Research
The Magid-Bernstein Lab studies the relationship between inflammation and outcomes after hemorrhagic stroke. We use multiplex assays to measure a panel of inflammatory markers and sequencing techniques to investigate presence of immune cells within cerebrospinal fluid collected from patients with external ventricular drains placed after hemorrhagic stroke. For patients with aneurysmal subarachnoid hemorrhage and those with intracerebral hemorrhage, we study whether central nervous system inflammation is associated with post-hemorrhagic hydrocephalus and neurologic outcomes. Additionally, for patients with aneurysmal subarachnoid hemorrhage, we analyze whether certain inflammatory markers are associated with complications, including vasospasm and delayed cerebral ischemia. Our goal is to understand whether immunomodulatory medications that target certain inflammatory markers can be employed in the future to prevent complications and improve outcomes in these patients.
Heat maps of cytokine concentrations in CSF vs. plasma Heat maps show first sample collected from hemorrhagic stroke patients (1-3 days after ictus) and CSF samples collected from control patients. Cytokines shown above were present in higher concentrations in the CSF compared to the plasma following hemorrhagic stroke.
Mechanisms of Injury after Intracerebral Hemorrhage Figure published in Circulation Research, doi: 10.1161/CIRCRESAHA.121.319949
Model of the relationship between CNS inflammation and shunt-dependent hydrocephalus Overview of Sample Collection and Analysis Heat maps of cytokine concentrations in CSF vs. plasma Heat maps show first sample collected from hemorrhagic stroke patients (1-3 days after ictus) and CSF samples collected from control patients. Cytokines shown above were present in higher concentrations in the CSF compared to the plasma following hemorrhagic stroke.
Mechanisms of Injury after Intracerebral Hemorrhage Figure published in Circulation Research, doi: 10.1161/CIRCRESAHA.121.319949
Model of the relationship between CNS inflammation and shunt-dependent hydrocephalus Overview of Sample Collection and Analysis Heat maps of cytokine concentrations in CSF vs. plasma Heat maps show first sample collected from hemorrhagic stroke patients (1-3 days after ictus) and CSF samples collected from control patients. Cytokines shown above were present in higher concentrations in the CSF compared to the plasma following hemorrhagic stroke.
Mechanisms of Injury after Intracerebral Hemorrhage Figure published in Circulation Research, doi: 10.1161/CIRCRESAHA.121.319949
Model of the relationship between CNS inflammation and shunt-dependent hydrocephalus Overview of Sample Collection and Analysis