Publications

Selected STEP Publications

Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain.Dedek A, Xu J, Lorenzo LÉ, Godin AG, Kandegedara CM, Glavina G, Landrigan JA, Lombroso PJ, De Koninck Y, Tsai EC, Hildebrand ME. Brain. 2022 Apr 29. PMID: 35323848.
Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP).Lambert LJ, Grotegut S, Celeridad M, Gosalia P, Backer LJ, Bobkov AA, Salaniwal S, Chung TD, Zeng FY, Pass I, Lombroso PJ, Cosford ND, Tautz L. Int J Mol Sci. 2021 Apr 23; 2021 Apr 23. PMID: 33922601.
STEP inhibition prevents Aβ-mediated damage in dendritic complexity and spine density in Alzheimer's disease.Chatterjee M, Kwon J, Benedict J, Kamceva M, Kurup P, Lombroso PJ. Exp Brain Res. 2021 Mar; 2021 Jan 9. PMID: 33420799.
Inhibition of striatal-enriched protein tyrosine phosphatase (STEP) activity reverses behavioral deficits in a rodent model of autism.Chatterjee M, Singh P, Xu J, Lombroso PJ, Kurup PK. Behav Brain Res. 2020 Aug 5; 2020 May 24. PMID: 32461127.
The activity of the Striatal-enriched protein tyrosine phosphatase in neuronal cells is modulated by adenosine A(2A) receptor.Mallozzi C, Pepponi R, Visentin S, Chiodi V, Lombroso PJ, Bader M, Popoli P, Domenici MR. J Neurochem. 2020 Feb; 2019 Oct 10. PMID: 31520531.
Altered Intracellular Calcium Homeostasis Underlying Enhanced Glutamatergic Transmission in Striatal-Enriched Tyrosine Phosphatase (STEP) Knockout Mice.Bosco F, Valente P, Milanese M, Piccini A, Messa M, Bonanno G, Lombroso P, Baldelli P, Benfenati F, Giovedì S. Mol Neurobiol. 2018 Oct; 2018 Mar 5. PMID: 29508281.
The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline.Castonguay D, Dufort-Gervais J, Ménard C, Chatterjee M, Quirion R, Bontempi B, Schneider JS, Arnsten AFT, Nairn AC, Norris CM, Ferland G, Bézard E, Gaudreau P, Lombroso PJ, Brouillette J. Curr Biol. 2018 Apr 2; 2018 Mar 22. PMID: 29576474.
Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP(61).Xu J, Kurup P, Nairn AC, Lombroso PJ. Mol Neurobiol. 2018 Apr; 2017 May 2. PMID: 28466270.
STEP inhibition reverses behavioral, electrophysiologic, and synaptic abnormalities in Fmr1 KO mice.Chatterjee M, Kurup PK, Lundbye CJ, Hugger Toft AK, Kwon J, Benedict J, Kamceva M, Banke TG, Lombroso PJ. Neuropharmacology. 2018 Jan; 2017 Sep 21. PMID: 28943283.
Intra-prelimbic cortical inhibition of striatal-enriched tyrosine phosphatase suppresses cocaine seeking in rats.Siemsen BM, Lombroso PJ, McGinty JF. Addict Biol. 2018 Jan; 2017 Mar 28. PMID: 28349660.
Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases.Tjin CC, Otley KD, Baguley TD, Kurup P, Xu J, Nairn AC, Lombroso PJ, Ellman JA. ACS Cent Sci. 2017 Dec 27; 2017 Dec 6. PMID: 29296673.
X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.Witten MR, Wissler L, Snow M, Geschwindner S, Read JA, Brandon NJ, Nairn AC, Lombroso PJ, Käck H, Ellman JA. J Med Chem. 2017 Nov 22; 2017 Nov 8. PMID: 29116812.
Molecular underpinnings of neurodegenerative disorders: striatal-enriched protein tyrosine phosphatase signaling and synaptic plasticity.Lombroso PJ, Ogren M, Kurup P, Nairn AC. F1000Res. 2016; 2016 Dec 29. PMID: 29098072.
STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit.Tian M, Xu J, Lei G, Lombroso PJ, Jackson MF, MacDonald JF. Sci Rep. 2016 Nov 18; 2016 Nov 18. PMID: 27857196.
BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome.Saavedra A, Puigdellívol M, Tyebji S, Kurup P, Xu J, Ginés S, Alberch J, Lombroso PJ, Pérez-Navarro E. Mol Neurobiol. 2016 Aug; 2015 Jul 30. PMID: 26223799.
Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice.Xu J, Kurup P, Baguley TD, Foscue E, Ellman JA, Nairn AC, Lombroso PJ. Cell Mol Life Sci. 2016 Apr; 2015 Oct 8. PMID: 26450419.
Striatal-enriched protein tyrosine phosphatase modulates nociception: evidence from genetic deletion and pharmacological inhibition.Azkona G, Saavedra A, Aira Z, Aluja D, Xifró X, Baguley T, Alberch J, Ellman JA, Lombroso PJ, Azkue JJ, Pérez-Navarro E. Pain. 2016 Feb. PMID: 26270590.
Role of Striatal-Enriched Tyrosine Phosphatase in Neuronal Function.Kamceva M, Benedict J, Nairn AC, Lombroso PJ. Neural Plast. 2016; 2016 Apr 12. PMID: 27190655.
Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61 ) levels.Xu J, Kurup P, Azkona G, Baguley TD, Saavedra A, Nairn AC, Ellman JA, Pérez-Navarro E, Lombroso PJ. J Neurochem. 2016 Jan; 2015 Sep 17. PMID: 26316048.
Striatal-enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway.Xu J, Kurup P, Foscue E, Lombroso PJ. J Neurochem. 2015 Aug; 2015 May 25. PMID: 25951993.
Striatal-enriched protein tyrosine phosphatase controls responses to aversive stimuli: implication for ethanol drinking.Legastelois R, Darcq E, Wegner SA, Lombroso PJ, Ron D. PLoS One. 2015; 2015 May 20. PMID: 25992601.
Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP.Baguley TD, Nairn AC, Lombroso PJ, Ellman JA. Bioorg Med Chem Lett. 2015 Mar 1; 2015 Jan 20. PMID: 25666825.
STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease.Kurup PK, Xu J, Videira RA, Ononenyi C, Baltazar G, Lombroso PJ, Nairn AC. Proc Natl Acad Sci U S A. 2015 Jan 27; 2015 Jan 12. PMID: 25583483.
Disruption of striatal-enriched protein tyrosine phosphatase (STEP) function in neuropsychiatric disorders.Karasawa T, Lombroso PJ. Neurosci Res. 2014 Dec; 2014 Sep 10. PMID: 25218562.
Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease.Xu J, Chatterjee M, Baguley TD, Brouillette J, Kurup P, Ghosh D, Kanyo J, Zhang Y, Seyb K, Ononenyi C, Foscue E, Anderson GM, Gresack J, Cuny GD, Glicksman MA, Greengard P, Lam TT, Tautz L, Nairn AC, Ellman JA, Lombroso PJ. PLoS Biol. 2014 Aug; 2014 Aug 5. PMID: 25093460.
Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP.Chiodi V, Mallozzi C, Ferrante A, Chen JF, Lombroso PJ, Di Stasi AM, Popoli P, Domenici MR. Neuropsychopharmacology. 2014 Feb; 2013 Aug 30. PMID: 23989619.
Neuroprotective role of a brain-enriched tyrosine phosphatase, STEP, in focal cerebral ischemia.Deb I, Manhas N, Poddar R, Rajagopal S, Allan AM, Lombroso PJ, Rosenberg GA, Candelario-Jalil E, Paul S. J Neurosci. 2013 Nov 6. PMID: 24198371.
Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase.Baguley TD, Xu HC, Chatterjee M, Nairn AC, Lombroso PJ, Ellman JA. J Med Chem. 2013 Oct 10; 2013 Oct 1. PMID: 24083656.
A common STEP in the synaptic pathology of diverse neuropsychiatric disorders.Johnson MA, Lombroso PJ. Yale J Biol Med. 2012 Dec; 2012 Dec 13. PMID: 23239949.
Striatal-enriched protein-tyrosine phosphatase (STEP) regulates Pyk2 kinase activity.Xu J, Kurup P, Bartos JA, Patriarchi T, Hell JW, Lombroso PJ. J Biol Chem. 2012 Jun 15; 2012 Apr 27. PMID: 22544749.
Striatal-enriched protein tyrosine phosphatase in Alzheimer's disease.Xu J, Kurup P, Nairn AC, Lombroso PJ. Adv Pharmacol. 2012. PMID: 22840751.
Therapeutic implications for striatal-enriched protein tyrosine phosphatase (STEP) in neuropsychiatric disorders.Goebel-Goody SM, Baum M, Paspalas CD, Fernandez SM, Carty NC, Kurup P, Lombroso PJ. Pharmacol Rev. 2012 Jan; 2011 Nov 16. PMID: 22090472.
Taking STEPs forward to understand fragile X syndrome.Goebel-Goody SM, Lombroso PJ. Results Probl Cell Differ. 2012. PMID: 22009355.
Reduced levels of the tyrosine phosphatase STEP block β amyloid-mediated GluA1/GluA2 receptor internalization.Zhang Y, Kurup P, Xu J, Anderson GM, Greengard P, Nairn AC, Lombroso PJ. J Neurochem. 2011 Nov; 2011 Sep 21. PMID: 21883219.
Striatal-enriched protein tyrosine phosphatase (STEP) knockout mice have enhanced hippocampal memory.Venkitaramani DV, Moura PJ, Picciotto MR, Lombroso PJ. Eur J Neurosci. 2011 Jun; 2011 Apr 19. PMID: 21501258.
Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model.Zhang Y, Kurup P, Xu J, Carty N, Fernandez SM, Nygaard HB, Pittenger C, Greengard P, Strittmatter SM, Nairn AC, Lombroso PJ. Proc Natl Acad Sci U S A. 2010 Nov 2; 2010 Oct 18. PMID: 20956308.
The role of STEP in Alzheimer's disease.Kurup P, Zhang Y, Venkitaramani DV, Xu J, Lombroso PJ. Channels (Austin). 2010 Sep-Oct; 2010 Sep 6. PMID: 20699650.
Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61.Kurup P, Zhang Y, Xu J, Venkitaramani DV, Haroutunian V, Greengard P, Nairn AC, Lombroso PJ. J Neurosci. 2010 Apr 28. PMID: 20427654.
Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP.Xu J, Kurup P, Zhang Y, Goebel-Goody SM, Wu PH, Hawasli AH, Baum ML, Bibb JA, Lombroso PJ. J Neurosci. 2009 Jul 22. PMID: 19625523.
A substrate trapping mutant form of striatal-enriched protein tyrosine phosphatase prevents amphetamine-induced stereotypies and long-term potentiation in the striatum.Tashev R, Moura PJ, Venkitaramani DV, Prosperetti C, Centonze D, Paul S, Lombroso PJ. Biol Psychiatry. 2009 Apr 15; 2008 Nov 20. PMID: 19026408.
Knockout of striatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation.Venkitaramani DV, Paul S, Zhang Y, Kurup P, Ding L, Tressler L, Allen M, Sacca R, Picciotto MR, Lombroso PJ. Synapse. 2009 Jan. PMID: 18932218.
The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation.Zhang Y, Venkitaramani DV, Gladding CM, Zhang Y, Kurup P, Molnar E, Collingridge GL, Lombroso PJ. J Neurosci. 2008 Oct 15. PMID: 18923032.
Translation of striatal-enriched protein tyrosine phosphatase (STEP) after beta1-adrenergic receptor stimulation.Hu Y, Zhang Y, Venkitaramani DV, Lombroso PJ. J Neurochem. 2007 Oct; 2007 Jul 10. PMID: 17623046.
The striatal-enriched protein tyrosine phosphatase gates long-term potentiation and fear memory in the lateral amygdala.Paul S, Olausson P, Venkitaramani DV, Ruchkina I, Moran TD, Tronson N, Mills E, Hakim S, Salter MW, Taylor JR, Lombroso PJ. Biol Psychiatry. 2007 May 1; 2006 Nov 1. PMID: 17081505.
NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling.Paul S, Nairn AC, Wang P, Lombroso PJ. Nat Neurosci. 2003 Jan. PMID: 12483215.
Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420.Nguyen TH, Liu J, Lombroso PJ. J Biol Chem. 2002 Jul 5; 2002 Apr 30. PMID: 11983687.

Development and Neurobiology Columns

Over the past decade, I have invited experts in the field of neuroscience to write a series of articles that were published in the Journal of the American Academy of Child and Adolescent Psychiatry. The goal of these columns was to provide the readership with an opportunity to share the excitement of neuroscience relevant to child development and psychopathology.

Disclaimer

NOTE: It was recently brought to our attention that certain individuals are trying to sell on the internet a nutritional approach to inhibit STEP activity. This nutritional approach is claimed to have "cured" the cognitive deficits in treated Alzheimer's patients. They cite our recent paper on TC-2153 and the finding that it reverses cognitive deficits in a mouse model of Alzheimer's disease. Anyone who sees this advertisement is strongly advised to question its validity, as the only experiments we have conducted to date have been on mice. There is no validity to claims that TC-2153 works in humans nor that the treatment proposed in the advertisement has any relationship to TC-2153 or to our research.