2024
Substance use patterns, quantities, and associated risk factors in women with polysubstance misuse
Fogelman N, Tate M, Wemm S, Sullivan L, Hart R, Vacey E, Fox H, Sinha R. Substance use patterns, quantities, and associated risk factors in women with polysubstance misuse. Addiction Biology 2024, 29: 10.1111/adb.13390. PMID: 38619491, PMCID: PMC11017971, DOI: 10.1111/adb.13390.Peer-Reviewed Original ResearchConceptsPolysubstance useDepressive symptomsSubstance use patternsDrug cravingRisk factorsPatterns of polysubstance useSingle substance useAssociated with polysubstance usePlacebo-controlled studyHigher cravingGuanfacine treatmentCross-sectional observational studyPolysubstance use patternsCraving managementLife eventsCravingPolysubstance misuseSubstance useOpioid amountsPain ratingsStress/traumaObservational studyAnxietyPainPolysubstance
2023
Patients with AUD exhibit dampened heart rate variability during sleep as compared to social drinkers
Wemm S, Golden M, Martins J, Fogelman N, Sinha R. Patients with AUD exhibit dampened heart rate variability during sleep as compared to social drinkers. Alcohol And Alcoholism 2023, 58: 653-661. PMID: 37756494, PMCID: PMC10642609, DOI: 10.1093/alcalc/agad061.Peer-Reviewed Original ResearchConceptsAlcohol use disorderHeart rate variabilitySocial drinkersAUD groupChronic heavy alcohol useRate variabilityLife-threatening cardiovascular diseaseHRV measuresPatient-related symptomsPatient-reported symptomsHF/LF ratioSevere alcohol use disorderNervous system processesHeavy alcohol useParasympathetic dysfunctionCardiovascular diseaseHeart rate monitoringObservational studySleep difficultiesHeart rateParasympathetic activationUse disordersRSA amplitudeCardiovascular systemDays of monitoring
2022
Daily Stress Predicts Later Drinking Initiation via Craving in Heavier Social Drinkers: A Prospective In-Field Daily Diary Study
Wemm SE, Tennen H, Sinha R, Seo D. Daily Stress Predicts Later Drinking Initiation via Craving in Heavier Social Drinkers: A Prospective In-Field Daily Diary Study. Journal Of Psychopathology And Clinical Science 2022, 131: 780-792. PMID: 36048091, PMCID: PMC9561019, DOI: 10.1037/abn0000771.Peer-Reviewed Original Research
2021
Alcohol craving and withdrawal at treatment entry prospectively predict alcohol use outcomes during outpatient treatment
Martins JS, Fogelman N, Wemm S, Hwang S, Sinha R. Alcohol craving and withdrawal at treatment entry prospectively predict alcohol use outcomes during outpatient treatment. Drug And Alcohol Dependence 2021, 231: 109253. PMID: 34998258, PMCID: PMC8818273, DOI: 10.1016/j.drugalcdep.2021.109253.Peer-Reviewed Original ResearchConceptsAlcohol use outcomesAlcohol cravingTreatment entryDays/weekSleep difficultiesOutpatient treatmentAbstinence symptomsUse outcomesPre-treatment alcohol useEffects of cravingTreatment-seeking adultsAlcohol useAlcohol use disorder treatmentRelapse prevention counselingDrinking-related outcomesHeavy drinkingDrinking days/weekOutpatient AUD treatmentGreater alcoholChronic alcohol useDistress symptomsUse disorder treatmentAUD treatmentAverage drinksCravingAlcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder
Sinha R, Fogelman N, Wemm S, Angarita G, Seo D, Hermes G. Alcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder. Addiction Biology 2021, 27: e13116. PMID: 34856641, PMCID: PMC9872962, DOI: 10.1111/adb.13116.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexFunctional magnetic resonance imagingAlcohol use disorderAlcohol cuesHeavy drinking daysStudy 2Alcohol withdrawal symptomsNeutral visual imagesDrinking daysStudy 1 resultsUse disordersCortico-striatal dysfunctionAlcohol treatment outcomesAlcohol intakeFMRI sessionsResilient copingStriatal responsesPrefrontal cortexStudy 1Chronic alcohol useCorticostriatal dysfunctionStriatal functioningAUD patientsVisual imagesPlacebo treatmentNoninvasive detection of human dehydroepiandrosterone, progesterone and testosterone using LC-MS/MS revealed effects of birth control pills/devices and body weight on ovulatory prediction
Han L, Wemm SE, Shen L, Spink DC, Wulfert E, Cao ZT. Noninvasive detection of human dehydroepiandrosterone, progesterone and testosterone using LC-MS/MS revealed effects of birth control pills/devices and body weight on ovulatory prediction. Journal Of Chromatography B 2021, 1174: 122716. PMID: 33946036, DOI: 10.1016/j.jchromb.2021.122716.Peer-Reviewed Original Research
2020
Moderation of Prazosin’s Efficacy by Alcohol Withdrawal Symptoms
Sinha R, Wemm S, Fogelman N, Milivojevic V, Morgan PM, Angarita GA, Hermes G, Fox HC. Moderation of Prazosin’s Efficacy by Alcohol Withdrawal Symptoms. American Journal Of Psychiatry 2020, 178: 447-458. PMID: 33207935, PMCID: PMC8119326, DOI: 10.1176/appi.ajp.2020.20050609.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-1 Receptor AntagonistsAdultAlcohol AbstinenceAlcoholismAnxietyCentral Nervous System DepressantsCounselingCravingDepressionDouble-Blind MethodEthanolFemaleHumansMaleMiddle AgedPrazosinProof of Concept StudySelf-Help GroupsSleep Wake DisordersSubstance Withdrawal SyndromeTreatment OutcomeConceptsAlcohol withdrawal symptomsHeavy drinking daysAlcohol use disorderDrinks/dayWithdrawal symptomsDrinking daysSecondary outcomesPrazosin efficacyAlcohol cravingSelf-reported drinking daysTreatment of AUDEfficacy of prazosinWithdrawal symptom scoresPoor treatment outcomesGlobal disease burdenCurrent alcohol dependencePrimary outcomeTreat analysisAlcohol use outcomesAlcohol intakeSymptom scoresWeek 12Prognostic indicatorDisease burdenSleep disturbancesAssociation of Prefrontal-Striatal Functional Pathology With Alcohol Abstinence Days at Treatment Initiation and Heavy Drinking After Treatment Initiation
Blaine SK, Wemm S, Fogelman N, Lacadie C, Seo D, Scheinost D, Sinha R. Association of Prefrontal-Striatal Functional Pathology With Alcohol Abstinence Days at Treatment Initiation and Heavy Drinking After Treatment Initiation. American Journal Of Psychiatry 2020, 177: 1048-1059. PMID: 32854534, PMCID: PMC7606814, DOI: 10.1176/appi.ajp.2020.19070703.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment initiationAlcohol abstinenceHeavy drinkingFunctional MRIEarly treatment outcomesEarly treatment phaseHealthy control subjectsEarly outpatient treatmentNumber of daysStress imagesDrinking outcomesChronic alcohol abuseHeavy drinking daysSignificant hyperreactivityControl subjectsOutpatient treatmentStriatal dysfunctionEarly treatmentTreatment outcomesBrain stressFunctional pathologyProspective assessmentTreatment phaseAlcohol abuse
2019
Fluctuations in progesterone moderate the relationship between daily mood and alcohol use in young adult women
Holzhauer CG, Wemm SE, Wulfert E, Cao ZT. Fluctuations in progesterone moderate the relationship between daily mood and alcohol use in young adult women. Addictive Behaviors 2019, 101: 106146. PMID: 31639640, PMCID: PMC6876695, DOI: 10.1016/j.addbeh.2019.106146.Peer-Reviewed Original ResearchConceptsLevels of progesteroneYoung adult womenAlcohol useMenstrual cycleProgesterone levelsAdult womenDaily ratingsMenstrual cycle phaseDaily moodWomen's alcohol useOdds of drinkingProtective effectHormonal fluctuationsSalivary samplesPremenstrual phaseProgesteroneLow moodMood changesWomenLinear mixed modelsStandard deviation increaseTwo-week periodWeeksDaily logsMoodA day-by-day prospective analysis of stress, craving and risk of next day alcohol intake during alcohol use disorder treatment
Wemm SE, Larkin C, Hermes G, Tennen H, Sinha R. A day-by-day prospective analysis of stress, craving and risk of next day alcohol intake during alcohol use disorder treatment. Drug And Alcohol Dependence 2019, 204: 107569. PMID: 31574406, PMCID: PMC6916671, DOI: 10.1016/j.drugalcdep.2019.107569.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlcohol intakeEarly treatmentAlcohol use disorder treatmentStressful eventsNovel treatment approachesAlcohol relapse riskUse disorder treatmentNext dayWeeks of outpatientStress-induced cravingAlcohol use outcomesRelapse riskProspective analysisUse disordersAUD patientsTreatment approachesDisorder treatmentHigher cravingDaily diariesUse outcomesIntakeAUD individualsCravingDrinking amountNoninvasive determination of human cortisol and dehydroepiandrosterone sulfate using liquid chromatography-tandem mass spectrometry
Cao Z, Wemm SE, Han L, Spink DC, Wulfert E. Noninvasive determination of human cortisol and dehydroepiandrosterone sulfate using liquid chromatography-tandem mass spectrometry. Analytical And Bioanalytical Chemistry 2019, 411: 1203-1210. PMID: 30612174, DOI: 10.1007/s00216-018-1549-x.Peer-Reviewed Original ResearchConceptsLC-MS/MS methodLiquid chromatography-tandem mass spectrometryChromatography-tandem mass spectrometryHuman salivaMeasurement of steroidsPsychoneuroendocrinological researchSalivary DHEADHEACortisolSalivary cortisolSaliva samplesNoninvasive meansCortisol assayYoung adultsSteroidsRegression analysisSalivaMS methodPassive droolNoninvasive determinationHuman cortisolCommon steroidsMales
2018
Stress responding and stress‐related changes in cue reactivity in heavy smokers, problem gamblers, and healthy controls
Wemm SE, Cao Z, Han L, Wulfert E. Stress responding and stress‐related changes in cue reactivity in heavy smokers, problem gamblers, and healthy controls. Addiction Biology 2018, 25: e12687. PMID: 30421575, PMCID: PMC6513727, DOI: 10.1111/adb.12687.Peer-Reviewed Original ResearchConceptsHealthy controlsBlunted cortisol responseMaladaptive stress responsesHigher subjective stressCue-related cravingHeavy smokersStress-related changesControl group responsesSmokersCortisol responseCortisol levelsSubjective stress responsesPsychosocial stressorsSalivary cortisolAcute stressorCue reactivityBehavioral addictionsCravingSubjective cravingSmokingSubstance addictionSubjective responsesCortisolStress responseSubjective stressAppetitive startle modulation in the human laboratory predicts Cannabis craving in the natural environment
Mereish EH, Padovano HT, Wemm S, Miranda R. Appetitive startle modulation in the human laboratory predicts Cannabis craving in the natural environment. Psychopharmacology 2018, 235: 1933-1943. PMID: 29623354, PMCID: PMC6015780, DOI: 10.1007/s00213-018-4890-z.Peer-Reviewed Original ResearchConceptsCue-elicited cravingStartle reactivityEcological momentary assessment protocolHuman laboratoryCannabis-related stimuliCannabis-related cuesFrequent cannabis usersCross-level interactionsCannabis cuesResultsMultilevel modelsDrug cuesMotivational processesResponse patternsMotivational systemsPicture cuesPleasant stimuliStartle modulationCannabis usersCannabis useCuesStartle magnitudeCravingReal-world environmentsAge 16Startle reflexPredictors of Topiramate Tolerability in Heavy Cannabis–Using Adolescents and Young Adults
Gray JC, Padovano H, Wemm SE, Miranda R. Predictors of Topiramate Tolerability in Heavy Cannabis–Using Adolescents and Young Adults. Journal Of Clinical Psychopharmacology 2018, 38: 134-137. PMID: 29424802, PMCID: PMC5825284, DOI: 10.1097/jcp.0000000000000843.Peer-Reviewed Original ResearchConceptsMemory difficultiesCannabis misuseYoung adultsPsychosocial treatment optionsSubstance use disordersPsychosocial interventionsCannabis problemsHeavy cannabisTreatment dropoutOverwhelming predictorPositive outcomesUse disordersEffective interventionsAdolescentsSide effectsMedication conditionRandomized placebo-controlled trialInteraction effectsSubstance abuse treatment admissionsTreatment admissionsPlacebo-controlled trialSecondary data analysisRecent clinical trialsIllicit drugsAdultsReal-time assessment of alcohol craving and naltrexone treatment responsiveness in a randomized clinical trial
Miranda R, Treloar Padovano H, Gray JC, Wemm SE, Blanchard A. Real-time assessment of alcohol craving and naltrexone treatment responsiveness in a randomized clinical trial. Addictive Behaviors 2018, 83: 72-78. PMID: 29395188, PMCID: PMC5964002, DOI: 10.1016/j.addbeh.2018.01.009.Peer-Reviewed Original Research
2017
Distress Tolerance and Physiological Reactivity to Stress Predict Women’s Problematic Alcohol Use
Holzhauer CG, Wemm S, Wulfert E. Distress Tolerance and Physiological Reactivity to Stress Predict Women’s Problematic Alcohol Use. Experimental And Clinical Psychopharmacology 2017, 25: 156-165. PMID: 28437123, DOI: 10.1037/pha0000116.Peer-Reviewed Original ResearchConceptsBehavioral distress toleranceDistress tolerancePhysiological reactivityStress reactivityAlcohol misuseNegative alcohol-related consequencesPhysiological stress reactivityAlcohol-related consequencesLow stress reactivityDrinking-related negative consequencesLower physiological reactivityWomen's alcohol misuseGreater urgeNonclinical sampleStressful taskYoung adult womenMeasures of reactivityCollege womenSubjective levelPrior findingsInteractive associationsAlcohol useNegative consequencesCurrent studyAdult womenEffects of Acute Stress on Decision Making
Wemm SE, Wulfert E. Effects of Acute Stress on Decision Making. Applied Psychophysiology And Biofeedback 2017, 42: 1-12. PMID: 28083720, PMCID: PMC5346059, DOI: 10.1007/s10484-016-9347-8.Peer-Reviewed Original ResearchConceptsHeart rateHigher heart rateSocial stressorsAcute stressSubstance useExploratory correlational analysesExploratory regression analysisMen’s higher levelsSkin conductance responsesRegression analysisIowa Gambling TaskStress respondingWomenControl conditionSkin conductancePhysiological reactivityConductance responsesFemale college studentsLow levelsGambling TaskParticipantsHigh levelsStressors
2013
Problematic drinking and physiological responses among female college students
Wemm S, Fanean A, Baker A, Blough ER, Mewaldt S, Bardi M. Problematic drinking and physiological responses among female college students. Alcohol 2013, 47: 149-157. PMID: 23333036, DOI: 10.1016/j.alcohol.2012.12.006.Peer-Reviewed Original ResearchConceptsProblematic drinkingLow DHEAS levelsImpaired physiological responseExcessive alcohol useCollege studentsHigher cortisol levelsHigh basal levelsMajority of participantsDHEAS levelsSalivary levelsBinge drinkingAdrenal activityCardiovascular measurementsAlcohol-related consequencesCortisol levelsBehavioral stress responsesAlcohol dependenceSelf-reported consequencesSelf-reported drinkingSaliva samplesAlcohol useBasal levelsFemale college studentsDistress tolerancePhysiological responses
2010
The role of DHEA in relation to problem solving and academic performance
Wemm S, Koone T, Blough ER, Mewaldt S, Bardi M. The role of DHEA in relation to problem solving and academic performance. Biological Psychology 2010, 85: 53-61. PMID: 20562010, DOI: 10.1016/j.biopsycho.2010.05.003.Peer-Reviewed Original ResearchConceptsGrade point averageAmerican College Testing (ACT) scoresCurrent grade point averageSets of anagramsTask demandsBehavioral tasksBehavioral flexibilityAcademic achievementMood disturbanceAcademic performanceProblem solvingCollege studentsPhysiological neuroprotectionPoint averageBehavioral responsesTaskTesting scoresCollege coursesParticipantsIndividualsAnagramsSame individualAnxietyChallenging taskHigh levels