-Evaluating the Transplant Glomerulopathy Lesion—Beyond Donor-Specific Antibodies
Chutani A, Guevara-Pineda D, Lerner G, Menon M. Re-Evaluating the Transplant Glomerulopathy Lesion—Beyond Donor-Specific Antibodies. Transplant International 2024, 37: 13365. PMID: 39640250, PMCID: PMC11617188, DOI: 10.3389/ti.2024.13365.
Peer-Reviewed Original Research
Concepts
Shroom3-Rock Interaction and Profibrotic Function: Resolving the Mechanism of a CKD Genome-Wide Association Study Risk Allele
Reghuvaran A, Kumar A, Barsotti G, Pell J, Tanvir E, He J, Menon M. Shroom3-Rock Interaction and Profibrotic Function: Resolving the Mechanism of a CKD Genome-Wide Association Study Risk Allele. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024qmq3drgr. DOI: 10.1681/asn.2024qmq3drgr.
Peer-Reviewed Original Research
Concepts
Genetic ancestry, proportion of African ancestry, and apolipoprotein L1 risk variants in kidney recipients
Zhang Z, Sun Z, Heeger P, Menon M. Genetic ancestry, proportion of African ancestry, and apolipoprotein L1 risk variants in kidney recipients. American Journal Of Transplantation 2024, 24: 1710-1712. PMID: 38734416, PMCID: PMC12124478, DOI: 10.1016/j.ajt.2024.05.004.
Peer-Reviewed Original Research
Clinical Characteristics and Outcomes of Neural Epidermal Growth Factor-like 1 Protein-Associated Membranous Nephropathy
Narayanasami S, Vijayakumar N, Trivedi M, Sekar A, Sulaiman S, Nayak S, Inamdar N, Sharma S, Parthasarathy R, Kadam V, Keskar V, Bagai S, Kumar A, Reen B, Kurien A, Sharma A, Khullar D, Hafeeq B, Krishnakumar A, Rahman Kv S, Na I, Nair S, Divyaveer S, Rathi M, Kohli H, Nada R, Ramachandran R. Clinical Characteristics and Outcomes of Neural Epidermal Growth Factor-like 1 Protein-Associated Membranous Nephropathy. Kidney International Reports 2024, 9: 1513-1516. PMID: 38707806, PMCID: PMC11068952, DOI: 10.1016/j.ekir.2024.02.1405.
Peer-Reviewed Original Research
Concepts
Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis
Barsotti G, Luciano R, Kumar A, Meliambro K, Kakade V, Tokita J, Naik A, Fu J, Peck E, Pell J, Reghuvaran A, Tanvir E, Patel P, Zhang W, Li F, Moeckel G, Perincheri S, Cantley L, Moledina D, Wilson F, He J, Menon M. Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis. Kidney International Reports 2024, 9: 1354-1368. PMID: 38707807, PMCID: PMC11068976, DOI: 10.1016/j.ekir.2024.02.006.
Peer-Reviewed Original Research
Concepts
Advancing mouse models for transplantation research
Cravedi P, Riella L, Ford M, Valujskikh A, Menon M, Kirk A, Alegre M, Alessandrini A, Feng S, Kehn P, Najafian N, Hancock W, Heeger P, Maltzman J, Mannon R, Nadig S, Odim J, Turnquist H, Shaw J, West L, Luo X, Chong A, Bromberg J, group A. Advancing mouse models for transplantation research. American Journal Of Transplantation 2024, 24: 1362-1368. PMID: 38219866, PMCID: PMC11239793, DOI: 10.1016/j.ajt.2024.01.006.
Peer-Reviewed Original Research
Concepts
Rationale and Design of a Phase 2, Double-blind, Placebo-controlled, Randomized Trial Evaluating AMPK-activation by Metformin in Focal Segmental Glomerulosclerosis
Gabriel C. Barsotti, Randy Luciano, Ashwani Kumar, Kristin Meliambro, Vijayakumar Kakade, Joji Tokita, Abhijit Naik, Jia Fu, Elizabeth Peck, John Pell, Anand Reghuvaran, E.M. Tanvir, Prashant Patel, Weijia Zhang, Fan Li, Gilbert Moeckel, Sudhir Perincheri, Lloyd Cantley, Dennis G. Moledina, F. Perry-Wilson, John C. He, Madhav C. Menon, Rationale and Design of a of a Phase 2, Double-blind, Placebo-controlled, Randomized Trial Evaluating AMPK-activation by Metformin in Focal Segmental Glomerulosclerosis, Kidney International Reports, 2024, , ISSN 2468-0249, https://doi.org/10.1016/j.ekir.2024.02.006. (https://www.sciencedirect.com/science/article/pii/S2468024924000950)
Peer-Reviewed Original Research In Press

2023

See All Publications

Menon Lab

2025

Mechanisms of Podocyte Injury in Kidney Allografts

Design and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx

Vincristine in FSGS: rediscovering an old therapeutic for FSGS

A T Cell Intrinsic Role for APOL1 Risk Alleles in Allograft Rejection

Role of GCC2 in T Cell Mediated Allograft Rejection in Mice

A T-cell intrinsic Role for APOL1 Risk Alleles in Allograft Rejection

Diagnosis of Fibrosis with Magnetization-Prepared Golden-angle RAdial Sparse Parallel (MP-GRASP) T1Mapping in Renal Allografts

GALNT14 deficiency: connecting multiple links in the IgA nephropathy pathogenetic chain

The Growth Hormone-IGF-1 axis is a risk factor for Long-Term Kidney Allograft Failure

Author Correction: LILRB3 genetic variation is associated with kidney transplant failure in African American recipients

Focus on a CKD-Associated Locus: SHROOM3 and Other Suspects

LILRB3 genetic variation is associated with kidney transplant failure in African American recipients

2024

Shroom3-Rock interaction and profibrotic function: Resolving mechanism of an intronic CKD risk allele

Re-Evaluating the Transplant Glomerulopathy Lesion—Beyond Donor-Specific Antibodies

Shroom3-Rock Interaction and Profibrotic Function: Resolving the Mechanism of a CKD Genome-Wide Association Study Risk Allele

Genetic ancestry, proportion of African ancestry, and apolipoprotein L1 risk variants in kidney recipients

Clinical Characteristics and Outcomes of Neural Epidermal Growth Factor-like 1 Protein-Associated Membranous Nephropathy

Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis

Advancing mouse models for transplantation research

Rationale and Design of a Phase 2, Double-blind, Placebo-controlled, Randomized Trial Evaluating AMPK-activation by Metformin in Focal Segmental Glomerulosclerosis

2023

Profilin1 is required to prevent mitotic catastrophe in murine and human glomerular diseases

A large-scale retrospective study enabled deep-learning based pathological assessment of frozen procurement kidney biopsies to predict graft loss and guide organ utilization

Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 mismatches associated with kidney transplant survival

Nonpodocyte Roles of APOL1 Variants: An Evolving Paradigm

Relationships between growth indicators, liver and kidney function markers, and blood concentrations of essential and potentially toxic elements in environmentally exposed young children.