Research

The Magid-Bernstein Lab studies the relationship between inflammation and outcomes after hemorrhagic stroke. We use multiplex assays to measure a panel of inflammatory markers and sequencing techniques to investigate presence of immune cells within cerebrospinal fluid collected from patients with external ventricular drains placed after hemorrhagic stroke. For patients with aneurysmal subarachnoid hemorrhage and those with intracerebral hemorrhage, we study whether central nervous system inflammation is associated with post-hemorrhagic hydrocephalus and neurologic outcomes. Additionally, for patients with aneurysmal subarachnoid hemorrhage, we analyze whether certain inflammatory markers are associated with complications, including vasospasm and delayed cerebral ischemia. Our goal is to understand whether immunomodulatory medications that target certain inflammatory markers can be employed in the future to prevent complications and improve outcomes in these patients.