2024
S143 Traumatic Events, Chronic Pain, and Multiple Substance Use in Women With Poly-Substance Use Disorder
Fogelman N, Tate M, Wemm S, Vacey E, Bera S, Hermes G, Swain J, Fox H, Sinha R. S143 Traumatic Events, Chronic Pain, and Multiple Substance Use in Women With Poly-Substance Use Disorder. Drug And Alcohol Dependence 2024, 260: 110254. DOI: 10.1016/j.drugalcdep.2023.110254.Peer-Reviewed Original ResearchM68 Individuals With Cannabis Use Disorder Display Altered Parasympathetic HRV During Waking and Sleeping Hours Relative to Light Cannabis Users
Pearlman M, Wemm S, Pearlman M, Liston J, Sinha R. M68 Individuals With Cannabis Use Disorder Display Altered Parasympathetic HRV During Waking and Sleeping Hours Relative to Light Cannabis Users. Drug And Alcohol Dependence 2024, 260: 110348. DOI: 10.1016/j.drugalcdep.2023.110348.Peer-Reviewed Original ResearchThe effects of simultaneous alcohol and cannabis use on subjective drug effects: A narrative review across methodologies
Bedillion M, Claus E, Wemm S, Fox H, Ansell E. The effects of simultaneous alcohol and cannabis use on subjective drug effects: A narrative review across methodologies. Alcohol Clinical And Experimental Research 2024, 48: 988-999. PMID: 38641546, PMCID: PMC11238947, DOI: 10.1111/acer.15322.Peer-Reviewed Original ResearchSAM useDrug effectsNaturalistic studySimultaneous alcoholSubstance useCombined effects of alcoholSubstance use disordersEffects of alcoholSubstance use historyFrequent substance useIndividual's subjective experienceReport drinking alcoholCannabis useNaturalistic settingsImpaired cognitionCannabisNarrative reviewYoung adultsDrinking alcoholSubjective experienceRecall biasUse historyIdentifying individualsAlcoholDisordersSubstance use patterns, quantities, and associated risk factors in women with polysubstance misuse
Fogelman N, Tate M, Wemm S, Sullivan L, Hart R, Vacey E, Fox H, Sinha R. Substance use patterns, quantities, and associated risk factors in women with polysubstance misuse. Addiction Biology 2024, 29: 10.1111/adb.13390. PMID: 38619491, PMCID: PMC11017971, DOI: 10.1111/adb.13390.Peer-Reviewed Original ResearchConceptsPolysubstance useDepressive symptomsSubstance use patternsDrug cravingRisk factorsPatterns of polysubstance useSingle substance useAssociated with polysubstance usePlacebo-controlled studyHigher cravingGuanfacine treatmentCross-sectional observational studyPolysubstance use patternsCraving managementLife eventsCravingPolysubstance misuseSubstance useOpioid amountsPain ratingsStress/traumaObservational studyAnxietyPainPolysubstance
2023
Cumulative adversity and emotion dysregulation effects on suicidal ideation and attempts in a community sample
Tate M, Sinha R, Wemm S. Cumulative adversity and emotion dysregulation effects on suicidal ideation and attempts in a community sample. Journal Of Psychiatric Research 2023, 170: 277-282. PMID: 38183699, DOI: 10.1016/j.jpsychires.2023.12.029.Peer-Reviewed Original ResearchEmotion dysregulationCumulative adversityCommunity adultsLifetime traumaLife eventsSuicidal ideationNonacceptance of emotionsHigher emotion dysregulationSuicide attemptsHighest cumulative stressMajor life eventsConcurrent suicidal ideationRecent life eventsTraumatic eventsDifficult emotionsEmotional responsesLife traumaCommunity sampleTrauma historyAdversityChronic stressorsNonacceptanceSuicidal thoughtsCumulative stressEmotionsPatients with AUD exhibit dampened heart rate variability during sleep as compared to social drinkers
Wemm S, Golden M, Martins J, Fogelman N, Sinha R. Patients with AUD exhibit dampened heart rate variability during sleep as compared to social drinkers. Alcohol And Alcoholism 2023, 58: 653-661. PMID: 37756494, PMCID: PMC10642609, DOI: 10.1093/alcalc/agad061.Peer-Reviewed Original ResearchConceptsAlcohol use disorderHeart rate variabilitySocial drinkersAUD groupChronic heavy alcohol useRate variabilityLife-threatening cardiovascular diseaseHRV measuresPatient-related symptomsPatient-reported symptomsHF/LF ratioSevere alcohol use disorderNervous system processesHeavy alcohol useParasympathetic dysfunctionCardiovascular diseaseHeart rate monitoringObservational studySleep difficultiesHeart rateParasympathetic activationUse disordersRSA amplitudeCardiovascular systemDays of monitoringThe effects of impulsivity and near misses on persistence in play on a slot machine
Broussard J, Wemm S, Brock S, Wulfert E. The effects of impulsivity and near misses on persistence in play on a slot machine. International Gambling Studies 2023, 24: 113-126. DOI: 10.1080/14459795.2023.2199052.Peer-Reviewed Original Research
2022
Daily Stress Predicts Later Drinking Initiation via Craving in Heavier Social Drinkers: A Prospective In-Field Daily Diary Study
Wemm SE, Tennen H, Sinha R, Seo D. Daily Stress Predicts Later Drinking Initiation via Craving in Heavier Social Drinkers: A Prospective In-Field Daily Diary Study. Journal Of Psychopathology And Clinical Science 2022, 131: 780-792. PMID: 36048091, PMCID: PMC9561019, DOI: 10.1037/abn0000771.Peer-Reviewed Original ResearchConfinement effects on older adults using ecological momentary assessment in the U.S.
Cheong S, Black A, Wemm S. Confinement effects on older adults using ecological momentary assessment in the U.S. Journal Of Affective Disorders Reports 2022, 9: 100358. DOI: 10.1016/j.jadr.2022.100358.Peer-Reviewed Original ResearchSubjective stress and alcohol use among young adult and adult drinkers: Systematic review of studies using Intensive Longitudinal Designs
Wolkowicz N, Peltier M, Wemm S, MacLean R. Subjective stress and alcohol use among young adult and adult drinkers: Systematic review of studies using Intensive Longitudinal Designs. Drug And Alcohol Dependence Reports 2022, 3: 100039. PMID: 36845979, PMCID: PMC9949329, DOI: 10.1016/j.dadr.2022.100039.Peer-Reviewed Original ResearchIntensive longitudinal designSubjective stressAlcohol useLongitudinal designSubsequent drinkingTension-reduction modelSubsequent alcohol useStress-dampening effectsModerators/mediatorsPerson variablesAdult drinkersDrinking behaviorPersonalized interventionsConcurrent assessmentYoung adultsNaturalistic reportsPreponderance of studiesFine grain resolution
2021
Alcohol craving and withdrawal at treatment entry prospectively predict alcohol use outcomes during outpatient treatment
Martins JS, Fogelman N, Wemm S, Hwang S, Sinha R. Alcohol craving and withdrawal at treatment entry prospectively predict alcohol use outcomes during outpatient treatment. Drug And Alcohol Dependence 2021, 231: 109253. PMID: 34998258, PMCID: PMC8818273, DOI: 10.1016/j.drugalcdep.2021.109253.Peer-Reviewed Original ResearchConceptsAlcohol use outcomesAlcohol cravingTreatment entryDays/weekSleep difficultiesOutpatient treatmentAbstinence symptomsUse outcomesPre-treatment alcohol useEffects of cravingTreatment-seeking adultsAlcohol useAlcohol use disorder treatmentRelapse prevention counselingDrinking-related outcomesHeavy drinkingDrinking days/weekOutpatient AUD treatmentGreater alcoholChronic alcohol useDistress symptomsUse disorder treatmentAUD treatmentAverage drinksCravingAlcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder
Sinha R, Fogelman N, Wemm S, Angarita G, Seo D, Hermes G. Alcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder. Addiction Biology 2021, 27: e13116. PMID: 34856641, PMCID: PMC9872962, DOI: 10.1111/adb.13116.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexFunctional magnetic resonance imagingAlcohol use disorderAlcohol cuesHeavy drinking daysStudy 2Alcohol withdrawal symptomsNeutral visual imagesDrinking daysStudy 1 resultsUse disordersCortico-striatal dysfunctionAlcohol treatment outcomesAlcohol intakeFMRI sessionsResilient copingStriatal responsesPrefrontal cortexStudy 1Chronic alcohol useCorticostriatal dysfunctionStriatal functioningAUD patientsVisual imagesPlacebo treatmentNoninvasive detection of human dehydroepiandrosterone, progesterone and testosterone using LC-MS/MS revealed effects of birth control pills/devices and body weight on ovulatory prediction
Han L, Wemm SE, Shen L, Spink DC, Wulfert E, Cao ZT. Noninvasive detection of human dehydroepiandrosterone, progesterone and testosterone using LC-MS/MS revealed effects of birth control pills/devices and body weight on ovulatory prediction. Journal Of Chromatography B 2021, 1174: 122716. PMID: 33946036, DOI: 10.1016/j.jchromb.2021.122716.Peer-Reviewed Original Research
2020
Moderation of Prazosin’s Efficacy by Alcohol Withdrawal Symptoms
Sinha R, Wemm S, Fogelman N, Milivojevic V, Morgan PM, Angarita GA, Hermes G, Fox HC. Moderation of Prazosin’s Efficacy by Alcohol Withdrawal Symptoms. American Journal Of Psychiatry 2020, 178: 447-458. PMID: 33207935, PMCID: PMC8119326, DOI: 10.1176/appi.ajp.2020.20050609.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-1 Receptor AntagonistsAdultAlcohol AbstinenceAlcoholismAnxietyCentral Nervous System DepressantsCounselingCravingDepressionDouble-Blind MethodEthanolFemaleHumansMaleMiddle AgedPrazosinProof of Concept StudySelf-Help GroupsSleep Wake DisordersSubstance Withdrawal SyndromeTreatment OutcomeConceptsAlcohol withdrawal symptomsHeavy drinking daysAlcohol use disorderDrinks/dayWithdrawal symptomsDrinking daysSecondary outcomesPrazosin efficacyAlcohol cravingSelf-reported drinking daysTreatment of AUDEfficacy of prazosinWithdrawal symptom scoresPoor treatment outcomesGlobal disease burdenCurrent alcohol dependencePrimary outcomeTreat analysisAlcohol use outcomesAlcohol intakeSymptom scoresWeek 12Prognostic indicatorDisease burdenSleep disturbancesAssociation of Prefrontal-Striatal Functional Pathology With Alcohol Abstinence Days at Treatment Initiation and Heavy Drinking After Treatment Initiation
Blaine SK, Wemm S, Fogelman N, Lacadie C, Seo D, Scheinost D, Sinha R. Association of Prefrontal-Striatal Functional Pathology With Alcohol Abstinence Days at Treatment Initiation and Heavy Drinking After Treatment Initiation. American Journal Of Psychiatry 2020, 177: 1048-1059. PMID: 32854534, PMCID: PMC7606814, DOI: 10.1176/appi.ajp.2020.19070703.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment initiationAlcohol abstinenceHeavy drinkingFunctional MRIEarly treatment outcomesEarly treatment phaseHealthy control subjectsEarly outpatient treatmentNumber of daysStress imagesDrinking outcomesChronic alcohol abuseHeavy drinking daysSignificant hyperreactivityControl subjectsOutpatient treatmentStriatal dysfunctionEarly treatmentTreatment outcomesBrain stressFunctional pathologyProspective assessmentTreatment phaseAlcohol abuse
2019
Fluctuations in progesterone moderate the relationship between daily mood and alcohol use in young adult women
Holzhauer CG, Wemm SE, Wulfert E, Cao ZT. Fluctuations in progesterone moderate the relationship between daily mood and alcohol use in young adult women. Addictive Behaviors 2019, 101: 106146. PMID: 31639640, PMCID: PMC6876695, DOI: 10.1016/j.addbeh.2019.106146.Peer-Reviewed Original ResearchConceptsLevels of progesteroneYoung adult womenAlcohol useMenstrual cycleProgesterone levelsAdult womenDaily ratingsMenstrual cycle phaseDaily moodWomen's alcohol useOdds of drinkingProtective effectHormonal fluctuationsSalivary samplesPremenstrual phaseProgesteroneLow moodMood changesWomenLinear mixed modelsStandard deviation increaseTwo-week periodWeeksDaily logsMoodA day-by-day prospective analysis of stress, craving and risk of next day alcohol intake during alcohol use disorder treatment
Wemm SE, Larkin C, Hermes G, Tennen H, Sinha R. A day-by-day prospective analysis of stress, craving and risk of next day alcohol intake during alcohol use disorder treatment. Drug And Alcohol Dependence 2019, 204: 107569. PMID: 31574406, PMCID: PMC6916671, DOI: 10.1016/j.drugalcdep.2019.107569.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlcohol intakeEarly treatmentAlcohol use disorder treatmentStressful eventsNovel treatment approachesAlcohol relapse riskUse disorder treatmentNext dayWeeks of outpatientStress-induced cravingAlcohol use outcomesRelapse riskProspective analysisUse disordersAUD patientsTreatment approachesDisorder treatmentHigher cravingDaily diariesUse outcomesIntakeAUD individualsCravingDrinking amountWeaker Memory Performance Exacerbates Stress-Induced Cannabis Craving in Youths’ Daily Lives
Miranda R, Wemm SE, Padovano H, Carpenter RW, Emery NN, Gray JC, Mereish EH. Weaker Memory Performance Exacerbates Stress-Induced Cannabis Craving in Youths’ Daily Lives. Clinical Psychological Science 2019, 7: 1094-1108. PMID: 31737439, PMCID: PMC6857838, DOI: 10.1177/2167702619841976.Peer-Reviewed Original ResearchCue exposureWeaker memory performanceDrug cue responseEcological momentary assessmentMemory performanceAddiction positCue responsesStressful momentsHigher cravingMomentary assessmentMomentary stressSubstance misuseWMYouthControl capacityReal-world settingDrug useCravingCuesMemoryAdolescentsPositStimuliCannabisAssociationDrug-induced stress responses and addiction risk and relapse
Wemm SE, Sinha R. Drug-induced stress responses and addiction risk and relapse. Neurobiology Of Stress 2019, 10: 100148. PMID: 30937354, PMCID: PMC6430516, DOI: 10.1016/j.ynstr.2019.100148.Peer-Reviewed Original ResearchDrug useDrug-induced stress responsesAddiction riskCo-occurring drug usePeripheral stress responsesAutonomic nervous system responsesNervous system responsesDrug use historyChronic drug useChronic drug usersAdrenal axisAcute effectsEvidence of alterationsDrug usersTonic levelsGlucocorticoid responseBinge/Prefrontal cortexDifferent drugsPsychoactive drugsDrug seekingDrugsStress responseRelapseHuman researchNoninvasive determination of human cortisol and dehydroepiandrosterone sulfate using liquid chromatography-tandem mass spectrometry
Cao Z, Wemm SE, Han L, Spink DC, Wulfert E. Noninvasive determination of human cortisol and dehydroepiandrosterone sulfate using liquid chromatography-tandem mass spectrometry. Analytical And Bioanalytical Chemistry 2019, 411: 1203-1210. PMID: 30612174, DOI: 10.1007/s00216-018-1549-x.Peer-Reviewed Original ResearchConceptsLC-MS/MS methodLiquid chromatography-tandem mass spectrometryChromatography-tandem mass spectrometryHuman salivaMeasurement of steroidsPsychoneuroendocrinological researchSalivary DHEADHEACortisolSalivary cortisolSaliva samplesNoninvasive meansCortisol assayYoung adultsSteroidsRegression analysisSalivaMS methodPassive droolNoninvasive determinationHuman cortisolCommon steroidsMales